The DOI matches its Crossref record; 163 of the 163 references it cites were found in a registry or an index.
The Akt pathway in oncology therapy and beyond (Review)
Open accessAbstract
Protein kinase B (Akt), similar to many other protein kinases, is at the crossroads of cell death and survival, playing a pivotal role in multiple interconnected cell signaling mechanisms implicated in cell metabolism, growth and division, apoptosis suppression and angiogenesis. Akt protein kinase displays important metabolic effects, among which are glucose uptake in muscle and fat cells or the suppression of neuronal cell death. Disruptions in the Akt‑regulated pathways are associated with cancer, diabetes, cardiovascular and neurological diseases. The regulation of the Akt signaling pathway renders Akt a valuable therapeutic target. The discovery process of Akt inhibitors using various strategies has led to the identification of inhibitors with great selectivity, low side‑effects and toxicity. The usefulness of Akt emerges beyond cancer therapy and extends to other major diseases, such as diabetes, heart diseases, or neurodegeneration. This review presents key features of Akt structure and functions, and presents the progress of Akt inhibitors in regards to drug development, and their preclinical and clinical activity in regards to therapeutic efficacy and safety for patients.
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Cites
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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
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“A low PTEN expression is a good predictor of poor responses to human epidermal growth factor receptor (HER2) antagonist therapies and it has been hypothesized that Akt inhibitors can overcome the development of resistance (57,58).”
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“AMPK controls glucose and lipid metabolism by sensing changes in nutrient and extracellular energy levels [26].”
BackgroundThe interplay between androgens and the immune response in polycystic ovary syndrome
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New drugs are not enough‑drug repositioning in oncology: An update
Armando, R., Mengual G�mez, D., & Gomez, D. (2020) · International Journal of Oncology · doi:10.3892/ijo.2020.4966 · Cited by 90
Mitochondria: The metabolic switch of cellular oncogenic transformation
Tan, Y. Q., Zhang, X., Zhang, S., Zhu, T., Garg, M., Lobie, P. E., & Pandey, V. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188534 · Cited by 75
Pre-existing Cell States Control Heterogeneity of Both EGFR and CXCR4 Signaling
Spinosa, P. C., Kinnunen, P. C., Humphries, B. A., Luker, G. D., Luker, K. E., & Linderman, J. J. (2021) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-020-00640-1 · Cited by 10
Metadata
- Authors
- Nitulescu, G., Van De Venter, M., Nitulescu, G., Ungurianu, A., Juzenas, P., Peng, Q., Olaru, O., Grădinaru, D., Tsatsakis, A., Tsoukalas, D., Spandidos, D., & Margina, D.
- Venue
- International Journal of Oncology
- Publisher
- Spandidos Publications
- Published
- 2018-10-16
- Volume
- 53
- Issue
- 6
- Pages
- 2319-2331
- ISSN
- 1019-6439 (ISSN-L)
- 1791-2423
- OpenAlex
- W2896744886
- Cited by
- 328
- References
- 163
- FWCI
- 10.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Nitulescu, G., Van De Venter, M., Nitulescu, G., Ungurianu, A., Juzenas, P., Peng, Q., Olaru, O., Grădinaru, D., Tsatsakis, A., Tsoukalas, D., Spandidos, D., & Margina, D. (2018). The Akt pathway in oncology therapy and beyond (Review). International Journal of Oncology. https://doi.org/10.3892/ijo.2018.4597
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