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Cited by 81Mollusks and Parasites StudiesHelicobacter pylori-related gastroenterology studiesInflammatory mediators and NSAID effects

Protective effect of snail secretion filtrate against ethanol-induced gastric ulcer in mice

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Gugliandolo, Enrico, Cordaro, Marika, Fusco, Roberta, Peritore, Alessio Filippo, Siracusa, Rosalba, Genovese, Tiziana, D’Amico, Ramona, Impellizzeri, Daniela +3 more·2021·Scientific Reports
DOI 10.1038/s41598-021-83170-8PMC PMC7878904
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Abstract

Gastric ulcer or peptic ulcer is a common disease worldwide. Basically, it develops when there is an imbalance between the protective and aggressive factors, especially at the luminal surface of epithelial cells. Thus, there is a constant interest in research new drugs for treatment of gastric ulcer. The snail secretion is a dense mucous, that covers the external surface of the snails, with important functions for the survival of snails. The biological proprieties of snail Helix Aspersa Muller mucus it has been known for centuries to treat human disorders in particular for skin disease. Recently the use of snail mucus has seen a worldwide increase, as a component in cosmetic product and it has been used in particular for the management of wound and skin disorders. In this study we use a murine model of ethanol intragastric administration which has been widely used to test the drugs efficacies and to explore the underlying mechanism for gastric ulcer development. The intragastric ethanol administration causes several mucosal damages and an induction of a severe inflammatory response. Our results show a significant protective effect of snail secretion filtrate in reducing macroscopic and histological lesions, as well the protective effect on mucus content, oxidative stress and inflammatory response. In conclusion this study demonstrate the protective effect of intragastrical snail secretion filtrate, in a model of ethanol-induced gastric ulcer in mice, suggesting its possible useful use in the treatment or prevention of gastric ulcer.

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Cited by

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Authors
Gugliandolo, E., Cordaro, M., Fusco, R., Peritore, A. F., Siracusa, R., Genovese, T., D’Amico, R., Impellizzeri, D., Di Paola, R., Cuzzocrea, S., & Crupi, R.
Affiliations
University of Messina (IT)
Corresponding author
Cuzzocrea, Salvatore
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2021-02-11
Volume
11
Issue
1
Pages
3638-3638
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-021-83170-8
PMC
PMC7878904
OpenAlex
W3129186289
Cited by
81
References
1
Citations by year
2026: 11 · 2025: 19 · 2024: 16 · 2023: 18 · 2022: 12 · 2021: 5
FWCI
8.54
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Insect Science › Mollusks and Parasites Studies
  • Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
  • Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
Keywords
Helix aspersa, gastric ulcer, ethanol-induced gastric injury, gastroprotection, oxidative stress, inflammation, gastric mucus, peptic ulcer, mucosal injury
MeSH terms
Ethanol, Animals, Collagen, Gastric Mucosa, Glycoproteins, Inflammation, Mucus, Snails, Stomach Ulcer, Tumor Necrosis Factor-alpha, Dinoprostone, Interleukin-6, Oxidative Stress, Protective Agents, Mice, Interleukin-1beta

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