Antiobesity Pharmacotherapy for Patients with Type 2 Diabetes: Focus on Long-Term Management
Open accessAbstract
Type 2 diabetes and obesity have a complex relationship; obesity is linked to insulin resistance, the precursor to type 2 diabetes. The management of obesity is an important method to delay onset of diabetes and improve the glycemic durability of antidiabetic agents. However, insulin and some of the oral hypoglycemic agents used to treat diabetes cause significant weight gain, and it is difficult for patients with diabetes to reduce and maintain their weight by life-style changes alone. Thus, antiobesity medications or bariatric surgery may be a necessary adjunct for certain obese patients with diabetes. In 2012, the U.S. Food and Drug Administration (FDA) approved lorcaserin and phentermine/topiramate extended-release for the management of chronic weight, and approval for naltrexone/bupropion sustained-release as an adjunct to exercise and reduced caloric intake followed in 2014. Liraglutide is pending FDA approval for antiobesity drug. Here we review the efficacy of approved and new promising drugs for the management of obesity.
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In COR-DM, no difference was observed between naltrexone/bupropion and placebo in the incidence of depression, suicidal ideation, or hypoglycemia.
“However, no difference was observed between both the groups in the incidence of depression, suicidal ideation, or hypoglycemia,”
From Long-Term Efficacy and Safety of Anti-Obesity Treatment: Where Do We Stand? (2021) · cites this paper as [46]
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- Authors
- Jeon, W. S., & Park, C.-Y.
- Affiliations
- Kangbuk Samsung Hospital (KR)
- Corresponding author
- Park, Cheol-Young
- ORCID
- Park, Cheol-Young
- Venue
- Endocrinology and Metabolism
- Publisher
- Korean Endocrine Society
- Published
- 2014
- Volume
- 29
- Issue
- 4
- Pages
- 410
- ISSN
- 2093-596X (ISSN-L)
- 2093-5978
- PMC
- PMC4285049
- OpenAlex
- W2140928188
- Cited by
- 18
- References
- 40
- Citations by year
- 2025: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 4
- FWCI
- 0.30
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Endocrinology and Metabolism (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Keywords
- type 2 diabetes, obesity, insulin resistance, lorcaserin, liraglutide, bariatric surgery, long-term weight management, glycemic control
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