Cited by 35Genetic Associations and EpidemiologyGenetic factors in colorectal cancerImmune Response and Inflammation

LBP and CD14 polymorphisms correlate with increased colorectal carcinoma risk in Han Chinese

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Chen, Rui·2011·World Journal of Gastroenterology

Abstract

AIM: To explore the associations of polymorphisms of lipopolysaccharide binding protein (LBP), cluster of differentiation 14 (CD14), toll-like receptor 4 (TLR-4), interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) with the colorectal carcinoma (CRC) risk in Han Chinese. METHODS: Polymorphisms of LBP (rs1739654, rs2232596, rs2232618), CD14 (rs77083413, rs4914), TLR-4 (rs5030719), IL-6 (rs13306435) and TNF-α (rs35131721) were genotyped in 479 cases of sporadic colorectal carcinoma and 486 healthy controls of Han Chinese in a case-control study. Single-nucleotide polymorphisms (SNPs) between cases and controls were analyzed by unconditional logistic regression. RESULTS: GA and GG genotypes of LBP rs2232596 were associated with a significantly increased risk of CRC [odds ratio (OR) = 1.51, 95% confidence interval (CI) 1.15-1.99, P = 0.003; OR = 2.49, 95% CI 1.16-5.38, P = 0.016, respectively]. A similar association was also observed for the CG genotype of CD14 rs4914 (OR= 1.69, 95% CI 1.20-2.36, P = 0.002). In addition, a combination of polymorphisms in LBP rs2232596 and CD14 rs4914 led to a 3.4-fold increased risk of CRC (OR = 3.44, 95% CI 1.94-6.10, P = 0.000). CONCLUSION: This study highlights the LBP rs2232596 and CD14 rs4914 polymorphisms as biomarkers for elevated CRC susceptibility in the Chinese Han population.

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  1. Zhao D, Sun T, Zhang X, Guo Y, Yu D, Yang M, Tan W, Wang G, Lin D. Role of CD14 promoter polymorphisms in Helicobacter pylori infection--related gastric carcinoma. Clin Cancer Res 2007; 13: 2362-2368 29

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Authors
Chen, R.
Affiliations
Army Medical University (CN)
Corresponding author
Chen, Rui
Venue
World Journal of Gastroenterology
Published
2011
Volume
17
Issue
18
Pages
2326
ISSN
1007-9327 (ISSN-L)
OpenAlex
W2097564816
Cited by
31
References
35
Citations by year
2025: 2 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 4 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 4 · 2012: 2
FWCI
1.39
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • World Journal of Gastroenterology (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
colorectal cancer, lipopolysaccharide-binding protein, CD14, TLR4, interleukin-6, TNF-α, single nucleotide polymorphisms, genetic susceptibility, Han Chinese
MeSH terms
Lipopolysaccharide-Binding Protein, Acute-Phase Proteins, Adult, Aged, Carrier Proteins, Female, Humans, Male, Membrane Glycoproteins, Middle Aged, Risk Factors, Colorectal Neoplasms, Case-Control Studies, DNA Primers, Lipopolysaccharide Receptors, Polymorphism, Single Nucleotide, Asian People

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