The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
Non invasive fibrosis biomarkers reduce but not substitute the need for liver biopsy
Open accessAbstract
Chronic liver diseases are very common worldwide, particularly those linked to viral hepatitis and to alcoholic and non-alcoholic fatty liver. Their natural history is variable and long-term evolution differs in individual patients. Optimised clinical management of compensated chronic liver diseases requires precise definition of the stage of liver fibrosis, the main determinant of prognosis and of most therapeutic decisions. Liver biopsy is the gold standard for assessment of hepatic fibrosis. However, it is invasive with possible complications, costly and prone to sampling errors. Many non-invasive markers of liver fibrosis have been recently proposed and assessed in the clinical setting as surrogates of liver biopsy. Direct markers are based on biochemical parameters directly linked to fibrogenesis while indirect markers use simple or more sophisticated parameters that correlate with liver fibrosis stages. Non-invasive markers of liver fibrosis have been tested in different forms of chronic liver disease and showed variable diagnostic performance, but accuracy rarely was above 75%-80%. Better results were obtained when markers were combined. On this line, we have recently proposed a set of algorithms that combine sequentially indirect non-invasive markers of liver fibrosis, reaching 90%-95% diagnostic accuracy with significant reduction in the need for liver biopsy. Based on available evidence, it can be anticipated that non-invasive markers of liver fibrosis and their combined use will soon become a most useful tool in the clinical management of many forms of chronic liver disease. However, their implementation is expected to reduce, but not to completely eliminate, the need for liver biopsy.
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Transient elastography: a new noninvasive method for assessment of hepatic fibrosis
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Sampling Variability of Liver Fibrosis in Chronic Hepatitis C
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Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection
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Liver fibrosis – from bench to bedside
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Cited by
Magnetic resonance imaging of hepatic fibrosis: Emerging clinical applications
Talwalkar, J. A., Yin, M., Fidler, J. L., Sanderson, S. O., Kamath, P. S., & Ehman, R. L. (2008) · Hepatology · doi:10.1002/hep.21972 · Cited by 314
Non-Invasive markers for hepatic fibrosis
Baranova, A., Lal, P., Birerdinc, A., & Younossi, Z. M. (2011) · BMC Gastroenterology · doi:10.1186/1471-230x-11-91 · Cited by 297
Comparison of blood tests for liver fibrosis specific or not to NAFLD
Calès, P., Lainé, F., Boursier, J., Deugnier, Y., Moal, V., Oberti, F., Hunault, G., Rousselet, M. C., Hubert, I., Laafi, J., et al. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2008.07.035 · Cited by 260
Ectopic and Visceral Fat Deposition in Lean and Obese Patients With Type 2 Diabetes
Levelt, E., Pavlides, M., Banerjee, R., Mahmod, M., Kelly, C., Sellwood, J., Ariga, R., Thomas, S., Francis, J., Rodgers, C., et al. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.03.597 · Cited by 222
Type V Collagen in Health, Disease, and Fibrosis
Mak, K. M., Png, C. Y. M., & Lee, D. J. (2016) · The Anatomical Record · doi:10.1002/ar.23330 · Cited by 197
Metadata
- Authors
- Sebastiani, G.
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2006
- Volume
- 12
- Issue
- 23
- Pages
- 3682
- ISSN
- 1007-9327 (ISSN-L)
- OpenAlex
- W1504293485
- Cited by
- 266
- References
- 101
- FWCI
- 16.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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