The DOI matches its Crossref record; 138 of the 138 references it cites were found in a registry or an index.
Gut microbiota and metabolic syndrome
Open accessAbstract
Gut microbiota exerts a significant role in the pathogenesis of the metabolic syndrome, as confirmed by studies conducted both on humans and animal models. Gut microbial composition and functions are strongly influenced by diet. This complex intestinal "superorganism" seems to affect host metabolic balance modulating energy absorption, gut motility, appetite, glucose and lipid metabolism, as well as hepatic fatty storage. An impairment of the fine balance between gut microbes and host's immune system could culminate in the intestinal translocation of bacterial fragments and the development of "metabolic endotoxemia", leading to systemic inflammation and insulin resistance. Diet induced weight-loss and bariatric surgery promote significant changes of gut microbial composition, that seem to affect the success, or the inefficacy, of treatment strategies. Manipulation of gut microbiota through the administration of prebiotics or probiotics could reduce intestinal low grade inflammation and improve gut barrier integrity, thus, ameliorating metabolic balance and promoting weight loss. However, further evidence is needed to better understand their clinical impact and therapeutic use.
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“Although the effects of probiotic and prebiotic supplementation on metabolic health have been examined in previous studies, the results are inconsistent due to the choice of probiotic strain, formulation of the probiotic, outcome of interest, and duration of the intervention [12,13,14].”
From Effects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study (2019) · cites this paper as [12]
In the citing paper
“Alterations in gut microbiota diversity, composition, and function were suggested to play a significant role in the development of MetS [12].”
From Effects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study (2019) · cites this paper as [12]
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Metadata
- Authors
- Festi, D., Schiumerini, R., Eusebi, L. H., Marasco, G., Taddia, M., & Colecchia, A.
- Affiliations
- IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
- ORCID
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2014
- Volume
- 20
- Issue
- 43
- Pages
- 16079
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC4239493
- OpenAlex
- W2754567481
- Cited by
- 534
- References
- 138
- Citations by year
- 2026: 16 · 2025: 43 · 2024: 39 · 2023: 42 · 2022: 74 · 2021: 71 · 2020: 54 · 2019: 46 · 2018: 41 · 2017: 43 · 2016: 37 · 2015: 28
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by-nc)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, metabolic syndrome, diet, energy absorption, intestinal motility, appetite regulation, glucose metabolism, lipid metabolism, bacterial translocation, metabolic endotoxemia, systemic inflammation, insulin resistance, bariatric surgery, weight loss, prebiotics, probiotics, intestinal barrier integrity
- MeSH terms
- Animals, Diet, Energy Metabolism, Humans, Intestinal Mucosa, Intestines, Obesity, Weight Loss, Treatment Outcome, Bacterial Translocation, Probiotics, Metabolic Syndrome, Caloric Restriction, Bariatric Surgery, Host-Pathogen Interactions, Prebiotics, Microbiota
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