Myelin Oligodendrocyte Glycoprotein (MOG35-55) Induced Experimental Autoimmune Encephalomyelitis (EAE) in C57BL/6 Mice
Open accessAbstract
Multiple sclerosis is a chronic neuroinflammatory demyelinating disorder of the central nervous system with a strong neurodegenerative component. While the exact etiology of the disease is yet unclear, autoreactive T lymphocytes are thought to play a central role in its pathophysiology. MS therapy is only partially effective so far and research efforts continue to expand our knowledge on the pathophysiology of the disease and to develop novel treatment strategies. Experimental autoimmune encephalomyelitis (EAE) is the most common animal model for MS sharing many clinical and pathophysiological features. There is a broad diversity of EAE models which reflect different clinical, immunological and histological aspects of human MS. Actively-induced EAE in mice is the easiest inducible model with robust and replicable results. It is especially suited for investigating the effects of drugs or of particular genes by using transgenic mice challenged by autoimmune neuroinflammation. Therefore, mice are immunized with CNS homogenates or peptides of myelin proteins. Due to the low immunogenic potential of these peptides, strong adjuvants are used. EAE susceptibility and phenotype depends on the chosen antigen and rodent strain. C57BL/6 mice are the commonly used strain for transgenic mouse construction and respond among others to myelin oligodendrocyte glycoprotein (MOG). The immunogenic epitope MOG35-55 is suspended in complete Freund's adjuvant (CFA) prior to immunization and pertussis toxin is applied on the day of immunization and two days later. Mice develop a "classic" self-limited monophasic EAE with ascending flaccid paralysis within 9-14 days after immunization. Mice are evaluated daily using a clinical scoring system for 25-50 days. Special considerations for care taking of animals with EAE as well as potential applications and limitations of this model are discussed.
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The experimental autoimmune encephalomyelitis (EAE) model has been developed in various species but is mainly used in mice, which is likely due to the plethora of well-studied, highly characterized wild-type strains together with the many established transgenic and knock-out substrains.
“The EAE model has been developed in various species but is mainly used in mice, which is likely due to the plethora of well-studied, highly characterized wild-type strains together with the many established transgenic and knock-out substrains [81].”
From Insights and challenges on animal models for progressive multiple sclerosis (2026) · cites this paper as [81]
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- Authors
- Bittner, S., Afzali, A. M., Wiendl, H., & Meuth, S. G.
- Affiliations
- University of Münster (DE)
- Venue
- Journal of Visualized Experiments
- Publisher
- MyJove Corporation
- Published
- 2014-04-15
- Issue
- 86
- ISSN
- 1940-087X (ISSN-L)
- PMC
- PMC4172026
- OpenAlex
- W2158157016
- Cited by
- 171
- References
- 12
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 14 · 2023: 19 · 2022: 20 · 2021: 20 · 2020: 17 · 2019: 25 · 2018: 15 · 2017: 13 · 2016: 7 · 2015: 3
- FWCI
- 5.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-nd
- Locations
- Journal of Visualized Experiments (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- experimental autoimmune encephalomyelitis, myelin oligodendrocyte glycoprotein, MOG35-55, multiple sclerosis, C57BL/6 mice, active immunization, complete Freund's adjuvant, pertussis toxin, autoreactive T cells, neuroinflammation, demyelination, clinical scoring, animal care
- MeSH terms
- Animals, Encephalomyelitis, Autoimmune, Experimental, Female, Mice, Inbred C57BL, Peptide Fragments, Mice, Myelin-Oligodendrocyte Glycoprotein
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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