Cited by 352Liver Disease Diagnosis and TreatmentProbiotics and Fermented FoodsGut microbiota and health

The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.

Effects of probiotics on nonalcoholic fatty liver disease: A meta-analysis

Open access

Ma, Yan-Yan·2013·World Journal of Gastroenterology

DOI 10.3748/wjg.v19.i40.6911PMC PMC3812493

Open this paper in CoChat — free account Open PDF

Abstract

AIM: To investigate the relationship between the gut-liver axis and nonalcoholic fatty liver disease (NAFLD), we performed a meta-analysis to evaluate the effects of probiotic therapy in NAFLD. METHODS: We searched PubMed, Medline, Embase, Web of Science, the Cochrane Library and Chinese Biomedicine Database for all relevant randomized controlled trials on probiotics in patients with NAFLD/nonalcoholic steatohepatitis (NASH). A statistical analysis was performed using RevMan 5.0 software. RESULTS: Four randomized trials involving 134 NAFLD/NASH patients were included. The results showed that probiotic therapy signiﬁcantly decreased alanine aminotransferase (ALT), aspartate transaminase (AST), total-cholesterol (T-chol), high density lipoprotein (HDL), tumor necrosis factor (TNF)-α and homeostasis model assessment of insulin resistance (HOMA-IR) [ALT: weighted mean difference (WMD) -23.71, 95%CI: -33.46--13.95, P < 0.00001; AST: WMD -19.77, 95%CI: -32.55--7.00, P = 0.002; T-chol: WMD -0.28, 95%CI: -0.55--0.01, P = 0.04; HDL: WMD -0.09, 95%CI: -0.16-0.01, P = 0.03; TNF-α: WMD -0.32, 95%CI: -0.48--0.17, P < 0.0001; HOMA-IR: WMD -0.46, 95%CI: -0.73--0.19, P = 0.0008]. However, the use of probiotics was not associated with changes in body mass index (BMI), glucose (GLU) and low density lipoprotein (LDL) (BMI: WMD 0.05, 95%CI: -0.18-0.29, P = 0.64; GLU: WMD 0.05, 95%CI: -0.25-0.35, P = 0.76; LDL: WMD -0.38, 95%CI: -0.78-0.02, P = 0.06). CONCLUSION: Probiotic therapies can reduce liver aminotransferases, total-cholesterol, TNF-α and improve insulin resistance in NAFLD patients. Modulation of the gut microbiota represents a new treatment for NAFLD.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3748/wjg.v19.i40.6911

Cites

63 of 63 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Correspondence - Tranexamic acid for traumatic brain injury
(2005) · London School of Economics and Political Science Theses Online (London School of Economics and Political Science) · doi:10.1016/s0140-6736 · Cited by 11,894
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics
Gibson, G. R., & Roberfroid, M. B. (1995) · Journal of Nutrition · doi:10.1093/jn/125.6.1401 · Cited by 7,659
Metagenomic Analysis of the Human Distal Gut Microbiome
Gill, S. R., Pop, M., DeBoy, R. T., Eckburg, P. B., Turnbaugh, P. J., Samuel, B. S., Gordon, J. I., Relman, D. A., Fraser-Liggett, C. M., & Nelson, K. E. (2006) · Science · doi:10.1126/science.1124234 · Cited by 4,699
Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans
Katz, A., Nambi, S. S., Mather, K., Baron, A. D., Follmann, D. A., Sullivan, G., & Quon, M. J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.7.6661 · Cited by 3,931
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543
Gut flora in health and disease
Guarner, F., & Malagelada, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12489-0 · Cited by 3,480
Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis
Tilg, H., & Moschen, A. R. (2010) · Hepatology · doi:10.1002/hep.24001 · Cited by 2,548

Show all 63 references

Research works printed but not linked: 2

Salminen S. Uniqueness of probiotic strains. IDF Nutr News- letter 1996; 5: 16-18 13
Hofacre CL, Mathis GF, Quiroz MA. Natural alternatives to prevent necrotic enteritis. Int Poult Prod 2005; 13: 7-9 60

Sorted by citations

Items 101–200 of 352

Probiotics as a complementary therapeutic approach in nonalcoholic fatty liver disease
Ferolla, S. M. (2015) · World Journal of Hepatology · doi:10.4254/wjh.v7.i3.559 · Cited by 55
Anti-obesity properties of probiotics; a considerable medical nutrition intervention: Findings from an umbrella meta-analysis
Musazadeh, V., Zarezadeh, M., Ghalichi, F., Ahrabi, S. S., Jamilian, P., Jamilian, P., & Ghoreishi, Z. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175069 · Cited by 55
The Effect of Probiotic and/or Prebiotic on Liver Function Tests in Patients with Nonalcoholic Fatty Liver Disease: A Double Blind Randomized Clinical Trial
Javadi, L., Ghavami, M., Khoshbaten, M., Safaiyan, A., Barzegari, A., & Gargari, B. P. (2017) · Iranian Red Crescent Medical Journal · doi:10.5812/ircmj.46017 · Cited by 54
Pharmacotherapy for Non-Alcoholic Fatty Liver Disease: Emerging Targets and Drug Candidates
Александровна, П. В., Bezborodkina, N. N., & Okovityi, S. V. (2022) · Biomedicines · doi:10.3390/biomedicines10020274 · Cited by 55
Nonalcoholic fatty liver disease: Diagnosis, pathogenesis, and management
Başaranoğlu, M., & Örmecı, N. (2014) · The Turkish Journal of Gastroenterology · doi:10.5152/tjg.2014.7675 · Cited by 53
Low-grade small intestinal bacterial overgrowth is common in patients with non-alcoholic steatohepatitis on quantitative jejunal aspirate culture
Ghoshal, U. C., Baba, C. S., Ghoshal, U., Alexander, G., Misra, A., Saraswat, V. A., & Choudhuri, G. (2017) · Indian Journal of Gastroenterology · doi:10.1007/s12664-017-0797-6 · Cited by 53
Postbiotics Prepared Using Lactobacillus paracasei CCFM1224 Prevent Nonalcoholic Fatty Liver Disease by Modulating the Gut Microbiota and Liver Metabolism
Pan, Z., Mao, B., Zhang, Q., Tang, X., Yang, B. K., Zhao, J., Cui, S., & Zhang, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113522 · Cited by 52
Probiotic Supplementation, Hepatic Fibrosis, and the Microbiota Profile in Patients with Nonalcoholic Steatohepatitis: A Randomized Controlled Trial
Escouto, G. S., Port, G. Z., Tovo, C. V., Fernandes, S. A., Peres, A., Dorneles, G. P., Houde, V. P., Varin, T. V., Pilon, G., Marette, A., et al. (2023) · Journal of Nutrition · doi:10.1016/j.tjnut.2023.05.019 · Cited by 52
The effects of prebiotic, probiotic or synbiotic supplementation on overweight/obesity indicators: an umbrella review of the trials’ meta-analyses
Rasaei, N., Heidari, M., Esmaeili, F., Khosravi, S., Baeeri, M., Tabatabaei‐Malazy, O., & Emamgholipour, S. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1277921 · Cited by 53
Gut microbiota-associated bile acid deconjugation accelerates hepatic steatosis in ob/ob mice
Park, M.-Y., Kim, S. J., Ko, E., Ahn, S., Seo, H., & Sung, M. (2016) · Journal of Applied Microbiology · doi:10.1111/jam.13158 · Cited by 52
Current and emerging pharmacological therapy for non-alcoholic fatty liver disease
Eshraghian, A. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i42.7495 · Cited by 52
Probiotics and their increasing importance in human health and infection control
Ghasemian, A., Eslami, M., Shafiei, M., Najafipour, S., & Rajabi, A. (2018) · Reviews in Medical Microbiology · doi:10.1097/mrm.0000000000000147 · Cited by 52
The promising role of probiotic and synbiotic therapy in aminotransferase levels and inflammatory markers in patients with nonalcoholic fatty liver disease – a systematic review and meta-analysis
Khan, M. Y., Mihali, A. B., Rawala, M. S., Aslam, A., & Siddiqui, W. J. (2019) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000001371 · Cited by 52
Modulating the Intestinal Microbiota: Therapeutic Opportunities in Liver Disease
Philips, C. A., Augustine, P., Yerol, P. K., Ramesh, G. N., Ahamed, R., Rajesh, S. K., George, T., & Kumbar, S. V. (2019) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2019.00035 · Cited by 52
A systematic review of the present and future of non-alcoholic fatty liver disease
Lucas, C., Lucas, G., Lucas, N., Krzowska-Firych, J., & Tomasiewicz, K. (2018) · Clinical and Experimental Hepatology · doi:10.5114/ceh.2018.78120 · Cited by 51
Effect of microbial cell preparation on renal profile and liver function among type 2 diabetics: a randomized controlled trial
Firouzi, S., Yusof, B. N. M., Majid, H. A., Ismail, A., & Kamaruddin, N. (2015) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-015-0952-5 · Cited by 50
Dietary supplements and pediatric non-alcoholic fatty liver disease: Present and the future
Rahimlou, M. (2015) · World Journal of Hepatology · doi:10.4254/wjh.v7.i25.2597 · Cited by 49
Integrative Medicine for Gastrointestinal Disease
Dossett, M. L., Cohen, E. M., & Cohen, J. (2017) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2017.02.002 · Cited by 49
Current investigations for liver fibrosis treatment: between repurposing the FDA-approved drugs and the other emerging approaches
Mohammed, O. S., Attia, H. G., Mohamed, B. M. S. A., Elbaset, M. A., & Fayed, H. M. (2023) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.3389/jpps.2023.11808 · Cited by 48
Gut microbiota and their metabolites in the progression of non-alcoholic fatty liver disease
Zhou, J., Tripathi, M., Sinha, R. A., Singh, B. K., & Yen, P. M. (2021) · Hepatoma Research · doi:10.20517/2394-5079.2020.134 · Cited by 49
Review article: the management of paediatric nonalcoholic fatty liver disease
Mitchel, E. B., & Lavine, J. E. (2014) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12972 · Cited by 47
Hepatic dysfunction after spinal cord injury: A vicious cycle of central and peripheral pathology?
Goodus, M. T., & McTigue, D. M. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113160 · Cited by 47
Gut microbiome, gut function, and probiotics: Implications for health
Hajela, N., Ramakrishna, B., Nair, G. B., Abraham, P., Gopalan, S., & Ganguly, N. K. (2015) · Indian Journal of Gastroenterology · doi:10.1007/s12664-015-0547-6 · Cited by 47
The pathogenic oral–gut–liver axis: new understandings and clinical implications
Imai, J., Kitamoto, S., & Kamada, N. (2021) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2021.1935877 · Cited by 46
Probiotic therapy, a novel and efficient adjuvant approach to improve glycemic status: An umbrella meta-analysis
Zarezadeh, M., Musazadeh, V., Faghfouri, A. H., Sarmadi, B., Jamilian, P., Jamilian, P., Tutunchi, H., & Dehghan, P. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106397 · Cited by 46
Effect of a Probiotic and a Synbiotic on Body Fat Mass, Body Weight and Traits of Metabolic Syndrome in Individuals with Abdominal Overweight: A Human, Double-Blind, Randomised, Controlled Clinical Study
Laue, C., Papazova, E., Pannenbeckers, A., & Schrezenmeir, J. (2023) · Nutrients · doi:10.3390/nu15133039 · Cited by 46
Increased Prevalence of Irritable Bowel Syndrome in a Cohort of French Morbidly Obese Patients Candidate for Bariatric Surgery
Schneck, A. S., Anty, R., Tran, A., Hastier, A., Amor, I. B., Gugenheim, J., Iannelli, A., & Piche, T. (2015) · Obesity Surgery · doi:10.1007/s11695-015-1907-0 · Cited by 45
The role of probiotic supplementation in inflammatory biomarkers in adults: an umbrella meta-analysis of randomized controlled trials
Faghfouri, A. H., Afrakoti, L. G. M. P., Kavyani, Z., Nogourani, Z. S., Musazadeh, V., Jafarlou, M., & Dehghan, P. (2023) · Inflammopharmacology · doi:10.1007/s10787-023-01332-8 · Cited by 44
Alcohol, microbiome, life style influence alcohol and non-alcoholic organ damage
Neuman, M. G., French, S. W., Zakhari, S., Malnick, S. D. H., Seitz, H. K., Cohen, L. B., Salaspuro, M. P., Voinea‐Griffin, A., Barasch, A., Kirpich, I., et al. (2017) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2017.01.003 · Cited by 44
Effects of probiotics combined with dietary and lifestyle modification on clinical, biochemical, and radiological parameters in obese children with nonalcoholic fatty liver disease/nonalcoholic steatohepatitis: a randomized clinical trial
Rodrigo, T., Dulani, S., Seneviratne, S. N., Silva, A. P. D., Fernando, J. L. T. K., de Silva, H. J., Jayasekera, & Wickramasinghe, P. (2021) · Korean Journal of Pediatrics · doi:10.3345/cep.2021.00787 · Cited by 44
Focus on emerging drugs for the treatment of patients with non-alcoholic fatty liver disease
Federico, A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i45.16841 · Cited by 43
The impact of gut microbiome-targeted therapy on liver enzymes in patients with nonalcoholic fatty liver disease: an umbrella meta-analysis
Amini-Salehi, E., Hassanipour, S., Keivanlou, M.-H., Shahdkar, M., Orang Goorabzarmakhi, M., Vakilpour, A., Joukar, F., Hashemi, M., Sattari, N., Javid, M., et al. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuad086 · Cited by 42
Non-pharmacological management options for MAFLD: a practical guide
Stefano, J. T., Duarte, S. M. B., Altikes, R. G., & de Oliveira, C. P. M. S. (2023) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/20420188231160394 · Cited by 42
The Effect of Oral Consumption of Probiotics in Prevention of Heart Injury in a Rat Myocardial Infarction Model: a Histopathological, Hemodynamic and Biochemical Evaluation
Sadeghzadeh, J., Vakili, A., Sameni, H. R., Shadnoush, M., Bandegi, A., & Khorasani, M. Z. (2017) · Iranian Biomedical Journal · doi:10.18869/acadpub.ibj.21.3.174 · Cited by 42
Beneficial effects of the Mediterranean spices and aromas on non-alcoholic fatty liver disease
Baselga‐Escudero, L., Souza‐Mello, V., Pascual‐Serrano, A., Rachid, T. L., Voci, A., Demori, I., & Grasselli, E. (2017) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2016.11.019 · Cited by 42
Effects of probiotics supplementation on macrophage migration inhibitory factor and clinical laboratory feature of polycystic ovary syndrome
Rashad, N. M., El‐Shal, A. S., Amin, A. I., & Soliman, M. H. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.06.029 · Cited by 42
Probiotics as a Complementary Therapy for Management of Obesity: A Systematic Review
Shirvani-Rad, S., Tabatabaei‐Malazy, O., Mohseni, S., Hasani‐Ranjbar, S., Soroush, A., Tavassol, Z. H., Ejtahed, H., & Larijani, B. A. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/6688450 · Cited by 42
Probiotics
Mizock, B. A. (2015) · Disease-a-Month · doi:10.1016/j.disamonth.2015.03.011 · Cited by 42
Treatment of nonalcoholic fatty liver disease: Where do we stand? an overview
Dajani, A. I., & Abu-Hammour, A. (2016) · Saudi Journal of Gastroenterology · doi:10.4103/1319-3767.178527 · Cited by 41
Lactobacillus casei YRL577 ameliorates markers of non-alcoholic fatty liver and alters expression of genes within the intestinal bile acid pathway
Zhang, Z., Zhou, H., Zhou, X., Sun, J., Liang, X., Lv, Y., Bai, L., Zhang, J., Gong, P., Liu, T., et al. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520003001 · Cited by 41
Effect of Microbiome on Non-Alcoholic Fatty Liver Disease and the Role of Probiotics, Prebiotics, and Biogenics
Nagashimada, M., & Honda, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158008 · Cited by 41
Gut Microbiota in Metabolic-associated Fatty Liver Disease and in Other Chronic Metabolic Diseases
Hernández-Ceballos, W., Córdova‐Gallardo, J., & Méndez‐Sánchez, N. (2021) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2020.00131 · Cited by 40
Non-alcoholic fatty liver disease in obese children and adolescents: a role for nutrition?
Bonsembiante, L., Targher, G., & Maffeis, C. (2021) · European Journal of Clinical Nutrition · doi:10.1038/s41430-021-00928-z · Cited by 40
Gut Microbiota and Liver Interaction through Immune System Cross-Talk: A Comprehensive Review at the Time of the SARS-CoV-2 Pandemic
Scarpellini, E., Fagoonee, S., Rinninella, E., Rasetti, C., Aquila, I., Larussa, T., Ricci, P., Luzza, F., & Abenavoli, L. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9082488 · Cited by 39
Influence of gut bacteria on development and progression of non-alcoholic fatty liver disease
Abdul‐Hai, A. (2015) · World Journal of Hepatology · doi:10.4254/wjh.v7.i12.1679 · Cited by 39
Efficacy of nanocurcumin supplementation on insulin resistance, lipids, inflammatory factors and nesfatin among obese patients with non-alcoholic fatty liver disease (NAFLD): a trial protocol
Jazayeri-Tehrani, S. A., Rezayat, S. M., Mansouri, S., Qorbani, M., Alavian, S. M., Daneshi‐Maskooni, M., & Hosseinzadeh‐Attar, M. J. (2017) · BMJ Open · doi:10.1136/bmjopen-2017-016914 · Cited by 38
Current evidence on the use of probiotics in liver diseases
Chávez-Tapia, N. C., González-Rodríguez, L., Jeong, M., López-Ramírez, Y., Barbero-Becerra, V. J., Juárez-Hernández, E., Romero-Flores, J. L., Arrese, M. A., Méndez‐Sánchez, N., & Uribe, M. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.05.009 · Cited by 38
Effects of gut microbial therapy on lipid profile in individuals with non-alcoholic fatty liver disease: an umbrella meta-analysis study
Naghipour, A., Amini-Salehi, E., Orang Gorabzarmakhi, M., Shahdkar, M., Fouladi, B., Alipourfard, I., & Sanat, Z. M. (2023) · Systematic Reviews · doi:10.1186/s13643-023-02299-x · Cited by 37
Anti-inflammatory effects of probiotics and synbiotics on patients with non-alcoholic fatty liver disease: An umbrella study on meta-analyses
Mahapatro, A., Bawna, F., Kumar, V., Daryagasht, A. A., Gupta, S., Raghuma, N., Moghdam, S. S., Kolla, A., Mahapatra, S. S., Sattari, N., et al. (2023) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2023.07.087 · Cited by 37
RETRACTED ARTICLE: The crucial role of oxidative stress in non-alcoholic fatty liver disease-induced male reproductive toxicity: the ameliorative effects of Iranian indigenous probiotics
Ommati, M. M., Li, H., Jamshidzadeh, A., Khoshghadam, F., Retana‐Márquez, S., Lu, Y., Farshad, O., Ahmadi, M. H. N., Gholami, A., & Heidari, R. (2022) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-021-02177-0 · Cited by 37
Retracted
The effects of a multispecies synbiotic on microbiome-related side effects of long-term proton pump inhibitor use: A pilot study
Horvath, A., Leber, B., Feldbacher, N., Steinwender, M., Komarova, I., Rainer, F., Blesl, A., & Stadlbauer, V. (2020) · Scientific Reports · doi:10.1038/s41598-020-59550-x · Cited by 37
Intestinal Permeability in Non-alcoholic Fatty LIVER Disease: The Gut-liver Axis
Scarpellini, E., Lupo, M., Iegri, C., Gasbarrini, A., Santis, A. D., & Tack, J. F. (2015) · Reviews on Recent Clinical Trials · doi:10.2174/1574887109666141216104334 · Cited by 36
Advances in Gut Microbiome Research, Opening New Strategies to Cope with a Western Lifestyle
Rodríguez-Castaño, G. P., Caro‐Quintero, A., Reyes, A., & Lizcano, F. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2016.00224 · Cited by 36
Combining probiotics and an angiotensin‐II type 1 receptor blocker has beneficial effects on hepatic fibrogenesis in a rat model of non‐alcoholic steatohepatitis
Sawada, Y., Kawaratani, H., Kubo, T., Fujinaga, Y., Furukawa, M., Saikawa, S., Sato, S., Seki, K., Takaya, H., Okura, Y., et al. (2018) · Hepatology Research · doi:10.1111/hepr.13281 · Cited by 35
Is There a Role for Probiotics in Liver Disease?
Lo, R., Austin, A. S., & Freeman, J. G. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/874768 · Cited by 34
Sparstolonin B attenuates early liver inflammation in experimental NASH by modulating TLR4 trafficking in lipid rafts via NADPH oxidase activation
Dattaroy, D., Seth, R. K., Das, S., Alhasson, F. A., Chandrashekaran, V., Michelotti, G. A., Fan, D., Nagarkatti, M., Nagarkatti, P. S., Diehl, A. M., et al. (2015) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00259.2015 · Cited by 34
The role of intestinal microbiota in the pathogenesis of NAFLD: starting points for intervention
Gentilucci, U. V., Gallo, P., & Picardi, A. (2016) · Archives of Medical Science · doi:10.5114/aoms.2016.58831 · Cited by 34
Role of Probiotics in Diabetes: A Review of Their Rationale and Efficacy
Shah, N. J., & Swami, O. C. (2017) · EMJ Diabetes · doi:10.33590/emjdiabet/10310327 · Cited by 34
Modulation of gut microbiota by probiotics to improve the efficacy of immunotherapy in hepatocellular carcinoma
Chen, P., Yang, C., Ren, K., Xu, M., Pan, C., Ye, X., & Li, L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1504948 · Cited by 33
Effects of probiotics on d -galactose-induced oxidative stress in plasma: A meta-analysis of animal models
Zhao, J., Tian, F., Zhao, N., Zhai, Q., Zhang, H., & Chen, W. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.09.055 · Cited by 32
Bifidobacteria and Their Health-Promoting Effects
Hidalgo-Cantabrana, C., Delgado, S., Ruíz, L., Ruas‐Madiedo, P., Sánchez, B., & Margollés, A. (2018) · ASM Press eBooks · doi:10.1128/9781555819705.ch3 · Cited by 32
Global trends and hotspots of treatment for nonalcoholic fatty liver disease: A bibliometric and visualization analysis (2010-2023)
Dai, J.-J., Zhang, Y., & Zhang, Z. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i37.5339 · Cited by 31
The effects of gut microbiome manipulation on glycemic indices in patients with non-alcoholic fatty liver disease: a comprehensive umbrella review
Vakilpour, A., Amini‐Salehi, E., Moghadam, A. S., Keivanlou, M., Letafatkar, N., Habibi, A., Hashemi, M., Eslami, N., Zare, R., Norouzi, N., et al. (2024) · Nutrition and Diabetes · doi:10.1038/s41387-024-00281-7 · Cited by 31
Gut‑liver axis in liver disease: From basic science to clinical treatment (Review)
Wang, J., Wang, X., Zhuo, E., Chen, B., & Chan, S. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13375 · Cited by 33
Effect of Lycium barbarum polysaccharide supplementation in non-alcoholic fatty liver disease patients: study protocol for a randomized controlled trial
Gao, L., Li, Y., Ma, J.-M., Guo, Y.-Q., Li, L., Gao, Q., Fan, Y., Zhang, M., Tao, X., Yu, J., et al. (2021) · Trials · doi:10.1186/s13063-021-05529-6 · Cited by 31
Effects of Synbiotics, Probiotics, and Prebiotics on Liver Enzymes of Patients With Non-alcoholic Fatty Liver Disease: A Systematic Review and Network Meta-Analysis
Kanchanasurakit, S., Kositamongkol, C., Lanoi, K., Nunta, M., Saetuan, T., Chaiyakunapruk, N., Saokaew, S., & Phisalprapa, P. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.880014 · Cited by 31
Metabolic-Associated Fatty Liver Disease and the Gut Microbiota
Barber, T. M., Hanson, P., & Weickert, M. O. (2023) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2023.01.004 · Cited by 31
Gut Microbiota Profiles in Nonalcoholic Fatty Liver Disease and Its Possible Impact on Disease Progression Evaluated with Transient Elastography: Lesson Learnt from 60 Cases
Bastian, W. P., Hasan, I., Lesmana, C. R. A., Rinaldi, I., & Gani, R. A. (2019) · Case Reports in Gastroenterology · doi:10.1159/000498946 · Cited by 31
Unlocking the gut-liver axis: microbial contributions to the pathogenesis of metabolic-associated fatty liver disease
Buchynskyi, M., Kamyshna, I., Halabitska, I., Petakh, P., Kunduzova, O., Oksenych, V., & Kamyshnyi, O. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1577724 · Cited by 30
Combined Amelioration of Ginsenoside (Rg1, Rb1, and Rg3)-enriched Korean Red Ginseng and Probiotic Lactobacillus on Non-alcoholic Fatty Liver Disease
Kim, J., Jeon, J.-Y., Yang, W., Kim, C., & Eom, D. (2019) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201020666190311143554 · Cited by 30
Treatment of Nonalcoholic Steatohepatitis in Adults: Present and Future
Gitto, S., Vitale, G., Villa, E., & Andreoné, P. (2015) · Gastroenterology Research and Practice · doi:10.1155/2015/732870 · Cited by 30
Consenso mexicano sobre probióticos en gastroenterología
Valdovinos, M. A., Montijo, E., y Abreu, A. T. A., Heller, S., Garay, A. G. G., Nogales, D. B., Bielsa-Fernández, M. V., Bojórquez-Ramos, M. D. C., Bosques‐Padilla, F., Burguete-García, A. I., et al. (2017) · Revista de Gastroenterología de México · doi:10.1016/j.rgmx.2016.08.004 · Cited by 31
The Effect of Synbiotic Supplementation on Body Composition and Lipid Profile in Patients with NAFLD: A Randomized, Double Blind, Placebo-Controlled Clinical Trial Study
Asgharian, A., Mohammadi, V., Gholi, Z., Esmaillzade, A., Feizi, A., & Askari, G. (2017) · Iranian Red Crescent Medical Journal · doi:10.5812/ircmj.42902 · Cited by 30
The pharmacological management of NAFLD in children and adolescents
Liyanagedera, S., Williams, R. P., Veraldi, S., Nobili, V., & Mann, J. P. (2017) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2017.1365599 · Cited by 30
Dietary Interventions and Physical Activity as Crucial Factors in the Prevention and Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease
Rajewski, P., Cieściński, J., Rajewski, P., Suwała, S., Rajewska, A., & Potasz, M. (2025) · Biomedicines · doi:10.3390/biomedicines13010217 · Cited by 29
Effect of 8-weeks prebiotics/probiotics supplementation on alcohol metabolism and blood biomarkers of healthy adults: a pilot study
Irwin, C. G., Khalesi, S., Cox, A. J., Grant, G. D., Davey, A. K., Bulmer, A. C., & Desbrow, B. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1437-8 · Cited by 29
Hepatoprotective Effect of Probiotic Lactobacillus rhamnosus GG Through the Modulation of Gut Permeability and Inflammasomes in a Model of Alcoholic Liver Disease in Zebrafish
Bertani, J. P. B., Cruz, C. U., Pasqualotto, A., Longo, L., Ayres, R., Beskow, C. B., Barth, A. L., de Lima-Morales, D., Meurer, F., Guerreiro, G. T. S., et al. (2019) · Journal of the American College of Nutrition · doi:10.1080/07315724.2019.1627955 · Cited by 28
A Specifically Tailored Multistrain Probiotic and Micronutrient Mixture Affects Nonalcoholic Fatty Liver Disease—Related Markers in Patients with Obesity after Mini Gastric Bypass Surgery
Crommen, S., Rheinwalt, K. P., Plamper, A., Simon, M., Rösler, D., Fimmers, R., Egert, S., & Metzner, C. (2021) · Journal of Nutrition · doi:10.1093/jn/nxab392 · Cited by 27
The Role of the Gut Microbiome in Nonalcoholic Fatty Liver Disease
Roychowdhury, S., Selvakumar, P. K. C., & Cresci, G. (2018) · Medical Sciences · doi:10.3390/medsci6020047 · Cited by 26
The Benefit of Probiotics in Pediatric Nonalcoholic Fatty Liver Disease
Gkiourtzis, Ν., Kalopitas, G., Vadarlis, A., Bakaloudi, D. R., Dionysopoulos, G., Karanika, E., Tsekitsidi, E., & Chourdakis, M. (2022) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000003537 · Cited by 24
Microbiota, immunity and the liver
Vaikunthanathan, T., Safinia, N., Lombardi, G., & Lechler, R. I. (2016) · Immunology Letters · doi:10.1016/j.imlet.2016.01.008 · Cited by 24
Gut Microbiota and the Liver
Koch, M. (2016) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000699 · Cited by 23
A review on the effect of gut microbiota on metabolic diseases
Shi, Q., Dai, L., Zhao, Q., & Zhang, X. (2022) · Archives of Microbiology · doi:10.1007/s00203-022-02802-3 · Cited by 23
Choline and Fructooligosaccharide: Non-alcoholic Fatty Liver Disease, Cardiac Fat Deposition, and Oxidative Stress Markers
Haubert, N. J. B. G. B., Marchini, J. S., Cunha, S. F. C., Suen, V. M. M., Padovan, G. J., Jordão, A. A., Alves, C. M. M. M., Marchini, J. F. M., & Vannucchi, H. (2015) · Nutrition and Metabolic Insights · doi:10.4137/nmi.s24385 · Cited by 23
Deciphering the role of gut metabolites in non-alcoholic fatty liver disease
Ralli, T., Saifi, Z., Tyagi, N., Vidyadhari, A., Aeri, V., & Kohli, K. (2022) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2022.2142091 · Cited by 22
The current findings on the gut-liver axis and the molecular basis of NAFLD/NASH associated with gut microbiome dysbiosis
Sharma, S., Tiwari, N., & Tanwar, S. S. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04069-z · Cited by 24
Dose-dependent and strain-dependent anti-obesity effects of Lactobacillus sakei in a diet induced obese murine model
Ji, Y., Chung, Y. M., Park, S., Jeong, D., Kim, B., & Holzapfel, W. H. (2019) · PeerJ · doi:10.7717/peerj.6651 · Cited by 22
Omics for Understanding the Gut‐Liver‐Microbiome Axis and Precision Medicine
Khalsa, J. H., Duffy, L. C., Riscuta, G., Starke-Reed, P. E., & Hubbard, V. S. (2017) · Clinical Pharmacology in Drug Development · doi:10.1002/cpdd.310 · Cited by 22
The Mexican consensus on probiotics in gastroenterology
Valdovinos, M. A., Montijo, E., y Abreu, A. T. A., Heller, S., Garay, A. G. G., Nogales, D. B., Bielsa-Fernández, M. V., Bojórquez-Ramos, M. D. C., Bosques‐Padilla, F., Burguete-García, A. I., et al. (2017) · Revista de Gastroenterología de México (English Edition) · doi:10.1016/j.rgmxen.2017.03.003 · Cited by 22
Nutritional Approach Targeting Gut Microbiota in NAFLD—To Date
Moszak, M., Szulińska, M., Walczak-Galezewska, M. K., & Bogdański, P. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18041616 · Cited by 21
Diabetic Kidney Disease, Cardiovascular Disease and Non-Alcoholic Fatty Liver Disease: A New Triumvirate?
Perdomo, C. M., Garcı́a-Fernández, N., & Escalada, J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10092040 · Cited by 21
Herbal therapy for ameliorating nonalcoholic fatty liver disease via rebuilding the intestinal microecology
Yang, X., Lü, M., You, L., Gen, H., Yuan, L., Tian, T., Li, C., Xu, K., Hou, J., & Lei, M. (2021) · Chinese Medicine · doi:10.1186/s13020-021-00470-x · Cited by 21
Probiotic and Lifestyle Modification in Obese Pediatrics with Non-Alcoholic Fatty Liver Disease
Goyal, P., Thapa, B. R., Sharma, N. R., & Bhatia, A. (2019) · Indian Journal of Community Health · doi:10.47203/ijch.2019.v31i01.009 · Cited by 21
Microbiota, Liver Diseases, and Alcohol
Cassard, A., Gérard, P., & Perlemuter, G. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.bad-0007-2016 · Cited by 21
Efficacy of proprietary Lactobacillus casei for anti-tuberculosis associated gastrointestinal adverse reactions in adult patients: a randomized, open-label, dose–response trial
Lin, S., Zhao, S., Liu, J., Zhang, J., Zhang, C., Hao, H., Sun, Y., Cai, J., Yang, Y., Ma, Y., et al. (2019) · Food & Function · doi:10.1039/c9fo01583c · Cited by 21
Self-citation
Helicobacter pylori and non-alcoholic fatty liver disease
Buzás, G. M. (2020) · Minerva Gastroenterologica e Dietologica · doi:10.23736/s1121-421x.20.02671-9 · Cited by 21
Nonalcoholic fatty liver disease, diet and gut microbiota
Finelli, C., & Tarantino, G. (2014) · Europe PMC (PubMed Central) · doi:10.17877/de290r-15828 · Cited by 20
Retracted
The role of intestinal flora in metabolic dysfunction-associated steatotic liver disease and treatment strategies
Wang, L. J., Sun, J., Chen, S., Sun, Y., Zheng, Y., & Feng, J. C. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2024.1490929 · Cited by 19
Gut microbiota in non-alcoholic fatty liver disease: Pathophysiology, diagnosis, and therapeutics
Pandey, H., Goel, P., Srinivasan, V. M., Tang, D. W. T., Wong, S. H., & Lal, D. (2025) · World Journal of Hepatology · doi:10.4254/wjh.v17.i6.106849 · Cited by 20
Probiotics and obesity associated disease: an extended view beyond traditional strains
Falalyeyeva, T. M., MAMULA, Y., Scarpellini, E., Leshchenko, I. V., HUMENIUK, A., Pankiv, І. V., & Kobyliak, N. M. (2022) · Minerva Gastroenterology · doi:10.23736/s2724-5985.21.02909-0 · Cited by 19

Authors: Ma, Y.-Y.
Venue: World Journal of Gastroenterology
Publisher: Baishideng Publishing Group Inc.
Published: 2013
Volume: 19
Issue: 40
Pages: 6911
ISSN: 1007-9327 (ISSN-L)
DOI: 10.3748/wjg.v19.i40.6911
PMC: PMC3812493
OpenAlex: W2151623669
Cited by: 352
References: 63
Citations by year: 2026: 7 · 2025: 21 · 2024: 23 · 2023: 23 · 2022: 26 · 2021: 39 · 2020: 19 · 2019: 35 · 2018: 24 · 2017: 42 · 2016: 24 · 2015: 42 · 2014: 26 · 2013: 1
FWCI: 3.67
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: World Journal of Gastroenterology (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: probiotics, non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, gut-liver axis, alanine aminotransferase, aspartate aminotransferase, insulin resistance, TNF-α, serum cholesterol, HDL cholesterol, LDL cholesterol, body mass index, glucose, liver enzymes, dyslipidemia, inflammation
MeSH terms: Fatty Liver, Humans, Insulin Resistance, Intestines, Liver, Chi-Square Distribution, Odds Ratio, Treatment Outcome, Probiotics, Lipid Metabolism, Non-alcoholic Fatty Liver Disease

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effects of probiotics on nonalcoholic fatty liver disease: A meta-analysis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks