Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease
Open accessAbstract
There are several interrelated mechanisms involving iron, dopamine, and neuromelanin in neurons. Neuromelanin accumulates during aging and is the catecholamine-derived pigment of the dopamine neurons of the substantia nigra and norepinephrine neurons of the locus coeruleus, the two neuronal populations most targeted in Parkinson's disease. Many cellular redox reactions rely on iron, however an altered distribution of reactive iron is cytotoxic. In fact, increased levels of iron in the brain of Parkinson's disease patients are present. Dopamine accumulation can induce neuronal death; however, excess dopamine can be removed by converting it into a stable compound like neuromelanin, and this process rescues the cell. Interestingly, the main iron compound in dopamine and norepinephrine neurons is the neuromelanin-iron complex, since neuromelanin is an effective metal chelator. Neuromelanin serves to trap iron and provide neuronal protection from oxidative stress. This equilibrium between iron, dopamine, and neuromelanin is crucial for cell homeostasis and in some cellular circumstances can be disrupted. Indeed, when neuromelanin-containing organelles accumulate high load of toxins and iron during aging a neurodegenerative process can be triggered. In addition, neuromelanin released by degenerating neurons activates microglia and the latter cause neurons death with further release of neuromelanin, then starting a self-propelling mechanism of neuroinflammation and neurodegeneration. Considering the above issues, age-related accumulation of neuromelanin in dopamine neurons shows an interesting link between aging and neurodegeneration.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Elevated iron in the CNS is associated with ND, possibly at levels higher than with normal aging.
“Indeed, elevated iron in the CNS is associated with ND (reviewed in [133] and [134]), possibly at levels higher than with normal aging [133].”
From Untangling senescent and damage‐associated microglia in the aging and diseased brain (2023) · cites this paper as [134]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691 · see citing works
Staging of brain pathology related to sporadic Parkinson’s disease
Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777 · see citing works
Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240 · see citing works
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
Esterbauer, H., Schaur, R. J., & Zollner, H. (1991) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(91)90192-6 · Cited by 6,672 · see citing works
Astrocyte-endothelial interactions at the blood-brain barrier
Abbott, N. J., Rönnbäck, L., & Hansson, E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1824 · Cited by 5,595 · see citing works
Structure and function of the blood–brain barrier
Abbott, N. J., Patabendige, A. A. K., Dolman, D. E. M., Yusof, S. R., & Begley, D. J. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.030 · Cited by 5,185 · see citing works
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
Block, M. L., Zecca, L., & Hong, J.-S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2038 · Cited by 4,110 · see citing works
Self-citationHereditary Early-Onset Parkinson's Disease Caused by Mutations in <i>PINK1</i>
Valente, E. M., Abou-Sleiman, P. M., Caputo, V., Muqit, M. M. K., Harvey, K., Gispert, S., Ali, Z., Del Turco, D., Bentivoglio, A. R., Healy, D. G., et al. (2004) · Science · doi:10.1126/science.1096284 · Cited by 3,481 · see citing works
McGeer, P. L., Itagaki, S., Boyes, B. E., & McGeer, E. G. (1988) · Neurology · doi:10.1212/wnl.38.8.1285 · Cited by 2,990 · see citing works
Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism
Bonifati, V., Rizzu, P., van Baren, M. J., Schaap, O., Breedveld, G. J., Krieger, E., Dekker, M. C. J., Squitieri, F., Ibáñez, P., Joosse, M., et al. (2003) · Science · doi:10.1126/science.1077209 · Cited by 2,800 · see citing works
Stages in the development of Parkinson’s disease-related pathology
Braak, H., Ghebremedhin, E., Rüb, U., Bratzke, H., & Del Tredici, K. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0956-9 · Cited by 2,689 · see citing works
Protein carbonyl groups as biomarkers of oxidative stress
Dalle‐Donne, I., Rossi, R., Giustarini, D., Milzani, A., & Colombo, R. (2003) · Clinica Chimica Acta · doi:10.1016/s0009-8981(03)00003-2 · Cited by 2,353 · see citing works
Two to tango: Regulation of Mammalian iron metabolism
Hentze, M. W., Muckenthaler, M. U., Galy, B., & Camaschella, C. (2010) · Cell · doi:10.1016/j.cell.2010.06.028 · Cited by 2,120 · see citing works
Mitochondria, oxidative stress and cell death
Ott, M., Gogvadze, V. G., Orrenius, S., & Zhivotovsky, B. (2007) · APOPTOSIS · doi:10.1007/s10495-007-0756-2 · Cited by 1,976 · see citing works
The role of iron in brain ageing and neurodegenerative disorders
Ward, R. J., Zucca, F. A., Duyn, J. H., Crichton, R. R., & Zecca, L. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70117-6 · Cited by 1,819 · see citing works
Self-citationIron, brain ageing and neurodegenerative disorders
Zecca, L., Youdim, M. B. H., Riederer, P., Connor, J. R., & Crichton, R. R. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1537 · Cited by 1,801 · see citing works
Self-citationA Medicinal Chemist’s Guide to Molecular Interactions
Bissantz, C., Kuhn, B., & Ståhl, M. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm100112j · Cited by 1,773 · see citing works
Copper Active Sites in Biology
Solomon, E. I., Heppner, D. E., Johnston, E. M., Ginsbach, J. W., Cirera, J., Qayyum, M. F., Kieber‐Emmons, M. T., Kjaergaard, C. H., Hadt, R. G., & Tian, L. (2014) · Chemical Reviews · doi:10.1021/cr400327t · Cited by 1,763 · see citing works
The Protective Role of Melanin Against UV Damage in Human Skin <sup>†</sup>
Brenner, M., & Hearing, V. J. (2008) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2007.00226.x · Cited by 1,741 · see citing works
Aromatic Rings in Chemical and Biological Recognition: Energetics and Structures
Salonen, L. M., Ellermann, M., & Diederich, F. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201007560 · Cited by 1,542 · see citing works
The effect of age on the non-haemin iron in the human brain
Hallgren, B., & Sourander, P. (1958) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1958.tb12607.x · Cited by 1,427 · see citing works
Alpha-synuclein and neurodegenerative diseases
Goedert, M. (2001) · Nature reviews. Neuroscience · doi:10.1038/35081564 · Cited by 1,402 · see citing works
Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains
Riederer, P., Sofic, E., Rausch, W., Schmidt, B., Reynolds, G. P., Jellinger, K., & Youdim, M. B. H. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb09150.x · Cited by 1,383 · see citing works
The therapeutic potential of monoamine oxidase inhibitors
Youdim, M. B. H., Edmondson, D. E., & Tipton, K. F. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1883 · Cited by 1,374 · see citing works
Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease
Hirsch, E., Graybiel, A. M., & Agid, Y. A. (1988) · Nature · doi:10.1038/334345a0 · Cited by 1,301 · cited 2× · see citing works
“Some studies suggested that neurons with the highest NM content are more susceptible to death, while other studies reported that lightly pigmented neurons are more vulnerable in PD (Gibb, 1992; Hirsch et al., 1988; Kastner et al., 1992; Mann and Yates, 1983; Pakkenberg et al., 1991).”
Ramirez, A., Heimbach, A., Gründemann, J., Stiller, B., Hampshire, D., Cid, L. P., Goebel, I., Mubaidin, A. F., Wriekat, A.-L., Roeper, J., et al. (2006) · Nature Genetics · doi:10.1038/ng1884 · Cited by 1,208 · see citing works
Brochard, V., Combadière, B., Prigent, A., Laouar, Y., Perrin, A., Beray-Berthat, V., Bonduelle, O., Alvarez-Fischer, D., Callebert, J., Launay, J.-M., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36470 · Cited by 1,172 · see citing works
Dexter, D. T., Wells, F. R., Lee, A. J., Agid, F., Agid, Y., Jenner, P., & Marsden, C. D. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb07264.x · Cited by 1,149 · see citing works
Metal-triggered Structural Transformations, Aggregation, and Fibrillation of Human α-Synuclein
Uversky, V. N., Li, J., & Fink, A. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105343200 · Cited by 1,103 · see citing works
Catecholamine Metabolism: A Contemporary View with Implications for Physiology and Medicine
Eisenhofer, G., Kopin, I. J., & Goldstein, D. S. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.3.1 · Cited by 1,072 · see citing works
DEXTER, D. T., CARAYON, A., JAVOY-AGID, F., AGID, Y., WELLS, F. R., DANIEL, S. E., LEES, A. J., JENNER, P., & MARSDEN, C. D. (1991) · Brain · doi:10.1093/brain/114.4.1953 · Cited by 1,043 · cited 2× · see citing works
“…specifically affects the SN, and several studies have strongly demonstrated an increase of total iron concentration in the SN of PD patients, with peak iron levels apparently correlating with disease severity (Dexter et al., 1987, 1989, 1991; Earle, 1968; Riederer et al., 1989; Sofic et al., 1988).”
The physical and chemical properties of eumelanin
Meredith, P., & Sarna, T. (2006) · Pigment Cell Research · doi:10.1111/j.1600-0749.2006.00345.x · Cited by 1,033 · see citing works
Self-citationIncreased nigral iron content in postmortem parkinsonian brain
Dexter, D. T., Wells, F. R., Agid, F., Agid, Y., Lees, A. J., Jenner, P., & Marsden, C. D. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91361-4 · Cited by 963 · see citing works
Protein carbonylation in human diseases
Dalle-Donne, I., Giustarini, D., Colombo, R., Rossi, R., & Milzani, A. (2003) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(03)00031-5 · Cited by 961 · see citing works
Blood–brain barrier: Ageing and microvascular disease – systematic review and meta-analysis
Farrall, A. J., & Wardlaw, J. M. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.07.015 · Cited by 882 · see citing works
Kakhlon, O., & Cabantchik, Z. I. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01006-7 · Cited by 839 · see citing works
Ascorbate regulation and its neuroprotective role in the brain
Rice, M. E. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01543-x · Cited by 835 · see citing works
Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression
Gao, H., & Hong, J. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.05.002 · Cited by 822 · see citing works
Chemistry and biology of eukaryotic iron metabolism
Aisen, P. (2001) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00063-2 · Cited by 804 · see citing works
Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain
Sofic, E., Riederer, P. F., Heinsen, H., Beckmann, H., Reynolds, G. P., Hebenstreit, G. F., & Youdim, M. B. H. (1988) · Journal of Neural Transmission · doi:10.1007/bf01244786 · Cited by 754 · see citing works
Catalá, A. (2009) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2008.09.004 · Cited by 745 · see citing works
Blood–brain barrier dysfunction in parkinsonian midbrain in vivo
Kortekaas, R., Leenders, K. L., van Oostrom, J. C. H., Vaalburg, W., Bart, J., Willemsen, A. T. M., & Hendrikse, N. H. (2005) · Annals of Neurology · doi:10.1002/ana.20369 · Cited by 733 · see citing works
Dopamine covalently modifies and functionally inactivates parkin
LaVoie, M. J., Ostaszewski, B. L., Weihofen, A., Schlossmacher, M. G., & Selkoe, D. J. (2005) · Nature Medicine · doi:10.1038/nm1314 · Cited by 722 · see citing works
Muckenthaler, M. U., Galy, B., & Hentze, M. W. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155521 · Cited by 701 · see citing works
Polydopamine and Eumelanin: From Structure–Property Relationships to a Unified Tailoring Strategy
d’Ischia, M., Napolitano, A., Ball, V., Chen, C.-T., & Buehler, M. J. (2014) · Accounts of Chemical Research · doi:10.1021/ar500273y · Cited by 668 · see citing works
Exner, N., Lutz, A. K., Haass, C., & Winklhofer, K. F. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.170 · Cited by 652 · see citing works
Blood brain barrier: ageing and microvascular disease-systematic review and meta-analysis
Farrall, A., & Wardlaw, J. M. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.02.089 · Cited by 639 · see citing works
Dopamine-modified α-synuclein blocks chaperone-mediated autophagy
Martínez‐Vicente, M., Tallóczy, Z., Kaushik, S., Massey, A. C., Mazzulli, J. R., Mosharov, E. V., Hodara, R., Fredenburg, R. A., Wu, D.-C., Follenzi, A., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32806 · Cited by 633 · see citing works
Self-citationPermanent human parkinsonism due to 1‐methy 1–4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)
Ballard, P., Tetrud, J. W., & Langston, J. W. (1985) · Neurology · doi:10.1212/wnl.35.7.949 · Cited by 630 · see citing works
Forging a field: the golden age of iron biology.
Andrews, N. C. (2008) · Blood · doi:10.1182/blood-2007-12-077388 · Cited by 623 · see citing works
Oligodendrocytes and myelination: The role of iron
Todorich, B., Pasquini, J. M., Garcia, C. I., Paez, P. M., & Connor, J. R. (2008) · Glia · doi:10.1002/glia.20784 · Cited by 615 · see citing works
A timeline for Parkinson's disease
Hawkes, C. H., Del Tredici, K., & Braak, H. (2010) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2009.08.007 · Cited by 594 · see citing works
Biology of Amyloid: Structure, Function, and Regulation
Greenwald, J., & Riek, R. (2010) · Structure · doi:10.1016/j.str.2010.08.009 · Cited by 573 · see citing works
Kachergus, J. M., Mata, I. F., Hulihan, M., Taylor, J. P., Lincoln, S., Aasly, J. O., Gibson, J. M., Ross, O. A., Lynch, T., Wiley, J. C., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/429256 · Cited by 536 · see citing works
Iron Deficiency Alters Brain Development and Functioning
Beard, J. (2003) · Journal of Nutrition · doi:10.1093/jn/133.5.1468s · Cited by 534 · see citing works
Labile iron pool: the main determinant of cellular response to oxidative stress
Kruszewski, M. K. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2003.08.004 · Cited by 529 · see citing works
Abbas, N., Lücking, C. B., Ricard, S., Dürr, A., Bonifati, V., Michele, G. D., Bouley, S., Vaughan, J. R., Gasser, T., Marconi, R., et al. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.4.567 · Cited by 529 · see citing works
Distinct Monoamine Oxidase A and B Populations in Primate Brain
Westlund, K. N., Denney, R. M., Kochersperger, L. M., Rose, R. M., & Abell, C. W. (1985) · Science · doi:10.1126/science.3875898 · Cited by 505 · see citing works
Chemistry of Mixed Melanogenesis—Pivotal Roles of Dopaquinone†
Ito, S., & Wakamatsu, K. (2007) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2007.00238.x · Cited by 504 · see citing works
Protective and toxic roles of dopamine in Parkinson's disease
Segura‐Aguilar, J., Paris, I. B., Muñoz, P., Ferrari, E., Zecca, L., & Zucca, F. A. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12686 · Cited by 499 · see citing works
Self-citationIron metabolism in the CNS: implications for neurodegenerative diseases
Rouault, T. A. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3453 · Cited by 496 · see citing works
Zecca, L., Stroppolo, A., Gatti, A., Tampellini, D., Toscani, M., Gallorini, M., Giaveri, G., Arosio, P., Santambrogio, P., Fariello, R. G., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403495101 · Cited by 495 · see citing works
Self-citationVolles, M. J., & Lansbury, P. T. (2002) · Biochemistry · doi:10.1021/bi0121353 · Cited by 485 · see citing works
Melanins and melanogenesis: Methods, standards, protocols
d'Ischia, M., Wakamatsu, K., Napolitano, A., Briganti, S., Garcia‐Borron, J., Kovacs, D., Meredith, P., Pezzella, A., Picardo, M., Sarna, T., et al. (2013) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12121 · Cited by 484 · see citing works
Self-citationKollias, N., Sayre, R. M., Zeise, L., & Chedekel, M. R. (1991) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/1011-1344(91)80147-a · Cited by 482 · see citing works
Cellular distribution of transferrin, ferritin, and iron in normal and aged human brains
Connor, J. R., Menzies, S. L., Martin, S. M. S., & Mufson, E. J. (1990) · Journal of Neuroscience Research · doi:10.1002/jnr.490270421 · Cited by 472 · see citing works
Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism
Hauser, D. N., & Hastings, T. G. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.10.011 · Cited by 470 · see citing works
Advances in the genetics of Parkinson disease
Trinh, J., & Farrer, M. J. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.132 · Cited by 465 · see citing works
Structures for amyloid fibrils
Makin, O. S., & Serpell, L. C. (2005) · FEBS Journal · doi:10.1111/j.1742-4658.2005.05025.x · Cited by 462 · see citing works
Sulzer, D. L., Bogulavsky, J. J., Larsen, K. E., Behr, G. G., Karatekin, E., Kleinman, M. H., Turro, N. J., Krantz, D. E., Edwards, R. H., Greene, L. A., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.22.11869 · Cited by 460 · see citing works
Self-citationAmorphous Semiconductor Switching in Melanins
McGinness, J. E., Corry, P. M., & Proctor, P. H. (1974) · Science · doi:10.1126/science.183.4127.853 · Cited by 447 · see citing works
Brain iron and ferritin in Parkinson’s and Alzheimer’s diseases
Jellinger, K., Paulus, W., Grundke-Iqbal, I., Riederer, P., & Youdim, M. B. H. (1990) · Journal of Neural Transmission - Parkinson's Disease and Dementia Section · doi:10.1007/bf02252926 · Cited by 445 · see citing works
Structure, function, and mechanism of ribonucleotide reductases
Kolberg, M., Strand, K. R., Graff, P., & Andersson, K. K. (2004) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2004.02.007 · Cited by 437 · see citing works
Glial pathology but absence of apoptotic nigral neurons in long‐standing Parkinson's disease
Banati, R. B., Daniel, S. E., & Blunt, S. B. (1998) · Movement Disorders · doi:10.1002/mds.870130205 · Cited by 430 · see citing works
Oxidative stress induces amyloid-like aggregate formation of NACP/α-synuclein in vitro
Hashimoto, M., Hsu, L. J., Xia, Y., Takeda, A., Sisk, A., Sundsmo, M., & Masliah, E. (1999) · NeuroReport · doi:10.1097/00001756-199903170-00011 · Cited by 429 · see citing works
Good, P. F., Olanow, C. W., & Perl, D. P. (1992) · Brain Research · doi:10.1016/0006-8993(92)91334-b · Cited by 427 · see citing works
Iron trafficking inside the brain
Moos, T., Nielsen, T. R., Skjørringe, T., & Morgan, E. H. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04976.x · Cited by 421 · see citing works
Potential oxidative pathways of brain catecholamines
Tse, D. C. S., McCreery, R. L., & Adams, R. N. (1976) · Journal of Medicinal Chemistry · doi:10.1021/jm00223a008 · Cited by 415 · cited 3× · see citing works
“dopaminergic neurons would be the consequence of the rapid nucleophilic addition of glutathione to DA-o-quinone with a rate constant of 200 s (1), generating 5-S-glutathionyl-DA (Tse et al., 1976).”
InfluentialSalazar, J., Mena, N., Hunot, S., Prigent, A., Alvarez-Fischer, D., Arredondo, M., Duyckaerts, C., Sazdovitch, V., Zhao, L., Garrick, L. M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804373105 · Cited by 409 · see citing works
Pakkenberg, B., Møller, A., Gundersen, H. J. G., Dam, A. M., & Pakkenberg, H. (1991) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.54.1.30 · Cited by 408 · see citing works
Zecca, L., Gallorini, M., Schünemann, V., Trautwein, A. X., Gerlach, M., Riederer, P., Vezzoni, P., & Tampellini, D. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00186.x · Cited by 401 · see citing works
Self-citationSarna, T. (1992) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/1011-1344(92)85027-r · Cited by 396 · see citing works
Self-citationRole of semiconductivity and ion transport in the electrical conduction of melanin
Mostert, A. B., Powell, B. J., Pratt, F. L., Hanson, G. R., Sarna, T., Gentle, I., & Meredith, P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119948109 · Cited by 379 · see citing works
Self-citationMúñoz, M., Villar, I., & García‐Erce, J. A. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.4617 · Cited by 371 · see citing works
Urrutia, P., Aguirre, P., Esparza, A., Tapia, V., Mena, N. P., Arredondo, M., González‐Billault, C., & Núñez, M. T. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12244 · Cited by 364 · see citing works
Enzymatic Oxidation of Dopamine: The Role of Prostaglandin H Synthase
Hastings, T. G. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64020919.x · Cited by 359 · see citing works
The relevance of iron in the pathogenesis of Parkinson’s disease
Sian‐Hülsmann, J., Mandel, S. A., Youdim, M. B. H., & Riederer, P. F. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07132.x · Cited by 349 · see citing works
Advanced Chemical Methods in Melanin Determination
Wakamatsu, K., & Ito, S. (2002) · Pigment Cell Research · doi:10.1034/j.1600-0749.2002.02017.x · Cited by 347 · see citing works
Conde, J. R., & Streit, W. J. (2006) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/01.jnen.0000202887.22082.63 · Cited by 344 · see citing works
Baez, S., Segura‐Aguilar, J., Widersten, M., Johansson, A.-S., & Mannervik, B. (1997) · Biochemical Journal · doi:10.1042/bj3240025 · Cited by 340 · see citing works
Self-citationMHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration
Cebrián, C., Zucca, F. A., Mauri, P., Steinbeck, J. A., Studer, L., Scherzer, C. R., Kanter, E., Budhu, S., Mandelbaum, J., Vonsattel, J. P., et al. (2014) · Nature Communications · doi:10.1038/ncomms4633 · Cited by 338 · see citing works
Self-citationWilms, H., Rosenstiel, P. C., Sievers, J., Deuschl, G., Zecca, L., & Lucius, R. (2003) · The FASEB Journal · doi:10.1096/fj.02-0314fje · Cited by 337 · see citing works
Self-citationBiogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease
Rouault, T. A. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.009019 · Cited by 332 · see citing works
Free radical scavenging properties of melanin
Rôżanowska, M., Sarna, T., Land, E. J., & Truscott, T. G. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00234-2 · Cited by 328 · see citing works
Self-citationConnor, J. R., Snyder, B. S., Arosio, P., Loeffler, D. A., & LeWitt, P. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65020717.x · Cited by 317 · cited 2× · see citing works
“In contrast, several studies reported unchanged levels (Mann et al., 1994) or a decrease of SN ferritin levels in PD patients (Connor et al., 1995; Dexter et al., 1990, 1991).”
Neuronal vulnerability, pathogenesis, and Parkinson's disease
Sulzer, D. L., & Surmeier, D. J. (2012) · Movement Disorders · doi:10.1002/mds.25095 · Cited by 315 · see citing works
Self-citationIron-melanin complex in substantia nigra of parkinsonian brains: an x-ray microanalysis
Jellinger, K., Kienzl, E., Rumpelmair, G., Riederer, P., Stachelberger, H., Ben‐Shachar, D., & Youdim, M. B. H. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb08362.x · Cited by 313 · see citing works
Yamamoto, A., Shin, R., Hasegawa, K., Naiki, H., Sato, H., Yoshimasu, F., & Kitamoto, T. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.t01-1-01061.x · Cited by 313 · see citing works
Mechanisms of Brain Iron Transport: Insight into Neurodegeneration and CNS Disorders
Mills, E., Dong, X.-P., Wang, F., & Xu, H. (2010) · Future Medicinal Chemistry · doi:10.4155/fmc.09.140 · Cited by 309 · see citing works
Neuroinflammation and oxidative stress: Co-conspirators in the pathology of Parkinson’s disease
Taylor, J. M., Main, B. S., & Crack, P. J. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2012.12.016 · Cited by 303 · see citing works
Kinetic and Structural Analysis of the Early Oxidation Products of Dopamine
Bisaglia, M., Mammi, S., & Bubacco, L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610893200 · Cited by 303 · see citing works
Structure, function, and mechanism of ribonucleotide reductases
Kolberg, M. (2004) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/s1570-9639(04)00054-8 · Cited by 298 · see citing works
Selectivity of the Parkinsonian Neurotoxin MPTP: Toxic Metabolite MPP + Binds to Neuromelanin
D’Amato, R. J., Lipman, Z. P., & Snyder, S. H. (1986) · Science · doi:10.1126/science.3080808 · Cited by 296 · see citing works
Simon, J. D., & Peles, D. N. (2010) · Accounts of Chemical Research · doi:10.1021/ar100079y · Cited by 296 · see citing works
α‐Synuclein oligomers and clinical implications for Parkinson disease
Kalia, L. V., Kalia, S. K., McLean, P. J., Lozano, A. M., & Lang, A. E. (2012) · Annals of Neurology · doi:10.1002/ana.23746 · Cited by 295 · see citing works
Hattori, N., Kitada, T., Matsumine, H., Asakawa, S., Yamamura, Y., Yoshino, H., Kobayashi, T., Yokochi, M., Wang, M., Yoritaka, A., et al. (1998) · Annals of Neurology · doi:10.1002/ana.410440612 · Cited by 295 · see citing works
THE ROLE OF VESICULAR TRANSPORT PROTEINS IN SYNAPTIC TRANSMISSION AND NEURAL DEGENERATION
Liu, Y., & Edwards, R. H. (1997) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.20.1.125 · Cited by 295 · see citing works
House, E., Collingwood, J., Khan, A., Korchazkina, O., Berthon, G., & Exley, C. (2004) · Journal of Alzheimer's Disease · doi:10.3233/jad-2004-6310 · Cited by 294 · see citing works
Iron‐Melanin Interaction and Lipid Peroxidation: Implications for Parkinson's Disease
Ben‐Shachar, D., Riederer, P. F., & Youdim, M. B. H. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb06358.x · Cited by 287 · see citing works
Zecca, L., Fariello, R. G., Riederer, P. F., Sulzer, D. L., Gatti, A., & Tampellini, D. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)03269-0 · Cited by 287 · see citing works
Self-citationIntraneuronal dopamine-quinone synthesis: a review
Sulzer, D., & Zecca, L. (1999) · Neurotoxicity Research · doi:10.1007/bf03033289 · Cited by 284 · see citing works
Self-citationFelix, C. C., Hyde, J. S., Sarna, T., & Sealy, R. C. (1978) · Journal of the American Chemical Society · doi:10.1021/ja00480a044 · Cited by 284 · see citing works
Self-citationRouault, T. A., & Cooperman, S. (2006) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2006.08.002 · Cited by 280 · see citing works
Taly, A. B., Meenakshi‐Sundaram, S., Sinha, S., Swamy, H. S., & Arunodaya, G. R. (2007) · Medicine · doi:10.1097/md.0b013e318045a00e · Cited by 278 · see citing works
Norris, E. H., Giasson, B. I., Hodara, R., Xu, S., Trojanowski, J. Q., Ischiropoulos, H., & Lee, V. M.-Y. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412621200 · Cited by 273 · see citing works
Transport of Iron in the Blood‐Brain‐Cerebrospinal Fluid System
Bradbury, M. W. B. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69020443.x · Cited by 270 · see citing works
Zecca, L., Zucca, F. A., Wilms, H., & Sulzer, D. L. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.08.009 · Cited by 265 · see citing works
Self-citationSequestration of iron by Lewy bodies in Parkinson's disease
Castellani, R. J., Siedlak, S. L., Perry, G., & Smith, M. A. (2000) · Acta Neuropathologica · doi:10.1007/s004010050001 · Cited by 265 · see citing works
Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease
Ayton, S., Lei, P., Duce, J. A., Wong, B. X. W., Sedjahtera, A., Adlard, P. A., Bush, A. I., & Finkelstein, D. I. (2013) · Annals of Neurology · doi:10.1002/ana.23817 · Cited by 264 · see citing works
Loss of melanin from human RPE with aging: possible role of melanin photooxidation
Sarna, T., Burke, J. M., Korytowski, W., Rôżanowska, M., Skumatz, C. M. B., Zaręba, A., & Zaręba, M. (2003) · Experimental Eye Research · doi:10.1016/s0014-4835(02)00247-6 · Cited by 263 · see citing works
Self-citationLopes, K. O., Sparks, D. L., & Streit, W. J. (2008) · Glia · doi:10.1002/glia.20678 · Cited by 262 · see citing works
Decreased ferritin levels in brain in Parkinson's disease
Dexter, D. T., Carayon, A., Vidailhet, M., Ruberg, M., Agid, F., Agid, Y., Lees, A. J., Wells, F. R., Jenner, P., & Marsden, C. D. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb08814.x · Cited by 258 · see citing works
Zhang, W., Phillips, K., Wielgus, A. R., Liu, J., Albertini, A., Zucca, F. A., Faust, R., Qian, S. Y., Miller, D. S., Chignell, C. F., et al. (2011) · Neurotoxicity Research · doi:10.1007/s12640-009-9140-z · Cited by 257 · see citing works
Self-citationProtein degradation pathways in Parkinson’s disease: curse or blessing
Ebrahimi‐Fakhari, D., Wahlster, L., & McLean, P. J. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1004-6 · Cited by 255 · see citing works
García-Borrón, J. C., & Solano, F. (2002) · Pigment Cell Research · doi:10.1034/j.1600-0749.2002.02012.x · Cited by 251 · see citing works
Complex I, iron, and ferritin in Parkinson's disease substantia nigra
Mann, V. M., Cooper, J. M., Daniel, S. E., Srai, K., Jenner, P., Marsden, C. D., & Schapira, A. H. V. (1994) · Annals of Neurology · doi:10.1002/ana.410360612 · Cited by 251 · see citing works
Estradiol protects mesencephalic dopaminergic neurons from oxidative stress-induced neuronal death
Sawada, H., Ibi, M., Kihara, T., Urushitani, M., Akaike, A., & Shimohama, S. (1998) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19981201)54:5 · Cited by 246 · see citing works
Yamamoto, A., Shin, R., Hasegawa, K., Naiki, H., Sato, H., YOSHIMASU, F., & Kitamoto, T. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01061.x · Cited by 246 · see citing works
Brain iron metabolism and its perturbation in neurological diseases
Crichton, R. R., Dexter, D. T., & Ward, R. J. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0470-z · Cited by 246 · see citing works
Inorganic Biochemistry of Iron Metabolism: From Molecular Mechanisms to Clinical Consequences
Crichton, R. R. (2001) · Cited by 244 · see citing works
Neuromelanin of the Human Substantia Nigra: An Update
Zucca, F. A., Basso, E., Cupaioli, F. A., Ferrari, E., Sulzer, D., Casella, L., & Zecca, L. (2014) · Neurotoxicity Research · doi:10.1007/s12640-013-9435-y · Cited by 243 · see citing works
Self-citationAggregation of α-synuclein by DOPAL, the monoamine oxidase metabolite of dopamine
Burke, W. J., Kumar, V. B., Pandey, N., Panneton, W. M., Gan, Q., Franko, M. W., Odell, M., Li, S. W., Pan, Y., Chung, H. D., et al. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0303-9 · Cited by 243 · see citing works
Zecca, L., Bellei, C., Costi, P., Albertini, A., Monzani, E., Casella, L., Gallorini, M., Bergamaschi, L., Moscatelli, A., Turro, N. J., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808768105 · Cited by 240 · see citing works
Self-citationLinert, W., Herlinger, E., Jameson, R. F., Kienzl, E., Jellinger, K. A., & Youdim, M. B. H. (1996) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(96)00020-8 · Cited by 238 · see citing works
Putative biological mechanisms of the effect of iron deficiency on brain biochemistry and behavior
Youdim, M. B. H., Ben‐Shachar, D., & Yehuda, S. (1989) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/50.3.607 · Cited by 238 · see citing works
Brain iron metabolism: Neurobiology and neurochemistry
Ke, Y., & Qian, Z. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.07.009 · Cited by 236 · see citing works
Phenylalanine hydroxylase: Function, structure, and regulation
Flydal, M. I., & Martı́nez, A. (2013) · IUBMB Life · doi:10.1002/iub.1150 · Cited by 236 · see citing works
Oxidative DNA damage and nucleotide excision repair
Melis, J. P. M., van Steeg, H., & Luijten, M. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5036 · Cited by 234 · see citing works
Zecca, L., Casella, L., Albertini, A., Bellei, C., Zucca, F. A., Engelen, M., Żądło, A. C., Szewczyk, G. M., Zaręba, M., & Sarna, T. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05541.x · Cited by 233 · see citing works
Self-citationFaucheux, B. A., Martin, M., Beaumont, C., Hauw, J., Agid, Y., & Hirsch, E. C. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01923.x · Cited by 229 · see citing works
Iron in the basal ganglia in Parkinson's disease
Griffiths, P. D., Dobson, B. R., Jones, G. R., & Clarke, D. T. (1999) · Brain · doi:10.1093/brain/122.4.667 · Cited by 229 · see citing works
Perluigi, M., Coccia, R., & Butterfield, D. A. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4406 · Cited by 229 · see citing works
Kästner, A., Hirsch, É. C., Lejeune, O., Javoy-Agid, F., Rascol, O., & Agid, Y. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb08350.x · Cited by 228 · see citing works
Earle, K. M. (1968) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-196801000-00001 · Cited by 227 · see citing works
Ramos, P., Santos, A., Pinto, N. R., Mendes, R., Magalhães, T., & Almeida, A. (2014) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2013.08.001 · Cited by 221 · see citing works
Blood vessels change in the mesencephalon of patients with Parkinson's disease
Faucheux, B. A., Agid, Y., Hirsch, É. C., & Bonnet, A.-M. (1999) · The Lancet · doi:10.1016/s0140-6736(99)00641-8 · Cited by 218 · see citing works
The Role of Iron in Neurodegeneration: Prospects for Pharmacotherapy of Parkinson??s Disease
Jellinger, K. A. (1999) · Drugs & Aging · doi:10.2165/00002512-199914020-00004 · Cited by 218 · see citing works
Faucheux, B. A., Nillesse, N., Damier, P., Spik, G., Prigent, A., Pierce, A., Leveugle, B., Kubis, N., Hauw, J., & Agid, Y. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9603 · Cited by 218 · see citing works
Parkinson’s disease: premotor clinico-pathological correlations
Wolters, E. C., & Braak, H. (2006) · Springer eBooks · doi:10.1007/978-3-211-45295-0_47 · Cited by 216 · see citing works
Dopamine Oxidation and Autophagy
Muñoz, P., Huenchuguala, S., Paris, I., & Segura-Aguilar, J. (2012) · Parkinson's Disease · doi:10.1155/2012/920953 · Cited by 214 · see citing works
Self-citationCellular management of iron in the brain
Connor, J. R., & Menzies, S. L. (1995) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(95)00206-h · Cited by 213 · see citing works
Possible role of neuromelanin in the pathogenesis of Parkinson's disease
Mann, D. M. A., & Yates, P. O. (1983) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(83)90074-x · Cited by 211 · see citing works
Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease
Goldstein, D. S., Sullivan, P., Holmes, C. S., Miller, G. W., Alter, S. P., Strong, R., Mash, D. C., Kopin, I. J., & Sharabi, Y. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12345 · Cited by 206 · see citing works
Zecca, L., Wilms, H., Geick, S., Claasen, J.-H., Brandenburg, L.-O., Holzknecht, C., Panizza, M. L., Zucca, F. A., Deuschl, G., Sievers, J., et al. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0361-7 · Cited by 205 · see citing works
Self-citationInteraction of neuromelanin and iron in substantia nigra and other areas of human brain
Zecca, L., Shima, T., Stroppolo, A., Goj, C., Battiston, G. A., Gerbasi, R., Sarna, T., & Swartz, H. M. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00047-4 · Cited by 197 · see citing works
Self-citationMastroberardino, P. G., Hoffman, E. K., Horowitz, M. P., Betarbet, R., Taylor, G., Cheng, D., Na, H. M., Gutekunst, C.-A., Gearing, M., Trojanowski, J. Q., et al. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.02.009 · Cited by 195 · see citing works
Reaction of oxidized dopamine with endogenous cysteine residues in the human dopamine transporter
Whitehead, R. E., Ferrer, J. V., Javitch, J. A., & Justice, J. B. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00125.x · Cited by 194 · see citing works
Zajac, G. W., Gallas, J. M., Cheng, J., Eisner, M., Moss, S. C., & Alvarado-Swaisgood, A. E. (1994) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(94)90006-x · Cited by 193 · see citing works
Segura‐Aguilar, J., & Lind, C. (1989) · Chemico-Biological Interactions · doi:10.1016/0009-2797(89)90006-9 · Cited by 192 · see citing works
Self-citationSulzer, D., Mosharov, E. V., Tallóczy, Z., Zucca, F. A., Simon, J. D., & Zecca, L. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05385.x · Cited by 190 · see citing works
Self-citationEPIDERMAL "TURNOVER TIME"—A RE-EXAMINATION
Halprin, K. M. (1972) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1972.tb01886.x · Cited by 189 · see citing works
An ERcentric view of Parkinson's disease
Mercado, G., Valdés, P., & Hetz, C. A. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.12.005 · Cited by 185 · see citing works
Neuronal vulnerability, pathogenesis, and Parkinson's disease
Sulzer, D., & Surmeier, D. J. (2013) · Movement Disorders · doi:10.1002/mds.25187 · Cited by 184 · see citing works
Self-citationIron-binding characteristics of neuromelanin of the human substantia nigra
Double, K. L., Gerlach, M., Schünemann, V., TRAUTWEIN, A. X., Zecca, L., Gallorini, M., Youdim, M. B. H., Riederer, P. F., & Ben‐Shachar, D. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00293-4 · Cited by 182 · see citing works
Self-citationα-synuclein implicated in Parkinson’s disease catalyses the formation of hydrogen peroxide in vitro
Turnbull, S., Tabner, B. J., El‐Agnaf, O. M. A., Moore, S., Davies, Y., & Allsop, D. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00513-5 · Cited by 181 · see citing works
Iron Storage within Dopamine Neurovesicles Revealed by Chemical Nano-Imaging
Ortega, R., Cloetens, P., Devès, G., Carmona, A., & Bohic, S. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000925 · Cited by 178 · see citing works
Comparison of Structural and Chemical Properties of Black and Red Human Hair Melanosomes¶
Liu, Y., Hong, L., Wakamatsu, K., Ito, S., Adhyaru, B. B., Cheng, C., Bowers, C. R., & Simon, J. D. (2005) · Photochemistry and Photobiology · doi:10.1562/2004-08-03-ra-259.1 · Cited by 173 · see citing works
The structure of neuromelanin as studied by chemical degradative methods
Wakamatsu, K., Fujikawa, K., Zucca, F. A., Zecca, L., & Ito, S. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01917.x · Cited by 172 · see citing works
Self-citationPathogenic implications of iron accumulation in multiple sclerosis
Williams, R., Buchheit, C., Berman, N. E., & LeVine, S. M. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07536.x · Cited by 171 · see citing works
Ion-Exchange in Melanin: An Electron Spin Resonance Study with Lanthanide Probes
Sarna, T., Hyde, J. S., & Swartz, H. M. (1976) · Science · doi:10.1126/science.179142 · Cited by 170 · see citing works
Self-citationGoldstein, D. S., Kopin, I. J., & Sharabi, Y. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.06.006 · Cited by 168 · see citing works
Characterization of a novel brain‐derived microglial cell line isolated from neonatal rat brain
Cheepsunthorn, P., Radov, L. A., Menzies, S. L., Reid, J., & Connor, J. R. (2001) · Glia · doi:10.1002/glia.1070 · Cited by 163 · see citing works
Iron and Other Metals in Neuromelanin, Substantia Nigra, and Putamen of Human Brain
Zecca, L., Pietra, R., Goj, C., Mecacci, C., Radice, D., & Sabbioni, E. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.62031097.x · Cited by 163 · see citing works
Self-citationBush, W. D., Garguilo, J., Zucca, F. A., Albertini, A., Zecca, L., Edwards, G. S., Nemanich, R. J., & Simon, J. D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604010103 · Cited by 159 · see citing works
Self-citationThe Role of Iron in Beta Amyloid Toxicity
Schubert, D. A., & Chevion, M. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2678 · Cited by 159 · see citing works
Essential and toxic element concentrations in fresh and formalin-fixed human autopsy tissues
Bush, V. J., Moyer, T. P., Batts, K. P., & Parisi, J. E. (1995) · Clinical Chemistry · doi:10.1093/clinchem/41.2.284 · Cited by 156 · see citing works
Ion‐Exchange and Adsorption of Fe(III) by Sepia Melanin
Liu, Y., Hong, L., Kempf, V. R., Wakamatsu, K., Ito, S., & Simon, J. D. (2004) · Pigment Cell Research · doi:10.1111/j.1600-0749.2004.00140.x · Cited by 153 · see citing works
Detection of 5-S-cysteinyldopamine in human brain
Rosengren, E., Linder-Eliasson, E., & Carlsson, A. (1985) · Journal of Neural Transmission · doi:10.1007/bf01252029 · Cited by 152 · see citing works
Gibb, W. R. G. (1992) · Brain Research · doi:10.1016/0006-8993(92)90719-p · Cited by 152 · see citing works
Prostaglandin H Synthetase‐Mediated Metabolism of Dopamine: Implication for Parkinson's Disease
Mattammal, M. B., Strong, R., Lakshmi, V. M., Chung, H. D., & Stephenson, A. H. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64041645.x · Cited by 151 · see citing works
Laar, V. S. V., Mishizen-Eberz, A. J., Cascio, M., & Hastings, T. G. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.03.004 · Cited by 151 · see citing works
Aggregation and neurotoxicity of α-synuclein and related peptides
EI-Agnaf, O. M. A., & Irvine, G. B. (2002) · Biochemical Society Transactions · doi:10.1042/bst0300559 · Cited by 151 · see citing works
α-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease
Mullin, S., & Schapira, A. H. V. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8394-x · Cited by 151 · see citing works
Andersen, H. H., Johnsen, K. B., & Moos, T. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1509-8 · Cited by 151 · see citing works
X‐Ray Characterization of Melanins—I
Cheng, J. Q., Moss, S. C., Eisner, M., & Zschack, P. R. (1994) · Pigment Cell Research · doi:10.1111/j.1600-0749.1994.tb00060.x · Cited by 149 · see citing works
Oxidation Chemistry of Catecholamines and Neuronal Degeneration: An Update
Napolitano, A., Manini, P., & d’Ischia, M. (2011) · Current Medicinal Chemistry · doi:10.2174/092986711795496863 · Cited by 149 · see citing works
Mobility Gaps: A Mechanism for Band Gaps in Melanins
McGinness, J. E. (1972) · Science · doi:10.1126/science.177.4052.896 · Cited by 147 · see citing works
X‐Ray Characterization of Melanins—II
Cheng, J. Q., Moss, S. C., & Eisner, M. (1994) · Pigment Cell Research · doi:10.1111/j.1600-0749.1994.tb00061.x · Cited by 147 · see citing works
Wakamatsu, K., Hu, D., McCormick, S. A., & Ito, S. (2007) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2007.00415.x · Cited by 144 · see citing works
Neuromelanin and Parkinson's disease.
MARSDEN, C. D. (1983) · PubMed · Cited by 143 · see citing works
Iron deficiency: Differential effects on monoamine transporters
Burhans, M. S., Dailey, C., Beard, Z., Wiesinger, J. A., Murray‐Kolb, L. E., Jones, B. C., & Beard, J. L. (2005) · Nutritional Neuroscience · doi:10.1080/10284150500047070 · Cited by 143 · see citing works
The neuromelanin of the human substantia nigra
Carstam, R., Brinck, C., Hindemith, A., Rorsman, H., & Rosengren, E. (1991) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(91)90100-n · Cited by 142 · see citing works
Altered monamine metabolism in caudate-putamen of iron-deficient rats
Beard, J. L., Chen, Q., Connor, J. R., & Jones, B. C. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90323-9 · Cited by 140 · see citing works
The effect of melanin on iron associated decomposition of hydrogen peroxide
Pilas, B., Sarna, T., Kalyanaraman, B., & Swartz, H. M. (1988) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(88)90049-4 · Cited by 139 · see citing works
Self-citationA potential pathogenetic role of iron in Alzheimer's disease
Silvestri, L., & Camaschella, C. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00356.x · Cited by 139 · see citing works
Shima, T., Sarna, T., Swartz, H. M., Stroppolo, A., Gerbasi, R., & Zecca, L. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00623-5 · Cited by 135 · see citing works
Self-citationProta, G. (2000) · Pigment Cell Research · doi:10.1034/j.1600-0749.2000.130412.x · Cited by 132 · see citing works
Zucca, F. A., Bellei, C., Giannelli, S. G., Terreni, M., Gallorini, M., Rizzio, E., Pezzoli, G., Albertini, A., & Zecca, L. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0453-2 · Cited by 132 · see citing works
Self-citationIron homeostasis in astrocytes and microglia is differentially regulated by TNF‐α and TGF‐β1
Rathore, K. I., Redensek, A., & David, S. (2012) · Glia · doi:10.1002/glia.22303 · Cited by 130 · see citing works
Segura‐Aguilar, J., Metodiewa, D., & Welch, C. J. (1998) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(98)00036-1 · Cited by 130 · see citing works
Self-citation
Flagged first, then by citations
5 of the 350 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- Brilliant MH Nordlund JJ Boissy RE Hearing VJ King RA Oetting WS Ortonne J-P Molecular Regulation of Melanin Formation: Melanosome Transport Proteins The Pigmentary System: Physiology and Pathophysiology 2006 Second edition Malden, MA, USA Blackwell Publishing 230 241
- Jimbow K Quevedo WC Fitzpatrick TB Szabo G Freeberg IA Eisen AZ Wolf K Austen KF Goldsimth LA Katz SI Fitzpatrick TB Biology of Melanocytes Fiotzpatrick’s Dermatology in General Medicine 1999 5th edition New York McGraw Hill 192 220
- Tiekink ERT Zukerman-Schpector J The Importance of Pi-Interactions in Crystal Engineering: Frontiers in Crystal Engineering 2012 John Wiley & Sons
- Zucca FA Cupaioli FA Zecca L Milardi D Rizzarelli E The role of iron in neurodegeneration Neurodegeneration: metallostasis and proteostasis 2011 Cambridge RSC Publishing 174 211
Cited by
Sorted by citations
Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases
Tan, B. L., Norhaizan, M. E., Liew, W.-P.-P., & Rahman, H. S. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01162 · Cited by 1,182 · see citing works
Selective neuronal vulnerability in Parkinson disease
Surmeier, D. J., Obeso, J. A., & Halliday, G. M. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.178 · Cited by 1,121 · see citing works
Obeso, J. A., Stamelou, M., Goetz, C. G., Poewe, W., Lang, A. E., Weintraub, D., Burn, D., Halliday, G. M., Bezard, E., Przedborski, S., et al. (2017) · Movement Disorders · doi:10.1002/mds.27115 · Cited by 859 · see citing works
“Misfolded and oxidized forms of alpha-synuclein are potent inflammogens in many assays, and even neuromelanin, which is presumably released on the death of dopaminergic neurons, can stimulate the activation of brain microglia.(260) However, clear proof that any of these are responsible is still lacking.”
The Locus Coeruleus: Essential for Maintaining Cognitive Function and the Aging Brain
Mather, M., & Harley, C. W. (2016) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2016.01.001 · Cited by 485 · see citing works
Determinants of dopaminergic neuron loss in Parkinson's disease
Surmeier, D. J. (2018) · FEBS Journal · doi:10.1111/febs.14607 · Cited by 455 · see citing works
Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases
Betts, M. J., Kirilina, E. P., Otaduy, M. C. G., Ivanov, D., Acosta‐Cabronero, J., Callaghan, M. F., Lambert, C., Cárdenas‐Blanco, A., Pine, K., Passamonti, L., et al. (2019) · Brain · doi:10.1093/brain/awz193 · Cited by 349 · see citing works
Self-citationKausar, S., Wang, F., & Cui, H. (2018) · Cells · doi:10.3390/cells7120274 · Cited by 315 · see citing works
Iron in Neurodegeneration – Cause or Consequence?
Ndayisaba, A., Kaindlstorfer, C., & Wenning, G. K. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00180 · Cited by 298 · see citing works
Eid, R., Arab, N. T. T., & Greenwood, M. T. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.12.002 · Cited by 286 · see citing works
Iron and dopamine: a toxic couple
Hare, D. J., & Double, K. L. (2016) · Brain · doi:10.1093/brain/aww022 · Cited by 284 · see citing works
Wang, Y., Spincemaille, P., Liu, Z., Dimov, A., Deh, K., Li, J., Zhang, Y., Yao, Y., Gillen, K. M., Wilman, A. H., et al. (2017) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.25693 · Cited by 278 · see citing works
Sulzer, D. L., Cassidy, C., Horga, G., Kang, U. J., Fahn, S., Casella, L., Pezzoli, G., Langley, J. A., Hu, X. P., Zucca, F. A., et al. (2018) · npj Parkinson s Disease · doi:10.1038/s41531-018-0047-3 · Cited by 277 · see citing works
Self-citationMonzani, E., Nicolis, S., Dell’Acqua, S., Capucciati, A., Bacchella, C., Zucca, F. A., Mosharov, E. V., Sulzer, D. L., Zecca, L., & Casella, L. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201811122 · Cited by 270 · see citing works
Self-citationChen, P., Miah, M. R., & Aschner, M. (2016) · F1000Research · doi:10.12688/f1000research.7431.1 · Cited by 260 · see citing works
Garza-Lombó, C., Posadas, Y., Quintanar, L., Gonsebatt, M. E., & Franco, R. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7272 · Cited by 254 · see citing works
Neuromelanin-sensitive MRI as a noninvasive proxy measure of dopamine function in the human brain
Cassidy, C., Zucca, F. A., Girgis, R. R., Baker, S. C., Weinstein, J. J., Sharp, M. E., Bellei, C., Valmadre, A., Vanegas‐Arroyave, N., Kegeles, L. S., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1807983116 · Cited by 247 · see citing works
Self-citationAparna, T. K., Sivasubramanian, R., & Dar, M. A. (2018) · Journal of Alloys and Compounds · doi:10.1016/j.jallcom.2018.01.205 · Cited by 246 · see citing works
Bioactivity of Olive Oil Phenols in Neuroprotection
Angeloni, C., Malaguti, M., Barbalace, M. C., & Hrelia, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112230 · Cited by 237 · see citing works
Oxidative Stress‐Related Mechanisms in Schizophrenia Pathogenesis and New Treatment Perspectives
Ermakov, E. A., Dmitrieva, E. M., Parshukova, D. A., Kazantseva, D. V., Vasilieva, A. R., & Smirnova, L. P. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/8881770 · Cited by 252 · see citing works
Jacobs, H. I. L., Becker, J. A., Kwong, K. K., Engels, N., Prokopiou, P. C., Papp, K. V., Properzi, M. J., Hampton, O. L., Uquillas, F. D., Sanchez, J. S., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abj2511 · Cited by 222 · see citing works
Oxidative stress factors in Parkinson’s disease
Dorszewska, J., Kowalska, M., Prendecki, M., Piekut, T., Kozłowska, J., & Kozubski, W. P. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.300980 · Cited by 211 · see citing works
Iron, myelin, and the brain: neuroimaging meets neurobiology
Möller, H. E., Bossoni, L., Connor, J. R., Crichton, R. R., Does, M. D., Ward, R. J., Zecca, L., Zucca, F. A., & Ronen, I. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.03.009 · Cited by 207 · see citing works
Self-citationCalcium and Parkinson's disease
Surmeier, D. J., Schumacker, P. T., Guzmán, J. D., Ilijić, E., Yang, B., & Zampese, E. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.08.168 · Cited by 203 · see citing works
Dovonou, A., Bolduc, C., Linan, V. S., Gora, C., Peralta, M. R., & Lévesque, M. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00368-8 · Cited by 203 · see citing works
Parkinson's Disease Is Not Simply a Prion Disorder
Surmeier, D. J., Obeso, J. A., & Halliday, G. M. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1787-16.2017 · Cited by 186 · see citing works
Gąsiorowska, A., Wydrych, M., Drapich, P., Zadrożny, M., Steczkowska, M., Niewiadomski, W., & Niewiadomska, G. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.654931 · Cited by 192 · see citing works
Ren, Y., Zhao, X., Liang, X., Ma, P. X., & Guo, B. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.07.130 · Cited by 188 · see citing works
The spatiotemporal changes in dopamine, neuromelanin and iron characterizing Parkinson’s disease
Biondetti, E., Santin, M. D., Valabrègue, R., Mangone, G., Gaurav, R., Pyatigorskaya, N., Hutchison, M., Yahia‐Cherif, L., Villain, N., Habert, M., et al. (2021) · Brain · doi:10.1093/brain/awab191 · Cited by 186 · see citing works
Neurotoxicity of Metal Mixtures
Andrade, V. M., Aschner, M., & dos Santos, A. P. M. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-60189-2_12 · Cited by 180 · see citing works
Betts, M. J., Cárdenas‐Blanco, A., Kanowski, M., Jessen, F., & Düzel, E. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.09.042 · Cited by 165 · see citing works
Neuroprotective Activities of Curcumin in Parkinson’s Disease: A Review of the Literature
Nebrisi, E. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011248 · Cited by 165 · see citing works
Matchett, B. J., Grinberg, L. T., Theofilas, P., & Murray, M. E. (2021) · Acta Neuropathologica · doi:10.1007/s00401-020-02248-1 · Cited by 162 · see citing works
Ashraf, A., Clark, M., & So, P. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00065 · Cited by 158 · see citing works
Cerebral Iron Deposition in Neurodegeneration
Dušek, P., Hofer, T., Alexander, J., Roos, P. M., & Aaseth, J. (2022) · Biomolecules · doi:10.3390/biom12050714 · Cited by 159 · see citing works
Morris, G., Berk, M., Carvalho, A. F., Maes, M. H. J., Walker, A. J., & Puri, B. K. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.12.036 · Cited by 154 · see citing works
Contrast mechanisms associated with neuromelanin‐MRI
Trujillo, P., Summers, P. E., Ferrari, E., Zucca, F. A., Sturini, M., Mainardi, L. T., Cerutti, S., Smith, A. K., Smith, S. A., Zecca, L., et al. (2016) · Magnetic Resonance in Medicine · doi:10.1002/mrm.26584 · Cited by 154 · see citing works
Self-citationZucca, F. A., Vanna, R., Cupaioli, F. A., Bellei, C., Palma, A. D., Silvestre, D. D., Mauri, P., Grassi, S., Prinetti, A., Casella, L., et al. (2018) · npj Parkinson s Disease · doi:10.1038/s41531-018-0050-8 · Cited by 152 · see citing works
Self-citationNeuromelanin, aging, and neuronal vulnerability in Parkinson's disease
Vila, M. (2019) · Movement Disorders · doi:10.1002/mds.27776 · Cited by 147 · see citing works
Parkinson's disease: Alterations in iron and redox biology as a key to unlock therapeutic strategies
Ma, L., Azad, M. G., Dharmasivam, M., Richardson, V., Quinn, R. J., Feng, Y., Pountney, D. L., Tonissen, K. F., Mellick, G. D., Yanatori, I., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101896 · Cited by 148 · see citing works
Duda, J., Pötschke, C., & Liss, B. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13572 · Cited by 149 · see citing works
Ferreira, A. C. E., Neves, P., & Gozzelino, R. (2019) · Pharmaceuticals · doi:10.3390/ph12030126 · Cited by 148 · see citing works
Derry, P. J., Hegde, M. L., Jackson, G. R., Kayed, R., Tour, J. M., Tsai, A.-L., & Kent, T. A. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101716 · Cited by 142 · see citing works
Neuromelanin in Parkinson’s Disease: Tyrosine Hydroxylase and Tyrosinase
Nagatsu, T., Nakashima, A., Watanabe, H., Ito, S., & Wakamatsu, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084176 · Cited by 142 · see citing works
Impact of Dopamine Oxidation on Dopaminergic Neurodegeneration
Zhang, S., Wang, R., & Wang, G. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00454 · Cited by 133 · see citing works
Iron deposition in Parkinson’s disease by quantitative susceptibility mapping
Chen, Q., Chen, Y., Zhang, Y., Wang, F., Yu, H., Zhang, C., Jiang, Z., & Luo, W. (2019) · BMC Neuroscience · doi:10.1186/s12868-019-0505-9 · Cited by 133 · see citing works
Iron chelation in the treatment of neurodegenerative diseases
Dušek, P., Schneider, S. A., & Aaseth, J. (2016) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2016.03.010 · Cited by 133 · see citing works
Development, wiring and function of dopamine neuron subtypes
Garritsen, O., van Battum, E. Y., Grossouw, L. M., & Pasterkamp, R. J. (2023) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00669-3 · Cited by 128 · see citing works
studygroups, T. F.-I. A. F.-I., Devos, D., Cabantchik, Z. I., Moreau, C., Danel-Brunaud, V., Mahoney‐Sanchez, L., Bouchaoui, H., Gouel, F., Rolland, A., Duce, J. A., et al. (2020) · Journal of Neural Transmission · doi:10.1007/s00702-019-02138-1 · Cited by 132 · see citing works
Neuroimaging and fluid biomarkers in Parkinson’s disease in an era of targeted interventions
Zarkali, A., Thomas, G. E. C., Zetterberg, H., & Weil, R. S. (2024) · Nature Communications · doi:10.1038/s41467-024-49949-9 · Cited by 128 · see citing works
Genoud, S., Roberts, B. R., Gunn, A. P., Halliday, G. M., Lewis, S. J. G., Ball, H. J., Hare, D. J., & Double, K. L. (2017) · Metallomics · doi:10.1039/c7mt00244k · Cited by 126 · see citing works
Yauger, Y. J., Bermudez, S., Moritz, K. E., Glaser, E. P., Stoica, B. A., & Byrnes, K. R. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1430-7 · Cited by 125 · see citing works
Role of iron in neurodegenerative diseases
Li, K., & Reichmann, H. (2016) · Journal of Neural Transmission · doi:10.1007/s00702-016-1508-7 · Cited by 117 · see citing works
α-Synuclein in Parkinson’s disease: causal or bystander?
Riederer, P. F., Berg, D., Casadei, N., Cheng, F., Claßen, J., Dresel, C., Jost, W. H., Krüger, R., Müller, T. H., Reichmann, H., et al. (2019) · Journal of Neural Transmission · doi:10.1007/s00702-019-02025-9 · Cited by 118 · see citing works
Neuromelanin, one of the most overlooked molecules in modern medicine, is not a spectator
Haining, R. L., & Achat‐Mendes, C. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.202928 · Cited by 116 · see citing works
Cheng, Z., He, N., Huang, P., Li, Y., Tang, R., Sethi, S. K., Ghassaban, K., Yerramsetty, K. K., Palutla, V. K., Chen, S., et al. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.102103 · Cited by 114 · see citing works
Weng, M., Xie, X., Liu, C., Lim, K., Zhang, C., & Li, L. (2018) · Parkinson s Disease · doi:10.1155/2018/9163040 · Cited by 114 · see citing works
Maturation of the human striatal dopamine system revealed by PET and quantitative MRI
Larsen, B., Olafsson, V., Calabro, F., Laymon, C., Tervo-Clemmens, B., Campbell, E., Minhas, D., Montez, D., Price, J., & Luna, B. (2020) · Nature Communications · doi:10.1038/s41467-020-14693-3 · Cited by 107 · see citing works
The Pathology of Parkinson’s Disease and Potential Benefit of Dietary Polyphenols
Aryal, S., Skinner, T., Bridges, B., & Weber, J. T. (2020) · Molecules · doi:10.3390/molecules25194382 · Cited by 109 · see citing works
Longitudinal Changes in Neuromelanin MRI Signal in Parkinson's Disease: A Progression Marker
Gaurav, R., Yahia‐Cherif, L., Pyatigorskaya, N., Mangone, G., Biondetti, E., Valabrègue, R., Ewenczyk, C., Hutchison, R. M., Cedarbaum, J. M., Corvol, J., et al. (2021) · Movement Disorders · doi:10.1002/mds.28531 · Cited by 107 · see citing works
Redox Signaling in Neurotransmission and Cognition During Aging
Kumar, A., Yegla, B., & Foster, T. C. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7111 · Cited by 104 · see citing works
Polydopamine Nanoparticles Prepared Using Redox-Active Transition Metals
Salomäki, M., Ouvinen, T., Marttila, L., Kivelä, H., Leiro, J. A., Mäkilä, E. M., & Lukkari, J. (2019) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.8b11994 · Cited by 102 · see citing works
Mulas, G., Espa, E., Fenu, S., Spiga, S., Cossu, G., Pillai, E., Carboni, E., Simbula, G., Jadzic, D., Angius, F., et al. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.09.013 · Cited by 103 · see citing works
Life span pigmentation changes of the substantia nigra detected by neuromelanin‐sensitive MRI
Xing, Y., Sapuan, A. H., Dineen, R. A., & Auer, D. P. (2018) · Movement Disorders · doi:10.1002/mds.27502 · Cited by 103 · see citing works
Liss, B., & Striessnig, J. (2019) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010818-021214 · Cited by 103 · see citing works
The usual suspects, dopamine and alpha‐synuclein, conspire to cause neurodegeneration
Mor, D. E., Daniels, M. J., & Ischiropoulos, H. (2019) · Movement Disorders · doi:10.1002/mds.27607 · Cited by 103 · see citing works
García‐Pardo, J., Novio, F., Nador, F., Cavaliere, I., Suárez–García, S., Lope‐Piedrafita, S., Candiota, A. P., Romero‐Giménez, J., Rodríguez-Galván, B., Bové, J., et al. (2021) · ACS Nano · doi:10.1021/acsnano.1c00453 · Cited by 103 · see citing works
Sharma, S., Aran, K. R., & Singh, S. (2019) · Neurotoxicity Research · doi:10.1007/s12640-019-00120-z · Cited by 102 · see citing works
Longitudinal Development of Brain Iron Is Linked to Cognition in Youth
Larsen, B., Bourque, J., Moore, T. M., Adebimpe, A., Calkins, M., Elliott, M., Gur, R., Gur, R., Moberg, P., Roalf, D., et al. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2434-19.2020 · Cited by 92 · see citing works
Wang, Y., Gao, L., Chen, J., Li, Q., Huo, L., Wang, Y., Wang, H., & Du, J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.757161 · Cited by 106 · see citing works
Iron homeostasis imbalance and ferroptosis in brain diseases
Long, H.-N., Zhu, W.-S., Wei, L.-M., & Zhao, J.-G. (2023) · MedComm · doi:10.1002/mco2.298 · Cited by 108 · see citing works
Redox active metals in neurodegenerative diseases
Acevedo, K. M., Masaldan, S., Opazo, C., & Bush, A. I. (2019) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-019-01731-9 · Cited by 101 · see citing works
Innate Immunity: A Common Denominator between Neurodegenerative and Neuropsychiatric Diseases
Novellino, F., Saccà, V., Donato, A., Zaffino, P., Spadea, M. F., Vismara, M. F. M., Arcidiacono, B., Malara, N., Presta, I., & Donato, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031115 · Cited by 104 · see citing works
Melanin: insights into structure, analysis, and biological activities for future development
Song, W. F., Yang, H., Liu, S., Yu, H., Li, D., Li, P., & Xing, R. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb01132a · Cited by 101 · see citing works
Calcium, mitochondrial dysfunction and slowing the progression of Parkinson's disease
Surmeier, D. J., Halliday, G. M., & Simuni, T. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.08.001 · Cited by 99 · see citing works
MRI biomarkers of motor and non-motor symptoms in Parkinson's disease
Ryman, S. G., & Poston, K. L. (2019) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2019.10.002 · Cited by 98 · see citing works
Xi, X., Wu, D., Ji, W., Zhang, S., Tang, W., Su, Y., Guo, X., & Liu, R. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201905361 · Cited by 97 · see citing works
Lee, J., & Lee, M. S. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00074 · Cited by 95 · see citing works
Zuo, Y., Xie, J., Li, X., Li, Y., Thirupathi, A., Zhang, J., Yu, P., Gao, G., Chang, Y., & Shi, Z. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9961628 · Cited by 95 · see citing works
Global Research Trends of Ferroptosis: A Rapidly Evolving Field With Enormous Potential
Wu, H., Wang, Y., Tong, L., Yan, H., & Sun, Z. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.646311 · Cited by 93 · see citing works
Brain Iron Metabolism, Redox Balance and Neurological Diseases
Gao, G., You, L., Zhang, J. J., Chang, Y., & Yu, P. (2023) · Antioxidants · doi:10.3390/antiox12061289 · Cited by 90 · see citing works
Immanuel, S., Aparna, T. K., & Sivasubramanian, R. (2018) · Surfaces and Interfaces · doi:10.1016/j.surfin.2018.11.010 · Cited by 87 · see citing works
Parkinson's disease: From bench to bedside
Draoui, A., Hiba, O. E., Aimrane, A., Khiat, A. E., & Gamrani, H. (2020) · Revue Neurologique · doi:10.1016/j.neurol.2019.11.002 · Cited by 82 · see citing works
Minakaki, G., Krainc, D., & Burbulla, L. F. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.580634 · Cited by 83 · see citing works
Luo, M., Lee, L. K. C., Peng, B., Choi, C. H. J., Tong, W. Y., & Voelcker, N. H. (2022) · Advanced Science · doi:10.1002/advs.202201740 · Cited by 81 · see citing works
Sun, J., Lin, X., Lu, D.-H., Wang, M., Li, K., Li, S., Li, Z., Zhu, C., Zhang, Z.-M., Yan, C., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci165228 · Cited by 82 · see citing works
Mauro, E. D., Xu, R., Soliveri, G., & Santato, C. (2017) · MRS Communications · doi:10.1557/mrc.2017.33 · Cited by 81 · see citing works
Diffusion tensor imaging of the substantia nigra in Parkinson's disease revisited
Langley, J. A., Huddleston, D. E., Merritt, M. D., Chen, X., McMurray, R., Silver, M., Factor, S. A., & Hu, X. P. (2016) · Human Brain Mapping · doi:10.1002/hbm.23192 · Cited by 78 · see citing works
Duce, J. A., Wong, B. X. W., Durham, H., Devedjian, J.-C., Smith, D. P., & Devos, D. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0186-8 · Cited by 80 · see citing works
Turner, R. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0349 · Cited by 78 · see citing works
Magnetic resonance imaging of noradrenergic neurons
Watanabe, T., Tan, Z., Wang, X., Martinez-Hernandez, A., & Frahm, J. (2019) · Brain Structure and Function · doi:10.1007/s00429-019-01858-0 · Cited by 77 · see citing works
Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite
Bruning, J. M., Wang, Y., Oltrabella, F., Tian, B., Kholodar, S. A., Liu, H., Bhattacharya, P., Guo, S., Holton, J. M., Fletterick, R. J., et al. (2019) · Cell chemical biology · doi:10.1016/j.chembiol.2019.02.002 · Cited by 78 · see citing works
Yue, H., Zhang, H., Huang, S., Lu, X. X., Gao, X., Song, S. S., Wang, Z., Wang, W. Q., & Guan, E. H. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.110490 · Cited by 76 · see citing works
l ‐DOPA‐induced dyskinesia and neuroinflammation: do microglia and astrocytes play a role?
Carta, A. R., Mulas, G., Bortolanza, M., Duarte, T. T., Pillai, E., Fisone, G., Raisman‐Vozari, R., & Bel, E. A. D. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13482 · Cited by 76 · see citing works
Lactoferrin as a nutraceutical protein from milk, an overview
Iglesias-Figueroa, B. F., Espinoza-Sánchez, E. A., Siqueiros-Cendón, T., & Rascón-Cruz, Q. (2018) · International Dairy Journal · doi:10.1016/j.idairyj.2018.09.004 · Cited by 76 · see citing works
Mi, H., Jing, X., Thomsom, J. A., & Turng, L. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb00654g · Cited by 75 · see citing works
Diabetes Mellitus as a Risk Factor for Parkinson’s Disease: a Molecular Point of View
Biosa, A., Outeiro, T. F., Bubacco, L., & Bisaglia, M. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1025-9 · Cited by 74 · see citing works
Relationship between neuromelanin and dopamine terminals within the Parkinson’s nigrostriatal system
Martín‐Bastida, A., Lao–Kaim, N. P., Roussakis, A., Searle, G. E., Xing, Y., Gunn, R. N., Schwarz, S. T., Barker, R. A., Auer, D. P., & Piccini, P. P. (2019) · Brain · doi:10.1093/brain/awz120 · Cited by 73 · see citing works
Dahl, M. J., Bachman, S. L., Dutt, S., Düzel, S., Bodammer, N., Lindenberger, U., Kühn, S., Werkle‐Bergner, M., & Mather, M. (2023) · Nature Aging · doi:10.1038/s43587-023-00469-z · Cited by 73 · see citing works
Parkinson’s Disease: The Mitochondria-Iron Link
Muñoz, Y., Carrasco, C. M., Campos, J., Aguirre, P., & Núñez, M. T. (2016) · Parkinson s Disease · doi:10.1155/2016/7049108 · Cited by 73 · see citing works
The Relevance of Iron in the Pathogenesis of Multiple System Atrophy: A Viewpoint
Kaindlstorfer, C., Jellinger, K. A., Eschlböck, S., Stefanova, N., Weiß, G., & Wenning, G. K. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170601 · Cited by 71 · see citing works
- Authors
- Zucca, F. A., Segura-Aguilar, J., Ferrari, E., Muñoz, P., Paris, I., Sulzer, D., Sarna, T., Casella, L., & Zecca, L.
- Affiliations
- Institute of Biomedical Technologies (IT)
- University of Chile (CL)
- Universidad Santo Tomás (CL)
- Columbia University Irving Medical Center (US)
- Jagiellonian University (PL)
- University of Pavia (IT)
- Corresponding author
- Zecca, Luigi
- ORCID
- Venue
- Progress in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 155
- Pages
- 96-119
- ISSN
- 0301-0082 (ISSN-L)
- PMC
- PMC4826627
- OpenAlex
- W1913653254
- Cited by
- 659
- References
- 350
- Citations by year
- 2026: 43 · 2025: 59 · 2024: 58 · 2023: 73 · 2022: 74 · 2021: 72 · 2020: 70 · 2019: 77 · 2018: 53 · 2017: 46 · 2016: 30 · 2015: 2 · 2012: 1
- FWCI
- 5.75
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Progress in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Jagiellonian University Repository (Jagiellonian University) (submittedVersion, cc-by-nc-nd)
- Universidad de Chile (submittedVersion, cc-by-nc-nd)
- Funders
- National Institute on Drug Abuse (P01DA010154, R01DA007418)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- neuromelanin, iron, dopamine, brain aging, Parkinson's disease, substantia nigra, locus coeruleus, noradrenergic neurons, oxidative stress, metal chelation, neuroinflammation, microglial activation, neurodegeneration, redox homeostasis
- MeSH terms
- Aging, Animals, Dopamine, Humans, Iron, Melanins, Parkinson Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review