The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
An update on iron physiology
Open accessAbstract
Iron is an essential micronutrient, as it is required for adequate erythropoietic function, oxidative metabolism and cellular immune responses. Although the absorption of dietary iron (1-2 mg/d) is regulated tightly, it is just balanced with losses. Therefore, internal turnover of iron is essential to meet the requirements for erythropoiesis (20-30 mg/d). Increased iron requirements, limited external supply, and increased blood loss may lead to iron deficiency (ID) and iron-deficiency anemia. Hepcidin, which is made primarily in hepatocytes in response to liver iron levels, inflammation, hypoxia and anemia, is the main iron regulatory hormone. Once secreted into the circulation, hepcidin binds ferroportin on enterocytes and macrophages, which triggers its internalization and lysosomal degradation. Thus, in chronic inflammation, the excess of hepcidin decreases iron absorption and prevents iron recycling, which results in hypoferremia and iron-restricted erythropoiesis, despite normal iron stores (functional ID), and anemia of chronic disease (ACD), which can evolve to ACD plus true ID (ACD + ID). In contrast, low hepcidin expression may lead to iron overload, and vice versa. Laboratory tests provide evidence of iron depletion in the body, or reflect iron-deficient red cell production. The appropriate combination of these laboratory tests help to establish a correct diagnosis of ID status and anemia.
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Cites
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Cited by
Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease
Zucca, F. A., Segura-Aguilar, J., Ferrari, E., Muñoz, P., Paris, I., Sulzer, D., Sarna, T., Casella, L., & Zecca, L. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.09.012 · Cited by 659
Iron deficiency: an ominous sign in patients with systolic chronic heart failure
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Iron and cancer: recent insights
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Iron Deficiency Predicts Impaired Exercise Capacity in Patients With Systolic Chronic Heart Failure
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Suchdev, P. S., Namaste, S. M., Aaron, G. J., Raiten, D. J., Brown, K. H., & Flores-Ayala, R. (2016) · Advances in Nutrition · doi:10.3945/an.115.010215 · Cited by 207
Metadata
- Authors
- Muñoz, M., Villar, I., & García-Erce, J. A.
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2009
- Volume
- 15
- Issue
- 37
- Pages
- 4617
- ISSN
- 1007-9327 (ISSN-L)
- OpenAlex
- W2113462770
- Cited by
- 371
- References
- 35
- FWCI
- 16.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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