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Cited by 28Mollusks and Parasites StudiesWound Healing and TreatmentsPhytochemistry and biological activity of medicinal plants

Chemical composition, mineral profile, anti-bacterial, and wound healing properties of snail slime of Helix aspersa Müller

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Aouji, Marouane, Rkhaila, Amine, Bouhaddioui, Bouchra, Zirari, Malak, Harifi, Hala, Taboz, Youness, Lrhorfi, Lalla Aicha, Bengueddour, Rachid·2023·BioMedicine
DOI 10.37796/2211-8039.1424PMC PMC10962538
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Abstract

Mucus is a substance made by snails that serves a variety of purposes and is increasingly employed in the medical and cosmetic industries. It includes bioactive compounds with a range of biological characteristics that could be useful in the treatment of particular issues. This study assessed the wound-healing efficiency, antibacterial activity, chemical and mineral composition of Helix aspersa Müller slime. Inductively Coupled Argon Plasma Atomic Emission Spectrometry (ICP-OES) was used for mineral analysis, while Gas chromatography coupled to mass spectrometry (GC-MS) analysis was used for chemical characterization. The findings showed that the H. aspersa Müller slime had inhibitory activity on the test samples. Additionally, it revealed significant healing activity. These findings point to the chemical composition and various biological activities of the H. aspersa Müller slime, which may be related to the animal’s particular functions and be useful for medical applications. Our findings suggest that the H. aspersa Müller slime has biological effects related to antimicrobial activities and wound healing, and they pave the way for a more thorough investigation of its potential therapeutic effects.

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  • A significant improvement was reported in rate and percentage of model wound closure in experimental groups of laboratory animals (mice and rats) vs control with topical application of filtered C. aspersum snail mucus, while wound-healing markers also improved (VEGF, alfa-sma).

    “A significant improvement was reported in the rate and percentage of model wound closure in experimental groups of the laboratory animals (mice and rats) vs. control with the topical application of filtered C. aspersum snail mucus, while wound-healing markers also improved (VEGF, alfa-sma (a marker of cell differentiation)) [21,76].”

    From Chemical Variability and Biological Potential of Cornu aspersum Mucus as a Source for the Development of New Cosmetic and Pharmaceutical Products (2025) · cites this paper as [21]

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  • Studies concerning angiogenesis indicate that snail mucus has different mechanisms of impact on the wound-healing process.

    “In addition, the studies concerning angiogenesis [21,70,74,75,76] indicate that snail mucus has different mechanisms of impact on the wound-healing process.”

    From Chemical Variability and Biological Potential of Cornu aspersum Mucus as a Source for the Development of New Cosmetic and Pharmaceutical Products (2025) · cites this paper as [21]

    Section 3.4 (page unavailable) reports greater wound contraction with H. aspersa Müller slime, and the Introduction describes bioactive compounds and antibacterial activity. The paper does not report angiogenesis findings or establish different mechanisms by which the slime affects wound healing; those parts of the claim are unsupported. (LLM, conf=0.84)

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Cited by

Sorted by citations

Authors
Aouji, M., Rkhaila, A., Bouhaddioui, B., Zirari, M., Harifi, H., Taboz, Y., Lrhorfi, L. A., & Bengueddour, R.
Affiliations
Université Ibn-Tofail (MA)
Corresponding author
Aouji, Marouane
ORCID
Venue
BioMedicine
Publisher
China Medical University
Published
2023-11-27
Volume
13
Issue
4
Pages
10-19
ISSN
  • 2211-8020 (ISSN-L)
  • 2211-8039
DOI
10.37796/2211-8039.1424
PMC
PMC10962538
OpenAlex
W4389074468
Cited by
28
References
0
Citations by year
2026: 9 · 2025: 11 · 2024: 8
FWCI
5.09
Type
journal article
Language
en
Open access
Licence
Locations
  • Biomedicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Insect Science › Mollusks and Parasites Studies
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and biological activity of medicinal plants
Keywords
Helix aspersa, snail slime, mucus, chemical composition, mineral composition, antibacterial activity, wound healing, bioactive compounds

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