The DOI matches its Crossref record; 141 of the 141 references it cites were found in a registry or an index.
Application of metagenomics in the human gut microbiome
Open accessAbstract
There are more than 1000 microbial species living in the complex human intestine. The gut microbial community plays an important role in protecting the host against pathogenic microbes, modulating immunity, regulating metabolic processes, and is even regarded as an endocrine organ. However, traditional culture methods are very limited for identifying microbes. With the application of molecular biologic technology in the field of the intestinal microbiome, especially metagenomic sequencing of the next-generation sequencing technology, progress has been made in the study of the human intestinal microbiome. Metagenomics can be used to study intestinal microbiome diversity and dysbiosis, as well as its relationship to health and disease. Moreover, functional metagenomics can identify novel functional genes, microbial pathways, antibiotic resistance genes, functional dysbiosis of the intestinal microbiome, and determine interactions and co-evolution between microbiota and host, though there are still some limitations. Metatranscriptomics, metaproteomics and metabolomics represent enormous complements to the understanding of the human gut microbiome. This review aims to demonstrate that metagenomics can be a powerful tool in studying the human gut microbiome with encouraging prospects. The limitations of metagenomics to be overcome are also discussed. Metatranscriptomics, metaproteomics and metabolomics in relation to the study of the human gut microbiome are also briefly discussed.
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Citations
Cites
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Cited by
The Human Intestinal Microbiome in Health and Disease
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BackgroundMetaWRAP—a flexible pipeline for genome-resolved metagenomic data analysis
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Metadata
- Authors
- Wang, W.-L., Xu, S.-Y., Ren, Z.-G., Tao, L., Jiang, J.-W., & Zheng, S.-S.
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2015
- Volume
- 21
- Issue
- 3
- Pages
- 803
- ISSN
- 1007-9327 (ISSN-L)
- OpenAlex
- W1577826155
- Cited by
- 397
- References
- 141
- FWCI
- 11.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
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