Endothelial-to-mesenchymal transition (EndoMT): roles in tumorigenesis, metastatic extravasation and therapy resistance
Open accessAbstract
Cancer cells evolve in a very complex tumor microenvironment, composed of several cell types, among which the endothelial cells are the major actors of the tumor angiogenesis. Today, these cells are also characterized for their plasticity, as endothelial cells have demonstrated their potential to modify their phenotype to differentiate into mesenchymal cells through the endothelial-to-mesenchymal transition (EndoMT). This cellular plasticity is mediated by various stimuli including transforming growth factor-β (TGF-β) and is modulated dependently of experimental conditions. Recently, emerging evidences have shown that EndoMT is involved in the development and dissemination of cancer and also in cancer cell to escape from therapeutic treatment. In this review, we summarize current updates on EndoMT and its main induction pathways. In addition, we discuss the role of EndoMT in tumorigenesis, metastasis, and its potential implication in cancer therapy resistance.
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Extravasation is known to be influenced by various environmental factors, such as ECM heterogeneity, immune cells, EMT, integrins, blood flow, and biochemical gradients.
“Extravasation is known to be influenced by various environmental factors, such as ECM heterogeneity [4], immune cells [68], epithelial-to-mesenchymal transition (EMT) [69], integrins [70,71], blood flow [4,72], and biochemical gradients [73].”
From Cancer-on-chip models for metastasis: importance of the tumor microenvironment (2024) · cites this paper as [69]
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Vetter, G., Saumet, A., Moes, M., Vallar, L., Béchec, A. L., Laurini, C., Sabbah, M., Arar, K., Theillet, C. G., Lecellier, C., et al. (2010) · Oncogene · doi:10.1038/onc.2010.181 · Cited by 122 · see citing works
RetractedHallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219 · see citing works
Tumor angiogenesis: therapeutic implications
Sherwood, L. M., Parris, E. E., & Folkman, J. (1971) · New England Journal of Medicine · doi:10.1056/nejm197111182852108 · Cited by 10,187 · see citing works
Microenvironmental regulation of tumor progression and metastasis
Quail, D. F., & Joyce, J. A. (2013) · Nature Medicine · doi:10.1038/nm.3394 · Cited by 7,994 · see citing works
Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
Hanahan, D., & Coussens, L. M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.022 · Cited by 4,632 · cited 1× · see citing works
“*is microenvironment is composed of numerous cell types: immune cells (bone marrow-derived inflammatory cells, monocytes/ macrophages, and lymphocytes), vascular cells (endothelial cells and pericytes), and stromal fibroblastic cells, and of an extracellular matrix composed of collagen and proteoglycans [3, 4].”
BackgroundKalluri, R., & Zeisberg, M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1877 · Cited by 4,538 · see citing works
Cano, A., Pérez‐Moreno, M., Rodrigo, I., Locascio, A., Blanco, M. J., Barrio, M. G. D., Portillo, F., & Nieto, M. A. (2000) · Nature Cell Biology · doi:10.1038/35000025 · Cited by 3,672 · see citing works
T cell exclusion, immune privilege, and the tumor microenvironment
Joyce, J. A., & Fearon, D. T. (2015) · Science · doi:10.1126/science.aaa6204 · Cited by 2,494 · see citing works
Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
Zeisberg, E. M., Tarnavski, O., Zeisberg, M., Dorfman, A. L., McMullen, J. R., Gustafsson, E., Chandraker, A. K., Yuan, X., Pu, W. T., Roberts, A. B., et al. (2007) · Nature Medicine · doi:10.1038/nm1613 · Cited by 2,224 · see citing works
Turning foes to friends: targeting cancer-associated fibroblasts
Chen, X., & Song, E. (2018) · Nature Reviews Drug Discovery · doi:10.1038/s41573-018-0004-1 · Cited by 1,884 · see citing works
Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
Vermeulen, L., De Sousa E Melo, F., van der Heijden, M., Cameron, K., de Jong, J. H., Borovski, T., Tuynman, J. B., Todaro, M., Merz, C., Rodermond, H., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2048 · Cited by 1,804 · see citing works
Zhou, B. P., Deng, J., Xia, W., Xu, J., Li, Y. M., Gunduz, M., & Hung, M.-C. (2004) · Nature Cell Biology · doi:10.1038/ncb1173 · Cited by 1,581 · see citing works
TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia
Bhowmick, N. A., Chytil, A., Plieth, D., Gorska, A. E., Dumont, N., Shappell, S., Washington, M. K., Neilson, E. G., & Moses, H. L. (2004) · Science · doi:10.1126/science.1090922 · Cited by 1,401 · see citing works
Direct regulation of TWIST by HIF-1α promotes metastasis
Yang, M.-H., Wu, M.-Z., Chiou, S.-H., Chen, P.-M., Chang, S.-Y., Liu, C.-J., Teng, S.-C., & Wu, K.-J. (2008) · Nature Cell Biology · doi:10.1038/ncb1691 · Cited by 1,345 · see citing works
Su, S., Chen, J., Yao, H., Liu, J., Yu, S., Lao, L., Wang, M., Luo, M., Xing, Y., Chen, F., et al. (2018) · Cell · doi:10.1016/j.cell.2018.01.009 · Cited by 1,230 · see citing works
TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis
Hao, Y., Baker, D. A., & ten Dijke, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112767 · Cited by 1,155 · see citing works
Discovery of Endothelial to Mesenchymal Transition as a Source for Carcinoma-Associated Fibroblasts
Zeisberg, E. M., Potenta, S., Xie, L., Zeisberg, M., & Kalluri, R. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-3127 · Cited by 1,011 · see citing works
Timmerman, L., Grego‐Bessa, J., Raya, Á., Bertrán, E., Pérez-Pomares, J. M., Díez, J., Aranda, S., Palomo‐Ponce, S., McCormick, F., Izpisúa‐Belmonte, J. C., et al. (2003) · Genes & Development · doi:10.1101/gad.276304 · Cited by 972 · see citing works
Fibroblasts in Kidney Fibrosis Emerge via Endothelial-to-Mesenchymal Transition
Zeisberg, E. M., Potenta, S. E., Sugimoto, H., Zeisberg, M., & Kalluri, R. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008050513 · Cited by 878 · see citing works
Reactive Oxygen Species: A Key Constituent in Cancer Survival
Kumari, S., Badana, A. K., Murali Mohan, G., Gugalavath, S., & Malla, R. R. (2018) · Biomarker Insights · doi:10.1177/1177271918755391 · Cited by 781 · see citing works
The Notch signalling system: recent insights into the complexity of a conserved pathway
Guruharsha, K. G., Kankel, M. W., & Artavanis‐Tsakonas, S. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3272 · Cited by 700 · see citing works
Conversion of vascular endothelial cells into multipotent stem-like cells
Medici, D., Shore, E. M., Lounev, V. Y., Kaplan, F. S., Kalluri, R., & Olsen, B. R. (2010) · Nature Medicine · doi:10.1038/nm.2252 · Cited by 678 · see citing works
Endothelial to Mesenchymal Transition: Role in Physiology and in the Pathogenesis of Human Diseases
Piera-Velázquez, S., & Jiménez, S. A. (2019) · Physiological Reviews · doi:10.1152/physrev.00021.2018 · Cited by 673 · see citing works
Caniggia, I., Mostachfi, H., Winter, J., Gassmann, M., Lye, S. J., Kuliszewski, M., & Post, M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8316 · Cited by 644 · see citing works
TGF-β signaling by Smad proteins
Miyazono, K. (2000) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(99)00025-8 · Cited by 626 · see citing works
The role of endothelial-to-mesenchymal transition in cancer progression
Potenta, S. E., Zeisberg, E. M., & Kalluri, R. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604662 · Cited by 553 · see citing works
Folkman, J. (1974) · Advances in cancer research · doi:10.1016/s0065-230x(08)60058-5 · Cited by 477 · see citing works
TGF-β signaling by Smad proteins
Miyazono, K., ten Dijke, P., & Heldin, C. (2000) · Advances in immunology · doi:10.1016/s0065-2776(00)75003-6 · Cited by 433 · see citing works
TGF-β signaling mediates endothelial to mesenchymal transition (EndMT) during vein graft remodeling
Cooley, B., Nevado, J., Mellad, J., Yang, D., Hilaire, C. S., Negro, A., Fang, F., Chen, G.-B., Hong, S., Walts, A., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3006927 · Cited by 414 · see citing works
Sánchez-Elsner, T., Botella, L. M., Velasco, B., Corbí, A. L., Attisano, L., & Bernabéu, C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104536200 · Cited by 379 · see citing works
Jekyll and Hyde: the role of the microenvironment on the progression of cancer
Allen, M. D., & Jones, J. L. (2010) · The Journal of Pathology · doi:10.1002/path.2803 · Cited by 370 · see citing works
Cell and molecular biology of Notch
Fiúza, U.-M., & Arias, A. M. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0242 · Cited by 370 · see citing works
Mesenchymal–endothelial transition contributes to cardiac neovascularization
Ubil, E., Duan, J., Pillai, I. C. L., Rosa‐Garrido, M., Wu, Y., Bargiacchi, F., Lu, Y., Stanbouly, S., Huang, J., Rojas, M., et al. (2014) · Nature · doi:10.1038/nature13839 · Cited by 358 · see citing works
Good, R. B., Gilbane, A. J., Trinder, S. L., Denton, C. P., Coghlan, G., Abraham, D. J., & Holmes, A. M. (2015) · The American Journal of Pathology · doi:10.1016/j.ajpath.2015.03.019 · Cited by 349 · see citing works
WNT Signaling in Cardiac and Vascular Disease
Foulquier, S., Daskalopoulos, E. P., Lluri, G., Hermans, K. C. M., Deb, A., & Blankesteijn, W. M. (2017) · Pharmacological Reviews · doi:10.1124/pr.117.013896 · Cited by 344 · see citing works
Inflammation-Induced Endothelial-to-Mesenchymal Transition
Rieder, F., Kessler, S. P., West, G. A., Bhilocha, S., de la Motte, C., Sadler, T. M., Gopalan, B., Stylianou, E., & Fiocchi, C. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.07.042 · Cited by 325 · see citing works
Kokudo, T., Suzuki, Y., Yoshimatsu, Y., Yamazaki, T., Watabe, T., & Miyazono, K. (2008) · Journal of Cell Science · doi:10.1242/jcs.028282 · Cited by 322 · see citing works
Medici, D., Potenta, S. E., & Kalluri, R. (2011) · Biochemical Journal · doi:10.1042/bj20101500 · Cited by 315 · see citing works
Franco, M., Roswall, P., Cortez, E., Hanahan, D., & Pietras, K. (2011) · Blood · doi:10.1182/blood-2011-01-331694 · Cited by 310 · see citing works
Aisagbonhi, O. A., Rai, M., Ryzhov, S. V., Atria, N., Feoktistov, I., & Hatzopoulos, A. K. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.006510 · Cited by 299 · see citing works
Cho, J. G., Lee, A., Chang, W., Lee, M.-S., & Kim, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00294 · Cited by 284 · see citing works
Reassessing endothelial-to-mesenchymal transition in cardiovascular diseases
Li, Y., Lui, K. O., & Zhou, B. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0023-y · Cited by 283 · see citing works
Epithelial-Mesenchymal Transition Events during Human Embryonic Stem Cell Differentiation
Eastham, A. M., Spencer, H., Soncin, F., Ritson, S., Merry, C. L. R., Stern, P. L., & Ward, C. M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2253 · Cited by 280 · see citing works
Endothelial to Mesenchymal Transition (EndoMT) in the Pathogenesis of Human Fibrotic Diseases
Piera-Velázquez, S., Mendoza, F. A., & Jiménez, S. A. (2016) · Journal of Clinical Medicine · doi:10.3390/jcm5040045 · Cited by 276 · see citing works
Structural analysis of endocardial cytodifferentiation
Markwald, R. R., Fitzharris, T. P., & Smith, W. N. A. (1975) · Developmental Biology · doi:10.1016/0012-1606(75)90321-8 · Cited by 265 · see citing works
Regulation of TGF‐β family signaling by E3 ubiquitin ligases
Inoue, Y., & Imamura, T. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2008.00925.x · Cited by 246 · see citing works
Hinck, A. P. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.05.028 · Cited by 241 · see citing works
GAL4 enhancer traps expressed in the embryo, larval brain, imaginal discs, and ovary of drosophila
Manseau, L. J., Baradaran, A., Brower, D. L., Budhu, A., Elefant, F., Phan, H., Philp, A. V., Yang, M., Glover, D. M., Kaiser, K., et al. (1997) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199707)209:3 · Cited by 241 · see citing works
Paranya, G., Vineberg, S., Dvorin, E. L., Kaushal, S., Roth, S. J., Aikawa, E. R., Schöen, F. J., & Bischoff, J. E. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62520-5 · Cited by 209 · see citing works
Pérez, L., Muñoz‐Durango, N., Riedel, C. A., Echeverría, C., Kalergis, A. M., Cabello‐Verrugio, C., & Simón, F. (2016) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2016.09.002 · Cited by 207 · see citing works
Post‐translational regulation of TGF‐β receptor and Smad signaling
Xu, P., Liu, J., & Derynck, R. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.05.010 · Cited by 198 · see citing works
A three-dimensional in vitro model of tumor cell intravasation
Ehsan, S. M., Welch-Reardon, K. M., Waterman, M. L., Hughes, C. C. W., & George, S. C. (2014) · Integrative Biology · doi:10.1039/c3ib40170g · Cited by 196 · see citing works
Wnt/Beta-Catenin Signaling Regulation and a Role for Biomolecular Condensates
Schaefer, K. N., & Peifer, M. A. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.01.025 · Cited by 194 · see citing works
Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition
Miele, L., Espinoza, I. C., Pochampally, Watabe, & Xing, F. (2013) · OncoTargets and Therapy · doi:10.2147/ott.s36162 · Cited by 185 · see citing works
The role of endothelial-mesenchymal transition in development and pathological process
Lin, F., Wang, N., & Zhang, T. (2012) · IUBMB Life · doi:10.1002/iub.1059 · Cited by 177 · see citing works
Jo, M., Lester, R. D., Montel, V., Eastman, B. M., Takimoto, S., & Gonias, S. L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.023960 · Cited by 174 · see citing works
Helfrich, I., Scheffrahn, I., Bartling, S. H., Weis, J., von Felbert, V., Middleton, M. R., Kato, M., Ergün, S., Augustin, H. G., & Schadendorf, D. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20091846 · Cited by 169 · see citing works
Yap1 Is Required for Endothelial to Mesenchymal Transition of the Atrioventricular Cushion
Zhang, H., von Gise, A., Liu, Q., Hu, T., Tian, X., He, L., Pu, W., Huang, X., He, L., Cai, C., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.554584 · Cited by 162 · see citing works
Helfrich, I., Scheffrahn, I., Bartling, S. H., Weis, J., von Felbert, V., Middleton, M. R., Kato, M., Ergün, S., Augustin, H. G., & Schadendorf, D. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.200918462104c · Cited by 162 · see citing works
Goumans, M., van Zonneveld, A. J., & ten Dijke, P. (2008) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2009.01.001 · Cited by 160 · see citing works
Mercado-Pimentel, M. E., & Runyan, R. B. (2007) · Cells Tissues Organs · doi:10.1159/000101315 · Cited by 152 · see citing works
Cellular response to hypoxia involves signaling via Smad proteins
Zhang, H., Akman, H. O., Smith, E. L., Zhao, J., Murphy-Ullrich, J. E., & Batuman, O. (2003) · Blood · doi:10.1182/blood-2002-02-0629 · Cited by 152 · see citing works
Montorfano, I., Becerra, Á., Cerro, R., Echeverría, C., Sáez, E., Morales, M. G., Fernández, R., Cabello‐Verrugio, C., & Simón, F. (2014) · Laboratory Investigation · doi:10.1038/labinvest.2014.100 · Cited by 148 · see citing works
Xavier, S., Vasko, R., Matsumoto, K., Zullo, J. A., Chen, R., Maizel, J., Chander, P. N., & Goligorsky, M. S. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013101137 · Cited by 147 · see citing works
Sánchez‐Duffhues, G., de Vinuesa, A. G., & ten Dijke, P. (2017) · Developmental Dynamics · doi:10.1002/dvdy.24589 · Cited by 143 · see citing works
Hypoxia-Induced Secretion of TGF-β1 in Mesenchymal Stem Cell Promotes Breast Cancer Cell Progression
Hung, S.-P., Yang, M.-H., Tseng, K.-F., & Lee, O. K. (2013) · Cell Transplantation · doi:10.3727/096368912x657954 · Cited by 137 · see citing works
Anderberg, C., Cunha, S. I., Zhai, Z., Cortez, E., Pardali, E., Johnson, J. R., Franco, M., Pàez‐Ribes, M., Cordiner, R. A., Fuxe, J., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20120662 · Cited by 136 · see citing works
Ullmann, U., Veld, P. I. '., Gilles, C., Sermon, K., Rycke, M. D., de Velde, H. V., Steirteghem, A. V., & Liebaers, I. (2006) · Molecular Human Reproduction · doi:10.1093/molehr/gal091 · Cited by 124 · see citing works
Azhar, M., Runyan, R. B., Gard, C., Sanford, L. P., Miller, M. L., Andringa, A., Pawlowski, S. A., Rajan, S., & Doetschman, T. (2009) · Developmental Dynamics · doi:10.1002/dvdy.21854 · Cited by 123 · see citing works
Hahn, J., Cho, H.-J., Bae, J.-W., Yuk, H.-S., Kim, K., Park, K. W., Koo, B.-K., Chae, I., Shin, C.-S., Oh, B., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603916200 · Cited by 122 · see citing works
Mendoza, F. A., Piera‐Velazquez, S., Farber, J. L., Feghali‐Bostwick, C., & Jiménez, S. A. (2016) · Arthritis & Rheumatology · doi:10.1002/art.39421 · Cited by 121 · see citing works
Choi, S., Kim, A.-R., Nam, J.-K., Kim, J., Kim, J.-Y., Seo, H. R., Lee, H., Cho, J., & Lee, Y. (2018) · Nature Communications · doi:10.1038/s41467-018-07470-w · Cited by 118 · see citing works
Matrix Biology of Idiopathic Pulmonary Fibrosis
Thannickal, V. J., Henke, C. A., Horowitz, J. C., Noble, P. W., Roman, J., Sime, P. J., Zhou, Y., Wells, R. G., White, E. S., & Tschumperlin, D. J. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.02.003 · Cited by 117 · see citing works
Calcification of Multipotent Prostate Tumor Endothelium
Dudley, A. C., Khan, Z. A., Shih, S., Kang, S.-Y., Zwaans, B. M. M., Bischoff, J. E., & Klagsbrun, M. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.06.017 · Cited by 117 · see citing works
Wang, F., Sun, W., Zhang, J., & Fan, Y. (2019) · Oncology Letters · doi:10.3892/ol.2019.9973 · Cited by 115 · see citing works
ON THE CAUSE OF THE LOCALIZATION OF SECONDARY TUMORS AT POINTS OF INJURY
Jones, F. S., & Rous, P. (1914) · The Journal of Experimental Medicine · doi:10.1084/jem.20.4.404 · Cited by 114 · see citing works
The human Nox4: gene, structure, physiological function and pathological significance
Guo, S., & Chen, X. (2015) · Journal of drug targeting · doi:10.3109/1061186x.2015.1036276 · Cited by 113 · see citing works
Angiogenic sprouting is regulated by endothelial cell expression of Slug (Snai2)
Welch, K. M., Ehsan, S. M., Wang, K., Wu, N., Newman, A. C., Romero-López, M., Fong, A. H., George, S. C., Edwards, R. A., & Hughes, C. C. W. (2014) · Journal of Cell Science · doi:10.1242/jcs.143420 · Cited by 111 · see citing works
Mihira, H., Suzuki, H. I., Akatsu, Y., Yoshimatsu, Y., Igarashi, T., Miyazono, K., & Watabe, T. (2011) · The Journal of Biochemistry · doi:10.1093/jb/mvr121 · Cited by 107 · see citing works
Piera-Velázquez, S., & Jiménez, S. A. (2012) · Fibrogenesis & Tissue Repair · doi:10.1186/1755-1536-5-s1-s7 · Cited by 104 · see citing works
Krizbai, I. A., Gasparics, Á., Nagyőszi, P., Fazakas, C., Molnár, J., Wilhelm, I., Bencs, R., Rosivall, L., & Sebe, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119655 · Cited by 103 · see citing works
Charytan, D. M., Padera, R. F., Helfand, A. M., Zeisberg, M., Xu, X., Liu, X., Himmelfarb, J., Cinelli, A., Kalluri, R., & Zeisberg, E. M. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.06.062 · Cited by 101 · see citing works
EndMT: A promising and controversial field
Hong, L., Du, X., Li, W., Mao, Y., Sun, L., & Li, X. (2018) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2018.07.005 · Cited by 100 · see citing works
Mechanistic insight into contextual TGF-β signaling
Zhang, Y. E. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.10.001 · Cited by 94 · see citing works
Troletti, C. D., Fontijn, R. D., Gowing, E., Charabati, M., Hof, B. V. H., Didouh, I., van der Pol, S. M. A., Geerts, D., Prat, A., van Horssen, J., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-018-1294-2 · Cited by 94 · see citing works
Huang, T., Chen, Y., Chou, T., Chen, C.-Y., Li, H., Huang, B., Tsai, H., Lan, H., Chang, C., Twu, N.-F., et al. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12300 · Cited by 90 · see citing works
Lee, J. G., & Kay, E. P. (2006) · Experimental Eye Research · doi:10.1016/j.exer.2006.04.007 · Cited by 89 · see citing works
Guo, Y., Li, P., Bledsoe, G., Yang, Z., Chao, L., & Chao, J. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.06.021 · Cited by 87 · see citing works
Zhong, A., Mirzaei, Z., & Simmons, C. A. (2018) · Cardiovascular Engineering and Technology · doi:10.1007/s13239-018-0363-0 · Cited by 83 · see citing works
Wang, S.-H., Chang, J. S.-M., Hsiao, J. R., Yen, Y.-C., Jiang, S. S., Liu, S.-H., Chen, Y.-L., Shen, Y.-Y., Chang, J.-Y., & Chen, Y.-W. (2016) · Oncogene · doi:10.1038/onc.2016.317 · Cited by 82 · see citing works
Sampson, N., Brunner, E., Weber, A., Puhr, M., Schäfer, G., Szyndralewiez, C., & Klocker, H. (2018) · International Journal of Cancer · doi:10.1002/ijc.31316 · Cited by 81 · see citing works
Isoform‐specific effects of transforming growth factor β on endothelial‐to‐mesenchymal transition
Sabbineni, H., Verma, A., & Somanath, P. R. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26801 · Cited by 80 · see citing works
Endothelial Plasticity: Shifting Phenotypes through Force Feedback
Krenning, G., Baraúna, V. G., Krieger, J. E., Harmsen, M. C., & Moonen, J.-R. A. J. (2016) · Stem Cells International · doi:10.1155/2016/9762959 · Cited by 75 · see citing works
Nagai, N., Ohguchi, H., Nakaki, R., Matsumura, Y., Kanki, Y., Sakai, J., Aburatani, H., & Minami, T. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007826 · Cited by 75 · see citing works
Nie, L., Lyros, O., Medda, R., Jovanović, N., Schmidt, J. L., Otterson, M. F., Johnson, C. P., Behmaram, B., Shaker, R., & Rafiee, P. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00081.2014 · Cited by 64 · see citing works
Song, S., Zhang, M., Yi, Z., Zhang, H., Shen, T., Yu, X., Zhang, C., Zheng, X., Yu, L., Ma, C., et al. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.06.022 · Cited by 61 · see citing works
Lu, C.-C., Liu, M., Clinton, M., Culshaw, G., Argyle, D. J., & CORCORAN, B. M. (2015) · The Veterinary Journal · doi:10.1016/j.tvjl.2015.08.011 · Cited by 57 · see citing works
Gasparics, Á., Rosivall, L., Krizbai, I. A., & Sebe, A. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00042.2016 · Cited by 57 · see citing works
Ghiabi, P., Jiang, J., Pasquier, J., Maleki, M., Abu-Kaoud, N., Halabi, N. M., Guerrouahen, B. S., Rafii, S., & Rafii, A. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0386-3 · Cited by 55 · see citing works
Cui, X., Lu, Y. W., Lee, V., Kim, D. J., Dorsey, T. B., Wang, Q., Lee, Y., Vincent, P. A., Schwarz, J. J., & Dai, G. (2015) · Scientific Reports · doi:10.1038/srep16193 · Cited by 55 · see citing works
Zhang, H., Liu, Y., Yan, L., Du, W., Zhang, X., Zhang, M., Chen, H., Zhang, Y., Zhou, J., Sun, H., et al. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26195 · Cited by 52 · see citing works
Fan, C.-S., Chen, W.-S., Chen, L.-L., Chen, C.-C., Hsu, Y.-T., Chua, K. V., Wang, H., & Huang, T. (2017) · Oncotarget · doi:10.18632/oncotarget.23578 · Cited by 51 · see citing works
Ciszewski, W. M., Sobierajska, K., Wawro, M. E., Kłopocka, W., Chefczyńska, N., Muzyczuk, A., Siekacz, K., Wujkowska, A., & Niewiarowska, J. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2017.09.004 · Cited by 50 · see citing works
Nwani, N. G., Deguiz, M. L., Jiménez, B., Vinokour, E. I., Dubrovskyi, O., Ugolkov, A. V., Mazar, A. P., & Volpert, O. V. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2468 · Cited by 49 · see citing works
Liu, J., Dong, F., Jeong, J., Masuda, T., & Lobe, C. G. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1818 · Cited by 48 · see citing works
Mintet, E., Rannou, E., Buard, V., West, G. A., Guipaud, O., Tarlet, G., Sabourin, J., Benderitter, M., Fiocchi, C., Milliat, F., et al. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.04.028 · Cited by 48 · see citing works
Slug Is Associated With Tumor Metastasis and Angiogenesis in Ovarian Cancer
Gu, A., Jie, Y., Yao, Q., Zhang, Y., & Mingyan, E. (2016) · Reproductive Sciences · doi:10.1177/1933719116654989 · Cited by 46 · see citing works
Kim, S.-H., Song, Y., & Seo, H. R. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1050-1 · Cited by 46 · see citing works
Ferreira, F. U., de Souza, L. E. B., Thomé, C. H., Pinto, M. T., Origassa, C. S. T., Salustiano, S. G., Faça, V. M., Câmara, N. O. S., Kashima, S. H., & Covas, D. T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030458 · Cited by 45 · see citing works
Herrera, A., Herrera, M., Guerra‐Pérez, N., Galindo-Pumariño, C., Larriba, M. J., García‐Barberán, V., Gil, B., Giménez-Moyano, S., Ferreiro, R., Veguillas, P., et al. (2018) · Oncogenesis · doi:10.1038/s41389-018-0085-z · Cited by 44 · see citing works
Sniegon, I., Prieß, M., Heger, J., Schulz, R., & Euler, G. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112290 · Cited by 41 · see citing works
Mintet, E., Lavigne, J., Paget, V., Tarlet, G., Buard, V., Guipaud, O., Sabourin, J., Iruela‐Arispe, M. L., Milliat, F., & François, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-05389-8 · Cited by 38 · see citing works
Isobe, S., Kataoka, M., Endo, J., Moriyama, H., Okazaki, S., Tsuchihashi, K., Katsumata, Y., Yamamoto, T., Shirakawa, K., Yoshida, N., et al. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2018-0231oc · Cited by 37 · see citing works
Marín‐Ramos, N. I., Jhaveri, N., Thein, T. Z., Fayngor, R. A., Chen, T. C., & Hofman, F. M. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.10.034 · Cited by 34 · see citing works
Wawro, M. E., Chojnacka, K., Wieczorek, K., Sobierajska, K., & Niewiarowska, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010053 · Cited by 33 · see citing works
Ishii, K., Mizokami, A., Tsunoda, T., Iguchi, K., Kato, M., Hori, Y., Arima, K., Namiki, M., & Sugimura, Y. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23291 · Cited by 32 · see citing works
Valproic Acid Induces Endothelial-to-Mesenchymal Transition-Like Phenotypic Switching
Murugavel, S., Bugyei‐Twum, A., Matkar, P. N., Al-Mubarak, H., Chen, H. H., Adam, M., Jain, S., Narang, T., Abdin, R., Qadura, M., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00737 · Cited by 31 · see citing works
Kamato, D., Rostam, M. A., Piva, T. J., Babaahmadi‐Rezaei, H., Getachew, R., Thach, L., Bernard, R., Zheng, W., Little, P. J., & Osman, N. (2014) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12298 · Cited by 30 · see citing works
GATA4-Twist1 Signalling in Disturbed Flow-Induced Atherosclerosis
Mahmoud, M. M., Souilhol, C., Serbanovic‐Canic, J., & Evans, P. C. (2019) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-019-06863-3 · Cited by 25 · see citing works
Patschan, D., Schwarze, K., Henze, E., Patschan, S. A., & Muller, G. A. (2016) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00306.2015 · Cited by 24 · see citing works
Rani, P., Stringa, E., Dharmavaram, R. M., Chatterjee, D., Tuan, R. S., & Khillan, J. S. (1999) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199901)214:1 · Cited by 20 · see citing works
Frías, A., Lambies, G., Viñas-Castells, R., Martínez-Guillamon, C., Dave, N., de Herreros, A. G., & Diaz, V. M. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.01074-15 · Cited by 20 · see citing works
Staff, T. P. O. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123845 · Cited by 19 · see citing works
Multiple growth factor mRNAS are expressed in chicken adipocyte precursor cells
Burt, D. W., Jm, B., Paton, I. R., & Butterwith, S. C. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)90444-p · Cited by 17 · see citing works
Zhou, C., Moustafa, M., Cao, L., Kriegsmann, M., Winter, M., Schwager, C., Jones, B., Wang, S., Bäuerle, T., Zhou, P., et al. (2018) · International Journal of Cancer · doi:10.1002/ijc.32059 · Cited by 16 · see citing works
Reversibility of the Snail-induced epithelial–mesenchymal transition revealed by the Cre–loxP system
Ozawa, M., & Kobayashi, W. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.02.012 · Cited by 15 · see citing works
Alterations in SCAI Expression during Cell Plasticity, Fibrosis and Cancer
Gasparics, Á., Kökény, G., Fintha, A., Bencs, R., Mozes, M. M., Ágoston, E. I., Buday, A., Ivics, Z., Hamar, P., Győrffy, B., et al. (2017) · Pathology & Oncology Research · doi:10.1007/s12253-017-0293-4 · Cited by 14 · see citing works
Ungefroren, H. (2019) · Cancers · doi:10.3390/cancers11030384 · Cited by 14 · see citing works
Nachmany, I., Bogoch, Y., Friedlander-Malik, G., Amar, O., Bondar, E., Zohar, N., Hantisteanu, S., Fainaru, O., Lubezky, N., Klausner, J. M., et al. (2019) · Genes and Immunity · doi:10.1038/s41435-019-0062-3 · Cited by 7 · see citing works
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Kumar, V., Ramnarayanan, K., Sundar, R., Padmanabhan, N., Srivastava, S., Koiwa, M., Yasuda, T., Koh, V., Huang, K. K., Tay, S. T., et al. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0683 · Cited by 573 · see citing works
TGF-β-Induced Endothelial to Mesenchymal Transition in Disease and Tissue Engineering
Ma, J., Sánchez‐Duffhues, G., Goumans, M., & ten Dijke, P. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00260 · Cited by 246 · see citing works
Single-cell atlas of the human brain vasculature across development, adulthood and disease
Wälchli, T., Ghobrial, M., Schwab, M., Takada, S., Zhong, H., Suntharalingham, S., Vetiska, S., Rodríguez, D. G., Wu, R., Rehrauer, H., et al. (2024) · Nature · doi:10.1038/s41586-024-07493-y · Cited by 199 · see citing works
Endothelial cells in tumor microenvironment: insights and perspectives
Leone, P., Malerba, E., Susca, N., Favoino, E., Perosa, F., Brunori, G., Prete, M., & Racanelli, V. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1367875 · Cited by 146 · see citing works
Endothelial-to-mesenchymal transition in anticancer therapy and normal tissue damage
Choi, K. J., Nam, J.-K., Kim, J.-H., Choi, S., & Lee, Y. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0439-4 · Cited by 112 · see citing works
EPISCORE: cell type deconvolution of bulk tissue DNA methylomes from single-cell RNA-Seq data
Teschendorff, A. E., Zhu, T., Breeze, C. E., & Beck, S. (2020) · Genome biology · doi:10.1186/s13059-020-02126-9 · Cited by 111 · see citing works
Endothelial cell plasticity at the single-cell level
Pasut, A., Becker, L. M., Cuypers, A., & Carmeliet, P. (2021) · Angiogenesis · doi:10.1007/s10456-021-09797-3 · Cited by 98 · see citing works
Troletti, C. D., Fontijn, R. D., Gowing, E., Charabati, M., Hof, B. V. H., Didouh, I., van der Pol, S. M. A., Geerts, D., Prat, A., van Horssen, J., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-018-1294-2 · Cited by 94 · see citing works
Sampson, N., Brunner, E., Weber, A., Puhr, M., Schäfer, G., Szyndralewiez, C., & Klocker, H. (2018) · International Journal of Cancer · doi:10.1002/ijc.31316 · Cited by 81 · see citing works
Metabolic Signatures of Distinct Endothelial Phenotypes
Dumas, S. J., García‐Caballero, M., & Carmeliet, P. (2020) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2020.05.009 · Cited by 80 · see citing works
Kang, E., Seo, J., Yoon, H., & Cho, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073591 · Cited by 78 · see citing works
Tumor Vessels Fuel the Fire in Glioblastoma
Rosińska, S., & Gavard, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126514 · Cited by 77 · see citing works
Lin, P. P. (2020) · Cells · doi:10.3390/cells9061539 · Cited by 76 · see citing works
Khouzam, R. A., Zaarour, R. F., Brodaczewska, K. K., Azakir, B., Venkatesh, G. H., Thiery, J., Terry, S., & Chouaı̈b, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.828875 · Cited by 80 · see citing works
Cancer-on-chip models for metastasis: importance of the tumor microenvironment
Jouybar, M., de Winde, C. M., Wolf, K., Friedl, P., Mebius, R. E., & den Toonder, J. M. J. (2024) · Trends in Biotechnology · doi:10.1016/j.tibtech.2023.10.001 · Cited by 66 · see citing works
Kanno, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021796 · Cited by 67 · see citing works
The hallmarks of severe pulmonary arterial hypertension: the cancer hypothesis—ten years later
Cool, C. D., Kuebler, W. M., Bogaard, H. J., Spiekerkoetter, E. F., Nicolls, M. R., & Voelkel, N. F. (2020) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00476.2019 · Cited by 64 · see citing works
Watabe, T., Takahashi, K., Pietras, K., & Yoshimatsu, Y. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.04.007 · Cited by 62 · see citing works
Osman, A., Afify, S. M., Hassan, G., Fu, X., Seno, A., & Seno, M. (2020) · Cancers · doi:10.3390/cancers12040879 · Cited by 62 · see citing works
Extracellular Vesicles Are Key Regulators of Tumor Neovasculature
Kuriyama, N., Yoshioka, Y., Kikuchi, S., Azuma, N., & Ochiya, T. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.611039 · Cited by 59 · see citing works
Gu, S., Liu, Y., Zou, J., Wang, W., Wei, T., Wang, X., Zhu, L., Zhang, M., Zhu, J., Xie, T., et al. (2020) · Experimental Eye Research · doi:10.1016/j.exer.2020.108271 · Cited by 59 · see citing works
Transforming Growth Factor-β: An Agent of Change in the Tumor Microenvironment
Stuelten, C. H., & Zhang, Y. E. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.764727 · Cited by 57 · see citing works
Angiogenesis and targeted therapy in the tumour microenvironment: From basic to clinical practice
Yang, S., Fang, Y., Ma, Y., Wang, F., Wang, Y., Jia, J., Yang, Y., Sun, W., Zhou, Q., & Li, Z. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70313 · Cited by 56 · see citing works
A bi-directional dialog between vascular cells and monocytes/macrophages regulates tumor progression
Delprat, V., & Michiels, C. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-09958-2 · Cited by 51 · see citing works
Endothelial-to-Mesenchymal Transition: Role in Cardiac Fibrosis
Cheng, W., Li, X., Liu, D., Cui, C., & Wang, X. (2020) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248420952233 · Cited by 45 · see citing works
Transforming growth factor-β in tumour development
Trelford, C. B., Dagnino, L., & Guglielmo, G. M. D. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.991612 · Cited by 43 · see citing works
To be or not to be: endothelial cell plasticity in development, repair, and disease
Greenspan, L. J., & Weinstein, B. M. (2021) · Angiogenesis · doi:10.1007/s10456-020-09761-7 · Cited by 44 · see citing works
Sun, Z., Zhao, H., Fang, D., Davis, C. T., Shi, D., Lei, K., Rich, B. E., Winter, J. M., Guo, L., Sorensen, L. K., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.07.015 · Cited by 42 · see citing works
Resident vascular endothelial progenitor definition and function: the age of reckoning
Dight, J., Zhao, J., Styke, C., Khosrotehrani, K., & Patel, J. (2021) · Angiogenesis · doi:10.1007/s10456-021-09817-2 · Cited by 39 · see citing works
Cadherin Signaling in Cancer and Autoimmune Diseases
Sisto, M., Ribatti, D., & Lisi, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413358 · Cited by 37 · see citing works
Liu, J., Yu, X., Braucht, A., Smith, S., & Wang, C. (2024) · ACS Nano · doi:10.1021/acsnano.3c12281 · Cited by 34 · see citing works
Wawro, M. E., Chojnacka, K., Wieczorek, K., Sobierajska, K., & Niewiarowska, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010053 · Cited by 33 · see citing works
Zhang, T., Zhang, L., Gao, Y. J., Wang, Y., Liu, Y., Zhang, H., Wang, Q., Hu, F., Li, J., Tan, J., et al. (2021) · Molecular Oncology · doi:10.1002/1878-0261.13092 · Cited by 33 · see citing works
Fonta, C. M., Loustau, T., Li, C., Surendran, S. P., Hansen, U. J., Murdamoothoo, D., Benn, M. C., Velázquez-Quesada, I., Carapito, R., Orend, G., et al. (2023) · Matrix Biology · doi:10.1016/j.matbio.2023.01.002 · Cited by 28 · see citing works
Zhao, J., Zhao, C., Yang, F., Jiang, Z., Zhu, J., Yao, W., Pang, W., & Zhou, J. (2023) · Theranostics · doi:10.7150/thno.84427 · Cited by 27 · see citing works
Yin, Z., & Wang, L. (2023) · Annals of Medicine · doi:10.1080/07853890.2023.2180155 · Cited by 26 · see citing works
Cooke, J. P., & Lai, L. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115118 · Cited by 25 · see citing works
Gonzales, J., Holbert, K., Czysz, K., George, J. T., Fernandes, C., & Fraidenburg, D. R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094763 · Cited by 23 · see citing works
Adnani, L., Spinelli, C., Tawil, N., & Rak, J. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.11.003 · Cited by 21 · see citing works
Bourreau, C., Treps, L., Faure, S., Fradin, D. D., & Clere, N. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108347 · Cited by 19 · see citing works
Self-citationShifting Shapes: The Endothelial-to-Mesenchymal Transition as a Driver for Cancer Progression
Giordanengo, L., Proment, A., Botta, V., Picca, F., Munir, H., Tao, J., Olivero, M., Taulli, R., Bersani, F., Sangiolo, D., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136353 · Cited by 20 · see citing works
Obesity-Related Fatty Acid and Cholesterol Metabolism in Cancer-Associated Host Cells
Ye, Y., Sun, X., & Lu, Y. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.600350 · Cited by 18 · see citing works
Hu, B., Gong, Y., Wang, Y., Xie, J., Cheng, J. Q., & Huang, Q. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.821454 · Cited by 18 · see citing works
Molecular atlas of the human brain vasculature at the single-cell levelPreprint
Wälchli, T., Ghobrial, M., Schwab, M., Takada, S., Zhong, H., Suntharalingham, S., Vetiska, S., Rodrigues, D. R., Rehrauer, H., Wu, R., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.18.464715 · Cited by 16 · see citing works
Ciccone, V., Filippelli, A., Bacchella, C., Monzani, E., & Morbidelli, L. (2022) · Cancers · doi:10.3390/cancers14174240 · Cited by 15 · see citing works
Endothelial-to-Mesenchymal Transition: Potential Target of Doxorubicin-Induced Cardiotoxicity
Feng, J., & Wu, Y. (2023) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-023-00573-w · Cited by 16 · see citing works
Slenders, L., Wesseling, M., Wei, S., Boltjes, A., Kapteijn, D., van der Kraak, P. H., Depuydt, M. A. C., Prange, K. H. M., van den Dungen, N. A. M., Benavente, E. D., et al. (2025) · Vascular Pharmacology · doi:10.1016/j.vph.2025.107498 · Cited by 15 · see citing works
ZC3H4 mediates silica-induced EndoMT via ER stress and autophagy
Jiang, R., Han, L., Gao, Q., & Chao, J. (2021) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2021.103605 · Cited by 15 · see citing works
Deluque, A. L., Oliveira, B. M., Souza, C. S., Maciel, A. L. D., Francescato, H. D. C., da Silva, C. G. A., de Almeida, L. F., de Paula, F. J. A., Costa, R. S., Antunes‐Rodrigues, J., et al. (2022) · Nutrients · doi:10.3390/nu14245316 · Cited by 15 · see citing works
Alternative Strategies to Inhibit Tumor Vascularization
Brossa, A., Buono, L., Fallo, S., Fiorio, A., Munaron, L., & Bussolati, B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246180 · Cited by 15 · see citing works
SUMOylation of Smad2 mediates TGF-β-regulated endothelial–mesenchymal transition
Su, Q., Chen, X., Ling, X., Li, D., Ren, X., Zhao, Y., Yang, Y., Liu, Y., He, A., Zhu, X., et al. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105244 · Cited by 14 · see citing works
Andreucci, E., Bugatti, K., Peppicelli, S., Ruzzolini, J., Lulli, M., Calorini, L., Battistini, L., Zanardi, F., Sartori, A. M., & Bianchini, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021475 · Cited by 13 · see citing works
Choi, S., Jang, J., Kim, Y., Park, C. G., Lee, S. Y., Kim, H.-J., & Kim, H. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06678-7 · Cited by 13 · see citing works
Metastatic Breast Cancer, Organotropism and Therapeutics: A Review
Waza, A. A., Tarfeen, N., Majid, S., Hassan, Y., Mir, R., Rather, M. Y., & Shah, N. U. D. (2021) · Current Cancer Drug Targets · doi:10.2174/1568009621666210806094410 · Cited by 13 · see citing works
Changchien, C., Chang, H., Dai, M., Tsai, W., Tsai, H., Wang, C., Shen, M., Cheng, L., Lee, H., Chen, Y., et al. (2020) · Cancer Science · doi:10.1111/cas.14772 · Cited by 12 · see citing works
Lu, Q., Ma, J., Zhao, Y., Ding, G., Wang, Y., Qiao, X., & Cheng, X. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117521 · Cited by 11 · see citing works
Verloy, R., Privat‐Maldonado, A., Audenaerde, J. R. M. V., Rovers, S., Zaryouh, H., Waele, J. D., Quatannens, D., Peeters, D. J. E., Roeyen, G., Deben, C., et al. (2025) · Cells · doi:10.3390/cells14060450 · Cited by 11 · see citing works
MEF2C and miR-194-5p: New Players in Triple Negative Breast Cancer Tumorigenesis
Caetano, S., Garcia, A. R., Figueira, I., & Brito, M. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814297 · Cited by 10 · see citing works
Metastasis prevention: How to catch metastatic seeds
Gerashchenko, T. S., Schegoleva, A. A., Khozyainova, A. A., Чойнзонов, Е. Л., & Denisov, E. V. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188867 · Cited by 9 · see citing works
Pham, T. P., van Bergen, A. S., Kremer, V., Glaser, S.-F., Dimmeler, S., & Boon, R. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158088 · Cited by 9 · see citing works
Platel, V., Lechevalier, D., Bourreau, C., Renault, S., Šoborová, I., Jeannière, C., Martin, L., Hérault, O., Corre, I., & Clere, N. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106097 · Cited by 9 · see citing works
Self-citationXie, J., Hu, B., Gong, Y., He, S., Lin, J., Huang, Q., & Cheng, J. Q. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04746-8 · Cited by 8 · see citing works
Single-cell analysis revealing the metabolic landscape of prostate cancer
Wang, J., Ding, H.-K., Xu, H., Hu, D.-K., Hankey, W., Chen, L., Xiao, J., Liang, C.-Z., Zhao, B. Q., & Xu, L. (2024) · Asian Journal of Andrology · doi:10.4103/aja20243 · Cited by 8 · see citing works
Smęda, M., Jasztal, A., Maleki, E. H., Bar, A., Sternak, M., Kwiatkowski, G., Suraj, J., Proniewski, B., Kieronska‐Rudek, A., Wojnar‐Lason, K., et al. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1050112 · Cited by 7 · see citing works
Mikula, M. W., Najjar, S. N., Jabbour, T. E., Dalvi, S., Umrau, K., Li, H., Koo, B. H., & Lee, H. (2020) · Applied immunohistochemistry & molecular morphology · doi:10.1097/pai.0000000000000888 · Cited by 7 · see citing works
Far-Infrared Therapy Decreases Orthotopic Allograft Transplantation Vasculopathy
Lin, Y.-W., Tsai, C., Huang, C., Tsai, Y., Shih, C.-M., Lin, S., Li, C., Lin, C., Sung, S.-Y., & Lin, F. (2022) · Biomedicines · doi:10.3390/biomedicines10051089 · Cited by 7 · see citing works
Crestani, M., Gerber, I., Miéville, A., Frauenknecht, K. B. M., Maragkou, T., Hortobágyi, T., & Viola Vogel, B. (2025) · Advanced Science · doi:10.1002/advs.202416526 · Cited by 6 · see citing works
Bourreau, C., Navarro, E., Cotinat, M., Krejbich, M., Guillonneau, F., Guette, C., Boissard, A., Henry, C., Corre, I., Treps, L., et al. (2025) · Cancer Medicine · doi:10.1002/cam4.70707 · Cited by 6 · see citing works
Self-citationLin, F., Lin, Y., Shih, C., Lin, S., Tung, Y., Li, C., Chen, Y., Lin, C.-Y., Tsai, Y.-T., & Huang, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105210 · Cited by 6 · see citing works
ADP-Ribosylation Factor 6 Pathway Acts as a Key Executor of Mesenchymal Tumor Plasticity
Hashimoto, A., & Hashimoto, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914934 · Cited by 6 · see citing works
New insights into the pathogenesis of cardiac papillary fibroelastomas
Matysiak, N., Mielańczyk, Ł., Kaczmarek, K., Zaba, M., Reichman-Warmusz, E., & Wojnicz, R. (2021) · Folia Histochemica et Cytobiologica · doi:10.5603/fhc.a2021.0027 · Cited by 5 · see citing works
Kageyama, T., Kato, M., Miyachi, S., Bao, X., Sekito, S., Sugino, Y., Higashi, S., Sasaki, T., Nishikawa, K., Murakawa, Y., et al. (2025) · Cancer Science · doi:10.1111/cas.70144 · Cited by 4 · see citing works
Kim, J. S., Choi, W., Kim, H. I., Chung, S. W., Choi, J., Lee, D., & Kim, K. M. (2025) · Journal of Liver Cancer · doi:10.17998/jlc.2024.12.27 · Cited by 6 · see citing works
Saha, D., Annadorai, R. K., Thannimangalath, S., Shroff, N. P., Kataria, S., Dam, B., Dutta, A., Hegde, A., Hiwale, A. A., Ravula, V., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci177123 · Cited by 3 · see citing works
Campbell, I., Glinka, M., Shaban, F., Kirkwood, K. J., Nadalin, F., Adams, D. J., Papatheodorou, I., Burger, A., Baldock, R., Arends, M. J., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12123884 · Cited by 3 · see citing works
Molecular and therapeutic bases of cancer
Fajardo-Orduña, G. R., & Chamorro-Plata, D. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819828-5.00002-4 · Cited by 3 · see citing works
Cell-Type Heterogeneity in DNA Methylation Studies: Statistical Methods and Guidelines
Teschendorff, A. E. (2022) · Springer eBooks · doi:10.1007/978-3-030-94475-9_4 · Cited by 2 · see citing works
Tsai, C., Huang, C., Tsai, Y., Shih, C., Lai, Z., Liu, C., Lin, Y., & Lin, F. (2024) · Molecular Oral Microbiology · doi:10.1111/omi.12453 · Cited by 3 · see citing works
Chiang, K., Chang, W.-J., Liu, Y., Lin, H.-L., Lin, C., Chiou, T., Wu, H., & Tung, Y. (2025) · Sensors and Actuators Reports · doi:10.1016/j.snr.2025.100396 · Cited by 2 · see citing works
Zhao, S., Liu, S., Shao, W., & Liu, D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262211128 · Cited by 3 · see citing works
Verloy, R., Peeters, E., Privat‐Maldonado, A., Rovers, S., Lau, H. W., Brants, L., Hermans, C., Waele, J. D., Deben, C., Smits, E., et al. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-01241-9 · Cited by 2 · see citing works
Francescato, R., Moretti, M., & Bersini, S. (2024) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10644 · Cited by 2 · see citing works
Zhuo, D., Mei, Y., Lin, C., Wu, A., Luo, Y., Lu, H., & Fu, J. (2024) · Journal of Cancer · doi:10.7150/jca.91566 · Cited by 2 · see citing works
Mirata, S., Almonti, V., Passalacqua, M., Vernazza, S., Bassi, A. M., Giuseppe, D. D., Gualtieri, A. F., & Scarfı̀, S. (2024) · Toxicology · doi:10.1016/j.tox.2024.154032 · Cited by 2 · see citing works
Pericytes Relationship with Cancer Stem Cells in the Colon
Garza-Treviño, E. N., González, P. D., Salgado, C. I. V., & Garcia, J. L. O. (2020) · Current Tissue Microenvironment Reports · doi:10.1007/s43152-020-00015-8 · Cited by 2 · see citing works
Shahriar, S., Biswas, S., Zhao, K., Akcan, U., Tuohy, M. C., Glendinning, M. D., Kurt, A., Wayne, C. R., Prochilo, G., Price, M. Z., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.15.516660 · Cited by 2 · see citing works
Tucureanu, M. M., & Mânduțeanu, I. (2025) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70835 · Cited by 1 · see citing works
Endothelial Notch1 drives multicellular remodelling during hyaloid vessel regression
Khazaal, S., Sango, A.-R., zouine, K., Silva, A., Megne, A. V., Chidiac, R., Bora, K., Mawambo, G., Chen, J., & Oubaha, M. (2026) · Angiogenesis · doi:10.1007/s10456-026-10062-8 · Cited by 1 · see citing works
Lorente-Herraiz, L., Cuesta, Á. M., Recio-Poveda, L., Botella, L. M., & Albiñana, V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116163 · Cited by 1 · see citing works
Kiéda, C., Wilkus, K., & Szczylik, C. A. (2022) · Onco Therapeutics · doi:10.1615/oncotherap.2022042541 · Cited by 1 · see citing works
Xie, J., Ruan, Z., Zheng, J., Gong, Y., Wang, Y., Hu, B., Cheng, J. Q., & Huang, Q. (2021) · Preprints.org · doi:10.20944/preprints202101.0129.v1 · Cited by 1 · see citing works
Verloy, R., Privat‐Maldonado, A., Audenaerde, J. R. M. V., Rovers, S., Zaryouh, H., Waele, J. D., Deben, C., Smits, E., & Bogaerts, A. (2024) · Research Square · doi:10.21203/rs.3.rs-3788739/v1
Koudstaal, T., Bogaard, H. J., & Boomars, K. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-822951-4.00019-9
Kosmac, K., Joshi, J. K., McDermott, M. M., Stewart, J. C., Zhang, D., Xu, S., Ho, K. J., Sufit, R. L., Ferrucci, L., Peterson, C. A., et al. (2025) · JVS Vascular Science · doi:10.1016/j.jvssci.2025.100294
Xie, J., Hu, B., Gong, Y., He, S., Lin, J., Huang, Q., & Cheng, J. (2024) · Figshare · doi:10.6084/m9.figshare.26648220
Xie, J., Hu, B., Gong, Y., He, S., Lin, J., Huang, Q., & Cheng, J. (2024) · Figshare · doi:10.6084/m9.figshare.26648217
Xie, J., Hu, B., Gong, Y., He, S., Lin, J., Huang, Q., & Cheng, J. (2024) · Figshare · doi:10.6084/m9.figshare.26648223
- Authors
- Platel, V., Faure, S., Corre, I., & Clere, N.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Corresponding author
- Corre, Isabelle
- Clere, Nicolas
- Venue
- Journal of Oncology
- Publisher
- Wiley
- Published
- 2019-08-01
- Volume
- 2019
- Pages
- 1-13
- ISSN
- 1687-8450 (ISSN-L)
- 1687-8469
- PMC
- PMC6701373
- OpenAlex
- W2953419714
- Cited by
- 101
- References
- 131
- Citations by year
- 2026: 2 · 2025: 14 · 2024: 16 · 2023: 17 · 2022: 14 · 2021: 18 · 2020: 16 · 2019: 2 · 2018: 2
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Oncology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Région Pays de la Loire
- Comité départemental du Maine et Loire de la Ligue contre le Cancer
- Comité départemental de Loire Atlantique de la Ligue contre le Cancer
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- endothelial-to-mesenchymal transition, endothelial cells, cellular plasticity, carcinogenesis, metastasis, cancer therapy resistance, tumor microenvironment, tumor angiogenesis, TGF-beta, mesenchymal differentiation
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