The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.
Anticancer Mechanisms of Cannabinoids
Open accessAbstract
In addition to the well-known palliative effects of cannabinoids on some cancer-associated symptoms, a large body of evidence shows that these molecules can decrease tumour growth in animal models of cancer. They do so by modulating key cell signalling pathways involved in the control of cancer cell proliferation and survival. In addition, cannabinoids inhibit angiogenesis and decrease metastasis in various tumour types in laboratory animals. In this review, we discuss the current understanding of cannabinoids as antitumour agents, focusing on recent discoveries about their molecular mechanisms of action, including resistance mechanisms and opportunities for their use in combination therapy. Those observations have already contributed to the foundation for the development of the first clinical studies that will analyze the safety and potential clinical benefit of cannabinoids as anticancer agents.
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Cites
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Cited by
The Endocannabinoid System: A Potential Target for the Treatment of Various Diseases
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Metadata
- Authors
- Velasco, G., Sánchez, C., & Guzmán, M.
- Venue
- Current Oncology
- Publisher
- MDPI AG
- Published
- 2016-03-01
- Volume
- 23
- Issue
- 11
- Pages
- 23-32
- ISSN
- 1198-0052 (ISSN-L)
- 1718-7729
- OpenAlex
- W2305988154
- Cited by
- 265
- References
- 95
- FWCI
- 16.34
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
