The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Mechanisms of heme iron absorption: Current questions and controversies
Open accessAbstract
Iron is a critical micronutrient, and iron derived from heme contributes a large proportion of the total iron absorbed in a typical Western diet. Heme iron is absorbed by different mechanisms than non-heme iron, but despite considerable study over many years these mechanisms remain poorly understood. This review provides an overview of the importance of heme iron in the diet and discusses the two prevailing hypotheses of heme absorption; namely receptor mediated endocytosis of heme, and direct transport into the intestinal enterocyte by recently discovered heme transporters. A specific emphasis is placed on the questions surrounding the site of heme catabolism and the identity of the enzyme that performs this task. Additionally, we present the hypothesis that a non-heme iron transport protein may be required for heme iron absorption and discuss the experiences of our laboratory in examining this hypothesis.
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Cites
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Cited by
Mechanisms of mammalian iron homeostasis
Pantopoulos, K., Porwal, S. K., Tartakoff, A., & Devireddy, L. (2012) · Biochemistry · doi:10.1021/bi300752r · Cited by 598
Regulation of iron transport and the role of transferrin
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Metadata
- Authors
- West, A. R., & Oates, P. S.
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2008
- Volume
- 14
- Issue
- 26
- Pages
- 4101
- ISSN
- 1007-9327 (ISSN-L)
- OpenAlex
- W2017433201
- Cited by
- 258
- References
- 14
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
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