Use of psychopharmacological agents for functional gastrointestinal disorders.
Open accessAbstract
In 1990 we asked clinicians attending a symposium during the annual meeting of the American Gastroenterological Association how many were using psychopharmacological agents, specifically antidepressants, to treat functional gastrointestinal disorders.1 Very few raised their hands. Over the subsequent 15 years, these agents increasingly have become used in the management of functional gastrointestinal symptoms, despite a limited amount of scientific information supporting this practice. It is now estimated that at least 1 in 8 patients with irritable bowel syndrome (IBS) is offered an antidepressant.2,3 Nearly every comprehensive current review of management strategies for IBS and other mainstream functional gastrointestinal disorders mentions their use, and prescribing among gastroenterologists has become commonplace.3–10 In parallel with this change, primary care physicians have become sufficiently comfortable in using antidepressants for treating not only anxiety and depression but also a host of somatic symptoms and syndromes that their use has nearly tripled in the past decade.11 Enhanced appreciation for the relative importance of central mechanisms (for example, signal processing alterations) in many if not most patients with IBS and other painful functional gastrointestinal disorders is an important factor responsible for prescribing shifts among gastroenterologists—more so than a new or improved understanding of the relationship of symptoms to anxiety or depression.8 The composite body of investigation over the past 15 years involving visceral stimulation, brain imaging, multidimensional clinical studies, and treatment trials designed to answer mechanistic questions has led us closer to understanding the pathways by which psychopharmacological agents may interrupt the symptomatic process in these common gastrointestinal disorders. Complemented by clinical observations, improved recommendations for their use have evolved.6,12 This review describes the types of psychopharmacological agents used in functional gastrointestinal disorders, new models for their potential benefits, a summary of the reported efficacy, and practical aspects …
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In an Australian inflammatory bowel disease service, antidepressants including tricyclic antidepressants were used in about one third of patients.
“In a case-note review, antidepressants, in general, including TCAs, were used in approximately one third of the patients in an Australian IBD service.11”
From Tricyclic Antidepressants for Management of Residual Symptoms in Inflammatory Bowel Disease (2014) · cites this paper as [11]
In that Australian service, the most common reason for antidepressant prescription was depression or anxiety, with very few prescribed for somatic complaints.
“The most common reason for this prescription was depression or anxiety, with very few prescribed for somatic complaints.”
From Tricyclic Antidepressants for Management of Residual Symptoms in Inflammatory Bowel Disease (2014) · cites this paper as [11]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Antidepressants for depression in medical illness
Gill, D. B. E. C., & Hatcher, S. (2000) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001312 · Cited by 123 · see citing works
RetractedDiagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Diagnostic and Statistical Manual of Mental Disorders
(2012) · Springer eBooks · doi:10.1007/springerreference_121117 · Cited by 20,769 · see citing works
Boyer, E. W., & Shannon, M. (2005) · New England Journal of Medicine · doi:10.1056/nejmra041867 · Cited by 1,821 · see citing works
AGA technical review on irritable bowel syndrome.
Drossman, D. A., Camilleri, M., Mayer, E. A., & Whitehead, W. E. (2002) · Gastroenterology · doi:10.1053/gast.2002.37095 · Cited by 1,384 · see citing works
Whitehead, W. E., Palsson, O., & Jones, K. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.32392 · Cited by 1,116 · see citing works
A systematic review of antidepressants in neuropathic pain
McQuay, H. J., Tramèr, M. R., Nye, B., Carroll, D., Wiffen, P. J., & Moore, A. (1996) · Pain · doi:10.1016/s0304-3959(96)03140-5 · Cited by 926 · see citing works
The role of psychological and biological factors in postinfective gut dysfunction
Gwee, K.-A., Leong, Y.-L., Graham, C., McKendrick, M. W., Collins, S. M., Walters, S. J., Underwood, J. E., & Read, N. W. (1999) · Gut · doi:10.1136/gut.44.3.400 · Cited by 764 · see citing works
Drossman, D. A., Toner, B. B., Whitehead, W. E., Diamant, N. E., Dalton, C. B., Duncan, S., Emmott, S., Proffitt, V., Akman, D., Frusciante, K., et al. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00669-3 · Cited by 614 · see citing works
Davis, M. S. (2002) · The Concise Dictionary of Crime and Justice · doi:10.4135/9781452229300.n390 · Cited by 507 · see citing works
A Review of the Evidence for Overlap among Unexplained Clinical Conditions
Aaron, L. A., & Buchwald, D. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-9_part_2-200105011-00011 · Cited by 501 · see citing works
Treatment of functional gastrointestinal disorders with antidepressant medications: a meta-analysis
Jackson, J. L., O’Malley, P. G., Tomkins, G., Balden, E., Santoro, J., & Kroenke, K. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00299-5 · Cited by 464 · see citing works
The cost-effectiveness of psychotherapy and paroxetine for severe irritable bowel syndrome
Creed, F., Fernandes, L., Guthrie, E., Palmer, S., Ratcliffe, J., Read, N., Rigby, C., Thompson, D., & Tomenson, B. (2003) · Gastroenterology · doi:10.1053/gast.2003.50055 · Cited by 443 · see citing works
Pharmacologic Treatment of the Irritable Bowel Syndrome
Jailwala, J., Imperiale, T. F., & Kroenke, K. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-2-200007180-00013 · Cited by 374 · see citing works
Kroenke, K. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830160080011 · Cited by 355 · see citing works
Antidepressant therapy for unexplained symptoms and symptom syndromes.
O’Malley, P. G., Jackson, J. L., Santoro, J., Tomkins, G., Balden, E., & Kroenke, K. (1999) · PubMed · Cited by 329 · see citing works
Morgan, V (2005) · Gut · doi:10.1136/gut.2004.047423 · Cited by 269 · see citing works
Overlap of gastrointestional symptom complexes in a US community
Locke, G., Zinsmeister, A., Fett, S., Melton, L., & Talley, N. (2005) · Neurogastroenterology and Motility · doi:10.1111/j.1365-2982.2004.00581.x · Cited by 254 · see citing works
Psychiatric illness and irritable bowel syndrome: a comparison with inflammatory bowel disease
Walker, E. A., Roy‐Byrne, P., Katon, W. J., Li, L., Amos, D., & Jiranek, G. (1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.12.1656 · Cited by 233 · see citing works
Meta‐analysis: the treatment of irritable bowel syndrome
Pantoflickova, D., Michetti, P., Fried, M., Beglinger, C., & Blum, A. L. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02267.x · Cited by 222 · see citing works
Antidepressant Discontinuation Syndromes: Clinical Relevance, Prevention and Management
Haddad, P. M. (2001) · Drug Safety · doi:10.2165/00002018-200124030-00003 · Cited by 214 · see citing works
GORARD, D. A., LIBBY, G. W., & FARTHING, M. J. G. (1994) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.1994.tb00273.x · Cited by 211 · see citing works
Kuiken, S. D., Tytgat, G. N. J., & Boeckxstaens, G. E. (2003) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(03)70039-1 · Cited by 206 · see citing works
Mertz, H. R. (2003) · New England Journal of Medicine · doi:10.1056/nejmra035579 · Cited by 206 · see citing works
Antidepressant medications: a review of the evidence for drug-induced sexual dysfunction
Montgomery, S. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(01)00313-5 · Cited by 205 · see citing works
Bomholt, S. F., Mikkelsen, J. D., & Blackburn-Munro, G. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.09.012 · Cited by 204 · see citing works
A prospective assessment of bowel habit in irritable bowel syndrome in women: Defining an alternator
Drossman, D. A., Morris, C. B., Hu, Y., Toner, B. B., Diamant, N. E., Leserman, J., Shetzline, M. A., Dalton, C. B., & Bangdiwala, S. I. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.12.006 · Cited by 201 · see citing works
Clinical Determinants of Health-Related Quality of Life in Patients With Irritable Bowel Syndrome
Spiegel, B. M. R., Gralnek, I. M., Bolus, R. R., Chang, L., Dulai, G. S., Mayer, E. A., & Naliboff, B. D. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.16.1773 · Cited by 198 · see citing works
Family Study of Affective Spectrum Disorder
Hudson, J. I., Mangweth, B., Pope, H. G., Col, C. D., Hausmann, A., Gutweniger, S., Laird, N. M., Biebl, W., & Tsuang, M. T. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.2.170 · Cited by 194 · see citing works
Tabas, G., Beaves, M., Wang, J., Friday, P., Mardini, H. E., & Arnold, G. L. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.04127.x · Cited by 192 · see citing works
A Symptom Checklist to Screen for Somatoform Disorders in Primary Care
Kroenke, K., Spitzer, R. L., deGruy, F. V., & Swindle, R. W. (1998) · Psychosomatics · doi:10.1016/s0033-3182(98)71343-x · Cited by 180 · see citing works
Clouse, R. E., Lustman, P. J., GEISMAN, R. A., & Alpers, D. (1994) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.1994.tb00308.x · Cited by 163 · see citing works
Self-citationVandvik, P. O., Wilhelmsen, I., Ihlebæk, C., & Farup, P. G. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02250.x · Cited by 160 · see citing works
Antidepressant discontinuation syndromes
Haddad, P. M., Anderson, I. M., & Rosenbaum, J. F. (2004) · Oxford University Press eBooks · doi:10.1093/med/9780198527480.003.0010 · Cited by 160 · see citing works
Antidepressants and Pediatric Depression — The Risk of Doing Nothing
Brent, D. A. (2004) · New England Journal of Medicine · doi:10.1056/nejmp048228 · Cited by 141 · see citing works
Camilleri, M., Heading, R. C., & Thompson, W. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2002.01305.x · Cited by 134 · see citing works
Antidepressants for functional gastrointestinal syndromes
Clouse, R. E. (1994) · Digestive Diseases and Sciences · doi:10.1007/bf02087651 · Cited by 124 · see citing works
Self-citationMelle, C., Ernst, G., Schimmel, B., Bleul, A., Thieme, H., Kaufmann, R., Mothes, H. K., Settmacher, U., Claussen, U., Kj, H., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.05.014 · Cited by 121 · see citing works
Ringel, Y., Sperber, A. D., & Drossman, D. A. (2001) · Annual Review of Medicine · doi:10.1146/annurev.med.52.1.319 · Cited by 117 · see citing works
Antidepressants and chronic pain: Fig 1
McQuay, H. J., & Moore, R. A. (1997) · BMJ · doi:10.1136/bmj.314.7083.763 · Cited by 115 · see citing works
Weight gain in the treatment of mood disorders.
Aronne, L. J., & Segal, K. R. (2003) · PubMed · Cited by 114 · see citing works
Duloxetine in the Long-Term Treatment of Major Depressive Disorder
Raskin, J., GOLDSTEIN, D. J., Mallinckrodt, C. H., & Ferguson, M. B. (2003) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v64n1015 · Cited by 111 · see citing works
Long-Term Outcome from Tricyclic Antidepressant Treatment of Functional Chest Pain
Gyawali, C. P., & Clouse, R. E. (1999) · Digestive Diseases and Sciences · doi:10.1023/a:1026645914933 · Cited by 105 · see citing works
Self-citationThe presentation of irritable bowel syndrome in the context of somatization disorder
North, C. S., Downs, D., Clouse, R. E., Alrakawi, A., Dokucu, M. E., Cox, J., Spitznagel, E. L., & Alpers, D. H. (2004) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00350-7 · Cited by 102 · see citing works
Self-citationTricyclic Antidepressants for Functional Nausea and Vomiting (Clinical Outcome in 37 Patients)
Gyawali, C. P., Lustman, P. J., Freedland, K. E., & Clouse, R. E. (1998) · Digestive Diseases and Sciences · doi:10.1023/a:1018878324327 · Cited by 98 · see citing works
Self-citationThe Association of Irritable Bowel Syndrome and Somatization Disorder
Miller, A., North, C., Clouse, R., Wetzel, R., Spitznagel, E., & Alpers, D. (2001) · Annals of Clinical Psychiatry · doi:10.3109/10401230109147126 · Cited by 98 · see citing works
Self-citationThe Association of Irritable Bowel Syndrome and Somatization Disorder
Miller, A. R., North, C. S., Clouse, R. E., Wetzel, R. D., Spitznagel, E. L., & Alpers, D. (2001) · Annals of Clinical Psychiatry · doi:10.1023/a:1009060731057 · Cited by 97 · see citing works
Self-citationComparison of various treatments for irritable bowel syndrome.
Ritchie, J. A., & Truelove, S. C. (1980) · BMJ · doi:10.1136/bmj.281.6251.1317 · Cited by 95 · see citing works
Gruber, A. J., Hudson, J. I., & Pope, H. G. (1996) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70292-6 · Cited by 93 · see citing works
Tack, J. F., & Fass, R. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.0953-0673.2004.01835.x · Cited by 92 · see citing works
The usual medical care for irritable bowel syndrome
Whitehead, W. E., Levy, R. L., Korff, M. V., Feld, A., Palsson, O. S., Turner, M. J., & Drossman, D. A. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02256.x · Cited by 88 · see citing works
Clinical experience with dual action antidepressants in different chronic pain syndromes
Briley, M. (2004) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.621 · Cited by 87 · see citing works
Evaluation of drug treatment in irritable bowel syndrome
Talley, N. J. (2003) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2003.01966.x · Cited by 78 · see citing works
Antidepressants and suicidal behaviour in unipolar depression
Yerevanian, B. I., Koek, R. J., Feusner, J. D., Hwang, S., & Mintz, J. (2004) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2004.00437.x · Cited by 76 · see citing works
Antidepressants for irritable bowel syndrome: Figure 1
Clouse, R. E. (2003) · Gut · doi:10.1136/gut.52.4.598 · Cited by 74 · see citing works
Self-citationThe role of psychological and biological factors in postinfective gut dysfunction
Gwee, K., Leong, Y. L., Graham, C. A., McKendrick, M. W., Collins, S. M., Walters, S. J., Greenwood, J. E., & Read, N. W. (1999) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-199904000-00028 · Cited by 64 · see citing works
TREATMENT FOR IRRITABLE BOWEL SYNDROME
Hadley, S. K., & Gaarder, S. M. (1980) · Inpharma Weekly · doi:10.1007/bf03290989 · Cited by 57 · see citing works
Irritable Bowel Syndrome: Diagnosis and Treatment
Syafiq, M., Kolopaking, M. S., Abdullah, M., & Mujaddid, E. (2003) · The Indonesian Journal of Gastroenterology Hepatology and Digestive Endoscopy · doi:10.24871/41200314-21 · Cited by 53 · see citing works
Spollett, G. R. (1989) · The Nurse Practitioner · doi:10.1097/00006205-198908000-00007 · Cited by 53 · see citing works
Kuiken, S. D., Tytgat, G. N. J., & Boeckxstaens, G. E. (2003) · Clinical Gastroenterology and Hepatology · doi:10.1053/cgh.2003.50032 · Cited by 49 · see citing works
Opportunity cost of antidepressant prescribing in England: analysis of routine data
Hollinghurst, S. P., Kessler, D. S., Peters, T. J., & Gunnell, D. (2005) · BMJ · doi:10.1136/bmj.38377.715799.f7 · Cited by 44 · see citing works
Managing functional bowel disorders from the top down: lessons from a well-designed treatment trial
Clouse, R. E. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00808-4 · Cited by 43 · see citing works
Self-citationKaplan & Sadock's Pocket Handbook of Psychiatric Drug Treatment
Sadock, B. J., Sadock, V. A., & Sussman, N. (2001) · Cited by 41 · see citing works
Functional dyspepsia: Impaired fundic accommodation
Tack, J. F. (2000) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-000-0042-7 · Cited by 41 · see citing works
Effects of Physical and Sexual Abuse in Facial Pain: Direct or Mediated?
Riley, J. L., Robinson, M. E., Kvaal, S. A., & Gremillion, H. A. (1998) · CRANIO® · doi:10.1080/08869634.1998.11746066 · Cited by 36 · see citing works
Irritable Bowel Syndrome Medications Side Effects Survey
Lembo, A. J. (2004) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000139029.00451.c7 · Cited by 34 · see citing works
Centrally acting agents and visceral sensitivity
Fioramonti, J., & Bueno, L. P. (2002) · Gut · doi:10.1136/gut.51.suppl_1.i91 · Cited by 34 · see citing works
Antidepressants in IBS: Are We Deluding Ourselves?
Talley, N. J. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.04128.x · Cited by 33 · see citing works
203-THE COST-EFFECTIVENESS OF PSYCHOTHERAPY AND PAROXETINE FOR SEVERE IRRITABLE BOWEL SYNDROME
Creed, F. H. (2004) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2004.04.074 · Cited by 32 · see citing works
Meta-analysis: the treatment of irritable bowel syndrome. Aliment Pharmacol Ther
Pantoflickova, D., Michetti, P., Fried, M., Beglinger, C., Al, B., & Blum, A. L. (2005) · Cited by 29 · see citing works
Psychiatric Symptoms Endorsed by Somatization Disorder Patients in a Psychiatric Clinic
Lenze, E. J., Miller, A. R., Munir, Z. B., Pornnoppadol, C., & North, C. S. (1999) · Annals of Clinical Psychiatry · doi:10.1023/a:1022342431514 · Cited by 23 · see citing works
Siproudhis, L., Dinasquet, M., Sebille, V., Reymann, J., & Bellissant, É. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02151.x · Cited by 20 · see citing works
The Effect of Medazepam in Relieving Symptoms of Functional Gastrointestinal Distress**
BAUME, P. E., & Cuthbert, J. A. (1973) · Australian and New Zealand Journal of Medicine · doi:10.1111/j.1445-5994.1973.tb03122.x · Cited by 19 · see citing works
Symptoms of Major Depression and Tricyclic Side Effects in Primary Care Patients
Rollman, B. L., Block, M. R., & Schulberg, H. C. (1997) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.1997.012005284.x · Cited by 19 · see citing works
Tricyclic antidepressants for persistent or recurrent vomiting in diabetic patients
Sawhney, M., Prakash, C., Lustman, P. J., & Clouse, R. E. (2001) · Gastroenterology · doi:10.1016/s0016-5085(08)81205-x · Cited by 17 · see citing works
Self-citationThe rationale for antidepressant therapy in functional gastrointestinal disorders
Castle, M. Z. D., Silk, D. B. A., & Libby, G. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.01879.x · Cited by 17 · see citing works
Wootton, J. C. (2000) · Journal of Women s Health & Gender-Based Medicine · doi:10.1089/15246090050147772 · Cited by 16 · see citing works
Rk, S., & Siegel, H. I. (1984) · PubMed · Cited by 16 · see citing works
Psychiatric Symptoms Endorsed by Somatization Disorder Patients in a Psychiatric Clinic
Lenze, E. J., Miller, A. B., Munir, Z. B., et al. (1999) · Annals of Clinical Psychiatry · doi:10.3109/10401239909147052 · Cited by 16 · see citing works
Brown, W. H., Chey, W. D., & Elta, G. H. (2003) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200303000-00008 · Cited by 14 · see citing works
Antidepressants for functional gastrointestinal symptoms and syndromes: A meta-analysis
Clouse, R. E., Prakash, C., ANDERSON, R., Lustman, P. J., & Univ, W. (2001) · Gastroenterology · doi:10.1016/s0016-5085(08)83189-7 · Cited by 14 · see citing works
Self-citationJAMISON, J. (2003) · Elsevier eBooks · doi:10.1016/b978-0-443-07193-5.50034-0 · Cited by 11 · see citing works
Mertz, H., Pickens, D. R., & Morgan, V. L. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)80233-0 · Cited by 9 · see citing works
Treatment of irritable bowel syndrome
Spiller, R. E. (2003) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-003-0025-6 · Cited by 9 · see citing works
The status of the clinicopathologic conference in academic medical centers
Heudebert, G. R., & McKinney, N. (1999) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.1999.00282.x · Cited by 6 · see citing works
Nair, D. (2001) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(01)03781-9 · Cited by 5 · see citing works
Prakash, C., Owens, M. M., Freedland, K. E., et al. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)83690-2 · Cited by 4 · see citing works
Bellissant, É. (2004) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2003.11.037 · Cited by 1 · see citing works
(2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00717-0 · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 4
- Jackson JL, O'Malley PG, Tomkins G, et al. Treatment of functional gastrointestinal disorders with antidepressant medication: a meta-analysis. Am J Med 2000;108:65-72.
- O'Malley PG, Jackson JL, Tomkins GE, et al. Efficacy of antidepressants for physical symptoms: a critical review. J Gen Intern Med 1999;14(suppl 2):60.
- McQuay HJ, Moore RA. Antidepressants and chronic pain: effective analgesia in neuropathic pain and other syndromes. BMJ 1997;314:763-4.
- Freedland KE, Carney RM, Lustman PJ. The impact of psychiatric disorders on medical illness. In: Rubin EH, Zorumski CF, eds. Adult psychiatry, 2nd edn. Oxford: Blackwell Publishing, 2005 (in press).
Cited by
Sorted by citations
Guidelines on the irritable bowel syndrome: mechanisms and practical management
Spiller, R., Aziz, Q., Creed, F., Emmanuel, A., Houghton, L., Hungin, P., Jones, R., Kumar, D., Rubin, G., Trudgill, N., et al. (2007) · Gut · doi:10.1136/gut.2007.119446 · Cited by 818 · see citing works
Mayer, E. A. (2008) · New England Journal of Medicine · doi:10.1056/nejmcp0801447 · Cited by 243 · see citing works
North, C. S. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i14.2020 · Cited by 122 · see citing works
Tricyclic Antidepressants for Management of Residual Symptoms in Inflammatory Bowel Disease
Iskandar, H. N., Cassell, B., Kanuri, N., Gyawali, C. P., Gutierrez, A., Dassopoulos, T., Ciorba, M. A., & Sayuk, G. S. (2014) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000049 · Cited by 96 · see citing works
Antidepressants in inflammatory bowel disease
Mikocka-Walus, A., Ford, A. C., & Drossman, D. A. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0259-y · Cited by 93 · see citing works
Central neuromodulators for treating functional GI disorders: a primer
Sobin, H. W., Heinrich, T. W., & Drossman, D. A. (2017) · American Journal of Gastroenterology · doi:10.1038/ajg.2017.57 · Cited by 64 · see citing works
High Somatic Symptom Burdens and Functional Gastrointestinal Disorders
Sayuk, G. S., Elwing, J. E., Lustman, P. J., & Clouse, R. E. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.11.024 · Cited by 26 · see citing works
Self-citation
- Authors
- Clouse, R. E., & Lustman, P. J.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Clouse, R E
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2005-08-11
- Volume
- 54
- Issue
- 9
- Pages
- 1332-1341
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC3260562
- OpenAlex
- W2008866516
- Cited by
- 76
- References
- 89
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 1 · 2014: 5 · 2013: 3 · 2012: 6
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Keywords
- antidepressants, psychopharmacological agents, functional gastrointestinal disorders, irritable bowel syndrome, visceral stimulation, neuroimaging, prescribing patterns, somatic symptoms
- MeSH terms
- Antidepressive Agents, Gastrointestinal Diseases, Humans, Psychophysiologic Disorders, Anti-Anxiety Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
