Weight Loss, Weight Maintenance, and Improved Cardiovascular Risk Factors after 2 Years Treatment with Orlistat for Obesity
Open accessAbstract
Objective: To determine the effect of orlistat, a new lipase inhibitor, on long‐term weight loss, to determine the extent to which orlistat treatment minimizes weight regain in a second year of treatment, and to assess the effects of orlistat on obesity‐related risk factors. Research Methods and Procedures: This was a 2‐year, multicenter, randomized, double‐blind, placebo‐controlled study. Obese patients (body mass index 28 to 43 kg/m 2) were randomized to placebo or orlistat (60 or 120 mg) three times a day, combined with a hypocaloric diet during the first year and a weight maintenance diet in the second year of treatment to prevent weight regain. Changes in body weight, lipid profile, glycemic control, blood pressure, quality of life, safety, and tolerability were measured. Results: Orlistat‐treated patients lost significantly more weight (p < 0.001) than placebo‐treated patients after Year 1 (6.6%, 8.6%, and 9.7% for the placebo, and orlistat 60 mg and 120 mg groups, respectively). During the second year, orlistat therapy produced less weight regain than placebo (p = 0.005 for orlistat 60 mg; p < 0.001 for orlistat 120 mg). Several obesity‐related risk factors improved significantly more with orlistat treatment than with placebo. Orlistat was generally well tolerated and only 6% of orlistat‐treated patients withdrew because of adverse events. Orlistat leads to predictable gastrointestinal effects related to its mode of action, which were generally mild, transient, and self‐limiting and usually occurred early during treatment. Discussion: Orlistat administered for 2 years promotes weight loss and minimizes weight regain. Additionally, orlistat therapy improves lipid profile, blood pressure, and quality of life.
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After 2 years of orlistat treatment, SBP was significantly reduced only with the higher dose.
“After 2 years of treatment, SBP was significantly reduced only with the higher dose.192”
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- Authors
- Rössner, S., Sjöström, L., Noack, R., Meinders, A. E., Noseda, G., & Study, O. B. O. T. E. O. O.
- Affiliations
- Sahlgrenska University Hospital (SE)
- Leiden University Medical Center (NL)
- Ospedale Regionale di Mendrisio (CH)
- Corresponding author
- Rössner, Stephan
- Venue
- Obesity Research
- Publisher
- Wiley
- Published
- 2000-01
- Volume
- 8
- Issue
- 1
- Pages
- 49-61
- ISSN
- 1071-7323 (ISSN-L)
- 1550-8528
- OpenAlex
- W1980641839
- Cited by
- 476
- References
- 30
- Citations by year
- 2026: 3 · 2025: 15 · 2024: 14 · 2023: 11 · 2022: 10 · 2021: 12 · 2020: 8 · 2019: 13 · 2018: 9 · 2017: 14 · 2016: 10 · 2015: 8 · 2014: 19 · 2013: 13 · 2012: 16
- FWCI
- 19.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- F. Hoffmann-La Roche
- Topics
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- orlistat, lipase inhibitors, obesity, weight loss, weight regain, weight maintenance, cardiovascular risk factors, lipid profile, blood pressure, glycemic control, hypocaloric diet, gastrointestinal adverse effects, quality of life, long-term treatment
- MeSH terms
- Orlistat, Adult, Cardiovascular System, Diet, Reducing, Double-Blind Method, Female, Humans, Lactones, Male, Middle Aged, Placebos, Risk Factors, Weight Loss, Treatment Outcome, Anti-Obesity Agents
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