The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Protective role of taurine against oxidative stress (Review)
Open accessAbstract
Taurine is a fundamental mediator of homeostasis that exerts multiple roles to confer protection against oxidant stress. The development of hypertension, muscle/neuro‑associated disorders, hepatic cirrhosis, cardiac dysfunction and ischemia/reperfusion are examples of some injuries that are linked with oxidative stress. The present review gives a comprehensive description of all the underlying mechanisms of taurine, with the aim to explain its anti‑oxidant actions. Taurine is regarded as a cytoprotective molecule due to its ability to sustain normal electron transport chain, maintain glutathione stores, upregulate anti‑oxidant responses, increase membrane stability, eliminate inflammation and prevent calcium accumulation. In parallel, the synergistic effect of taurine with other potential therapeutic modalities in multiple disorders are highlighted. Apart from the results derived from research findings, the current review bridges the gap between bench and bedside, providing mechanistic insights into the biological activity of taurine that supports its potential therapeutic efficacy in clinic. In the future, further clinical studies are required to support the ameliorative effect of taurine against oxidative stress.
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Cites
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling.
Lee, J., Giordano, S., & Zhang, J. (2012) · Biochemical Journal · doi:10.1042/bj20111451 · Cited by 1,438
Role of taurine supplementation to prevent exercise-induced oxidative stress in healthy young men
Liu, Z., Qi, B., Zhang, M., Izumi, I., Kagamimori, S., Sokejima, S., & Yamagami, T. (2004) · Amino Acids · doi:10.1007/s00726-003-0002-3 · Cited by 200
Rutherford, J. A., Spriet, L. L., & Stellingwerff, T. (2010) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.20.4.322 · Cited by 101 · cited 3×
“Experiments in well‑trained cyclists showed the high dietary intake of taurine (204).”
InfluentialRa, S.-G., Miyazaki, T., Ishikura, K., Nagayama, H., Komine, S., Nakata, Y., Maeda, S., Matsuzaki, Y., & Ohmori, H. (2013) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-10-51 · Cited by 94
The effect of acute taurine ingestion on 3-km running performance in trained middle-distance runners
Balshaw, T. G., Bampouras, T. M., Barry, T. J., & Sparks, S. A. (2013) · Amino Acids · doi:10.1007/s00726-012-1372-1 · Cited by 71
Metadata
- Authors
- Baliou, S., Adamaki, M., Ioannou, P., Pappa, A., Panayiotidis, M., Spandidos, D., Christodoulou, I., Kyriakopoulos, A., & Zoumpourlis, V.
- Venue
- Molecular Medicine Reports
- Publisher
- Spandidos Publications
- Published
- 2021-06-24
- Volume
- 24
- Issue
- 2
- ISSN
- 1791-2997 (ISSN-L)
- 1791-3004
- OpenAlex
- W3175798988
- Cited by
- 343
- References
- 6
- FWCI
- 17.24
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Baliou, S., Adamaki, M., Ioannou, P., Pappa, A., Panayiotidis, M., Spandidos, D., Christodoulou, I., Kyriakopoulos, A., & Zoumpourlis, V. (2021). Protective role of taurine against oxidative stress (Review). Molecular Medicine Reports. https://doi.org/10.3892/mmr.2021.12242
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