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Cited by 358

The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.

Treatment of severe acute pancreatitis and its complications

Open access
Zerem, Enver·2014·World Journal of Gastroenterology

Abstract

Severe acute pancreatitis (SAP), which is the most serious type of this disorder, is associated with high morbidity and mortality. SAP runs a biphasic course. During the first 1-2 wk, a pro-inflammatory response results in systemic inflammatory response syndrome (SIRS). If the SIRS is severe, it can lead to early multisystem organ failure (MOF). After the first 1-2 wk, a transition from a pro-inflammatory response to an anti-inflammatory response occurs; during this transition, the patient is at risk for intestinal flora translocation and the development of secondary infection of the necrotic tissue, which can result in sepsis and late MOF. Many recommendations have been made regarding SAP management and its complications. However, despite the reduction in overall mortality in the last decade, SAP is still associated with high mortality. In the majority of cases, sterile necrosis should be managed conservatively, whereas in infected necrotizing pancreatitis, the infected non-vital solid tissue should be removed to control the sepsis. Intervention should be delayed for as long as possible to allow better demarcation and liquefaction of the necrosis. Currently, the step-up approach (delay, drain, and debride) may be considered as the reference standard intervention for this disorder.

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Metadata

Authors
Zerem, E.
Venue
World Journal of Gastroenterology
Published
2014
Volume
20
Issue
38
Pages
13879
ISSN
1007-9327 (ISSN-L)
OpenAlex
W2028556625
Cited by
358
References
72
FWCI
15.23
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Treatment of severe acute pancreatitis and its complications. https://app.cochat.ai/papers/10.3748/wjg.v20.i38.13879
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Zerem, E. (2014). Treatment of severe acute pancreatitis and its complications. World Journal of Gastroenterology. https://doi.org/10.3748/wjg.v20.i38.13879

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.