Reactive hypoglycemia—An interdisciplinary approach of the disease of XXI Century
Open accessAbstract
Reactive hypoglycemia is characterized by low blood glucose level in non-diabetic patients. It manifests as a syndrome of adrenergic and neuroglycopenic symptoms in the postprandial period, and their resolution occurs after consuming carbohydrates. The etiology of reactive hypoglycemia is not fully understood. It may occur in patients after gastrointestinal surgery due to too fast gastric emptying. Decreases in postprandial glucose are also observed in people with a pre-diabetes condition in which insulin secretion is disturbed. Hypoglycaemia can also be seen in patients with insulin resistance and hyperinsulinism. The aim of this study was to summarize existing knowledge about reactive hypoglycemia – etiology, diagnostic model and treatment.
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RH may serve as a marker of impaired glucose regulation and heightened risk for developing type 2 diabetes.
“In such cases, RH may serve as a marker of impaired glucose regulation and heightened risk for developing type 2 diabetes (T2D) [4,5].”
From Defining and Characterizing Postprandial Reactive Hypoglycemia (2026) · cites this paper as [5]
A passage labeled Abstract (page unavailable) says late reactive hypoglycemia may occur with prediabetes, including impaired fasting glucose or glucose tolerance. It also says reactive hypoglycemia can occur in an early phase of type 2 diabetes. These passages support a possible link to impaired glucose regulation, but they do not establish that reactive hypoglycemia predicts a heightened risk of developing type 2 diabetes. (LLM, conf=0.83)
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Cryer, P. E., Axelrod, L., Grossman, A. B., Heller, S. R., Montori, V. M., Seaquist, E. R., & Service, F. J. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1410 · Cited by 1,277 · cited 2× · see citing works
“Schorzenia, takie jak: nadczynność tarczycy, niedoczynność kory nadnerczy czy też alkoholizm mogą powodować hipoglikemię na czczo, jak również po posiłkach [9] zatem w toku diagnostyki należy przeprowadzić badania, które pozwolą na ich wykluczenie.”
BackgroundGlucagon-like peptide 1 in health and disease
Andersen, A., Lund, A., Knop, F. K., & Vilsbøll, T. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0016-2 · Cited by 543 · see citing works
Natali, A., & Ferrannini, E. (2006) · Diabetologia · doi:10.1007/s00125-006-0141-7 · Cited by 377 · see citing works
Low-glycemic index diets as an intervention for diabetes: a systematic review and meta-analysis
Zafar, M. I., Mills, K. E., Zheng, J., Regmi, A., Hu, S. Q., Gou, L., & Chen, L.-L. (2019) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz149 · Cited by 245 · see citing works
Impact of cereal fibre on glucose-regulating factors
Weickert, M. O., Mohlig, M., Koebnick, C., Holst, J. J., Namsolleck, P., Ristow, M., Osterhoff, M., Rochlitz, H., Rudovich, N., Spranger, J., et al. (2005) · Diabetologia · doi:10.1007/s00125-005-1941-x · Cited by 194 · see citing works
Solomon, T. P., Haus, J. M., Kelly, K. R., Cook, M. D., Filion, J., Rocco, M., Kashyap, S. R., Watanabe, R. M., Barkoukis, H., & Kirwan, J. P. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29771 · Cited by 165 · see citing works
Berlin, I., Grimaldi, A., Landault, C., Cesselin, F., & Puech, A. J. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.5.7962339 · Cited by 34 · see citing works
Flagged first, then by citations
Research works printed but not linked: 44
- Kandaswamy L, Raghavan R, Pappachan JM. Spontaneous hypoglycemia: diagnostic evaluation and management. Endocrine. 2016;53(1):47-57.
- Wilson V. Non-diabetic hypoglycaemia: causes and pathophysiology. Nurs Stand, 2011;25(46):35-9.
- Augustin LS, Kendall CW, Jenkins DJ et al. Glycemic index, glycemic load and glycemic response: An International Scientific Consensus Summit from the International Carbohydrate Quality Consortium (ICQC). Nutr Metab Cardiovasc Dis. 2015;25(9):795-815.
- Hirose S, Iwahashi Y, Seo A et al. Concurrent Therapy with a Low- carbohydrate Diet and Miglitol Remarkably Improved the Postprandial Blood Glucose and Insulin Levels in a Patient with Reactive Hypoglycemia due to Late Dumping Syndrome. Intern Med. 2016;55(9):1137-1142.
- Hofeldt FD. Reactive hypoglycemia. Endocrinol Metab Clin North Am. 1989;18(1):185-201.
- Leonetti F, Morviducci L, Giaccari A et al, Idiopathic reactive hypoglycemia: a role for glucagon? J Endocrinol Invest. 1992;15(4):273-278.
- Galati SJ, Rayfield EJ. Approach to the patient with postprandial hypoglycemia. Endocr Pract. 2014;20(4):331-340.
- Cryer PE, Binder C, Bolli GB et al. Hypoglycemia in IDDM. Diabetes 1989;38(9):1193-1199.
- Mongraw-Chaffin M, Beavers DP, McClain DA. Hypoglycemic symptoms in the absence of diabetes: Pilot evidence of clinical hypoglycemia in young women. J Clin Transl Endocrinol. 2019;18:100202.
- Middleton SJ, Balan K. Idiopathic accelerated gastric emptying presenting in adults with post-prandial diarrhea and reactive hypoglycemia: a case series. J Med Case Rep. 2012;6:132.
- Luyckx AS, Lefebvre PJ, Plasma insulin in reactive hypoglycemia. Diabetes. 1971;20(6):435-442.
- Laurenius A, Hedberg S, Olbers T. Possible relation between partial small bowel obstruction and severe postprandial reactive hypoglycemia after Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2019;15(6):1024-1028.
- Capristo E, Panunzi S, De Gaetano A et al. Incidence of Hypoglycemia After Gastric Bypass vs Sleeve Gastrectomy: A Randomized Trial. J Clin Endocrinol Metab. 2018;103(6):2136-2146.
- Mayans L. Metabolic Syndrome: Insulin Resistance and Prediabetes. FP Essent. 2015;435:11-6.
- Palardy J. Blood glucose measurements during symptomatic episodes in patients with suspected postprandial hypoglycemia. N Engl J Med. 1989;321(21):1421-1425.
- Açbay O, Celik AF, Kadioğlu P et al. Helicobacter pylori-induced gastritis may contribute to occurrence of postprandial symptomatic hypoglycemia. Dig Dis Sci. 1999; 44(9):1837-1842.
- Snorgaard O, Binder C. Monitoring of blood glucose concentration in subjects with hypoglycaemic symptoms during everyday life. BMJ. 1990;300(6716):16-8.
- Miki T et al. ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis. Nat Neurosci. 2001;4(5):507-12.
- Bednářová A, Kodrík D, Krishnan N. Unique roles of glucagon and glucagon-like peptides: Parallels in understanding the functions of adipokinetic hormones in stress responses in insects. Comp Biochem Physiol A Mol Integr Physiol. 2013;164(1):91-100.
- Meier JJ, Nauck MA. The potential role of glucagon-like peptide 1 in diabetes. Curr Opin Investig Drugs. 2004;5(4):402-10.
- Kreymann B, Williams G, Ghatei MA et al. Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet. 1987;2(8571):1300-1304.
- Tamburrano G. Increased insulin sensitivity in patients with idiopathic reactive hypoglycemia. J Clin Endocrinol Metab. 1989;69(4):885-890.
- Cersosimo E, Miles JM. Hormonal, Metabolic and Hemodynamic Adaptations to Glycosuria in Type 2 Diabetes Patients Treated with Sodium-Glucose Co-Transporter Inhibitors. Curr Diabetes Rev. 2019;15(4):314-327.
- Barry JA, Bouloux P, Hardiman PJ. The impact of eating behavior on psychological symptoms typical of reactive hypoglycemia. A pilot study comparing women with polycystic ovary syndrome to controls. Appetite. 2011;57(1):73-76.
- Leichter SB. Alimentary hypoglycemia: a new appraisal. Am J Clin Nutr. 1979;32(10):2104-2114.
- Goodpaster BH, Kelley DE, Wing RR et al. Effects of weight loss on regional fat distribution and insulin sensitivity in obesity. Diabetes. 1999;48(4):839-847.
- Delibas IB, Tanriverdi S, Cakmak B, Does reactive hypoglycemia during the 100 g oral glucose tolerance test adversely affect perinatal outcomes? Ginekol Pol. 2018;89(1):25-29.
- Pupo A. Reactive hypoglycemia: a clinical rarity. AMB Rev Assoc Med Bras. 1987;33(3-4):71-73.
- Anderson JW, Herman RH, Treatment of reactive hypoglycemia with sulfonylureas. Am J Med Sci. 1971;261(1):16-23.
- Fariss BL. Prevalence of post-glucose-load glycosuria and hypoglycemia in a group of healthy young men. Diabetes. 1974;23(3):189-191.
- Meier JJ, Baller B, Menge BA et al. Excess glycaemic excursions after an oral glucose tolerance test compared with a mixed meal challenge and self- measured home glucose profiles: is the OGTT a valid predictor of postprandial hyperglycaemia and vice versa? Diabetes Obes Metab. 2009;11(3):213-222.
- Hogan MJ, Service FJ, Sharbrough FW et al. Oral glucose tolerance test compared with a mixed meal in the diagnosis of reactive hypoglycemia. A caveat on stimulation. Mayo Clin Proc. 1983;58(8):491-496.
- Traub ML, Jain A, Maslow BS et al. The "muffin test"--an alternative to the oral glucose tolerance test for detecting impaired glucose tolerance. Menopause. 2012;19(1):62-66.
- Davi MV, Pia A, Guarnotta V et al. The treatment of hyperinsulinemic hypoglycaemia in adults: an update. J Endocrinol Invest. 2017;40(1):9-20.
- Soh AW, Kek PC, Insulinoma in a patient with normal results from prolonged fast and glucagon-induced hypoglycemia. Endocr Pract. 2010;16(5):838-841.
- LaLonde CD, Van Lieshout RJ. Treating generalized anxiety disorder with second generation antipsychotics: a systematic review and meta- analysis. J Clin Psychopharmacol. 2011;31(3):326-333.
- An J, Yoon SR1, Lee JH et al. Importance of Adherence to Personalized Diet Intervention in Obesity Related Metabolic Improvement in Overweight and Obese Korean Adults. Clin Nutr Res. 2019;8(3):171-183.
- Gaesser GA. Carbohydrate quantity and quality in relation to body mass index. J Am Diet Assoc. 2007;107(10):1768-1780.
- Myette-Côté É, Durrer C1, Neudorf H et al. The effect of a short-term low-carbohydrate, high-fat diet with or without postmeal walks on glycemic control and inflammation in type 2 diabetes: a randomized trial. Am J Physiol Regul Integr Comp Physiol. 2018; 315(6):1210-1219.
- Rao TS, Asha MR, Ramesh BN et al. Understanding nutrition, depression and mental illnesses. Indian J Psychiatry. 2008;50(2):77-82.
- Astrup A, Geiker NR, Efficacy of higher protein diets for long-term weight control. How to assess quality of randomized controlled trials? Nutr Metab Cardiovasc Dis. 2014;24(3):220-223.
- Lee A. Preventive treatment with acarbose in diabetic reactive hypoglycemia. J Am Med Dir Assoc. 2010;11(5):377-8.
- Hostalek U, Gwilt M, Hildemann S. Therapeutic Use of Metformin in Prediabetes and Diabetes Prevention. Drugs. 2015;75(10):1071-1094.
- Hidayat K, Du X, Wu MJ, Shi BM. The use of metformin, insulin, sulphonylureas, and thiazolidinediones and the risk of fracture: Systematic review and meta-analysis of observational studies. Obes Rev. 2019;20(10):1494-1503.
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Nutritional guidelines for the management of insulin resistance
Muscogiuri, G., Barrea, L., Caprio, M., Ceriani, F., Chavez, A. O., El Ghoch, M., Frias-Toral, E., Mehta, R. J., Mendez, V., Paschou, S. A., et al. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1908223 · Cited by 63 · see citing works
Defining and Characterizing Postprandial Reactive Hypoglycemia
Sweatt, S. K., Thomas, D. M., LaPorte, G. J., Chauff, S., Stefanovski, D., & Gower, B. A. (2026) · Nutrients · doi:10.3390/nu18050822 · Cited by 2 · see citing works
- Authors
- Hall, M., Walicka, M., & Traczyk, I.
- Affiliations
- Medical University of Warsaw (PL)
- Klinika Chorób Wewnętrznych, Endokrynologii i Diabetologii CSK MSWiA w Warszawie, Warszawa, Polska
- Corresponding author
- Hall, Marianna
- Venue
- Wiadomości Lekarskie
- Publisher
- ALUNA
- Published
- 2020
- Volume
- 73
- Issue
- 2
- Pages
- 384-389
- ISSN
- 0043-5147 (ISSN-L)
- OpenAlex
- W3027585405
- Cited by
- 6
- References
- 7
- Citations by year
- 2026: 2 · 2022: 2 · 2021: 1 · 2020: 1
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Wiadomości Lekarskie (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Neurological and metabolic disorders
- Keywords
- reactive hypoglycemia, postprandial hypoglycemia, adrenergic symptoms, neuroglycopenic symptoms, gastric emptying, gastrointestinal surgery, prediabetes, insulin secretion, insulin resistance, hyperinsulinism, etiology, diagnosis, treatment
- MeSH terms
- Blood Glucose, Humans, Hyperinsulinism, Hypoglycemia, Insulin, Insulin Resistance, Postprandial Period
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