Type V Collagen in Health, Disease, and Fibrosis

Mak, Ki M.; Png, Chien Yi M.; Lee, Danielle J.

doi:10.1002/ar.23330

Cited by 197Collagen: Extraction and CharacterizationConnective tissue disorders researchTGF-β signaling in diseases

Type V Collagen in Health, Disease, and Fibrosis

Open access

Mak, Ki M., Png, Chien Yi M., Lee, Danielle J.·2016·The Anatomical Record

DOI 10.1002/ar.23330

Open this paper in CoChat — free account Open PDF

Abstract

Type V collagen (COLV) is a regulatory fibril‐forming collagen. It has at least three different molecular isoforms—α1(V)2 α2(V), α1(V)3, and α1(V)α2(V)α3(V)—formed by combinations of three different polypeptide α chains—α1(V), α2(V), and α3(V). COL V is a relatively minor collagen of the extracellular matrix (ECM). Morphologically, COLV occurs as heterotypic fibrils with type I collagen (COLI), microfilaments, or 12‐nm‐thick fibrils. COLV is synthesized in various mesenchymal cells and its gene expression is modulated by TGF‐β and growth factors. While resistant to digestion by interstitial collagenases, native and denatured COLV are degraded by metalloproteinases and gelatinases, thereby promoting ECM remodeling. COLV interacts with matrix collagens and structural proteins, conferring structural integrity to tissue scaffolds. It binds matrix macromolecules, modulating cellular behavior, and functions. COLV co‐assembles with COLI into heterotypic fibrils in the cornea and skin dermis, acting as a dominant regulator of collagen fibrillogenesis. COLV deficiency is associated with loss of corneal transparency and classic Ehlers–Danlos syndrome, while COLV overexpression is found in cancer, granulation tissue, inflammation, atherosclerosis, and fibrosis of lungs, skin, kidneys, adipose tissue, and liver. COLV isoform containing the α3(V) chain is involved in mediating pancreatic islet cell functions. In the liver, COLV is a minor but regular component of the ECM. Increases in COLV are associated with both early and advanced hepatic fibrosis. The neoepitopes of COLV have been shown to be a useful noninvasive serum biomarker for assessing fibrotic progression and resolution in experimental hepatic fibrosis. COLV is multifunctional in health, disease, and fibrosis. Anat Rec, 299:613–629, 2016. © 2016 Wiley Periodicals, Inc.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1002/ar.23330

Cites

130 of 130 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Collagen V has a crucial role for embryonic development.
“Collagen V knockout mice synthesize and secrete normal amounts of collagen I, but collagen fibrils are absent, and the animals die at the onset of organogenesis, supporting the crucial role of collagen V for embryonic development [43].”
From Cellular and Molecular Mechanisms in the Pathogenesis of Classical, Vascular, and Hypermobile Ehlers‒Danlos Syndromes (2019) · cites this paper as [43]
Collagen V knockout mice synthesize and secrete normal amounts of collagen I, but collagen fibrils are absent, and the animals die at the onset of organogenesis.
“Collagen V knockout mice synthesize and secrete normal amounts of collagen I, but collagen fibrils are absent, and the animals die at the onset of organogenesis, supporting the crucial role of collagen V for embryonic development [43].”
From Cellular and Molecular Mechanisms in the Pathogenesis of Classical, Vascular, and Hypermobile Ehlers‒Danlos Syndromes (2019) · cites this paper as [43]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Collagens—structure, function, and biosynthesis
Gelse, K. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.08.002 · Cited by 2,663 · see citing works
Biochemical and immunological characterization of the secreted forms of human neutrophil gelatinase.
Hibbs, M. S., Hasty, K. A., Seyer, J. M., Kang, A. H., & Mainardi, C. L. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89580-1 · Cited by 613 · see citing works
Collagen fibrillogenesis <i>in vitro:</i> interaction of types I and V collagen regulates fibril diameter
Birk, D. E., Fitch, J. M., Babiarz, J. P., Doane, K. J., & Linsenmayer, T. F. (1990) · Journal of Cell Science · doi:10.1242/jcs.95.4.649 · Cited by 596 · see citing works
Type V collagen controls the initiation of collagen fibril assembly
Wenstrup, R. J., Florer, J. B., Brunskill, E. W., Bell, S. M., Chervoneva, I., & Birk, D. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409622200 · Cited by 545 · see citing works
Matrix as a Modulator of Hepatic Fibrogenesis
Schuppan, D., Ruehl, M., Somasundaram, R., & Hahn, E. G. (2001) · Seminars in Liver Disease · doi:10.1055/s-2001-17556 · Cited by 540 · see citing works
Collagen Types in Normal and Cirrhotic Liver
Rojkind, M., Giambrone, M. A., & Biempica, L. (1979) · Gastroenterology · doi:10.1016/s0016-5085(79)80170-5 · Cited by 527 · see citing works
Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity
Henegar, C., Tordjman, J., Achard, V., Lacasa, D., Cremer, I., Guerre-Millo, M., Poitou, C., Basdevant, A., Stich, V., Viguerie, N., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-1-r14 · Cited by 471 · see citing works
Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation
Spencer, M., Yao-Borengasser, A., Unal, R., Rasouli, N., Gurley, C. M., Zhu, B., Peterson, C. A., & Kern, P. A. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00329.2010 · Cited by 439 · see citing works
Type V collagen: heterotypic type I/V collagen interactions in the regulation of fibril assembly
Birk, D. E. (2001) · Micron · doi:10.1016/s0968-4328(00)00043-3 · Cited by 429 · see citing works
Collagen type I and type V are present in the same fibril in the avian corneal stroma.
Birk, D. E., Fitch, J. M., Babiarz, J. P., & Linsenmayer, T. F. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.106.3.999 · Cited by 391 · see citing works
Fetal membrane collagens: identification of two new collagen alpha chains.
Burgeson, R. E., Adli, F. A. E., Kaitila, I., et al. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.8.2579 · Cited by 385 · see citing works
Structure of the Extracellular Matrix in Normal and Fibrotic Liver: Collagens and Glycoproteins
Schuppan, D. (1990) · Seminars in Liver Disease · doi:10.1055/s-2008-1040452 · Cited by 369 · see citing works
Isolation of three collagenous components of probable basement membrane origin from several tissues
Chung, E., Rhodes, R. K., & Miller, E. J. (1976) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(76)90776-2 · Cited by 353 · see citing works
Regulation of corneal collagen fibrillogenesis in vitro by corneal proteoglycan (lumican and decorin) core proteins
Rada, J. A., Cornuet, P. K., & Hassell, J. R. (1993) · Experimental Eye Research · doi:10.1006/exer.1993.1081 · Cited by 345 · see citing works
The extracellular matrix in the kidney: a source of novel non-invasive biomarkers of kidney fibrosis?
Genovese, F., Manresa, A. A., Leeming, D. J., Karsdal, M. A., & Boor, P. (2014) · Fibrogenesis & Tissue Repair · doi:10.1186/1755-1536-7-4 · Cited by 336 · see citing works
International Review of Connective Tissue Research.
(1965) · Annals of Internal Medicine · doi:10.7326/0003-4819-62-3-633_1 · Cited by 310 · see citing works
Type V collagen: molecular structure and fibrillar organization of the chicken alpha 1(V) NH2-terminal domain, a putative regulator of corneal fibrillogenesis.
Linsenmayer, T. F., Gibney, E. P., Igoe, F., Gordon, M. K., Fitch, J. M., Fessler, L. I., & Birk, D. E. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.121.5.1181 · Cited by 297 · see citing works
Adipose Tissue Extracellular Matrix and Vascular Abnormalities in Obesity and Insulin Resistance
Spencer, M. L., Ünal, R., Zhu, B., Rasouli, N., McGehee, R. E., Peterson, C. A., & Kern, P. A. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1567 · Cited by 291 · see citing works
Clinical and genetic aspects of Ehlers-Danlos syndrome, classic type
Malfait, F., WENSTRUP, R. J., & Paepe, A. D. (2010) · Genetics in Medicine · doi:10.1097/gim.0b013e3181eed412 · Cited by 288 · see citing works
Non invasive fibrosis biomarkers reduce but not substitute the need for liver biopsy
Sebastiani, G. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i23.3682 · Cited by 266 · see citing works
Expression of a metalloproteinase that degrades native type V collagen and denatured collagens by cultured human alveolar macrophages.
Hibbs, M. S., Hoidal, J. R., & Kang, A. H. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113253 · Cited by 232 · see citing works
Genetic evidence for the coordinated regulation of collagen fibrillogenesis in the cornea by decorin and biglycan
Zhang, G., Chen, S., Goldoni, S., Calder, B. W., Simpson, H. C., Owens, R. T., McQuillan, D. J., Young, M. F., Iozzo, R. V., & Birk, D. E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806590200 · Cited by 224 · see citing works
Another look at collagen V and XI molecules
Fichard, A., Kleman, J.-P., & Ruggiero, F. (1995) · Matrix Biology · doi:10.1016/s0945-053x(05)80001-0 · Cited by 218 · see citing works
Targeted mutation in the col5a2 gene reveals a regulatory role for type V collagen during matrix assembly
Andrikopoulos, K., Liu, X., Keene, D. R., Jaenisch, R., & Ramirez, F. (1995) · Nature Genetics · doi:10.1038/ng0195-31 · Cited by 217 · see citing works
Increased content of Type V Collagen in desmoplasia of human breast carcinoma.
Barsky, S. H., Rao, C. N., Grotendorst, G. R., & Liotta, L. A. (1982) · PubMed Central · Cited by 215 · see citing works
Biomarkers of liver fibrosis: Clinical translation of molecular pathogenesis or based on liver-dependent malfunction tests
Gressner, O. A., Weiskirchen, R., & Gressner, A. M. (2007) · Clinica Chimica Acta · doi:10.1016/j.cca.2007.02.038 · Cited by 207 · see citing works
Collagens in human atherosclerosis. Immunohistochemical analysis using collagen type-specific antibodies.
Katsuda, S., Okada, Y., Minamoto, T., Oda, Y., Matsui, Y., & Nakanishi, I. (1992) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.12.4.494 · Cited by 205 · see citing works
Collagen V is a dominant regulator of collagen fibrillogenesis: dysfunctional regulation of structure and function in a corneal-stroma-specificCol5a1-null mouse model
Sun, M., Chen, S., Adams, S. M., Florer, J. B., Liu, H., Kao, W. W. ‐., WENSTRUP, R. J., & Birk, D. E. (2011) · Journal of Cell Science · doi:10.1242/jcs.091363 · Cited by 193 · see citing works
Colorectal carcinogenesis is associated with stromal expression of COL11A1 and COL5A2
Fischer, H. (2001) · Carcinogenesis · doi:10.1093/carcin/22.6.875 · Cited by 188 · see citing works
In vitro Formation of Hybrid Fibrils of Type v Collagen and Type I Collagen Limited Growth of Type I Collagen Into Thick Fibrils by Type V Collagen
Adachi, E., & Hayashi, T. (1986) · Connective Tissue Research · doi:10.3109/03008208609017469 · Cited by 186 · see citing works
The Extracellular Matrix of the Liver
Rojkind, M., & Ponce‐Noyola, P. (1982) · Collagen and Related Research · doi:10.1016/s0174-173x(82)80031-9 · Cited by 176 · see citing works
Murine Model of the Ehlers-Danlos Syndrome
WENSTRUP, R. J., Florer, J. B., Davidson, J. M., Phillips, C. L., Pfeiffer, B. J., Menezes, D. W., Chervoneva, I., & Birk, D. E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511528200 · Cited by 173 · see citing works
Molecular Serum Markers of Liver Fibrosis
Liu, T., Wang, X., Karsdal, M. A., Leeming, D. J., & Genovese, F. (2012) · Biomarker Insights · doi:10.4137/bmi.s10009 · Cited by 169 · see citing works
Comprehensive molecular analysis demonstrates type V collagen mutations in over 90% of patients with classic EDS and allows to refine diagnostic criteria
Symoens, S., Syx, D., Malfait, F., Callewaert, B., De Backer, J., Vanakker, O., Coucke, P., & De Paepe, A. (2012) · Human Mutation · doi:10.1002/humu.22137 · Cited by 165 · see citing works
Collagen polymorphism in the normal and diseased blood vessel wall
Morton, L. F., & Barnes, M. J. (1982) · Atherosclerosis · doi:10.1016/0021-9150(82)90124-1 · Cited by 164 · see citing works
Monoclonal antibodies against chicken type V collagen: production, specificity, and use for immunocytochemical localization in embryonic cornea and other organs
Linsenmayer, T. F., Fitch, J. M., Schmid, T., et al. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.96.1.124 · Cited by 160 · see citing works
Ultrastructural localization of type V collagen in rat kidney.
Martínez-Hernández, A., Gay, S., & Miller, E. J. (1982) · The Journal of Cell Biology · doi:10.1083/jcb.92.2.343 · Cited by 152 · see citing works
Nanomechanical Heterogeneity in the Gap and Overlap Regions of Type I Collagen Fibrils with Implications for Bone Heterogeneity
Minary‐Jolandan, M., & Yu, M.-F. (2009) · Biomacromolecules · doi:10.1021/bm900519v · Cited by 147 · see citing works
Collagen αB Chain: Increased Proportion in Human Atherosclerosis
Ooshima, A. (1981) · Science · doi:10.1126/science.7256267 · Cited by 140 · see citing works
Biosynthesis and regulation of type V collagen in diploid human fibroblasts.
Narayanan, A. S., & Page, R. C. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44284-0 · Cited by 138 · see citing works
Null Alleles of the COL5A1 Gene of Type V Collagen Are a Cause of the Classical Forms of Ehlers-Danlos Syndrome (Types I and II)
Schwarze, U., Atkinson, M., Hoffman, G. G., Greenspan, D. S., & Byers, P. H. (2000) · The American Journal of Human Genetics · doi:10.1086/302933 · Cited by 136 · see citing works
Biochemical markers and the FDA Critical Path: How biomarkers may contribute to the understanding of pathophysiology and provide unique and necessary tools for drug development
Karsdal, M. A., Henriksen, K., Leeming, D. J., Mitchell, P. G., Duffin, K. L., Barascuk, N., Klickstein, L. B., Aggarwal, P., Nemirovskiy, O. V., Byrjalsen, I., et al. (2009) · Biomarkers · doi:10.1080/13547500902777608 · Cited by 135 · see citing works
Collagens, Suprastructures, and Collagen Fibril Assembly
Birk, D. E., & Brückner, P. (2010) · Springer eBooks · doi:10.1007/978-3-642-16555-9_3 · Cited by 114 · see citing works
Human placenta type V collagens. Evidence for the existence of an alpha 1(V) alpha 2(V) alpha 3(V) collagen molecule.
Niyibizi, C., Fietzek, P. P., & REST, M. V. D. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89872-6 · Cited by 114 · see citing works
Prevention of bronchiolitis obliterans in rat lung allografts by type V collagen-induced oral tolerance1
Yasufuku, K., Heidler, K. M., Woods, K., et al. (2002) · Transplantation · doi:10.1097/00007890-200202270-00002 · Cited by 113 · see citing works
Localization of type V collagen and type IV collagen in human cornea, lung, and skin. Immunohistochemical evidence by anti-collagen antibodies characterized by immunoelectroblotting.
Konomi, H., Hayashi, T., Nakayasu, K., & Arima, M. (1984) · PubMed Central · Cited by 111 · see citing works
The Supramolecular Organization of Collagen VI Microfibrils
Baldock, C., Sherratt, M. J., Shuttleworth, C. A., & Kielty, C. M. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(03)00585-0 · Cited by 111 · see citing works
Type V collagen in human amnion is a 12 nm fibrillar component of the pericellular interstitium.
Modesti, A., Kalebic, T., Scarpa, S., Togo, S., Grotendorst, G. R., Liotta, L. A., & Triche, T. J. (1984) · PubMed · Cited by 108 · see citing works
Characterization of the tissue form of type V collagen from chick bone.
Broek, D., Madri, J. A., Eikenberry, E. F., et al. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89768-x · Cited by 107 · see citing works
Organization of collagen types I and V in the embryonic chicken cornea: monoclonal antibody studies.
Fitch, J. M., Gross, J., Mayne, R., et al. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.9.2791 · Cited by 104 · see citing works
Oral Tolerance Induction by Type V Collagen Downregulates Lung Allograft Rejection
Yasufuku, K., Heidler, K. M., O'Donnell, P. W., et al. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.25.1.4431 · Cited by 99 · see citing works
Purification of a Type V Collagen Degrading Metalloproteinase from Rabbit Alveolar Macrophages
Mainardi, C. L., Hibbs, M. S., Hasty, K. A., et al. (1984) · Collagen and Related Research · doi:10.1016/s0174-173x(84)80014-x · Cited by 98 · see citing works
Serological Investigation of the Collagen Degradation Profile of Patients with Chronic Obstructive Pulmonary Disease or Idiopathic Pulmonary Fibrosis
Leeming, D. J., Sand, J. M. B., Nielsen, M. J., Genovese, F., Martínez, F. J., Hogaboam, C. M., Han, M. K., Klickstein, L. B., & Karsdal, M. A. (2012) · Biomarker Insights · doi:10.4137/bmi.s9415 · Cited by 97 · see citing works
Th-17, Monokines, Collagen Type V, and Primary Graft Dysfunction in Lung Transplantation
Bobadilla, J. L., Love, R. B., Jankowska−Gan, E., Xu, Q., Haynes, L. D., Braun, R. K., Hayney, M. S., del Río, A. M., Meyer, K. C., Greenspan, D. S., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200612-1901oc · Cited by 95 · see citing works
Complete primary structure of human collagen alpha 1 (V) chain
Takahara, K., Sato, Y., Okazawa, K., et al. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98813-7 · Cited by 92 · see citing works
Chinese hamster lung cells synthesize and confine to the cellular domain a collagen composed solely of B chains.
Haralson, M. A., Mitchell, W. M., Rhodes, R. K., et al. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.9.5206 · Cited by 92 · see citing works
Biosynthetic Processing of the Pro-α1(V)2Pro-α2(V) Collagen Heterotrimer by Bone Morphogenetic Protein-1 and Furin-like Proprotein Convertases
Unsöld, C., Pappano, W. N., Imamura, Y., Steiglitz, B. M., & Greenspan, D. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110003200 · Cited by 91 · see citing works
Development of a Functional Skin Matrix Requires Deposition of Collagen V Heterotrimers
Chanut-Delalande, H., Bonod‐Bidaud, C., Cogne, S., Malbouyres, M., Ramirez, F., Fichard, A., & Ruggiero, F. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.13.6049-6057.2004 · Cited by 90 · see citing works
Collagens of Normal and Cirrhotic Human Liver
Aycock, R. S., & Seyer, J. M. (1989) · Connective Tissue Research · doi:10.3109/03008208909103901 · Cited by 86 · see citing works
The Pro-α3(V) Collagen Chain
Imamura, Y., Scott, I. C., & Greenspan, D. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8749 · Cited by 86 · see citing works
Progression of chronic renal disease in humans is associated with the deposition of basement membrane components and decorin in the interstitial extracellular matrix.
Vleming, L. J., Baelde, H. J., Westendorp, R. G. J., et al. (1995) · PubMed · Cited by 84 · see citing works
The pro-alpha 1(V) collagen chain. Complete primary structure, distribution of expression, and comparison with the pro-alpha 1(XI) collagen chain.
Greenspan, D. S., Cheng, W., & Hoffman, G. G. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54290-3 · Cited by 81 · see citing works
Transforming growth factor beta 1 stimulates type V collagen expression in bovine vascular smooth muscle cells
Lawrence, R., Hartmann, D. J., & Sonenshein, G. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36924-7 · Cited by 79 · see citing works
ECM roles in the function of metabolic tissues
Huang, G., & Greenspan, D. S. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.09.006 · Cited by 78 · see citing works
Abnormal collagen V deposition in dermis correlates with skin thickening and disease activity in systemic sclerosis
Martin, P., Teodoro, W. R., Velosa, A. P. P., de Morais, J., Carrasco, S., Christmann, R., Goldenstein‐Schainberg, C., Parra, E. R., Katayama, M. L. H., Sotto, M. N., et al. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2012.02.017 · Cited by 77 · see citing works
Type V Collagen Induced Tolerance Suppresses Collagen Deposition, TGF-β and Associated Transcripts in Pulmonary Fibrosis
Vittal, R., Mickler, E. A., Fisher, A. J., Zhang, C., Rothhaar, K., Gu, H., Brown, K. M., Emtiazdjoo, A., Lott, J. M., Frye, S. B., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076451 · Cited by 77 · see citing works
DLPC decreases TGF-β1-induced collagen mRNA by inhibiting p38 MAPK in hepatic stellate cells
Cao, Q., Mak, K. M., & Lieber, C. S. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00128.2002 · Cited by 72 · see citing works
Self-citation
α3(V) Collagen is critical for glucose homeostasis in mice due to effects in pancreatic islets and peripheral tissues
Huang, G., Ge, G., Wang, D., Gopalakrishnan, B., Butz, D. H., Colman, R. J., Nagy, A., & Greenspan, D. S. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45096 · Cited by 71 · see citing works
Immunoelectron microscopic localization of collagens type I, V, VI and of procollagen type III in human periodontal ligament and cementum.
Becker, J. C., Schuppan, D., Rabanus, J. P., et al. (1991) · Journal of Histochemistry & Cytochemistry · doi:10.1177/39.1.1983870 · Cited by 71 · see citing works
Control of Heterotypic Fibril Formation by Collagen V Is Determined by Chain Stoichiometry
Chanut-Delalande, H., Fichard, A., Bernocco, S., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101182200 · Cited by 70 · see citing works
A Fibronectin-Independent Mechanism of Collagen Fibrillogenesis in Adult Liver Remodeling
Moriya, K., Bae, E., Honda, K., Sakai, K., Sakaguchi, T., Tsujimoto, I., Kamisoyama, H., Keene, D. R., Sasaki, T., & Sakai, T. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.02.005 · Cited by 70 · see citing works
Interactions between Cells and Collagen V Molecules or Single Chains Involve Distinct Mechanisms
Ruggiero, F., Champliaud, M.-F., Garrone, R., et al. (1994) · Experimental Cell Research · doi:10.1006/excr.1994.1032 · Cited by 67 · see citing works
Value of Fibrosis Markers for Staging Liver Fibrosis in Patients With Precirrhotic Alcoholic Liver Disease
Lieber, C. S., Weiss, D. G., Paronetto, F., & for the Veterans Affairs Cooperative Study 391 Group (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00664.x · Cited by 66 · see citing works
Collagen, type V, α1 (COL5A1) is regulated by TGF-β in osteoblasts
Kahai, S., Vary, C., Gao, Y., & Seth, A. K. (2004) · Matrix Biology · doi:10.1016/j.matbio.2004.09.004 · Cited by 65 · see citing works
Interstitial and Vascular Type V Collagen Morphologic Disorganization in Usual Interstitial Pneumonia
Parra, E. R., Teodoro, W. R., Velosa, A. P. P., et al. (2006) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.6a6969.2006 · Cited by 63 · see citing works
Distribution of Collagen Type I and Type III and of two Collagenous Components of Basement Membranes in the Human Liver
Voß, B., Rauterberg, J., Allam, S., et al. (1980) · Pathology - Research and Practice · doi:10.1016/s0344-0338(80)80155-5 · Cited by 62 · see citing works
Immunofluorescent localization of type-V collagen as a fibrillar component of the interstitial connective tissue of human oral mucosa, artery and liver
Schuppan, D., Becker, J. C., Boehm, H., et al. (1986) · Cell and Tissue Research · doi:10.1007/bf00218060 · Cited by 61 · see citing works
Identification of binding partners interacting with the α1-N-propeptide of type V collagen
Symoens, S., Renard, M., Bonod‐Bidaud, C., Syx, D., Vaganay, E., Malfait, F., Ricard‐Blum, S., Kessler, E., Laer, L. V., Coucke, P. J., et al. (2010) · Biochemical Journal · doi:10.1042/bj20101061 · Cited by 60 · see citing works
Protein fingerprints — Relying on and understanding the information of serological protein measurements
Karsdal, M. A., Delvin, E. E., & Christiansen, C. (2011) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2011.08.1135 · Cited by 60 · see citing works
Involvement of mast cells in adipose tissue fibrosis
Hirai, S., Ohyane, C., Kim, Y., Lin, S., Goto, T., Takahashi, N., Kim, C.-S., Kang, J., Yu, R., & Kawada, T. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00056.2013 · Cited by 59 · see citing works
Extracellular matrices in the developing avian eye: type V collagen in corneal and noncorneal tissues.
Linsenmayer, T. F., Fitch, J. M., & Mayne, R. (1984) · PubMed · Cited by 58 · see citing works
Interleukin-17–Dependent Autoimmunity to Collagen Type V in Atherosclerosis
Dart, M. L., Jankowska−Gan, E., Huang, G., Roenneburg, D. A., Keller, M. R., Torrealba, J. R., Rhoads, A., Kim, B., Bobadilla, J. L., Haynes, L. D., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.221069 · Cited by 58 · see citing works
Biosynthesis of type V procollagen by A204, a human rhabdomyosarcoma cell line.
Alitalo, K. K., Myllylä, R., Sage, H., et al. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34234-0 · Cited by 55 · see citing works
Architectural remodelling in lungs of rabbits induced by type V collagen immunization: a preliminary morphologic model to study diffuse connective tissue diseases
Teodoro, W. R., Velosa, A. P. P., Witzel, S. S., et al. (2004) · Pathology - Research and Practice · doi:10.1016/j.prp.2004.05.007 · Cited by 54 · see citing works
Amino-terminal propeptide of human pro-α2(V) collagen conforms to the structural criteria of a fibrillar procollagen molecule
Woodbury, D. J., Benson-Chanda, V., & Ramirez, F. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)81674-5 · Cited by 53 · see citing works
Immunological detection of the type V collagen propeptide fragment, PVCP-1230, in connective tissue remodeling associated with liver fibrosis
Vassiliadis, E., Veidal, S. S., Simonsen, H., Larsen, D. V., Vainer, B., Chen, X., Zheng, Q., Karsdal, M. A., & Leeming, D. J. (2011) · Biomarkers · doi:10.3109/1354750x.2011.584131 · Cited by 53 · see citing works
A comprehensive study of the spatial and temporal expression of the col5a1 gene in mouse embryos: a clue for understanding collagen V function in developing connective tissues
Roulet, M., Ruggiero, F., Karsenty, G., & Guellec, D. L. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0294-1 · Cited by 53 · see citing works
Protein fingerprinting of the extracellular matrix remodelling in a rat model of liver fibrosis—a serological evaluation
Leeming, D. J., Byrjalsen, I., Jiménez, W., Christiansen, C., & Karsdal, M. A. (2012) · Liver International · doi:10.1111/liv.12044 · Cited by 53 · see citing works
Type V collagen selectively inhibits human endothelial cell proliferation
Fukuda, K., Koshihara, Y., Oda, H., et al. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)80473-x · Cited by 50 · see citing works
Molecular Packing in Network-Forming Collagens
Knupp, C., & Squire, J. M. (2005) · Advances in protein chemistry · doi:10.1016/s0065-3233(05)70011-5 · Cited by 48 · see citing works
A 92 kDa Gelatinase (MMP-9) Cleavage Site in Native Type V Collagen
Niyibizi, C., Chan, R., Wu, J.-J., et al. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1931 · Cited by 48 · see citing works
Epidermal growth factor stimulates type-V collagen synthesis in cultured murine palatal shelves
Silver, M. H., Murray, J., & Pratt, R. M. (1984) · Differentiation · doi:10.1111/j.1432-0436.1984.tb01430.x · Cited by 48 · see citing works
In Vivo Evidence for a Bridging Role of a Collagen V Subtype at the Epidermis–Dermis Interface
Bonod‐Bidaud, C., Roulet, M., Hansen, U. J., Elsheikh, A., Malbouyres, M., Ricard‐Blum, S., Faye, C., Vaganay, E., Rousselle, P., & Ruggiero, F. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.56 · Cited by 46 · see citing works
Immunocytochemical localization of type B collagen: a component of basement membrane in human liver.
Biempica, L., Morecki, R., Wu, C. H., et al. (1980) · PubMed · Cited by 45 · see citing works
Biosynthetic Processing of the Pro-α1(V)Pro-α2(V)Pro-α3(V) Procollagen Heterotrimer
Gopalakrishnan, B., Wang, W.-M., & Greenspan, D. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402252200 · Cited by 45 · see citing works
Type v collagen synthesis and deposition by chicken embryo corneal fibroblasts in vitro
Mclaughlin, J. S., Linsenmayer, T. F., & Birk, D. E. (1989) · Journal of Cell Science · doi:10.1242/jcs.94.2.371 · Cited by 45 · see citing works
Tyrosine sulfation in precursors of collagen V.
Fessler, L. I., BROSH, S., Chapin, S., et al. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)89211-6 · Cited by 44 · see citing works
Collagen type V modulates fibroblast behavior dependent on substrate stiffness
Breuls, R. G. M., Klumpers, D. D., Everts, V. E., & Smit, T. H. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.01.110 · Cited by 44 · see citing works
The mRNAs for the three chains of human collagen type XI are widely distributed but not necessarily co-expressed: implications for homotrimeric, heterotrimeric and heterotypic collagen molecules
Lui, V. C. H., Kong, R. Y. C., Nicholls, J. M., et al. (1995) · Biochemical Journal · doi:10.1042/bj3110511 · Cited by 44 · see citing works
Corneal collagen fibrils: dissection with specific collagenases and monoclonal antibodies.
Fitch, J. M., Birk, D. E., Mentzer, A., et al. (1988) · PubMed · Cited by 43 · see citing works
Serum markers of the extracellular matrix remodeling reflect antifibrotic therapy in bile-duct ligated rats
Schierwagen, R., Leeming, D. J., Klein, S., Granzow, M., Nielsen, M. J., Sauerbruch, T., Krag, A. A., Karsdal, M. A., & Trebicka, J. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00195 · Cited by 42 · see citing works
DISTRIBUTION OF COLLAGEN TYPES I, III, AND V IN FIBROTIC AND NEOPLASTIC HUMAN LIVER
Yamamoto, M., Sumiyoshi, H., Nakagami, K., & Tahara, E. (1984) · Acta Pathologica Japonica · doi:10.1111/j.1440-1827.1984.tb02184.x · Cited by 41 · see citing works
Cell-specific regulation of 1(III) and 2(V) collagen by TGF- 1 in tubulointerstitial cell models
Bertelli, R., Valenti, F., Oleggini, R., et al. (1998) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/13.3.573 · Cited by 36 · see citing works
Inhibition of bleomycin-induced pulmonary fibrosis through pre-treatment with collagen type V
Braun, R. K., Martin, A. A., Shah, S., Iwashima, M., Medina, M. G., Byrne, K., Sethupathi, P., Wigfield, C. H., Brand, D. D., & Love, R. B. (2010) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2010.03.012 · Cited by 36 · see citing works
Autoantibody profile in the experimental model of scleroderma induced by type V human collagen
Callado, M. R. M., Viana, V. S. T., Vendramini, M. B. G., Leon, E. P., Bueno, C., Velosa, A. P. P., Teodoro, W. R., & Yoshinari, N. H. (2007) · Immunology · doi:10.1111/j.1365-2567.2007.02610.x · Cited by 36 · see citing works
International Review of Connective Tissue Research
Muir, H. (1982) · Annals of the Rheumatic Diseases · doi:10.1136/ard.41.4.439-b · Cited by 36 · see citing works
Collagen V and vascular injury promote lung architectural changes in systemic sclerosis
Parra, E. R., Aguiar, A. C., Teodoro, W. R., et al. (2008) · The Clinical Respiratory Journal · doi:10.1111/j.1752-699x.2008.00118.x · Cited by 35 · see citing works
Cyanogen Bromide Peptides of the Fibrillar Collagens I, III, and V and Their Mass Spectrometric Characterization: Detection of Linear Peptides, Peptide Glycosylation, and Cross-Linking Peptides Involved in Formation of Homo- and Heterotypic Fibrils
Henkel, W., & Dreisewerd, K. (2007) · Journal of Proteome Research · doi:10.1021/pr070318r · Cited by 33 · see citing works
A hepatic fibrogenic factor stimulates the synthesis of types I, III, and V procollagens in cultured cells.
Choe, I.-S., Aycock, R. S., Raghow, R., et al. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61203-7 · Cited by 31 · see citing works
A comparison of the immunofluorescent localization of collagen types I, III, and V with the distribution of reticular fibers on the same liver sections of the snow monkey (Macaca fuscata)
Adachi, E., Hayashi, T., & Hashimoto, P. H. (1991) · Cell and Tissue Research · doi:10.1007/bf00305716 · Cited by 31 · see citing works
Scleroderma-like remodeling induced by type V collagen
Bezerra, M. C., Teodoro, W. R., de Oliveira, C. C., et al. (2006) · Archives of Dermatological Research · doi:10.1007/s00403-006-0645-5 · Cited by 28 · see citing works
Type V Collagen Distribution in Liver Is Reconstructed in Coculture System of Hepatocytes and Stellate Cells; The Possible Functions of Type V Collagen in Liver under Normal and Pathological Conditions.
Takai, K. K., Hattori, S., & Irie, S. (2001) · Cell Structure and Function · doi:10.1247/csf.26.289 · Cited by 27 · see citing works
Disassembly of F-actin filaments in human endothelial cells cultured on type V collagen
Yamamoto, K., Yamamoto, M., & Noumura, T. (1992) · Experimental Cell Research · doi:10.1016/0014-4827(92)90347-b · Cited by 26 · see citing works
Hepatic Steatosis, Fibrosis, and Cancer in Elderly Cadavers
Mak, K. M., Kwong, A. J., Chu, E. W., & Hoo, N. M. (2011) · The Anatomical Record · doi:10.1002/ar.21525 · Cited by 26 · see citing works
Self-citation
Increased mRNA expression of collagen V gene in pulmonary fibrosis of systemic sclerosis
Parra, E. R., Teodoro, W. R., de Morais, J., et al. (2009) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2009.02224.x · Cited by 22 · see citing works
Intracellular transport and tyrosine sulfation of procollagens V
Fessler, L. I., CHAPIN, S., BROSH, S., et al. (1986) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1986.tb09784.x · Cited by 22 · see citing works
Skin tumor promotion is associated with increased Type V collagen content in the dermis
Marian, B., & Danner, M. (1987) · Carcinogenesis · doi:10.1093/carcin/8.1.151 · Cited by 21 · see citing works
The chemical morphology of extracellular matrix in experimental rat liver fibrosis resembles that of normal developing connective tissue
Scott, J. E., Bosworth, T. R., Cribb, A. M., & Gressner, A. M. (1994) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00197398 · Cited by 20 · see citing works
Evidence that the collagen in the culture medium of Chinese hamster lung cells contains components related at the primary structural level to the α1(V) collagen chain
Haralson, M. A., Mitchell, W. M., Rhodes, R. K., & Miller, E. J. (1984) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(84)90182-6 · Cited by 19 · see citing works
Isolation and Characterization of Type V Collagen from Human Post-Burn Granulation Tissues
Hashimoto, Y., Shieh, T., Aoyama, H., et al. (1986) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12455645 · Cited by 18 · see citing works
Type V Collagen in Experimental Granulation Tissue
Inkinen, K. A., Wolff, H. J., von Boguslawski, K., et al. (1998) · Connective Tissue Research · doi:10.3109/03008209809021503 · Cited by 15 · see citing works
Atherofibrosis - a unique and common process of the disease pathogenesis of atherosclerosis and fibrosis - lessons for biomarker development.
Vassiliadis, E., Barascuk, N., & Karsdal, M. A. (2013) · PubMed · Cited by 14 · see citing works
Tacrolimus Increases Nox4 Expression in Human Renal Fibroblasts and Induces Fibrosis-Related Genes by Aberrant TGF-Beta Receptor Signalling
Kern, G., Mair, S., Noppert, S.-J., Jennings, P., Schramek, H., Rudnicki, M., Muller, G. A., Mayer, G. J., & Koppelstaetter, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096377 · Cited by 14 · see citing works
Intercellular Accumulation of Type V Collagen Fibrils in Accordance with Cell Aggregation
Kihara, T., Imamura, Y., Takemura, Y., et al. (2008) · The Journal of Biochemistry · doi:10.1093/jb/mvn109 · Cited by 11 · see citing works
Circulating Levels of a Collagen Type V Propeptide Fragment in a Carbon Tetrachloride Reversible Model of Liver Fibrosis
Vassiliadis, E., Veidal, S. S., Hansen, C., Karsdal, M. A., & Leeming, D. J. (2012) · Biomarker Insights · doi:10.4137/bmi.s10975 · Cited by 10 · see citing works
Type V and VI collagen for cohesion of dermal fibrillar structures.
Kobayasi, T., & Karlsmark, T. (2007) · PubMed · Cited by 9 · see citing works
Basement Membranes
Miner, J. H. (2010) · Springer eBooks · doi:10.1007/978-3-642-16555-9_4 · Cited by 6 · see citing works
Codistribution of Collagens V and VI with Collagens I and III in Hepatic Fibrosis of Elderly Cadavers
Mak, K. M. (2015) · The FASEB Journal · doi:10.1096/fasebj.29.1_supplement.544.4 · Cited by 3 · see citing works
Self-citation
Detection of type V collagen-degrading enzyme activity in human liver.
Kobayashi, M., Nakatsukasa, H., Watanabe, A., et al. (1986) · PubMed · doi:10.18926/amo/31933 · Cited by 1 · see citing works
THE ELISHA MITCHELL SCIENTIFIC SOCIETY, UNIVERSITY OF NORTH CAROLINA
Baskerville, C. (1901) · Science · doi:10.1126/science.13.330.666-a · Cited by 1 · see citing works

Flagged first, then by citations

Sorted by citations

The good and the bad collagens of fibrosis – Their role in signaling and organ function
Karsdal, M. A., Nielsen, S. H., Leeming, D. J., Langholm, L. L., Nielsen, M. J., Manon-Jensen, T., Siebuhr, A., Gudmann, N. S., Rønnow, S., Sand, J. M., et al. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.07.014 · Cited by 509 · see citing works
Proteomic analysis of decellularized pancreatic matrix identifies collagen V as a critical regulator for islet organogenesis from human pluripotent stem cells
Bi, H., Ye, K., & Jin, S. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2019.119673 · Cited by 105 · see citing works
Cellular and Molecular Mechanisms in the Pathogenesis of Classical, Vascular, and Hypermobile Ehlers‒Danlos Syndromes
Chiarelli, N., Ritelli, M., Zoppi, N., & Colombi, M. (2019) · Genes · doi:10.3390/genes10080609 · Cited by 82 · see citing works
The Matrisome, Inflammation, and Liver Disease
Dolin, C. E., & Arteel, G. E. (2020) · Seminars in Liver Disease · doi:10.1055/s-0039-3402516 · Cited by 38 · see citing works
Molecular insights in the pathogenesis of classical Ehlers-Danlos syndrome from transcriptome-wide expression profiling of patients’ skin fibroblasts
Chiarelli, N., Carini, G., Zoppi, N., Ritelli, M., & Colombi, M. (2019) · PLOS ONE · doi:10.1371/journal.pone.0211647 · Cited by 35 · see citing works

Authors: Mak, K. M., Png, C. Y. M., & Lee, D. J.
Affiliations: Icahn School of Medicine at Mount Sinai (US)
Corresponding author: Mak, Ki M.
ORCID: Mak, Ki M.
Png, Chien Yi M.
Lee, Danielle J.
Venue: The Anatomical Record
Publisher: Wiley
Published: 2016-03-15
Volume: 299
Issue: 5
Pages: 613-629
ISSN: 1932-8486 (ISSN-L)
1932-8494
DOI: 10.1002/ar.23330
OpenAlex: W2285081944
Cited by: 197
References: 130
Citations by year: 2026: 12 · 2025: 31 · 2024: 22 · 2023: 23 · 2022: 25 · 2021: 19 · 2020: 19 · 2019: 19 · 2018: 13 · 2017: 10 · 2016: 4
FWCI: 0.82
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: other-oa
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The Anatomical Record (publishedVersion, other-oa)
PubMed (publishedVersion)
Funders: Mount Sinai Health System
Topics: Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Keywords: type V collagen, collagen fibrillogenesis, extracellular matrix, collagen isoforms, Ehlers-Danlos syndrome, corneal transparency, liver fibrosis, serum biomarkers, TGF-beta, matrix metalloproteinases, collagen degradation, pancreatic islet cells, fibrosis
MeSH terms: Disease, Extracellular Matrix, Fibrosis, Humans, Collagen Type V

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Type V Collagen in Health, Disease, and Fibrosis

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks