Resveratrol Inhibits Oligomeric Aβ-Induced Microglial Activation via NADPH Oxidase
Open accessAbstract
Microglia‑mediated neuroinflammation is key in the pathogenesis of Alzheimer's disease (AD). Several studies have suggested that NADPH oxidase contributes to microglia‑mediated neuroinflammation. Resveratrol, which is a natural polyphenolic compound, exerts neuroprotective effects in AD due to its anti‑inflammatory properties. The present study aimed to investigate the effects of resveratrol on the activation of oligomeric amyloid β (oAβ)‑induced BV‑2 microglia, and to determine the role of NADPH oxidase in these effects. Microglial proliferation was measured by high‑content screening cell counting and using a bromodeoxyuridine incorporation assay. In addition, the levels of reactive oxygen species (ROS), nitric oxide (NO), tumor necrosis factor (TNF)‑α and interleukin (IL)‑1β were assessed. The results of the present study demonstrated that resveratrol inhibited the proliferation of oAβ‑induced microglia and the production of pro‑inflammatory factors, including ROS, NO, TNF‑α and IL‑1β. Subsequent mechanistic investigations demonstrated that resveratrol inhibited the oAβ‑induced mRNA and protein expression levels of p47phox and gp91phox. These results suggested that NADPH oxidase may be a potential target for AD treatment, and resveratrol may be a valuable natural product possessing therapeutic potential against AD.
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Resveratrol inhibits production of NO, TNF-α and IL-1β in astrocytic and microglial cells.
“it has been shown to inhibit the production of pro-inflammatory factors such as NO, TNF-α and IL-1β in both astrocytic and microglial cells (Yao et al., 2015; Zhao et al., 2018)”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Yao et al., 2015
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Freyssin, A. (2020) · theses.fr (ABES) · doi:10.70675/0db2e37dz547bz4731z852dz9b843c062cba
- Authors
- YAO, Y., LI, J., NIU, Y., YU, J.-Q., YAN, L., MIAO, Z.-H., ZHAO, X.-X., LI, Y.-J., YAO, W.-X., ZHENG, P., & LI, W.-Q.
- Affiliations
- Ningxia Medical University (CN)
- China Academy of Chinese Medical Sciences (CN)
- Venue
- Molecular Medicine Reports
- Publisher
- Spandidos Publications
- Published
- 2015-08-07
- Volume
- 12
- Issue
- 4
- Pages
- 6133-6139
- ISSN
- 1791-2997 (ISSN-L)
- 1791-3004
- OpenAlex
- W2107120526
- Cited by
- 55
- References
- 32
- Citations by year
- 2025: 5 · 2024: 5 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 8 · 2019: 5 · 2018: 6 · 2017: 9 · 2016: 6
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Medicine Reports (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81460665)
- China Postdoctoral Science Foundation
- Natural Science Foundation of Ningxia Province
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- resveratrol, amyloid-beta oligomers, microglial activation, NADPH oxidase, Alzheimer's disease, neuroinflammation, reactive oxygen species, nitric oxide, TNF-α, IL-1β, p47phox, gp91phox, BV-2 cells, microglial proliferation, anti-inflammatory activity
- MeSH terms
- NADPH Oxidase 2, Resveratrol, Animals, Anti-Inflammatory Agents, Cells, Cultured, Membrane Glycoproteins, Nitric Oxide, Stilbenes, Tumor Necrosis Factor-alpha, Amyloid beta-Peptides, Reactive Oxygen Species, Microglia, Neuroprotective Agents, NADPH Oxidases, Cell Proliferation, Mice, Interleukin-1beta
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