Cancer related inflammation: the macrophage connection
Abstract
Tumor-associated macrophages (TAM) are key regulators of the link between inflammation and cancer. In the tumor microenvironment neoplastic cells shape the differentiation and functional orientation of TAM which, in turn, express several protumoral functions, including secretion of growth factors and matrix-proteases, promotion of angiogenesis and suppression of adaptive immunity. This review analyzes our current knowledge of TAM and their involvement in tumor development and progression. The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches.
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Immunity, Inflammation, and Cancer
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P53, GHRH, inflammation and cancer
Barabutis, N., Schally, A. V., & Siejka, A. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.10.034 · Cited by 106 · see citing works
- Authors
- Sica, A., Allavena, P., & Mantovani, A.
- Affiliations
- Fondazione Humanitas per la Ricerca (IT)
- University of Milan (IT)
- Corresponding author
- Allavena, Paola
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 267
- Issue
- 2
- Pages
- 204-215
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W2141487097
- Cited by
- 601
- References
- 96
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 22 · 2023: 36 · 2022: 30 · 2021: 36 · 2020: 36 · 2019: 30 · 2018: 29 · 2017: 39 · 2016: 32 · 2015: 35 · 2014: 47 · 2013: 35 · 2012: 37
- FWCI
- 3.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- tumor-associated macrophages, tumor inflammation, tumor microenvironment, macrophage polarization, tumor progression, angiogenesis, immunosuppression, growth factors, carcinogenesis, therapeutic target
- MeSH terms
- Animals, Humans, Inflammation, Macrophage Activation, Macrophages, Neoplasms, NF-kappa B, Cell Polarity, Disease Progression, STAT3 Transcription Factor, Hypoxia-Inducible Factor 1, alpha Subunit
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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