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Cited by 61Antifungal resistance and susceptibilityYeasts and Rust Fungi StudiesFungal Infections and Studies

Epidemiology of Candida blood stream infections: experience of a tertiary care centre in North India

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Chander, Jagdish, Singla, Nidhi, Sidhu, Shailpreet Kaur, Gombar, Satinder·2013·The Journal of Infection in Developing Countries
DOI 10.3855/jidc.2623
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Abstract

INTRODUCTION: Bloodstream infections due to Candida species are becoming a major cause of morbidity and mortality in hospitalized patients. The spectrum of candidemia has changed with the emergence of non-albicans Candida species, especially among critically ill patients. METHODOLOGY: In a retrospective study (July 2009 to December 2009) on candidemia, various Candida species isolated from blood cultures were characterized and studied along with the determination of their antifungal susceptibility to amphotericin B, itraconazole, and fluconazole by Etest. Probable risk factors for patients in the intensive care unit (ICU) presenting with candidemia were also analyzed. RESULTS: During the study period, a total of 4651 samples were received, out of which 468 samples (10.06%) were positive for growth of organisms: 441 (94.20%) aerobic bacterial pathogens and 27 (5.79%) Candida species. The most common Candida spp. isolate was C. tropicalis (40.8%) followed by C. albicans (29.6%), C. glabrata (18.5%) and others (11.1%). Out of the 27 Candida strains, 24 (88.9%) were isolated from patients treated in the ICU. Among these, association of previous use of broad-spectrum antibiotics in 22 patients (91.6%) and central line catheter insertion in 20 patients (83.3%) were found to be statistically significant as compared to non-candidemia patients (p <0.05). Antifungal susceptibility testing of the isolates revealed a lower level of drug resistance to amphotericin B (18.5% of the isolates) versus 77.8% resistance to fluconazole. CONCLUSION: Rapid changes in the rate of infection, potential risk factors, and emergence of non-albicans Candida demand continued surveillance of this serious bloodstream fungal infection.

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  1. Eickhoff TC (1992) Antibiotics and nosocomial infections. In: Bennet JV, Branchman PS, editors. Hospital Infections, 3 rd edition. Boston: Little, Brown and Company 245-264.

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Authors
Chander, J., Singla, N., Sidhu, S. K., & Gombar, S.
Affiliations
Government Medical College and Hospital (IN)
ORCID
Venue
The Journal of Infection in Developing Countries
Publisher
Journal of Infection in Developing Countries
Published
2013-09-16
Volume
7
Issue
09
Pages
670-675
ISSN
1972-2680 (ISSN-L)
DOI
10.3855/jidc.2623
OpenAlex
W2158275536
Cited by
61
References
22
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 7 · 2018: 4 · 2017: 8 · 2016: 3 · 2015: 8 · 2014: 6
FWCI
4.12
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • The Journal of Infection in Developing Countries (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords
candidemia, Candida species, fungemia, non-albicans Candida, Candida tropicalis, Candida albicans, Candida glabrata, antifungal susceptibility, fluconazole resistance, amphotericin B resistance, intensive care unit, risk factors, broad-spectrum antibiotic use, central venous catheters, critically ill patients
MeSH terms
Aged, Aged, 80 and over, Amphotericin B, Antifungal Agents, Candida, Humans, India, Microbial Sensitivity Tests, Middle Aged, Retrospective Studies, Risk Factors, Fluconazole, Prevalence, Itraconazole, Drug Resistance, Fungal, Candidemia, Tertiary Care Centers

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