The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Nonalcoholic fatty liver disease and mitochondrial dysfunction
Open accessAbstract
Nonalcoholic fatty liver disease (NAFLD) includes hepatic steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. NAFLD is the most common liver disorder in the United States and worldwide. Due to the rapid rise of the metabolic syndrome, the prevalence of NAFLD has recently dramatically increased and will continue to increase. NAFLD has also the potential to progress to hepatocellular carcinoma (HCC) or liver failure. NAFLD is strongly linked to caloric overconsumption, physical inactivity, insulin resistance and genetic factors. Although significant progress in understanding the pathogenesis of NAFLD has been achieved in years, the primary metabolic abnormalities leading to lipid accumulation within hepatocytes has remained poorly understood. Mitochondria are critical metabolic organelles serving as "cellular power plants". Accumulating evidence indicate that hepatic mitochondrial dysfunction is crucial to the pathogenesis of NAFLD. This review is focused on the significant role of mitochondria in the development of NAFLD.
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BackgroundMolecular mediators of hepatic steatosis and liver injury
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Cited by
Sunny, N. E., Parks, E. J., Browning, J. D., & Burgess, S. C. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.11.004 · Cited by 672
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miR-33 deletion in hepatocytes attenuates MASLD-MASH-HCC progression
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Chen, K. L. A., Zhao, Y. C., Hieronymi, K., Smith, B. P., & Madak-Erdogan, Z. (2017) · PLOS ONE · doi:10.1371/journal.pone.0189911 · Cited by 19
Metadata
- Authors
- Wei, Y., Rector, R. S., Thyfault, J. P., & Ibdah, J. A.
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2008
- Volume
- 14
- Issue
- 2
- Pages
- 193
- ISSN
- 1007-9327 (ISSN-L)
- OpenAlex
- W1979283297
- Cited by
- 369
- References
- 23
- FWCI
- 12.92
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
