Amelioration of Asthmatic Inflammation by an Aqueous Extract of Spinacia oleracea Linn
Open accessAbstract
Inflammation of the respiratory tract is a crucial process in immune diseases, including asthma, and atopic rhinitis. To establish whether an aqueous extract of Spinacia oleracea Linn (SoL) has a beneficial influence in terms of anti-asthmatic activity, we examined its effects on an ovalbumin-induced asthmatic model. Mice sensitized to ovalbumin were orally administered the SoL extract, and their lungs examined by hematoxylin and eosin staining to determine IL-4/13 cytokine expression. The SoL extract exerted strong anti-asthmatic effects by inducing a decrease in the CD4+ cell number, IL-4/13, and other molecular markers in the lung. Our results collectively indicate that the aqueous SoL extract ameliorates asthmatic symptoms effectively in a mouse ovalbumin-challenge model.
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Spinach is associated with numerous health advantages, such as antioxidant characteristics, lipid-lowering effects, appetite regulation, tissue regeneration, and protection against oxidative stress-induced damage.
“These results show that spinach is associated with numerous health advantages, such as antioxidant characteristics, lipid-lowering effects, appetite regulation, tissue regeneration, and protection against oxidative stress-induced damage [156,162,164,165,166,167,168,169,170].”
From Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition (2024) · cites this paper as [168]
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- Authors
- Lee
- Affiliations
- Kyungpook National University (KR)
- Corresponding author
- Lee
- Venue
- International Journal of Molecular Medicine
- Publisher
- Spandidos Publications
- Published
- 2010-01-22
- Volume
- 25
- Issue
- 3
- Pages
- 409-14
- ISSN
- 1107-3756 (ISSN-L)
- 1791-244X
- OpenAlex
- W2145596368
- Cited by
- 18
- References
- 18
- Citations by year
- 2024: 2 · 2022: 1 · 2021: 2 · 2019: 2 · 2016: 2 · 2015: 1 · 2013: 1 · 2012: 3
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Keywords
- spinach, asthma, antiasthmatic activity, ovalbumin-induced asthma, airway inflammation, CD4+ T cells, atopic rhinitis, herbal medicine
- MeSH terms
- Administration, Oral, Animals, Asthma, Cell Line, Immunoglobulin E, Inflammation, Lung, Male, Ovalbumin, Plant Extracts, Interleukin-4, Spinacia oleracea, Interleukin-13, Anti-Asthmatic Agents, Mice
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