Relationship of functional gastrointestinal disorders and psychiatric disorders: Implications for treatment
Open accessAbstract
This article revisits the links between psychopathology and functional gastrointestinal disorders such as irritable bowel syndrome (IBS), discusses the rational use of antidepressants as well as non-pharmacological approaches to the management of IBS, and suggests guidelines for the treatment of IBS based on an interdisciplinary perspective from the present state of knowledge. Relevant published literature on psychiatric disorders, especially somatization disorder, in the context of IBS, and literature providing direction for management is reviewed, and new directions are provided from findings in the literature. IBS is a heterogeneous syndrome with various potential mechanisms responsible for its clinical presentations. IBS is typically complicated with psychiatric issues, unexplained symptoms, and functional syndromes in other organ systems. Most IBS patients have multiple complaints without demonstrated cause, and that these symptoms can involve systems other than the intestine, e.g. bones and joints (fibromyalgia, temporomandibular joint syndrome), heart (non-cardiac chest pain), vascular (post-menopausal syndrome), and brain (anxiety, depression). Most IBS patients do not have psychiatric illness per se, but a range of psychoform (psychological complaints in the absence of psychiatric disorder) symptoms that accompany their somatoform (physical symptoms in the absence of medical disorder) complaints. It is not correct to label IBS patients as psychiatric patients (except those more difficult patients with true somatization disorder). One mode of treatment is unlikely to be universally effective or to resolve most symptoms. The techniques of psychotherapy or cognitive-behavioral therapy can allow IBS patients to cope more readily with their illness. Specific episodes of depressive or anxiety disorders can be managed as appropriate for those conditions. Medications designed to improve anxiety or depression are not uniformly useful for psychiatric complaints in IBS, because the psychoform symptoms that sound similar to those seen in psychiatric disorders may not have the same significance in patients with IBS.
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The various functional disorders have important characteristics in common, including epidemiology (female predominance), pathophysiology, diagnosis (symptom-based), the central role of the patient-physician relationship in therapy, and common therapeutic modalities.
“The various functional disorders have important characteristics in common, including epidemiology (female predominance), pathophysiology (inflammation, hypersensitivity, impaired central processing of afferent sensory information, role of serotonin, psychological distress and somatization, and the role of stress and life events), diagnosis (symptom-based), the central role of the patient-physician”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [10]
The Introduction (page unavailable) says functional disorders are diagnosed from subjective symptoms. The Psychiatric Angle and treatment sections discuss psychological comorbidity, possible biological mechanisms, and the importance of physicians’ approach to IBS care. The copy does not establish female predominance or a shared set of pathophysiological features and therapeutic modalities across the various functional disorders. (LLM, conf=0.86)
Experimental — accuracy not yet measuredMost IBS patients do not have psychiatric illness per se but do manifest psychoform symptoms and somatoform complaints.
“However, as discussed by North et al.10 most IBS patients do not have psychiatric illness per se but do manifest psychoform symptoms and somatoform complaints.”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [10]
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Cites
O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448 · see citing works
Cytokines and major depression
Schiepers, O. J. G., Wichers, M. C., & Maes, M. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.11.003 · Cited by 1,235 · see citing works
Whitehead, W. E., Palsson, O., & Jones, K. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.32392 · Cited by 1,116 · see citing works
Drossman, D. A., Toner, B. B., Whitehead, W. E., Diamant, N. E., Dalton, C. B., Duncan, S., Emmott, S., Proffitt, V., Akman, D., Frusciante, K., et al. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00669-3 · Cited by 614 · see citing works
Cassano, P., & D, M. F. M. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00304-5 · Cited by 558 · see citing works
(2011) · Springer eBooks · doi:10.1007/springerreference_44317 · Cited by 549 · see citing works
Treatment of functional gastrointestinal disorders with antidepressant medications: a meta-analysis
Jackson, J. L., O’Malley, P. G., Tomkins, G., Balden, E., Santoro, J., & Kroenke, K. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00299-5 · Cited by 464 · see citing works
Psychiatric Consultation in Somatization Disorder
Smith, G. R., Monson, R. A., & Ray, D. C. (1986) · New England Journal of Medicine · doi:10.1056/nejm198605293142203 · Cited by 459 · see citing works
The cost-effectiveness of psychotherapy and paroxetine for severe irritable bowel syndrome
Creed, F., Fernandes, L., Guthrie, E., Palmer, S., Ratcliffe, J., Read, N., Rigby, C., Thompson, D., & Tomenson, B. (2003) · Gastroenterology · doi:10.1053/gast.2003.50055 · Cited by 443 · see citing works
Somatization and psychiatric disorder in the NIMH Epidemiologic Catchment Area study
Simon, G. E., & VonKorff, M. (1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.11.1494 · Cited by 411 · see citing works
Pharmacologic Treatment of the Irritable Bowel Syndrome
Jailwala, J., Imperiale, T. F., & Kroenke, K. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-2-200007180-00013 · Cited by 374 · see citing works
Low-Dose Trazodone for Symptomatic Patients With Esophageal Contraction Abnormalities
Clouse, R. E., Lustman, P. J., Eckert, T. C., Ferney, D. M., & Griffith, L. S. (1987) · Gastroenterology · doi:10.1016/0016-5085(87)90979-6 · Cited by 353 · see citing works
Generalized anxiety disorder: nature and course.
Wïttchen, H., & Hoyer, J. (2001) · PubMed · Cited by 341 · see citing works
Psychiatric Illness and The Irritable Bowel Syndrome
Young, S. J., Alpers, D., Norland, C. C., & Woodruff, R. A. (1976) · Gastroenterology · doi:10.1016/s0016-5085(76)80002-9 · Cited by 275 · see citing works
Prevalence of Psychiatric Disorders in Patients with Irritable Bowel Syndrome
Lydiard, R. B., Fossey, M. D., Marsh, W., & Ballenger, J. C. (1993) · Psychosomatics · doi:10.1016/s0033-3182(93)71884-8 · Cited by 229 · see citing works
Cytokines as a Precipitant of Depressive Illness: Animal and Human Studies
Anisman, H., Merali, Z., Poulter, M. O., & Hayley, S. P. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612053381701 · Cited by 212 · see citing works
Cognitive-Behavioral Therapy for Somatization Disorder: A Randomized Controlled Trial
Allen, L. A., Woolfolk, R. L., Escobar, J. I., Gara, M. A., & Hamer, R. M. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.14.1512 · Cited by 209 · see citing works
Mertz, H. R. (2003) · New England Journal of Medicine · doi:10.1056/nejmra035579 · Cited by 206 · see citing works
Bomholt, S. F., Mikkelsen, J. D., & Blackburn-Munro, G. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.09.012 · Cited by 204 · see citing works
Quartero, A. O., Meiniche-Schmidt, V., Muris, J., Rubin, G., & de Wit, N. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003460.pub2 · Cited by 190 · see citing works
Walker, E. A., Gelfand, A. N., Gelfand, M. D., & Katon, W. J. (1995) · Psychological Medicine · doi:10.1017/s0033291700033225 · Cited by 181 · see citing works
Houghton, L. A., Atkinson, W., Whitaker, R. P., Whorwell, P. J., & Rimmer, M. J. (2003) · Gut · doi:10.1136/gut.52.5.663 · Cited by 176 · see citing works
van Hemert, A. M., Hengeveld, M. W., Bolk, J. H., Rooijmans, H. G. M., & Vandenbroucke, J. P. (1993) · Psychological Medicine · doi:10.1017/s0033291700038952 · Cited by 154 · see citing works
Smith, G. R. (1992) · General Hospital Psychiatry · doi:10.1016/0163-8343(92)90097-t · Cited by 134 · see citing works
The irritable colon syndrome and psychiatric illness.
Liss, J. L., Alpers, D., & Woodruff, R. A. (1973) · PubMed · Cited by 126 · see citing works
The validity and significance of the clinical diagnosis of hysteria (Briquet's syndrome)
Guzé, S. B. (1975) · American Journal of Psychiatry · doi:10.1176/ajp.132.2.138 · Cited by 107 · see citing works
The presentation of irritable bowel syndrome in the context of somatization disorder
North, C. S., Downs, D., Clouse, R. E., Alrakawi, A., Dokucu, M. E., Cox, J., Spitznagel, E. L., & Alpers, D. H. (2004) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00350-7 · Cited by 102 · see citing works
Self-citationLydiard, R. B., & Falsetti, S. A. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00082-0 · Cited by 97 · see citing works
The Association of Irritable Bowel Syndrome and Somatization Disorder
Miller, A. R., North, C. S., Clouse, R. E., Wetzel, R. D., Spitznagel, E. L., & Alpers, D. (2001) · Annals of Clinical Psychiatry · doi:10.1023/a:1009060731057 · Cited by 97 · see citing works
Self-citationImmunological differences between patients with major depression and somatization syndrome
Rief, W., Pilger, F., Ihle, D., Bosmans, E., Egyed, B., & Maes, M. H. J. (2001) · Psychiatry Research · doi:10.1016/s0165-1781(01)00338-9 · Cited by 89 · see citing works
Psychologic Considerations in the Irritable Bowel Syndrome
Whitehead, W. E., & Crowell, M. D. (1991) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(21)00549-5 · Cited by 88 · see citing works
Use of psychopharmacological agents for functional gastrointestinal disorders.
Clouse, R. E., & Lustman, P. J. (2005) · Gut · doi:10.1136/gut.2004.048884 · Cited by 76 · see citing works
Antidepressants for irritable bowel syndrome: Figure 1
Clouse, R. E. (2003) · Gut · doi:10.1136/gut.52.4.598 · Cited by 74 · see citing works
The prevalence of mental disorders in rural office practice
Philbrick, J. T., Connelly, J. E., & Wofford, A. B. (1996) · Journal of General Internal Medicine · doi:10.1007/bf02603478 · Cited by 66 · see citing works
Dietary factors in functional dyspepsia
Feinle‐Bisset, C., & Horowitz, M. (2006) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00790.x · Cited by 66 · see citing works
Mechanisms in IBS: something old, something new, something borrowed…
Camilleri, M. (2005) · Neurogastroenterology and Motility · doi:10.1111/j.1365-2982.2004.00632.x · Cited by 61 · see citing works
Gastrointestinal symptoms and psychiatric disorders in the general population
North, C. S., Alpers, D., Thompson, S. J., & Spitznagel, E. L. (1996) · Digestive Diseases and Sciences · doi:10.1007/bf02213117 · Cited by 48 · see citing works
Self-citationLacy, B. E., & Lee, R. D. (2005) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000156110.69232.bb · Cited by 38 · see citing works
Multiple Personalities, Multiple Disorders
Dell, P. F. (1994) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-199412000-00015 · Cited by 38 · see citing works
Antidepressants in IBS: Are We Deluding Ourselves?
Talley, N. J. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.04128.x · Cited by 33 · see citing works
203-THE COST-EFFECTIVENESS OF PSYCHOTHERAPY AND PAROXETINE FOR SEVERE IRRITABLE BOWEL SYNDROME
Creed, F. H. (2004) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2004.04.074 · Cited by 32 · see citing works
Diet and irritable bowel syndrome
Alpers, D. (2006) · Current Opinion in Gastroenterology · doi:10.1097/01.mog.0000208462.92136.02 · Cited by 30 · see citing works
Inpatients with Briquet's syndrome: Presence of additional psychiatric syndromes and MMPI results
Liskow, B. I., Penick, E. C., Powell, B. J., Haefele, W. F., & Campbell, J. L. (1986) · Comprehensive Psychiatry · doi:10.1016/0010-440x(86)90034-9 · Cited by 29 · see citing works
Dewsnap, P., Gomborone, J., Libby, G., & Farthing, M. J. G. (1996) · Psychosomatics · doi:10.1016/s0033-3182(96)71553-0 · Cited by 27 · see citing works
Medically unexplained symptoms and the concept of somatization.
Heinrich, T. W. (2004) · PubMed · Cited by 26 · see citing works
CONVERSION SYMPTOMS IN CRIMINALS
Guzé, S. B. (1964) · American Journal of Psychiatry · doi:10.1176/ajp.121.6.580 · Cited by 26 · see citing works
Treatments targeting putative mechanisms in irritable bowel syndrome
Cremonini, F., & Talley, N. J. (2005) · Nature Clinical Practice Gastroenterology & Hepatology · doi:10.1038/ncpgasthep0096 · Cited by 23 · see citing works
Psychiatric Symptoms Endorsed by Somatization Disorder Patients in a Psychiatric Clinic
Lenze, E. J., Miller, A. R., Munir, Z. B., Pornnoppadol, C., & North, C. S. (1999) · Annals of Clinical Psychiatry · doi:10.1023/a:1022342431514 · Cited by 23 · see citing works
Self-citationSimplified approach to somatization disorder
Holloway, K. L., & Zerbe, K. J. (2000) · Postgraduate Medicine · doi:10.3810/pgm.2000.11.1290 · Cited by 22 · see citing works
Multiple Personalities, Multiple Disorders: Psychiatric Classification and Media Influence
Findling, R. L. (1995) · Psychiatric Services · doi:10.1176/ps.46.1.90 · Cited by 20 · see citing works
Ketterer, M. W., & Buckholtz, C. D. (1989) · The Journal of the American Osteopathic Association · doi:10.1515/jom-1989-890411 · Cited by 20 · see citing works
Treatment of the severe refractory irritable bowel patient
Olden, K. W., & Brown, A. R. (2006) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-006-0014-7 · Cited by 13 · see citing works
JAMISON, J. (2003) · Elsevier eBooks · doi:10.1016/b978-0-443-07193-5.50034-0 · Cited by 11 · see citing works
Irritable bowel syndrome in a psychiatric patient population
North, C. S., & Alpers, D. (2000) · Comprehensive Psychiatry · doi:10.1016/s0010-440x(00)90144-5 · Cited by 6 · see citing works
Self-citationIrritable Bowel Syndrome - A Syndrome in Evolution
KWAN, A. C., & Lai, T. S. (2005) · Cited by 6 · see citing works
New and emerging treatments for irritable bowel syndrome and functional dyspepsia
Talley, N. J. (2002) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.7.1.91 · Cited by 6 · see citing works
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- Drossman DA, Toner BB, Whitehead WE, Diamant NE, Dalton CB, Duncan S, Emmott S, Proffitt V, Akman D, Frusciante K, Le T, Meyer K, Bradshaw B, Mikula K, Morris CB, Blackman CJ, Hu Y, Jia H, Li JZ, Koch GG, Bangdiwala SI. Cognitive- behavioral therapy versus education and desipramine versus placebo for moderate to severe functional bowel disorders. Gastroenterology 2003; 125: 19-31 40
Cited by
Sorted by citations
The nutritional and health attributes of kiwifruit: a review
Richardson, D. P., Ansell, J., & Drummond, L. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1627-z · Cited by 411 · see citing works
Langguth, B., Landgrebe, M., Kleinjung, T., Sand, G. P., & Hajak, G. (2011) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.575178 · Cited by 321 · see citing works
Elsenbruch, S., Rosenberger, C., Enck, P., Forsting, M., Schedlowski, M., & Gizewski, E. R. (2010) · Gut · doi:10.1136/gut.2008.175000 · Cited by 242 · see citing works
zarate, N., farmer, A. D., grahame, R., mohammed, S. D., knowles, C. H., scott, S. M., & aziz, Q. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01421.x · Cited by 178 · see citing works
Gosselin, R., Gibney, S. M., O’Malley, D., Dinan, T. G., & Cryan, J. F. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2008.10.018 · Cited by 166 · see citing works
Brain and gut CRF signaling: biological actions and role in the gastrointestinal tract
Tache, Y., Larauche, M., Yuan, P.-Q., & Million, M. (2018) · Current Molecular Pharmacology · doi:10.2174/1874467210666170224095741 · Cited by 147 · see citing works
Potentiation of ghrelin signaling attenuates cancer anorexia–cachexia and prolongs survival
Fujitsuka, N., Asakawa, A., Uezono, Y., Minami, K., Yamaguchi, T., Niijima, A., Yada, T., Maejima, Y., Sedbazar, U., Sakai, T., et al. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.25 · Cited by 142 · see citing works
Corticotropin-releasing factor signaling and visceral response to stress
Stengel, A., & Taché, Y. (2010) · Experimental Biology and Medicine · doi:10.1258/ebm.2010.009347 · Cited by 139 · see citing works
Vagal sensory neurons and gut-brain signaling
Yu, C. D., Xu, Q. J., & Chang, R. B. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.03.006 · Cited by 125 · see citing works
Fujitsuka, N., Asakawa, A., Hayashi, M., Sameshima, M., Amitani, H., Kojima, S., Fujimiya, M., & Inui, A. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.10.031 · Cited by 113 · see citing works
Icenhour, A., Langhorst, J., Benson, S., Schlamann, M. U., Hampel, S., Engler, H., Forsting, M., & Elsenbruch, S. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12489 · Cited by 109 · see citing works
A role for corticotropin-releasing factor in functional gastrointestinal disorders
Taché, Y., Kiank, C., & Stengel, A. (2009) · Current Gastroenterology Reports · doi:10.1007/s11894-009-0040-4 · Cited by 109 · see citing works
Resistance to Early-Life Stress in Mice: Effects of Genetic Background and Stress Duration
Savignac, H. M., Dinan, T. G., & Cryan, J. F. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00013 · Cited by 103 · see citing works
The Classification of Hysteria and Related Disorders: Historical and Phenomenological Considerations
North, C. (2015) · Behavioral Sciences · doi:10.3390/bs5040496 · Cited by 104 · see citing works
Self-citationEffect of Yoga in the Therapy of Irritable Bowel Syndrome: A Systematic Review
Schumann, D., Anheyer, D., Lauche, R., Dobos, G. J., Langhorst, J., & Cramer, H. (2016) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2016.04.026 · Cited by 104 · see citing works
Taché, Y., & Million, M. (2015) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm14162 · Cited by 102 · see citing works
Randomised clinical trial: yoga vs a low‐ FODMAP diet in patients with irritable bowel syndrome
Schumann, D., Langhorst, J., Dobos, G. J., & Cramer, H. (2017) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14400 · Cited by 100 · see citing works
Gut microbiome interventions in human health and diseases
Nie, P., Li, Z., Wang, Y., Zhang, Y., Zhao, M., Luo, J., Du, S., Deng, Z., Chen, J., Wang, Y., et al. (2019) · Medicinal Research Reviews · doi:10.1002/med.21584 · Cited by 93 · see citing works
Kattoor, J., Gizewski, E. R., Kotsis, V., Benson, S., Gramsch, C., Theysohn, N., Maderwald, S., Forsting, M., Schedlowski, M., & Elsenbruch, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0051149 · Cited by 92 · see citing works
Bryant, R. V., van Langenberg, D. R., Holtmann, G., & Andrews, J. M. (2011) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2011.06624.x · Cited by 87 · see citing works
Gosselin, R., O’Connor, R. M., Tramullas, M., Julio‐Pieper, M., Dinan, T. G., & Cryan, J. F. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.03.003 · Cited by 87 · see citing works
Sperber, A. D., & Dekel, R. (2010) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2010.16.2.113 · Cited by 85 · see citing works
Mitchell, H., Porter, J. A., Gibson, P. R., Barrett, J. S., & Garg, M. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15079 · Cited by 84 · see citing works
Pharmacological Approach for Managing Pain in Irritable Bowel Syndrome: A Review Article
Chen, L., Ilham, S., & Feng, B. (2017) · Anesthesiology and Pain Medicine · doi:10.5812/aapm.42747 · Cited by 73 · see citing works
Enteric Microbiota-Mediated Serotonergic Signaling in Pathogenesis of Irritable Bowel Syndrome
Mishima, Y., & Ishihara, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910235 · Cited by 77 · see citing works
Taché, Y., & Brunnhuber, S. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1410.007 · Cited by 76 · see citing works
Bouchoucha, M. L., Hejnar, M., Devroede, G. J., Babba, T., Bon, C., & Benamouzig, R. (2012) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2012.10.011 · Cited by 74 · see citing works
Savignac, H. M., Hyland, N. P., Dinan, T. G., & Cryan, J. F. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.08.049 · Cited by 73 · see citing works
Gramsch, C., Kattoor, J., Icenhour, A., Forsting, M., Schedlowski, M., Gizewski, E. R., & Elsenbruch, S. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.08.003 · Cited by 67 · see citing works
Polster, A., Van Oudenhove, L., Jones, M., Öhman, L., Törnblom, H., & Simrén, M. (2017) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14207 · Cited by 65 · see citing works
Updates on treatment of irritable bowel syndrome
Hammerle, C. W., & Surawicz, C. M. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.2639 · Cited by 65 · see citing works
Rates and Predictors of Oral Medication Adherence in Pediatric Patients with IBD
LeLeiko, N. S., Lobato, D. J., Hagin, S., McQuaid, E. L., Seifer, R., Kopel, S. J., Boergers, J., Nassau, J. H., Suorsa, K. I., Shapiro, J. M., et al. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e3182802b57 · Cited by 63 · see citing works
Role of negative affects in pathophysiology and clinical expression of irritable bowel syndrome
Muscatello, M. R. A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i24.7570 · Cited by 58 · see citing works
Bengtsson, M., Hammar, O., Mandl, T., & Ohlsson, B. (2011) · BMC Gastroenterology · doi:10.1186/1471-230x-11-122 · Cited by 57 · see citing works
Arranz, L.-I., Canela, M.-Á., & Rafecas, M. (2011) · Rheumatology International · doi:10.1007/s00296-011-2010-z · Cited by 55 · see citing works
Sperber, A. D., Morris, C. B., Greemberg, L., Bangdiwala, S. I., Goldstein, D., Sheiner, E., Rusabrov, Y., Hu, Y., Katz, M. E., Freud, T., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.10.041 · Cited by 55 · see citing works
Irritable Bowel Syndrome: Modern Concepts and Management Options
Sayuk, G. S., & Gyawali, C. P. (2015) · The American Journal of Medicine · doi:10.1016/j.amjmed.2015.01.036 · Cited by 50 · see citing works
Centrally Acting Therapies for Irritable Bowel Syndrome
Grover, M., & Drossman, D. A. (2011) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2010.12.003 · Cited by 49 · see citing works
Polysymptomatic, Polysyndromic Presentation of Patients With Urological Chronic Pelvic Pain Syndrome
Lai, H. H., North, C. S., Andriole, G. L., Sayuk, G. S., & Hong, B. A. (2012) · The Journal of Urology · doi:10.1016/j.juro.2012.01.081 · Cited by 45 · see citing works
Self-citationOroian, B. A., Ciobica, A. S., Timofte, D. V., Ștefănescu, C., & Șerban, I. L. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5599265 · Cited by 45 · see citing works
The role of experimental models in developing new treatments for irritable bowel syndrome
Holschneider, D. P., Bradesi, S., & Mayer, E. A. (2011) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.10.88 · Cited by 40 · see citing works
Interactions Between Diabetes and Anxiety and Depression
Bystritsky, A., Danial, J., & Kronemyer, D. (2013) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.10.001 · Cited by 40 · see citing works
Corticotrophin‐releasing factor 1 activation in the central amygdale and visceral hyperalgesia
Taché, Y. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12495 · Cited by 36 · see citing works
Role of brain orexin in the pathophysiology of functional gastrointestinal disorders
Okumura, T., & Nozu, T. (2011) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2011.06626.x · Cited by 35 · see citing works
Low-dose amitriptyline combined with proton pump inhibitor for functional chest pain
Park, S. W. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i30.4958 · Cited by 35 · see citing works
Reisner, S. L., Benyishay, M., Stott, B., Vedilago, V., Almazan, A. N., & Keuroghlian, A. S. (2021) · Transgender Health · doi:10.1089/trgh.2021.0010 · Cited by 33 · see citing works
Riedl, A., Maass, J., Fliege, H., Stengel, A., Schmidtmann, M., Klapp, B. F., & Mönnikes, H. (2009) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2009.02.001 · Cited by 33 · see citing works
Cojocariu, R. O., Balmuș, I.-M., Lefter, R. M., Hrițcu, L. D., Ababei, D. C., Ciobica, A. S., Copaci, S., Mot, S. E. L., Copolovici, L. O., Copolovici, D. M., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/9510305 · Cited by 31 · see citing works
Rosenberger, C., Thürling, M., Forsting, M., Elsenbruch, S., Timmann, D., & Gizewski, E. R. (2012) · The Cerebellum · doi:10.1007/s12311-012-0413-3 · Cited by 30 · see citing works
Psychopharmacologic and Behavioral Treatments for Functional Gastrointestinal Disorders
Grover, M., & Drossman, D. A. (2009) · Gastrointestinal Endoscopy Clinics of North America · doi:10.1016/j.giec.2008.12.001 · Cited by 30 · see citing works
Cojocariu, R. O., Ciobica, A. S., Balmuș, I.-M., Guenné, S., Trifan, A. V., Stanciu, C., Hrițcu, L. D., & Lefter, R. M. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3492767 · Cited by 27 · see citing works
Post-traumatic Stress Disorder Is Associated With Irritable Bowel Syndrome in African Americans
Iorio, N., Makipour, K., Palit, A., & Friedenberg, F. K. (2014) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm14040 · Cited by 26 · see citing works
Psychologists in Academic Health Centers and Medical Centers: Being Visible, Relevant and Integral
Hong, B. A., & Robiner, W. N. (2016) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-016-9450-2 · Cited by 26 · see citing works
Bugs on the brain; brain in the gut—seeking explanations for common gastrointestinal symptoms
Quigley, E. M. M. (2012) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-012-0865-y · Cited by 25 · see citing works
The Association between Irritable Bowel Syndrome and the Anxiety Vulnerability Factors
Keough, M. E., Timpano, K. R., Zawilinski, L., & Schmidt, N. B. (2010) · Journal of Health Psychology · doi:10.1177/1359105310367689 · Cited by 25 · see citing works
KIT as a therapeutic target for non-oncological diseases
Martínez‐Antón, A., Gras, D., BOURDIN, A. A., Dubreuil, P. C., & Chanez, P. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.12.008 · Cited by 24 · see citing works
The new Medical College Admission Test: Implications for teaching psychology.
Mitchell, K., Lewis, R. S., Satterfield, J. M., & Hong, B. A. (2016) · American Psychologist · doi:10.1037/a0039975 · Cited by 24 · see citing works
General practitioners’ perceptions of irritable bowel syndrome: a Q-methodological study
Bradley, S. H., Alderson, S. L., Ford, A. C., & Foy, R. (2017) · Family Practice · doi:10.1093/fampra/cmx053 · Cited by 24 · see citing works
Coşkun, M., & Alyanak, B. (2011) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2011.17.3.305 · Cited by 23 · see citing works
Adhamian, P., Sharbafchi, M., Afshar, H., Feizi, A., Daghaghzadeh, H., & Adibi, P. (2020) · Journal of Research in Medical Sciences · doi:10.4103/jrms.jrms_699_19 · Cited by 21 · see citing works
Avorio, F., Irelli, E. C., Morano, A., Fanella, M., Orlando, B., Albini, M., Basili, L. M., Ruffolo, G., Fattouch, J., Manfredi, M., et al. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.705126 · Cited by 21 · see citing works
Li, P. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i5.1518 · Cited by 21 · see citing works
Prospero, L., Riezzo, G., Linsalata, M., Orlando, A., D’Attoma, B., Masi, M. D., Martulli, M., & Russo, F. (2021) · BMC Gastroenterology · doi:10.1186/s12876-021-01820-7 · Cited by 17 · see citing works
Wong, R. K. M., Oudenhove, L. V., Li, X., Cao, Y., Ho, K. Y., & Wilder‐Smith, C. H. (2015) · United European Gastroenterology Journal · doi:10.1177/2050640615580888 · Cited by 17 · see citing works
Lai, H. H., North, C. S., Andriole, G. L., Cupps, L., Song, D., Ness, T. J., & Hong, B. A. (2013) · The Journal of Urology · doi:10.1016/j.juro.2013.12.031 · Cited by 15 · see citing works
Self-citationGastrointestinal somatization in males and females with depressive disorder.
Afridi, M. I., Siddiqui, M. A., & Ansari, A. (2009) · PubMed · Cited by 14 · see citing works
Cognitive-Behavioral Therapy, Psychotherapy and Psychosocial Interventions in the Medically Ill
Balon, R. (2009) · Psychotherapy and Psychosomatics · doi:10.1159/000228246 · Cited by 14 · see citing works
Padhy, S. K., Mishra, S., Sarkar, S., Bang, G., & Panigrahi, M. (2016) · Industrial Psychiatry Journal · doi:10.4103/0972-6748.196038 · Cited by 13 · see citing works
Bui, T. A., O’Croinin, B. R., Dennett, L., Winship, I. R., & Greenshaw, A. J. (2025) · Microbiology · doi:10.1099/mic.0.001568 · Cited by 14 · see citing works
Emerging Roles of the Nervous System in Gastrointestinal Cancer Development
Wan, C., Yan, X., Hu, B., & Zhang, X. (2022) · Cancers · doi:10.3390/cancers14153722 · Cited by 12 · see citing works
Assesment of Psychiatric Symptoms and Co-morbidities in Patients with Irritable Bowel Syndrome
Sertbaş, Y., Belli, H., Pişkinpaşa, N., Ural, C., Akbudak, M., Sertbaş, M., & Öncü, F. (2012) · West Indian Medical Journal · doi:10.7727/wimj.2012.166 · Cited by 12 · see citing works
Mazaheri, M., Nikneshan, S., Daghaghzadeh, H., & Afshar, H. (2015) · PubMed Central · Cited by 10 · see citing works
Gh.R., K., Bagherian, R., Nemati, K., Daghaghzadeh, H., Maracy, M. R., & Gholamrezaei, A. (2010) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 10 · see citing works
Enhancing Self-management for Adults With Functional Abdominal Pain
Niesen, C. R., Olson, D. M., Nowdesha, K. D., Tynsky, D. A., Loftus, C. G., & Meiers, S. J. (2018) · Gastroenterology Nursing · doi:10.1097/sga.0000000000000322 · Cited by 10 · see citing works
Maekawa, T., Tsushima, H., Kawakami, F., Kawashima, R., Kodo, M., Imai, M., & Ichikawa, T. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00905 · Cited by 10 · see citing works
Lechín, F., & van der Dijs, B. (2009) · doi:10.1093/acprof:oso/9780195326697.003.0005 · Cited by 10 · see citing works
Lin, X.-L., Tang, X., Cai, Z.-X., Wang, F., Li, P., Sui, H., & Guo, H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149031 · Cited by 9 · see citing works
Sobański, J. A., Klasa, K., Mielimąka, M., Rutkowski, K., Dembińska, E., Müldner-Nieckowski, Ł., CYRANKA, K. M., Smiatek-Mazgaj, B., & Popiołek, L. (2015) · Gastroenterology Review · doi:10.5114/pg.2015.51213 · Cited by 8 · see citing works
Ferreira, N. B., Mikocka‐Walus, A. A., van Tilburg, M. A. L., Graff, L. A., Apputhurai, P., Acosta, M. B., Evertsz, F. B., Burisch, J. M., Lo, B. Z. S., Petrik, M. L., et al. (2021) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2021.110561 · Cited by 8 · see citing works
Neural Circuitry of Stress, Fear, and Anxiety
Paul, E. D., & Chen, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802175-0.00008-5 · Cited by 7 · see citing works
Dainty, A. D., Fox, M., Lewis, N. R., Hunt, M. G., Holtham, E., Timmons, S., Kinsella, P., Wragg, A., & Callaghan, P. (2014) · BMJ Open · doi:10.1136/bmjopen-2014-005262 · Cited by 6 · see citing works
Do MicroRNAs Modulate Visceral Pain?
Tao, Z.-Y., Yang, X. W., Li, J., Traub, R. J., & Cao, D. (2018) · BioMed Research International · doi:10.1155/2018/5406973 · Cited by 6 · see citing works
Tamannaifar, M. R., & Akhavan-Hejazi, Z. S. (2013) · Fiyz̤. · Cited by 6 · see citing works
Biologische und psychosoziale Einflussfaktoren auf geschlechterbezogene Unterschiede beim Schmerz
Icenhour, A., Elsenbruch, S., & Benson, S. (2015) · GENDER – Zeitschrift für Geschlecht Kultur und Gesellschaft · doi:10.3224/gender.v7i2.19310 · Cited by 6 · see citing works
Multiple drug intolerance in antihypertensive patients: what is known and what is missing
Palermiti, A., Pappaccogli, M., Rabbia, F., D’Avolio, A., & Veglio, F. (2024) · Journal of Hypertension · doi:10.1097/hjh.0000000000003737 · Cited by 5 · see citing works
The Gut Microbiome May Help Address Mental Health Disparities in Hispanics: A Narrative Review
Vera-Urbina, F., Santos-Torres, M. F. D., Godoy‐Vitorino, F., & Torres-Hernández, B. A. (2022) · Microorganisms · doi:10.3390/microorganisms10040763 · Cited by 5 · see citing works
SERT models of emotional dysregulation
Tripp, A., & Sibille, E. L. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511729935.005 · Cited by 5 · see citing works
COVID-19 Outbreak and its Burden on a New Wave of Functional Gastrointestinal Disorders
Nozari, N. (2021) · Middle East Journal of Digestive Diseases · doi:10.34172/mejdd.2021.210 · Cited by 4 · see citing works
Irritable bowel syndrome in primary care
Bijkerk, C. J. (2008) · Utrecht University Repository (Utrecht University) · Cited by 4 · see citing works
Dainty, A. D. (2012) · Gastrointestinal Nursing · doi:10.12968/gasn.2012.10.10.44 · Cited by 3 · see citing works
The Clinical Characteristics and Related Factors of Centrally Mediated Abdominal Pain Syndrome
Yuming, T., Jiani, S., Hefeng, C., Ying, Z., Weiyan, Y., & Duowu, Z. (2023) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000624 · Cited by 3 · see citing works
Evaluation of gastric emptying rate in patients with fibromyalgia: a case control study
Erdoğan, S., Gurer, G., Afşin, H., & Küçükzeybek, Y. (2010) · Modern Rheumatology · doi:10.1007/s10165-010-0355-x · Cited by 3 · see citing works
Post-traumatic Stress Disorder Is Associated With Irritable Bowel Syndrome in African Americans
Iorio, N., Makipour, K., Palit, A., & Friedenberg, F. K. (2014) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.20.523 · Cited by 3 · see citing works
Sayuk, G. S., North, C. S., Pollio, D. E., Gott, B. M., & Alpers, D. (2022) · Frontiers in Pain Research · doi:10.3389/fpain.2022.892313 · Cited by 2 · see citing works
Self-citationDepressive Störungen bei internistischen und neurologischen Erkrankungen
Juckel, G., Norra, C., Herpertz, S., Baghai, T., Lieb, M., & Schäfer, M. (2013) · Nervenheilkunde · doi:10.1055/s-0038-1628508
Clinical Pearls for Irritable Bowel Syndrome
Lacy, B. E., & OʼShana, T. (2014) · Gastroenterology Nursing · doi:10.1097/sga.0000000000000056 · Cited by 2 · see citing works
Saúde mental em perspetiva – o papel da nutrição e da microbiota intestinal
Charneca, S., & Guerreiro, C. S. (2021) · Acta Portuguesa de Nutrição · doi:10.21011/apn.2021.2710 · Cited by 4 · see citing works
Alexandru, B. A., Rat, L. A., Moldovan, A. F., MIHANCEA, P., & Mariș, L. (2022) · Medicina · doi:10.3390/medicina58060763 · Cited by 2 · see citing works
Angina-Like Chest Pain as a Symptom of Digestive Tract Disorders
Budzyński, J. (2011) · InTech eBooks · doi:10.5772/17454 · Cited by 1 · see citing works
Psychopharmakotherapie somatoformer Störungen und funktioneller somatischer Syndrome
Kapfhammer, H. (2007) · Psychiatrie und Psychotherapie · doi:10.1007/s11326-007-0072-z · Cited by 1 · see citing works
- Authors
- North, C. S.
- Affiliations
- VA North Texas Health Care System (US)
- Corresponding author
- North, Carol S
- ORCID
- North, Carol S
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2007
- Volume
- 13
- Issue
- 14
- Pages
- 2020
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC4319119
- OpenAlex
- W39026146
- Cited by
- 122
- References
- 56
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 4 · 2022: 6 · 2021: 11 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 6 · 2016: 7 · 2015: 8 · 2014: 12 · 2013: 7 · 2012: 6
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Digital Commons@Becker (Washington University School of Medicine) (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Health Professions › Pharmacy › Infant Health and Development
- Keywords
- irritable bowel syndrome, functional gastrointestinal disorders, psychiatric comorbidity, somatization disorder, antidepressants, cognitive behavioral therapy, psychotherapy, depression, anxiety, treatment guidelines, fibromyalgia, temporomandibular disorders, non-cardiac chest pain
- MeSH terms
- Antidepressive Agents, Mental Disorders, Gastrointestinal Diseases, Humans, Psychotherapy, Psychotropic Drugs, Somatoform Disorders, Inflammatory Bowel Diseases, Cognitive Behavioral Therapy
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