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Cited by 366

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Autologous Bone Marrow Stromal Cell Transplantation for Repair of Full-Thickness Articular Cartilage Defects in Human Patellae: Two Case Reports

Open access
Wakitani, Shigeyuki, Mitsuoka, Tomoki, Nakamura, Norimasa, Toritsuka, Yukiyoshi, Nakamura, Yukio, Horibe, Shuji·2004·Cell Transplantation
DOI 10.3727/000000004783983747
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Abstract

This study assessed the effectiveness of autologous bone marrow stromal cell transplantation for the repair of full-thickness articular cartilage defects in the patellae of a 26-year-old female and a 44-year-old male. These two patients presented in our clinic because their knee pain prevented them from walking normally. After thorough examination, we concluded that the knee pain was due to the injured articular cartilage and decided to repair the defect with bone marrow stromal cell transplantation. Three weeks before transplantation, bone marrow was aspirated from the iliac crest of each patient. After erythrocytes had been removed by use of dextran, the remaining nucleated cells were placed in culture. When the attached cells reached subconfluence, they were passaged to expand in culture. Adherent cells were subsequently collected, embedded in a collagen gel, transplanted into the articular cartilage defect in the patellae, and covered with autologous periosteum. Six months after transplantation, clinical symptoms (pain and walking ability) had improved significantly and the improvement has remained in effect (5 years and 9 months posttransplantation in one case, and 4 years in the other), and both patients have been satisfied with the outcome. As early as 2 months after transplantation, the defects were covered with tissue that showed slight metachromatic staining. Two years after the first and 1 year after the second transplantation, arthroscopy was performed and the defects were repaired with fibrocartilage. Results indicate autologous bone marrow stromal cell transplantation is an effective approach in promoting the repair of articular cartilage defects.

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Metadata

Authors
Wakitani, S., Mitsuoka, T., Nakamura, N., Toritsuka, Y., Nakamura, Y., & Horibe, S.
Venue
Cell Transplantation
Publisher
SAGE Publications
Published
2004-07
Volume
13
Issue
5
Pages
595-600
ISSN
  • 0963-6897 (ISSN-L)
  • 1555-3892
DOI
10.3727/000000004783983747
OpenAlex
W1990226086
Cited by
366
References
13
FWCI
4.41
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Autologous Bone Marrow Stromal Cell Transplantation for Repair of Full-Thickness Articular Cartilage Defects in Human Patellae: Two Case Reports. https://app.cochat.ai/papers/10.3727/000000004783983747
The paper
Wakitani, S., Mitsuoka, T., Nakamura, N., Toritsuka, Y., Nakamura, Y., & Horibe, S. (2004). Autologous Bone Marrow Stromal Cell Transplantation for Repair of Full-Thickness Articular Cartilage Defects in Human Patellae: Two Case Reports. Cell Transplantation. https://doi.org/10.3727/000000004783983747

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.