Characterization of smooth muscle, enteric nerve, interstitial cells of Cajal, and fibroblast-like cells in the gastric musculature of patients with diabetes mellitus
Open accessAbstract
AIM: To investigate histologic abnormalities in the gastric smooth muscle of patients with diabetes mellitus (DM). METHODS: Full-thickness gastric specimens were obtained from patients undergoing surgery for gastric cancer. H&E stain and Masson's Trichrome stain were performed to assess the degree of fibrosis. Immunohistochemical staining using various antibodies was also performed [antibodies against protein gene product 9.5 (PGP9.5), neuronal nitric oxide synthase (nNOS), vasoactive intestinal peptide (VIP), neurokinin-1 (NK1) receptor, c-Kit, and platelet-derived growth factor receptor-alpha, (PDGFRα)]. Immunofluorescent staining and evaluation with confocal microscopy were also conducted. RESULTS: < 0.05). There were no statistically significant differences in PGP9.5, nNOS, VIP, and neurokinin 1 expression. On immunofluorescent staining, cellularity of interstitial cells of Cajal (ICC) was observed to decrease with increasing duration of DM. CONCLUSION: Our study suggests that increased intercellular fibrosis, loss of ICC, and loss of fibroblast-like cells are found in the smooth muscle of DM patients. These abnormalities may contribute to changes in gastric motor activity in patients with DM.
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Advanced diabetic gastroparesis can be associated with smooth-muscle degeneration, fibrosis, collagen deposition, and ultrastructural abnormalities such as thickened basal lamina, changes that likely contribute to a hypocontractile phenotype and delayed gastric emptying.
“Moreover, advanced diabetic gastroparesis can be associated with smooth-muscle degeneration, fibrosis, collagen deposition, and ultrastructural abnormalities such as thickened basal lamina, changes that likely contribute to a hypocontractile phenotype and delayed gastric emptying [23, 42–45].”
From Diabetic gastroparesis: pathophysiology and impact on insulin timing choices (2026) · cites this paper as [44]
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- Authors
- Park, K. S., Cho, K. B., Hwang, I. S., Park, J. H., Jang, B. I., Kim, K. O., Jeon, S. W., Kim, E. S., Park, C. S., & Kwon, J. G.
- Affiliations
- Kyungpook National University (KR)
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2016
- Volume
- 22
- Issue
- 46
- Pages
- 10131
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC5155172
- OpenAlex
- W2563810215
- Cited by
- 38
- References
- 44
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 2 · 2013: 1
- FWCI
- 2.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- KUMeL Repository (Keimyung University) (submittedVersion, cc-by-nc-nd)
- Funders
- National Research Foundation (2014R1A5A2010008)
- Keimyung University
- National Research Foundation of Korea (2014R1A5A2010008, No. 2014R1A5A2010008)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal Tumor Research and Treatment
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Keywords
- diabetes mellitus, gastric smooth muscle, interstitial cells of Cajal, fibroblast-like cells, gastric fibrosis, enteric nervous system, gastric motility, CD117, PDGFRA, neuronal nitric oxide synthase, vasoactive intestinal peptide, neurokinin-1 receptor, PGP 9.5, diabetes duration
- MeSH terms
- Telocytes, Aged, Diabetes Mellitus, Female, Fluorescent Antibody Technique, Gastric Mucosa, Humans, Immunohistochemistry, Male, Middle Aged, Muscle, Smooth, Stomach, Time Factors, Vasoactive Intestinal Peptide, Case-Control Studies, Enteric Nervous System, Receptors, Neurokinin-1, Microscopy, Confocal, Proto-Oncogene Proteins c-kit, Receptor, Platelet-Derived Growth Factor alpha, Ubiquitin Thiolesterase, Nitric Oxide Synthase Type I
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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