LBP and CD14 polymorphisms correlate with increased colorectal carcinoma risk in Han Chinese
Open accessAbstract
AIM: To explore the associations of polymorphisms of lipopolysaccharide binding protein (LBP), cluster of differentiation 14 (CD14), toll-like receptor 4 (TLR-4), interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) with the colorectal carcinoma (CRC) risk in Han Chinese. METHODS: Polymorphisms of LBP (rs1739654, rs2232596, rs2232618), CD14 (rs77083413, rs4914), TLR-4 (rs5030719), IL-6 (rs13306435) and TNF-α (rs35131721) were genotyped in 479 cases of sporadic colorectal carcinoma and 486 healthy controls of Han Chinese in a case-control study. Single-nucleotide polymorphisms (SNPs) between cases and controls were analyzed by unconditional logistic regression. RESULTS: GA and GG genotypes of LBP rs2232596 were associated with a significantly increased risk of CRC [odds ratio (OR) = 1.51, 95% confidence interval (CI) 1.15-1.99, P = 0.003; OR = 2.49, 95% CI 1.16-5.38, P = 0.016, respectively]. A similar association was also observed for the CG genotype of CD14 rs4914 (OR= 1.69, 95% CI 1.20-2.36, P = 0.002). In addition, a combination of polymorphisms in LBP rs2232596 and CD14 rs4914 led to a 3.4-fold increased risk of CRC (OR = 3.44, 95% CI 1.94-6.10, P = 0.000). CONCLUSION: This study highlights the LBP rs2232596 and CD14 rs4914 polymorphisms as biomarkers for elevated CRC susceptibility in the Chinese Han population.
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A polymorphism in the LBP gene rs2232596 was associated with higher colorectal cancer risk.
“A polymorphism in the LBP gene (rs2232596) was associated with higher risk of CRC.106”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [106]
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Cites
A genetic model for colorectal tumorigenesis
Fearon, E. R., & Vogelstein, B. (1990) · Cell · doi:10.1016/0092-8674(90)90186-i · Cited by 12,132 · see citing works
LPS/TLR4 signal transduction pathway
Lu, Y.-C., Yeh, W.-C., & Ohashi, P. S. (2008) · Cytokine · doi:10.1016/j.cyto.2008.01.006 · Cited by 3,301 · see citing works
Smoldering and polarized inflammation in the initiation and promotion of malignant disease
Balkwill, F., Charles, K. A., & Mantovani, A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.02.013 · Cited by 1,769 · see citing works
Sica, A., Schioppa, T., Mantovani, A., & Allavena, P. (2006) · European Journal of Cancer · doi:10.1016/j.ejca.2006.01.003 · Cited by 1,451 · see citing works
The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages.
Allavena, P., Sica, A., Solinas, G., Porta, C., & Mantovani, A. (2008) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2007.07.004 · Cited by 1,044 · see citing works
Increasing incidence of colorectal cancer in Asia: implications for screening
Sung, J. J. �., Lau, J., Goh, K., & Leung, W. K. (2005) · The Lancet Oncology · doi:10.1016/s1470-2045(05)70422-8 · Cited by 740 · see citing works
Lipopolysaccharide recognition: CD14, TLRs and the LPS-activation cluster
Triantafilou, M., & Triantafilou, K. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02233-0 · Cited by 731 · see citing works
Biswas, S. K. (2005) · Blood · doi:10.1182/blood-2005-01-0428 · Cited by 693 · see citing works
Cancer related inflammation: the macrophage connection
Sica, A., Allavena, P., & Mantovani, A. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.03.028 · Cited by 601 · see citing works
Agnese, D. M., Calvano, J. E., Hahm, S. J., Coyle, S. M., Corbett, S., Calvano, S. E., & Lowry, S. F. (2002) · The Journal of Infectious Diseases · doi:10.1086/344893 · Cited by 570 · see citing works
At the Crossroads of Inflammation and Cancer
Clevers, H. C. (2004) · Cell · doi:10.1016/j.cell.2004.09.005 · Cited by 494 · see citing works
Giovannucci, E. L. (2001) · PubMed · Cited by 437 · see citing works
Initial responses to endotoxins and Gram-negative bacteria
Heumann, D., & Roger, T. (2002) · Clinica Chimica Acta · doi:10.1016/s0009-8981(02)00180-8 · Cited by 359 · see citing works
Influence of cytokine gene polymorphisms on the development of prostate cancer.
McCarron, S. L., Edwards, S. M., Evans, P. R., Gibbs, R., Dearnaley, D. P., Dowe, A., Southgate, C., Easton, D. F., Eeles, R. A., & Howell, W. M. (2002) · PubMed · Cited by 336 · see citing works
Cellular and molecular pathways linking inflammation and cancer
Porta, C., Larghi, P., Rimoldi, M., Totaro, M. G., Allavena, P., Mantovani, A., & Sica, A. (2009) · Immunobiology · doi:10.1016/j.imbio.2009.06.014 · Cited by 250 · see citing works
Genetic Polymorphisms in Sepsis and Septic Shock
Holmes, C. L., Russell, J. A., & Walley, K. R. (2003) · CHEST Journal · doi:10.1378/chest.124.3.1103 · Cited by 219 · see citing works
Takayama, H., Nishimura, K., Tsujimura, A., Nakai, Y., Nakayama, M., Aozasa, K., Okuyama, Ä., & Nonomura, N. (2009) · The Journal of Urology · doi:10.1016/j.juro.2008.11.090 · Cited by 130 · see citing works
Interleukin‐1B and interleukin‐1 RN polymorphisms and gastric carcinoma risk: A meta‐analysis
Xue, H., Lin, B., Ni, P., Xu, H. W., & Huang, G. (2010) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2010.06428.x · Cited by 122 · see citing works
Garza‐González, E., Bosques‐Padilla, F., Mendoza-Ibarra, S. I., Gutiérrez, J. P. I., Maldonado-Garza, H. J., & Perez-Perez, G. I. (2007) · BMC Cancer · doi:10.1186/1471-2407-7-70 · Cited by 118 · see citing works
Association of TNF-α polymorphism with susceptibility to and severity of non-small cell lung cancer
Shih, C., Lee, Y.-L., Chiou, H., Chen, W., Chang, G., Chou, M., & Lin, L. (2006) · Lung Cancer · doi:10.1016/j.lungcan.2005.11.011 · Cited by 103 · see citing works
Impact of Toll-like receptor 4 polymorphisms on risk of cancer
Kutikhin, A. G. (2010) · Human Immunology · doi:10.1016/j.humimm.2010.11.003 · Cited by 83 · see citing works
Pathogen recognition receptors, cancer and inflammation in the gut
Fukata, M., & Abreu, M. T. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.09.006 · Cited by 83 · see citing works
Song, J., Kim, D. Y., Kim, C., Kim, H. J., Lee, D. H., Lee, H. M., Ko, W., & Lee, G. (2009) · Cancer Genetics and Cytogenetics · doi:10.1016/j.cancergencyto.2008.12.011 · Cited by 57 · see citing works
Analysis of Gene Expression in the Tumor-Associated Macrophage
Duff, M. D., MESTRE, J. R., Maddali, S., Yan, Z., Stapleton, P. P., & Daly, J. M. (2007) · Journal of Surgical Research · doi:10.1016/j.jss.2006.12.542 · Cited by 48 · see citing works
Role ofCD14Promoter Polymorphisms inHelicobacter pyloriInfection–Related Gastric Carcinoma
Zhao, D., Sun, T., Zhang, X., Guo, Y., Yu, D., Yang, M. W., Tan, W., Wang, G., & Lin, D. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2612 · Cited by 43 · see citing works
Genetic polymorphisms of inflammatory cytokines and myocardial infarction in the elderly
Olivieri, F., Antonicelli, R., Cardelli, M., Marchegiani, F., Cavallone, L., Mocchegiani, E., & Franceschi, C. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.01.013 · Cited by 41 · see citing works
Alcohol Intake and Colorectal Cancer
Thygesen, L. C., Wu, K., Grønbæk, M., Fuchs, C. S., Willett, W. C., & Giovannucci, E. L. (2008) · Epidemiology · doi:10.1097/ede.0b013e31816339e0 · Cited by 40 · see citing works
Interleukin-6 polymorphisms and the risk of cervical cancer
Nogueira-de-Souza, N. C., Brenna, S. M. F., Campos, F. M. F., Syrjänen, K. J., Baracat, E. C., & Silva, I. D. C. G. (2006) · International Journal of Gynecological Cancer · doi:10.1111/j.1525-1438.2006.00521.x · Cited by 39 · see citing works
Guo, Q., Zhu, J., & Xia, B. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2005.04156.x · Cited by 37 · see citing works
Association of CD14 variant with prostate cancer in African American men
Mason, T. E., Ricks‐Santi, L. J., Chen, W., Apprey, V., Joykutty, J., Ahaghotu, C. A., Kittles, R. A., Bonney, G. E., & Dunston, G. M. (2009) · The Prostate · doi:10.1002/pros.21060 · Cited by 28 · see citing works
Cellular and molecular pathways linking inflammation and cancer. Immunobiology
Porta, C., Totaro, M. G., Larghi, P., Rimoldi, M., Allavena, P., Mantovani, A., & Sica, A. (2009) · Cited by 13 · see citing works
Vollmer, T., Kleesiek, K., & Dreier, J. (2009) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2009.06.010 · Cited by 12 · see citing works
Dhir, R. (2010) · Yearbook of Pathology and Laboratory Medicine · doi:10.1016/s1077-9108(09)79381-8 · Cited by 9 · see citing works
Interleukin-6 polymorphisms and the risk of cervical cancer
Souza, N. C. N. D., Brenna, S., Campos, F., et al. (2006) · International Journal of Gynecological Cancer · doi:10.1136/ijgc-00009577-200605000-00049 · Cited by 9 · see citing works
Molecular mechanisms regulating TNF-α production by tumor-associated macrophages
Dougherty, S. T., Eaves, C. J., McBride, W. H., & Dougherty, G. J. (1997) · Cancer Letters · doi:10.1016/s0304-3835(96)04490-4 · Cited by 4 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Zhao D, Sun T, Zhang X, Guo Y, Yu D, Yang M, Tan W, Wang G, Lin D. Role of CD14 promoter polymorphisms in Helicobacter pylori infection--related gastric carcinoma. Clin Cancer Res 2007; 13: 2362-2368 29
Cited by
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Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer
Song, M., Chan, A. T., & Sun, J. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.06.048 · Cited by 752 · see citing works
Gut Microbes, Diet, and Cancer
Hullar, M. A. J., Burnett‐Hartman, A. N., & Lampe, J. W. (2013) · Cancer treatment and research · doi:10.1007/978-3-642-38007-5_22 · Cited by 135 · see citing works
Zhang, W., Ou, X., & Wu, X. (2019) · International Journal of Oncology · doi:10.3892/ijo.2019.4742 · Cited by 118 · see citing works
Multiple Roles of Toll-Like Receptor 4 in Colorectal Cancer
Yesudhas, D., Gosu, V., Anwar, M. A., & Choi, S. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00334 · Cited by 108 · see citing works
Meng, L., Song, Z., Liu, A., Dahmen, U., Yang, X., & Fang, H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.681810 · Cited by 77 · see citing works
LPS receptor subunits have antagonistic roles in epithelial apoptosis and colonic carcinogenesis
Kuo, W.-T., Lee, T.-C., Yang, H., Chen, C.-Y., Au, Y.-C., Lu, Y., Wu, L., Wei, S.-C., Ni, Y., Lin, B.-R., et al. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2014.240 · Cited by 66 · see citing works
González‐Sarrías, A., Núñez‐Sánchez, M. Á., Ávila‐Gálvez, M. Á., Monedero‐Saiz, T., Rodríguez‐Gil, F. J., Martínez‐Díaz, F., Selma, M. V., & Espı́n, J. C. (2018) · Food & Function · doi:10.1039/c8fo00264a · Cited by 46 · see citing works
IL6 gene polymorphisms and susceptibility to colorectal cancer: a meta-analysis and review
Yu, Y., Wang, W., Zhai, S., Dang, S., & Sun, M. (2012) · Molecular Biology Reports · doi:10.1007/s11033-012-1699-4 · Cited by 41 · see citing works
Shi, M., Zong, X., Hur, J., Birmann, B. M., Martı́nez-Maza, O., Epeldegui, M., Chan, A. T., Giovannucci, E. L., & Cao, Y. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104566 · Cited by 26 · see citing works
Innate immunity gene polymorphisms and the risk of colorectal neoplasia
Chang, C. M., Chia, V. M., Gunter, M. J., Zanetti, K. A., Ryan, B. M., Goodman, J. E., Harris, C. C., Weissfeld, J. L., Huang, W., Chanock, S. J., et al. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt228 · Cited by 17 · see citing works
The footprint of gut microbiota in gallbladder cancer: a mechanistic review
Liu, S., Li, W., Chen, J., Li, M., Geng, Y., Liu, Y., & Wu, W. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1374238 · Cited by 14 · see citing works
Dyke, A. L. V., Kemp, T. J., Corbel, A., Zhu, B., Gao, Y.-T., Wang, B.-S., Rashid, A., Shen, M.-C., Hildesheim, A., Hsing, A. W., et al. (2016) · Annals of Epidemiology · doi:10.1016/j.annepidem.2016.08.009 · Cited by 13 · see citing works
Colorectal Cancer Prevention with a Plant-Based diet
Rose, S. (2019) · Cancer therapy & Oncology International Journal · doi:10.19080/ctoij.2019.15.555906 · Cited by 11 · see citing works
The clinical significance of lipopolysaccharide binding protein in hepatocellular carcinoma
Cai, Q., Jiang, J., Jin, R., Jin, G., & Jia, N. (2019) · Oncology Letters · doi:10.3892/ol.2019.11119 · Cited by 10 · see citing works
Citronberg, J. S., Wilkens, L. R., Marchand, L. L., Lim, U., Monroe, K. R., Hullar, M. A. J., White, E., Newcomb, P. A., & Lampe, J. W. (2017) · Cancer Causes & Control · doi:10.1007/s10552-017-0990-z · Cited by 9 · see citing works
Urbiola-Salvador, V., Jabłońska, A., Miroszewska, D., Kamysz, W., Duzowska, K., Drężek-Chyła, K., Baber, R., Thieme, R., Gockel, I., Zdrenka, M., et al. (2024) · Biomarker Insights · doi:10.1177/11772719241257739 · Cited by 8 · see citing works
Zhang, W., Yang, Z., Zhou, F., Wei, Y., & Ma, X. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.935906 · Cited by 7 · see citing works
Lipopolysaccharide‐binding protein as a biomarker in oral and maxillofacial tumors
Qiao, B., Chen, Z., Huang, J., Lam, A. K.-Y., Mei, Z., Li, Y., & Qiao, J. (2021) · Oral Diseases · doi:10.1111/odi.14042 · Cited by 6 · see citing works
Wang, Z., Li, X., Yi, Q. X., Jia, Z., Li, Y. X., Zou, Y. Y., Xu, C., & Gong, A. (2016) · OncoTargets and Therapy · doi:10.2147/ott.s95807 · Cited by 6 · see citing works
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Zaher, K. A., & Basingab, F. S. (2023) · Biomedicines · doi:10.3390/biomedicines11123196 · Cited by 5 · see citing works
Hu, Y., Yoshida, K., COLOGNE, J. B., Maki, M., Morishita, Y., Sasaki, K., Hayashi, I., Ohishi, W., Hida, A., Kyoizumi, S., et al. (2015) · Human Genome Variation · doi:10.1038/hgv.2015.35 · Cited by 5 · see citing works
Turgunov, Y. M., Ogizbayeva, A. V., Akhmaltdinova, L., & Shakeyev, K. T. (2021) · Współczesna Onkologia · doi:10.5114/wo.2021.110051 · Cited by 5 · see citing works
Ariff, A., Song, Y., Aguilar, R., Nhabomba, A. J., Manaca, M. N., Khoo, S., Wiertsema, S. P., Bassat, Q., Barbosa, A., Quintó, L., et al. (2023) · Malaria Journal · doi:10.1186/s12936-023-04549-8 · Cited by 3 · see citing works
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Li, N., Zhou, W., Jia, L., Guo, S., Hu, Q., & Shen, Y. (2013) · OncoTargets and Therapy · doi:10.2147/ott.s54547 · Cited by 3 · see citing works
Ganesan, H., Souček, P., Liška, V., Genua, F., Holý, P., Daniel, N., Doherty, G. A., & Hughes, D. J. (2025) · Digestive Diseases and Sciences · doi:10.1007/s10620-025-09603-w · Cited by 2 · see citing works
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Ariff, A., Song, Y., Aguilar, R., Nhabomba, A. J., Manaca, M. N., Khoo, S., Wiertsema, S. P., Bassat, Q., Barbosa, A., Quintó, L., et al. (2023) · UWA Profiles and Research Repository (University of Western Australia) · doi:10.6084/m9.figshare.23354322
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Ariff, A., Song, Y., Aguilar, R., Nhabomba, A. J., Manaca, M. N., Khoo, S., Wiertsema, S. P., Bassat, Q., Barbosa, A., Quintó, L., et al. (2023) · UWA Profiles and Research Repository (University of Western Australia) · doi:10.6084/m9.figshare.23354325
- Authors
- Chen, R.
- Affiliations
- Army Medical University (CN)
- Corresponding author
- Chen, Rui
- ORCID
- Chen, Rui
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2011
- Volume
- 17
- Issue
- 18
- Pages
- 2326
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC3098400
- OpenAlex
- W2097564816
- Cited by
- 31
- References
- 35
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 4 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 4 · 2012: 2
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- colorectal cancer, lipopolysaccharide-binding protein, CD14, TLR4, interleukin-6, TNF-α, single nucleotide polymorphisms, genetic susceptibility, Han Chinese
- MeSH terms
- Lipopolysaccharide-Binding Protein, Acute-Phase Proteins, Adult, Aged, Carrier Proteins, Female, Humans, Male, Membrane Glycoproteins, Middle Aged, Risk Factors, Colorectal Neoplasms, Case-Control Studies, DNA Primers, Lipopolysaccharide Receptors, Polymorphism, Single Nucleotide, Asian People
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