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Cited by 178Inflammatory Bowel DiseaseOcular Diseases and Behçet’s SyndromeMicroscopic Colitis

An analysis of 10218 ulcerative colitis cases in China

Open access
Jiang, Xue-Liang·2002·World Journal of Gastroenterology
DOI 10.3748/wjg.v8.i1.158PMC PMC4656610
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Abstract

AIM: To analyze the characteristics of ulcerative colitis(UC) in China. METHODS: From 1981 to 2000, a total of 10218 patients of UC reported in Chinese medical literature and including our cases diagnosed were analyzed according to the diagnostic criteria of Lennard-Jones. RESULTS: The number of cases increased by 3.08 times over the past 10 years (2506 patients were diagnosed from 1981 to 1990 while 7512 patients were diagnosed from 1991 to 2000). Lesion range were described in 7966 patients, 5592 (70.20%) were proctosigmoiditis or proctitis, 1792(22.50%) left-sided colitis, 582(7.30%) pancolitis. Among the 8122 patients, 2826 (34.8%) had first episode, 4272 (52.6%) had chronic relapse, 869 (10.7%) were of chronic persist type, 154 (1.9%) were of acute fulminant type. The course of the illness were described in 5867 patients, 4427(75.5%) were less than 5 years, 910 (15.5%) between 5 and 10 years,530 (9.1%) more than 10 years. Six hundred and sixteen patients 618 patients(6.1%) had extraintestinal manifestations. The mean age at the diagnosis was 40.7 years( range 6-80 years, and the peak ages 30-49 years). The male to female ratio was 1.09. Among 270 patients diagnosed in our hospital,36 had histories of smoking, there was no negative association between the severity of UC and smoking(P>0.05), 21 smokers were followed up for one year, 15 of them had given up smoking when the disease were diagnosed, and one year later, 7 patients relapsed, another 6 patients continued smoking, and one year later,2 patients relapsed. Among 270 UC patients diagnosed in our hospital, 4 patients(1.48%) from 2 families had familial history of UC. Treatment was mentioned in 6859 patients, only 5-ASA and/or corticosteroid only in 1276 patients(18.6%), only Chinese herbs in 1377 patients(20.1%), combined Chinese and western medicine in 4056 patients(59.1%), surgery was performed in 87 patients(1.3%),other treatments in 63 patients(0.9%). CONCLUSIONS: In China, number of UC patients increased significantly in the past 10 years. Lesions are commonly located to left side colon. The course is short with rare extraintestinal manifestations. The age of onset is relatively high. Males and females are nearly equally affected. No negative relation was found between smoking and severity of the disease. Familial relatives are rarely involved Traditional Chinese medicine(TCM) is widely used in the treatment of UC.

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Authors
Jiang, X.-L.
Affiliations
General Hospital of Jinan Military Command (CN)
Corresponding author
Jiang, Xue-Liang
ORCID
Jiang, Xue-Liang
Venue
World Journal of Gastroenterology
Publisher
Baishideng Publishing Group Inc.
Published
2002
Volume
8
Issue
1
Pages
158
ISSN
1007-9327 (ISSN-L)
DOI
10.3748/wjg.v8.i1.158
PMC
PMC4656610
OpenAlex
W1236393439
Cited by
177
References
34
Citations by year
2026: 1 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 9 · 2021: 2 · 2020: 4 · 2019: 11 · 2018: 9 · 2017: 13 · 2016: 12 · 2015: 10 · 2014: 5 · 2013: 15 · 2012: 5
FWCI
0.74
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • World Journal of Gastroenterology (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
  • Health Sciences › Medicine › Epidemiology › Microscopic Colitis
Keywords
ulcerative colitis, clinical course, proctosigmoiditis, pancolitis, extraintestinal manifestations, smoking, relapse, family history, treatment outcomes, China, disease severity, age and sex distribution, relapse prevention, smoking cessation
MeSH terms
China, Colitis, Ulcerative, Drugs, Chinese Herbal, Humans

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