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Cited by 194Food composition and propertiesNatural Antidiabetic Agents StudiesDiabetes Treatment and Management

Impact of cereal fibre on glucose-regulating factors

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Weickert, M. O., Mohlig, M., Koebnick, C., Holst, J. J., Namsolleck, P., Ristow, M., Osterhoff, M., Rochlitz, H. +3 more·2005·Diabetologia
DOI 10.1007/s00125-005-1941-x
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Abstract

Aims/hypothesis Insoluble dietary fibre intake is associated, by unknown mechanisms, with a reduced risk of type 2 diabetes. We investigated whether a short-term dietary intervention with purified insoluble fibres influences acute and delayed responses of glucose, insulin, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1.Methods Fourteen healthy women with NGT were studied for 300 min on six to eight occasions. Subjects consumed three matched portions of control (C) or fibre-enriched bread (10.4-10.6 g/portion; wheat fibre [WF], oat fibre [OF], and, in a substudy [n=9], resistant starch [RS]) followed by control (C-C, C-WF, C-OF, C-RS) on subsequent days.Results Fibre enrichment accelerated the early insulin response (fibrextime interaction p=0.026 for WF, p<0.001 for OF, p=0.126 for RS; time of maximal concentration [T(max)], C 57.9+/-5.9, WF 49.3+/-2.5 [p=0.086], OF 46.1+/-2.9 [p=0.026], RS 46.7+/-5.8 min [p=0.029]). It was also associated with an earlier postprandial GIP response after OF (T(max), C 83.6+/-7.2, WF 70.7+/-6.0 [p=0.054], OF 64.3+/-6.9 [p=0.022], RS 60.0+/-5.0 [p>0.15]). Increased fibre intake for 24 h was further associated with a reduced postprandial glucose response on the following day subsequent to ingestion of a control meal (AUC(C-C) 4,140+/-401, AUC(C-WF) 2,850+/-331 [p=0.007], AUC(C-OF) 2,830+/-277 [p=0.011]), with no difference in maximal concentration and T(max) of glucose responses. No differences in insulin responses were observed 24 h after the fibre-enriched diets compared with control (p>0.15). Colonic fermentation was increased only on study days C-OF (p=0.017) and C-RS (p=0.016).Conclusions/interpretation The consumption of highly purified insoluble dietary fibres accelerated the acute GIP and insulin response and was further associated with enhanced postprandial carbohydrate handling the following day upon ingestion of a control meal.

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  • There is much evidence in the literature to support an association between dietary fibre intake and insulin sensitivity.

    “There is much evidence in the literature to support an association between dietary fibre intake and insulin sensitivity [30,31,32,33,34,35].”

    From The Health Benefits of Dietary Fibre (2020) · cites this paper as [30]

    The Discussion (page unavailable) reports a prior study finding improved peripheral insulin sensitivity after a high-fibre diet, which supports an association. But this paper did not measure insulin sensitivity in its own participants; it presents that mechanism as one possible explanation for improved glucose handling, so it does not by itself establish the claim's breadth of evidence. (LLM, conf=0.82)

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Authors
Weickert, M. O., Mohlig, M., Koebnick, C., Holst, J. J., Namsolleck, P., Ristow, M., Osterhoff, M., Rochlitz, H., Rudovich, N., Spranger, J., & Pfeiffer, A. F. H.
Affiliations
  • German Institute of Human Nutrition (DE)
  • University of Copenhagen (DK)
Corresponding author
Weickert, M. O.
ORCID
Venue
Diabetologia
Publisher
Springer Science and Business Media LLC
Published
2005-09-20
Volume
48
Issue
11
Pages
2343-2353
ISSN
  • 0012-186X (ISSN-L)
  • 1432-0428
DOI
10.1007/s00125-005-1941-x
OpenAlex
W2072769007
Semantic Scholar
b10feda04b4d8ed4862c51ab6b94b48bd97681f1
Cited by
194
References
54
Citations by year
2026: 2 · 2025: 1 · 2024: 7 · 2023: 10 · 2022: 12 · 2021: 10 · 2020: 9 · 2019: 11 · 2018: 6 · 2017: 9 · 2016: 9 · 2015: 6 · 2014: 7 · 2013: 9 · 2012: 19
FWCI
7.92
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Diabetologia (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
insoluble dietary fiber, cereal fiber, type 2 diabetes prevention, glycemic response, insulin response, glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1, wheat fiber, oat fiber, resistant starch, colonic fermentation, postprandial blood glucose, healthy women, gastrointestinal hormones, dietary intervention
MeSH terms
Adult, Blood Glucose, Bread, Edible Grain, Colon, Dietary Fiber, Gastric Inhibitory Polypeptide, Glucose, Humans, Hydrogen, Insulin, Random Allocation, Starch, Cross-Over Studies, Area Under Curve, Glucagon-Like Peptide 1

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