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Cited by 133Clinical Nutrition and GastroenterologyDigestive system and related healthGastrointestinal motility and disorders

Intestinal mucosal atrophy and adaptation

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Shaw, Darcy·2012·World Journal of Gastroenterology
DOI 10.3748/wjg.v18.i44.6357PMC PMC3508630
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Abstract

Mucosal adaptation is an essential process in gut homeostasis. The intestinal mucosa adapts to a range of pathological conditions including starvation, short-gut syndrome, obesity, and bariatric surgery. Broadly, these adaptive functions can be grouped into proliferation and differentiation. These are influenced by diverse interactions with hormonal, immune, dietary, nervous, and mechanical stimuli. It seems likely that clinical outcomes can be improved by manipulating the physiology of adaptation. This review will summarize current understanding of the basic science surrounding adaptation, delineate the wide range of potential targets for therapeutic intervention, and discuss how these might be incorporated into an overall treatment plan. Deeper insight into the physiologic basis of adaptation will identify further targets for intervention to improve clinical outcomes.

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Authors
Shaw, D.
Affiliations
Michigan State University (US)
Corresponding author
Shaw, Darcy
Venue
World Journal of Gastroenterology
Publisher
Baishideng Publishing Group Inc.
Published
2012
Volume
18
Issue
44
Pages
6357
ISSN
1007-9327 (ISSN-L)
DOI
10.3748/wjg.v18.i44.6357
PMC
PMC3508630
OpenAlex
W2000172393
Cited by
133
References
1
Citations by year
2026: 2 · 2025: 9 · 2024: 12 · 2023: 13 · 2022: 10 · 2021: 14 · 2020: 11 · 2019: 10 · 2018: 9 · 2017: 10 · 2016: 11 · 2015: 11 · 2014: 7 · 2013: 4
FWCI
0.86
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • World Journal of Gastroenterology (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (R56DK096137)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Digestive system and related health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
intestinal mucosal atrophy, mucosal adaptation, intestinal homeostasis, intestinal epithelial cell proliferation, intestinal epithelial differentiation, short bowel syndrome, starvation, obesity, bariatric surgery, hormonal regulation, immune regulation, dietary regulation, neural regulation, mechanical regulation, therapeutic target
MeSH terms
Adaptation, Physiological, Animals, Atrophy, Cell Differentiation, Combined Modality Therapy, Humans, Intestinal Diseases, Intestinal Mucosa, Nutritional Status, Cell Proliferation

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