The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
The Tail Suspension Test
Open accessAbstract
The tail-suspension test is a mouse behavioral test useful in the screening of potential antidepressant drugs, and assessing of other manipulations that are expected to affect depression related behaviors. Mice are suspended by their tails with tape, in such a position that it cannot escape or hold on to nearby surfaces. During this test, typically six minutes in duration, the resulting escape oriented behaviors are quantified. The tail-suspension test is a valuable tool in drug discovery for high-throughput screening of prospective antidepressant compounds. Here, we describe the details required for implementation of this test with additional emphasis on potential problems that may occur and how to avoid them. We also offer a solution to the tail climbing behavior, a common problem that renders this test useless in some mouse strains, such as the widely used C57BL/6. Specifically, we prevent tail climbing behaviors by passing mouse tails through a small plastic cylinder prior to suspension. Finally, we detail how to manually score the behaviors that are manifested in this test.
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Cites
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Can, A., Dao, D. T., Arad, M., Terrillion, C. E., Piantadosi, S. C., & Gould, T. D. (2011) · Journal of Visualized Experiments · doi:10.3791/3638 · Cited by 521
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FGF21 Regulates Sweet and Alcohol Preference
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Browne, C. A., & Lucki, I. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00161 · Cited by 285
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Metadata
- Authors
- Can, A., Dao, D. T., Terrillion, C. E., Piantadosi, S. C., Bhat, S., & Gould, T. D.
- Venue
- Journal of Visualized Experiments
- Publisher
- MyJove Corporation
- Published
- 2011-12-13
- Issue
- 58
- Pages
- e3769-e3769
- ISSN
- 1940-087X (ISSN-L)
- DOI
- 10.3791/3769
- OpenAlex
- W2024861481
- Cited by
- 526
- References
- 28
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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