Cited by 804Gut microbiota and healthParkinson's Disease Mechanisms and TreatmentsGastrointestinal motility and disorders

Microbiota-Brain-Gut Axis and Neurodegenerative Diseases

Quigley, Eamonn M. M.·2017·Current Neurology and Neuroscience Reports

Abstract

Purpose of review The purposes of this review were as follows: first, to provide an overview of the gut microbiota and its interactions with the gut and the central nervous system (the microbiota-gut-brain axis) in health, second, to review the relevance of this axis to the pathogenesis of neurodegenerative diseases, such as Parkinson's disease, and, finally, to assess the potential for microbiota-targeted therapies.Recent findings Work on animal models has established the microbiota-gut-brain axis as a real phenomenon; to date, the evidence for its operation in man has been limited and has been confronted by considerable logistical challenges. Animal and translational models have incriminated a disturbed gut microbiota in a number of CNS disorders, including Parkinson's disease; data from human studies is scanty. While a theoretical basis can be developed for the use of microbiota-directed therapies in neurodegenerative disorders, support is yet to come from high-quality clinical trials. In theory, a role for the microbiota-gut-brain axis is highly plausible; clinical confirmation is awaited.

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Crossref · 10.1007/s11910-017-0802-6

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Authors
Quigley, E. M. M.
Affiliations
Houston Methodist (US)
Corresponding author
Quigley, Eamonn M. M.
Venue
Current Neurology and Neuroscience Reports
Published
2017-10-17
Volume
17
Issue
12
Pages
94-94
ISSN
  • 1528-4042 (ISSN-L)
  • 1534-6293
OpenAlex
W2766853085
Cited by
804
References
218
Citations by year
2026: 46 · 2025: 86 · 2024: 111 · 2023: 150 · 2022: 126 · 2021: 130 · 2020: 80 · 2019: 46 · 2018: 29
FWCI
4.18
Type
journal article
Language
en
Open access
closed
Locations
  • Current Neurology and Neuroscience Reports (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
microbiota-gut-brain axis, gut microbiota, neurodegenerative diseases, Parkinson's disease, microbiota-targeted therapy, central nervous system disorders, animal models of neurodegeneration, translational model
MeSH terms
Gastrointestinal Microbiome, Animals, Brain, Humans, Neurodegenerative Diseases, Molecular Targeted Therapy

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