MicroRNA-378b regulates α-1-type 1 collagen expression via sirtuin 6 interference
Open accessAbstract
Ultraviolet (UV) light mediates skin aging and induces destruction of the dermis by modulating the expression levels of extracellular matrix‑associated genes, including collagen and matrix metalloproteinases. Sirtuin 6 (SIRT6), a member of the sirtuin family of proteins, regulates collagen metabolism and is an established anti‑aging protein. However, the exact underlying mechanism by which SIRT6 expression is regulated in dermal fibroblasts during the aging process is unclear. The present study demonstrated that expression of microRNA‑378b (miR‑378b) is induced in UVB‑exposed human dermal fibroblasts (HDFs), and this was inversely associated with the mRNA expression levels of α‑1‑type 1 collagen (COL1A1). In addition, knockdown of miR‑378b enhanced the mRNA expression levels of COL1A1 in HDFs. A target analysis for miR‑378b was performed, and the results revealed that SIRT6, a regulator of COL1A1, contains a target sequence for miR‑378b in its 3'untranslated region. Notably, the present study demonstrated that an miR‑378b mimic and inhibitor may directly regulate SIRT6 expression in HDFs. In conclusion, the present study suggested that miR‑378b represses the mRNA expression levels of COL1A1 via interference with SIRT6 in HDFs, and may contribute to the underlying molecular mechanism by which UVB inhibits collagen I in dermal fibroblasts.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
MicroRNAs regulate the skin aging process.
“These studies thus show that microRNAs regulate the skin aging process [43,44,45,46,47].”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [46]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714 · see citing works
Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005) · Cell · doi:10.1016/j.cell.2004.12.035 · Cited by 11,855 · see citing works
Ambros, V. (2001) · Cell · doi:10.1016/s0092-8674(01)00616-x · Cited by 1,704 · see citing works
Daynes, R. A., Araneo, B. A., Ershler, W. B., Maloney, C., Li, G. Z., & Ryu, S. Y. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.12.5219 · Cited by 1,264 · see citing works
Decreased Collagen Production in Chronologically Aged Skin
Varani, J., Dame, M. K., Rittie, L., Fligiel, S. E. G., Kang, S., Fisher, G. J., & Voorhees, J. J. (2006) · The American Journal of Pathology · doi:10.2353/ajpath.2006.051302 · Cited by 910 · see citing works
Quan, T., & Fisher, G. J. (2015) · Gerontology · doi:10.1159/000371708 · Cited by 464 · see citing works
Sorting out functions of sirtuins in cancer
Roth, M., & Chen, W. (2013) · Oncogene · doi:10.1038/onc.2013.120 · Cited by 239 · see citing works
Skin aging and natural photoprotection
Wulf, H. C., Sandby‐Møller, J., Kobayasi, T., & Gniadecki, R. (2003) · Micron · doi:10.1016/j.micron.2003.11.005 · Cited by 233 · see citing works
SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA
Fan, W., & Luo, J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.07.006 · Cited by 223 · see citing works
NAD+, Sirtuins, and Cardiovascular Disease
Borradaile, N. M., & Pickering, J. G. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209787185742 · Cited by 140 · see citing works
The Role of SIRT6 Protein in Aging and Reprogramming of Human Induced Pluripotent Stem Cells
Sharma, A. S., Diecke, S., Zhang, W. Y., Lan, F., He, C., Mordwinkin, N. M., Chua, K. F., & Wu, J. C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.405928 · Cited by 128 · see citing works
Law, I. K. M., Liu, L., Xu, A., Lam, K. S. L., Vanhoutte, P. M., Che, C., Leung, P. T. Y., & Wang, Y. (2009) · PROTEOMICS · doi:10.1002/pmic.200800738 · Cited by 115 · see citing works
Dynamic Chromatin Localization of Sirt6 Shapes Stress- and Aging-Related Transcriptional Networks
Kawahara, T. L. A., Rapicavoli, N. A., Wu, A. R., Qu, K., Quake, S. R., & Chang, H. Y. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002153 · Cited by 101 · see citing works
Egbert, M., Ruetze, M., Sattler, M., Wenck, H., Gallinat, S., Lucius, R., & Weise, J. M. (2014) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.08.010 · Cited by 77 · see citing works
MicroRNAs in pancreas development
Dumortier, O., & OBBERGHEN, E. V. (2012) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2012.01656.x · Cited by 54 · see citing works
Therapeutic potential of activators and inhibitors of sirtuins
Balcerczyk, A., & Pirola, L. (2010) · BioFactors · doi:10.1002/biof.112 · Cited by 50 · see citing works
MicroRNAs: From Female Fertility, Germ Cells, and Stem Cells to Cancer in Humans
Virant‐Klun, I., Ståhlberg, A., Kubista, M., & Skutella, T. (2015) · Stem Cells International · doi:10.1155/2016/3984937 · Cited by 49 · see citing works
New insights into microRNAs in skin wound healing
Fahs, F., Bi, X., Yu, F. X., Zhou, L., & Mi, Q. (2015) · IUBMB Life · doi:10.1002/iub.1449 · Cited by 48 · see citing works
Chou, W., Chen, K., Wang, Y., Wang, J., Liang, C.-L., & Juo, S. H. (2013) · Toxicology in Vitro · doi:10.1016/j.tiv.2013.05.002 · Cited by 45 · see citing works
MicroRNAs, stem cells and cancer stem cells
Garg, M. (2012) · World Journal of Stem Cells · doi:10.4252/wjsc.v4.i7.62 · Cited by 41 · see citing works
Xia, J., Wu, X., Yang, Y., Zhao, Y., Fang, M., Xie, W., Wang, H., & Xu, Y. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.10.043 · Cited by 37 · see citing works
Potential Role of Sirtuin as a Therapeutic Target for Neurodegenerative Diseases
Han, S. (2009) · Journal of Clinical Neurology · doi:10.3988/jcn.2009.5.3.120 · Cited by 37 · see citing works
Non-coding RNAs in Uterine Development, Function and Disease
Nothnick, W. B. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-94-017-7417-8_9 · Cited by 37 · see citing works
Skin aging: molecular pathology, dermal remodelling and the imaging revolution.
Newton, V. L., McConnell, J. C., Hibbert, S. A., Graham, H. K., & Watson, R. E. B. (2015) · PubMed · Cited by 33 · see citing works
LEE, M. J., Cha, H. J., Lim, K. M., Lee, O.-K., Bae, S., Kim, C., Lee, K., Lee, Y. N., Ahn, K. J., & An, S. (2012) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3478 · Cited by 31 · see citing works
Self-citationEffects of SIRT6 silencing on collagen metabolism in human dermal fibroblasts
Baohua, Y., & Li, L. (2011) · Cell Biology International · doi:10.1042/cbi20110268 · Cited by 30 · see citing works
An, I., An, S., Park, S., Lee, S. N., & Bae, S. (2012) · Oncology Reports · doi:10.3892/or.2012.2083 · Cited by 27 · see citing works
Self-citationLee, Y. K., Cha, H. J., Hong, M., Yoon, Y., Lee, H., & An, S. (2012) · Archives of Dermatological Research · doi:10.1007/s00403-011-1176-2 · Cited by 21 · see citing works
Self-citationEffect of UVB irradiation on microRNA expression in mouse epidermis
Zhou, B., Xu, Y., & Luo, D. (2012) · Oncology Letters · doi:10.3892/ol.2012.551 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Diet and Skin Aging—From the Perspective of Food Nutrition
Cao, C., Xiao, Z., Wu, Y., & Ge, C. (2020) · Nutrients · doi:10.3390/nu12030870 · Cited by 231 · see citing works
Epigenetic Regulation of Skin Cells in Natural Aging and Premature Aging Diseases
Orioli, D., & Dellambra, E. (2018) · Cells · doi:10.3390/cells7120268 · Cited by 144 · see citing works
Targeting type I collagen for cancer treatment
Shi, R., Zhang, Z., Zhu, A.-K., Xiong, X., Zhang, J., Xu, J., Sy, M., & Li, C. (2022) · International Journal of Cancer · doi:10.1002/ijc.33985 · Cited by 71 · see citing works
Nanomaterials as Inhibitors of Epithelial Mesenchymal Transition in Cancer Treatment
Cordani, M., Strippoli, R., & Somoza, Á. (2019) · Cancers · doi:10.3390/cancers12010025 · Cited by 37 · see citing works
miR29a and miR378b Influence CpG-Stimulated Dendritic Cells and Regulate cGAS/STING Pathway
Shah, A. U., Cao, Y., Siddique, N., Lin, J., & Yang, Q. (2019) · Vaccines · doi:10.3390/vaccines7040197 · Cited by 36 · see citing works
Lee, J., Ng, S., Ni, Y.-T., Liu, J., Chen, C., Padma, V. V., Huang, C., & Kuo, W. (2021) · Aging · doi:10.18632/aging.203750 · Cited by 31 · see citing works
Zhang, Y., Lu, J., Zhong, Y., Yang, C., Chen, L., Wu, D., Song, M., Shi, L., Ma, Z., Li, L., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112462 · Cited by 23 · see citing works
Role of non‑coding RNAs in UV‑induced radiation effects (Review)
Liang, X., Zhang, C., Shen, L., Ding, L., & Guo, H. (2024) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2024.12550 · Cited by 18 · see citing works
Li, Y., Zhong, Y., Cheng, Q., Wang, Y., Fan, Y., Yang, C., Ma, Z., Li, Y., & Li, L. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00717 · Cited by 13 · see citing works
The role of sirtuins in dermal fibroblast function
Gilbert, M. M., Mathes, S. C., Mahajan, A. S., Rohan, C. A., Travers, J. B., & Thyagarajan‐Sahu, A. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1021908 · Cited by 12 · see citing works
UVB-Induced ciRS-7 Activates Melanogenesis by Paracrine Effects
Ouyang, Y., Chen, J., Jiang, L., Li, Y., Hu, Y., Li, S., Huang, J., & Zeng, Q. (2021) · DNA and Cell Biology · doi:10.1089/dna.2020.5489 · Cited by 12 · see citing works
Lehmann, T. P., Guderska, U., Kałek, K., Marzec, M., Urbanek, A. N., Czernikiewicz, A., Sasiadek, M. M., Karpiński, P., Pławski, A., Głowacki, M., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010091 · Cited by 10 · see citing works
MicroRNA dysregulation in the heart and lung of infants with bronchopulmonary dysplasia
Koussa, S., Dombkowski, A. A., Cukovic, D., Poulik, J. M., & Sood, B. G. (2023) · Pediatric Pulmonology · doi:10.1002/ppul.26422 · Cited by 6 · see citing works
Zhang, X., Liu, X., Wang, Y., Zhu, C., Liu, D., Zheng, Y., Zhang, Y., Yang, H., Xu, Y., & Shi, Q. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124254
Ren, S., Zhou, S., Xu, G., Chen, Z., Li, S., Xian, J., Wang, Y. P., & Yang, B. (2026) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2026.113567
- Authors
- Joo, D., An, S., Choi, B. G., Kim, K., Choi, Y. M., Ahn, K. J., An, I.-S., & Cha, H. J.
- Affiliations
- Konkuk University (KR)
- Osan University (KR)
- Venue
- Molecular Medicine Reports
- Publisher
- Spandidos Publications
- Published
- 2017-09-28
- Volume
- 16
- Issue
- 6
- Pages
- 8520-8524
- ISSN
- 1791-2997 (ISSN-L)
- 1791-3004
- OpenAlex
- W2757138425
- Cited by
- 15
- References
- 30
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 1
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Medicine Reports (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Konkuk University
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- SIRT6, COL1A1, type I collagen, dermal fibroblasts, extracellular matrix, 3' untranslated region, microRNA target regulation, collagen expression
- MeSH terms
- Collagen Type I, alpha 1 Chain, Fibroblasts, Gene Expression Regulation, Humans, Protein Binding, RNA, Messenger, Ultraviolet Rays, Down-Regulation, Dermis, 3' Untranslated Regions, Collagen Type I, RNA Interference, MicroRNAs, Sirtuins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
