Cited by 602Immune cells in cancerAngiogenesis and VEGF in CancerCancer, Stress, Anesthesia, and Immune Response

Cancer related inflammation: the macrophage connection

Sica, Antonio, Allavena, Paola, Mantovani, Alberto·2008·Cancer Letters

Abstract

Tumor-associated macrophages (TAM) are key regulators of the link between inflammation and cancer. In the tumor microenvironment neoplastic cells shape the differentiation and functional orientation of TAM which, in turn, express several protumoral functions, including secretion of growth factors and matrix-proteases, promotion of angiogenesis and suppression of adaptive immunity. This review analyzes our current knowledge of TAM and their involvement in tumor development and progression. The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches.

Integrity signals

Registry

Crossref · 10.1016/j.canlet.2008.03.028

Cites

96 of 96 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Sica, A., Allavena, P., & Mantovani, A.
Affiliations
  • Fondazione Humanitas per la Ricerca (IT)
  • University of Milan (IT)
Corresponding author
Allavena, Paola
Venue
Cancer Letters
Publisher
Elsevier BV
Published
2008-08
Volume
267
Issue
2
Pages
204-215
ISSN
0304-3835 (ISSN-L)
OpenAlex
W2141487097
Cited by
601
References
96
Citations by year
2026: 10 · 2025: 17 · 2024: 22 · 2023: 36 · 2022: 30 · 2021: 36 · 2020: 36 · 2019: 30 · 2018: 29 · 2017: 39 · 2016: 32 · 2015: 35 · 2014: 47 · 2013: 35 · 2012: 37
FWCI
3.20
Type
journal article
Language
en
Open access
closed
Locations
  • Cancer Letters (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
Keywords
tumor-associated macrophages, tumor inflammation, tumor microenvironment, macrophage polarization, tumor progression, angiogenesis, immunosuppression, growth factors, carcinogenesis, therapeutic target
MeSH terms
Animals, Humans, Inflammation, Macrophage Activation, Macrophages, Neoplasms, NF-kappa B, Cell Polarity, Disease Progression, STAT3 Transcription Factor, Hypoxia-Inducible Factor 1, alpha Subunit

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review