Activation of STAT3 is a marker of poor prognosis in human colorectal cancer

Kusaba, Takafumi, Nakayama, Toshiyuki, Yamazumi, Kazuyuki, Yakata, Yuichi, Yoshizaki, Ayumi, Inoue, Kenichiro, Nagayasu, Takeshi, Sekine, Ichiro·2006·Oncology Reports

DOI 10.3892/or.15.6.1445

Cited by (238)

Items 101–200 of 238

Prognostic Role of Phospho-STAT3 in Patients with Cancers of the Digestive System: A Systematic Review and Meta-Analysis
Mu-xing Li, Xin-Yu Bi, Zhen Huang, Jian-jun Zhao, Yue Han, Zhi-yu Li, Ye-fan Zhang, Yuan Li, Xiao Chen, Xu-hui Hu et al. · 2015 · PLoS ONE
Relationship between expression and prognostic ability of PTEN, STAT3 and VEGF-C in colorectal cancer
Canhui Jin, Aihong Wang, JIANMIN CHEN, Xiao-Min Liu, Gongping Wang · 2012 · Experimental and Therapeutic Medicine
Pharmacological Targeting SHP-1-STAT3 Signaling Is a Promising Therapeutic Approach for the Treatment of Colorectal Cancer
Li-Ching Fan, Hao‐Wei Teng, Chung‐Wai Shiau, Wei‐Tien Tai, Man‐Hsin Hung, Shung-Haur Yang, Jeng‐Kai Jiang, Kuen‐Feng Chen · 2015 · Neoplasia
MPC1 deficiency accelerates lung adenocarcinoma progression through the STAT3 pathway
Hongbo Zou, Qian Chen, Anmei Zhang, Songtao Wang, Hong Wu, Ye Yuan, Shuang Wang, Jing Hong Yu, Mao Luo, Xianmei Wen et al. · 2019 · Cell Death and Disease
Role of tumor microenvironment in the regulation of PD‐L1: A novel role in resistance to cancer immunotherapy
Nirvana Kalantari Khandani, Atefeh Ghahremanloo, Seyed Isaac Hashemy · 2020 · Journal of Cellular Physiology
Blockade of IL-6 inhibits tumor immune evasion and improves anti-PD-1 immunotherapy.
Wen-Yi Li, Zhaokun Wu, Weidong Meng, Chao-Ting Zhang, Ming-Zhen Cheng, Yue-Hong Chen, Yini Zou, Ke-Jun Li, S. Lin, Wenjun Xiong et al. · 2022 · Cytokine
The role of protein tyrosine phosphatases in colorectal cancer
Elmer Hoekstra, Maikel Petrus Peppelenbosch, Gwenny Manel Fuhler · 2012 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Prognostic value of phosphorylated STAT3 in advanced rectal cancer: a study from 104 French patients included in the EORTC 22921 trial
Franck Monnien, Harouna Mahamadou Zaki, Christophe Borg, Christiane Mougin, Jean-François Bosset, Mariette Mercier, Francine Arbez‐Gindre, Bernadette M. Kantelip · 2010 · Journal of Clinical Pathology
Allosteric inhibitors of the STAT3 signaling pathway
Junhong Qin, Xiaofei Shen, Jian Zhang, Da Jia · 2020 · European Journal of Medicinal Chemistry
Novel Histopathological Biomarkers in Prostate Cancer: Implications and Perspectives
Paweł Kiełb, Kamil Kowalczyk, Adam Gurwin, Łukasz Nowak, Wojciech R. Krajewski, Roman Sosnowski, Tomasz Szydełko, Bartosz Małkiewicz · 2023 · Biomedicines
The prognostic significance of STAT3 in invasive breast cancer: analysis of protein and mRNA expressions in large cohorts
Mohammed A. Aleskandarany, Devika Agarwal, Ola H. Negm, Graham Ball, Ahmed Elmouna, Ibraheem Ashankyty, Edem Nuglozeh, Mohammad Feroze Fazaludeen, Maria Diez, Christopher C. Nolan et al. · 2016 · Breast Cancer Research and Treatment
SLCO1B3 promotes colorectal cancer tumorigenesis and metastasis through STAT3
Lianghui Zhi, Lianmei Zhao, Xue Zhang, Wei Liu, Bo Gao, Feifei Wang, Xiaoran Wang, Guiying Wang · 2021 · Aging
Patrinia scabiosaefolia extract suppresses proliferation and promotes apoptosis by inhibiting the STAT3 pathway in human multiple myeloma cells
Sferra · 2011 · Molecular Medicine Reports
Napabucasin Plus FOLFIRI in Patients With Previously Treated Metastatic Colorectal Cancer: Results From the Open-Label, Randomized Phase III CanStem303C Study
Manish A. Shah, Takayuki Yoshino, Niall Christopher Tebbutt, Axel F. Grothey, Josep M. Tabernero, Rui‐Hua Xu, Andrès M.R. Cervantes, Sang Cheul Oh, Kensei Yamaguchi, Marwan Fakih et al. · 2022 · Clinical Colorectal Cancer
Expression of phosphorylated Stat5 predicts expression of cyclin D1 and correlates with poor prognosis of colonic adenocarcinoma
Yinling Mao, Zhiwei Li, Changjie Lou, Yanqiao Zhang · 2010 · International Journal of Colorectal Disease
IFITM3/STAT3 axis promotes glioma cells invasion and is modulated by TGF-β
Hongliang Wang, Feng Ru Tang, Erbao Bian, Yile Zhang, Xinghu Ji, Zhihao Yang, Bing Zhao · 2019 · Molecular Biology Reports
Nitidine chloride inhibits hepatic cancer growth via modulation of multiple signaling pathways
Jiumao Lin, Aling Shen, Hongwei Chen, Jun Liao, Teng Xu, Liya Liu, Jing Lin, Jun Peng · 2014 · BMC Cancer
DJ-1 promotes development of DEN-induced hepatocellular carcinoma and proliferation of liver cancer cells
Bijun Qiu, Junqi Wang, Yingxue Yu, Zhen Chao, Jinyang Gu, Wenjun Liu, Yankai Wen, Lili Chen, Yueqiu Gao, Qiang Xia et al. · 2016 · Oncotarget
Upregulation of phosphorylated sphingosine kinase 1 expression in colitis-associated cancer
Kizuki Yuza, Masayuki Nagahashi, Yoshifumi Shimada, Mae Nakano, Yosuke Tajima, Hitoshi Kameyama, Masato Nakajima, Kazuaki Takabe, Toshifumi Wakai · 2018 · Journal of Surgical Research
Hedyotis diffusa willd extract suppresses colorectal cancer growth through multiple cellular pathways
Jianyu Feng, Yiyi Jin, Jun Peng, Lihui Wei, Qiaoyan Cai, Zhaokun Yan, Zijun Lai, Jiumao Lin · 2017 · Oncology Letters
STAT3 Signaling in Cancer
Ioannis Gkouveris, Nikolaos G. Nikitakis, John J. Sauk · 2015 · Journal of Cancer Therapy
Overcoming Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutated Tumours
Emily L. Paton, Jacqueline A. Turner, Isabel R. Schlaepfer · 2020 · Journal of Oncology
Novel Morphologic and Genetic Analysis of Cancer Cells in a 3D Microenvironment Identifies STAT3 as a Regulator of Tumor Permeability Barrier Function
Min‐Chul Park, Hyobin Jeong, Sung Hwa Son, YounHa Kim, Daeyoung Han, Peter C. Goughnour, Taehee Kang, Nam Hoon Kwon, Hyo Eun Moon, Sun Ha Paek et al. · 2015 · Cancer Research
STAT3 silencing enhances the efficacy of the HSV.tk suicide gene in gastrointestinal cancer therapy
Ye-Hyeon Ahn, Hwajung Yi, Ji-Young Shin, Kang-Duck Lee, Seung-Pil Shin, Sang-Jin Lee, Jaewhan Song, Kyung‐Hee Chun · 2012 · Clinical & Experimental Metastasis
Interplay of miRNAs and lncRNAs in STAT3 signaling pathway in colorectal cancer progression
Omid Rahbar Farzam, Souzan Najafi, Mohammad Ali Amini, Zohreh Rahimi, Reza Dabbaghipour, Omid Zohdi, Ghazale Asemani Shahgoli, Behzad Baradaran, Bahman Akbari · 2024 · Cancer Cell International
PAC exhibits potent anti‐colon cancer properties through targeting cyclin D1 and suppressing epithelial‐to‐mesenchymal transition
Abeer J. Al-Qasem, Huda A. Al‐Howail, Mashael Al‐Swailem, Amer Al‐Mazrou, Basem Al‐Otaibi, Ibrahim Al‐Jammaz, Huda H. Al‐Khalaf, Abdelilah Aboussekhra · 2015 · Molecular Carcinogenesis
A systems biology approach to the global analysis of transcription factors in colorectal cancer
Meeta P. Pradhan, Nagendra K. Prasad, Mathew J. Palakal · 2012 · BMC Cancer
High JAK2 Protein Expression Predicts a Poor Prognosis in Patients with Resectable Pancreatic Ductal Adenocarcinoma
Song Tao Yang, Meiyue Tang, Wei Chen, Zhe Wang, Si-Liang Wang · 2020 · Disease Markers
EGFR signaling pathway occupies an important position in cancer‐related downstream signaling pathways of Pyk2
Ting Shen, Qiang Guo · 2019 · Cell Biology International
Targeted activation of Stat3 in combination with paclitaxel results in increased apoptosis in epithelial ovarian cancer cells and a reduced tumour burden
Hongyi Li, Yanping Qian, Xi Wang, Ruyu Pi, Xia Zhao, Xiawei Wei · 2019 · Cell Proliferation
Robust Prognostic Subtyping of Muscle-Invasive Bladder Cancer Revealed by Deep Learning-Based Multi-Omics Data Integration
Zhang, Xiaolong, Wang, Jiayin, Lu, Jiabin, Su, Lili, Wang, Changxi, Huang, Yuhua, Zhang, Xuanping, Zhu, Xiaoyan · 2021 · Frontiers in Oncology
Activated STAT3 may participate in tumor progression through increasing CD133/survivin expression in early stage of colon cancer
Wanlu Li, Mi-Ra Lee, Taeyeong Kim, Young Wan Kim, Mee-Yon Cho · 2018 · Biochemical and Biophysical Research Communications
Genetic Interactions of STAT3 and Anticancer Drug Development
Bingliang Fang · 2014 · Cancers
Research progress of STAT3-based dual inhibitors for cancer therapy
Xiao-Juan Yang, Lu Xu, Li Yang, Shaohong Xu · 2023 · Bioorganic & Medicinal Chemistry
Bifidobacterium boosts anti-PD-1 effectiveness through JAK pathway in hepatocellular carcinoma
Ran Huo, Quan-Guo Xu, Yiqing You, Yanlin Chen, Guang-Jian Su, Kun-rong Yang, Yan-ping Xiao, Xue Zhong, Yang-jin Li, Pei Sun et al. · 2025 · npj Precision Oncology
Expressional STAT3/STAT5 Ratio is an Independent Prognostic Marker in Colon Carcinoma
Fee Klupp, Johannes Diers, Christoph Kahlert, Lena Neumann, Niels Halama, Clemens Franz, Thomas Schmidt, Felix Lasitschka, Arne Warth, Juergen Weitz et al. · 2015 · Annals of Surgical Oncology
Carnosic acid induces apoptosis through inactivation of Src/STAT3 signaling pathway in human renal carcinoma Caki cells
Ji Eun Park, Byoungduck Park, In Gyeong Chae, Do‐Hee Kim, Juthika Kundu, Joydeb Kumar Kundu, Kyung‐Soo Chun · 2016 · Oncology Reports
Posttranslational modifications as therapeutic targets for intestinal disorders
Jieun Choo, Gwangbeom Heo, Charalabos Pothoulakis, Eunok Im · 2021 · Pharmacological Research
Synthesis and Biological Evaluation of Novel N-phenyl-5-carboxamidyl Isoxazoles as Potential Chemotherapeutic Agents for Colon Cancer
Jiajiu Shaw, Ben Chen, Jean P. Bourgault, Hao Jiang, Narendra Kumar, Jayshree Mishra, Frederick A. Valeriote, Joe Media, Kevin R. Bobbitt, Halina Pietraszkiewicz et al. · 2012 · American Journal of Biomedical Sciences
The Immunohistochemical Expression of STAT3, Bcl-xL, and MMP-2 Proteins in Colon Adenoma and Adenocarcinoma
Seung Woo Lee, Young Yong Ahn, Yon Soo Kim, Sang Beum Kang, Soon Woo Nam, Dong Soo Lee, Hyun Yong Jeong, Jin‐Man Kim · 2012 · Gut and Liver
Retinoic acid-loaded PLGA nanocarriers targeting cell cholesterol potentialize the antitumour effect of PD-L1 antibody by preventing epithelial-mesenchymal transition mediated by M2-TAM in colorectal cancer
Raimundo Fernandes de Araújo Júnior, George Alexandre Lira, Timo Schomann, Rômulo S. Cavalcante, Natalia Feitosa Vilar, Regina C.M. de Paula, Raelle F. Gomes, Chih Kit Chung, Carla Jorquera‐Cordero, Olena Vepris et al. · 2023 · Translational Oncology
Significance of p-STAT3 expression in human colorectal adenocarcinoma
Parkash · 1994 · Oncology Reports
Comprehensive Gene Expression Analyses of Immunohistochemically Defined Subgroups of Muscle-Invasive Urinary Bladder Urothelial Carcinoma
Bohyun Kim, Insoon Jang, Kwangsoo Kim, Minsun Jung, Chul Lee, Jeong Hwan Park, Young A Kim, Kyung Chul Moon · 2021 · International Journal of Molecular Sciences
Inhibition of STAT3 Reduces Astrocytoma Cell Invasion and Constitutive Activation of STAT3 Predicts Poor Prognosis in Human Astrocytoma
Qinchuan Liang, Chenkai Ma, Zhao Yang, Guodong Gao, Jie Ma · 2013 · PLoS ONE
Phospho-flow detection of constitutive and cytokine-induced pSTAT3/5, pAKT and pERK expression highlights novel prognostic biomarkers for patients with multiple myeloma
Ross Duncan Brown, S Samuel Yang, Claire Weatherburn, John Gibson, Phoebe Joy Ho, Hayley Suen, Derek N.J. Hart, D. E. Joshua · 2014 · Leukemia
Chrysophanic Acid Induces Necrosis but not Necroptosis in Human Renal Cell Carcinoma Caki-2 Cells
Joon‐Seok Choi · 2016 · Journal of Cancer Prevention
Clinicopathological significance and prognostic role of p-STAT3 in patients with hepatocellular carcinoma
Chaojie Liang, Yingchen Xu, Hua Ge, Guangming Li, Jixiang Wu · 2018 · OncoTargets and Therapy
STAT3 and the STAT3‑regulated inhibitor of apoptosis protein survivin as potential therapeutic targets in colorectal cancer (Review)
Liliana Guadalupe Cortes-Ballinas, Tania V. López-Pérez, Leticia Rocha‐Zavaleta · 2024 · Biomedical Reports
Long non-coding RNAs (lncRNAs) in cancer development: new insight from STAT3 signaling pathway to immune evasion
Lie Ma, XuQing Liu, Rangaswamy Roopashree, Syeda Wajida Kazmi, Saade Abdalkareem Jasim, K. Phaninder Vinay, Ata Fateh, Fang Yang, Mansour Rajabivahid, Mahmoud Dehghani-Ghorbi et al. · 2025 · Clinical and Experimental Medicine
STAT3 inactivation suppresses stemness properties in gastric cancer stem cells and promotes Th17 in Treg/Th17 balance
Monireh Hajimoradi, Alaleh Rezalotfi, Parvaneh Esmaeilnejad-Ahranjani, Zuhair Mohammad Hassan, Marzieh Ebrahimi · 2022 · International Immunopharmacology
Hybridization Approach to Identify Salicylanilides as Inhibitors of Tubulin Polymerization and Signal Transducers and Activators of Transcription 3 (STAT3)
Marta Gargantilla, Leentje Persoons, Tereza Kauerová, Natalia del Río, Dirk Daelemans, Eva‐María Priego, Péter Kollár, María‐Jesús Pérez‐Pérez · 2022 · Pharmaceuticals
p66Shc promotes HCC progression in the tumor microenvironment via STAT3 signaling
Peixin Huang, Xuemei Feng, Zhiying Zhao, Biwei Yang, Tingting Fang, Mengzhou Guo, Jinglin Xia · 2019 · Experimental Cell Research
High expression of ALDH1A3 might independently influence poor progression‐free and overall survival in patients with glioma via maintaining glucose uptake and lactate production
Wei Min NI, Yaoxiong Xia, Lin Luo, Fan Wen, Dong Gui Hu, Yuxu Bi, Junhui Qi · 2019 · Cell Biology International
PHOSPHO-STAT5 Expression is Associated with Poor Prognosis of Human Colonic Adenocarcinoma
Yinling Mao, Zhi-Wei Li, Changjie Lou, Da Pang, Yanqiao Zhang · 2011 · Pathology & Oncology Research
High M2-TAM Infiltration and STAT3/NF-κB Signaling Pathway as a Predictive Factor for Tumor Progression and Death in Cervical Cancer
G. A. Lira, F. M. de Azevedo, Ingrid Gabrielle Dos Santos Lins, Isabelle de Lima Marques, G. A. Lira, C. Eich, R. D. de Araújo · 2024 · Cancers
Nutraceutical potential of polyphenol-rich Sargassum species grown off the Korean coast: a review
Chan Seo, Seung Jin Jeong, Hyun Jung Yun, Hye Ju Lee, Joo Won Lee, Hyun Woo An, Nara Han, Won‐Kyo Jung, Sang Gil Lee · 2022 · Food Science and Biotechnology
Suppressor of cytokine signaling 1 inhibits the maturation of dendritic cells involving the nuclear factor kappa B signaling pathway in the glioma microenvironment
Minghui He, Xi Chen, M Luo, L Ouyang, Lihui Xie, Ziye Huang, Anmin Liu · 2020 · Clinical & Experimental Immunology
Physalis alkekengi var. franchetii Extracts Exert Antitumor Effects on Non-Small Cell Lung Cancer and Multiple Myeloma by Inhibiting STAT3 Signaling
Yu‐Fei Fu, Fanfan Zhu, Zhongjun Ma, Bin Lü, Xi Wang, Chunyan Dai, Xiaoqiong Ma, Pei Liu, Hang Lv, Xin Chen et al. · 2021 · OncoTargets and Therapy
Lichen-Derived Depsides and Depsidones Modulate the Nrf2, NF-κB and STAT3 Signaling Pathways in Colorectal Cancer Cells
Katarzyna Papierska, Violetta Krajka‐Kuźniak, Jarosław Paluszczak, Robert Kleszcz, Marcin Skalski, Elżbieta Studzińska-Sroka, Wanda Baer‐Dubowska · 2021 · Molecules
STAT5 deficiency in hepatocytes reduces diethylnitrosamine-induced liver tumorigenesis in mice
Doris Kaltenecker, Madeleine Themanns, Kristina M. Mueller, Katrin Spirk, Nicole Golob‐Schwarzl, Katrin Friedbichler, Lukas Kenner, Johannes Haybaeck, Richard Moriggl · 2018 · Cytokine
The Unfolding Story of ATF6, Microbial Dysbiosis, and Colorectal Cancer
Sydney Lavoie, Wendy S. Garrett · 2018 · Gastroenterology
Impact of STAT-signaling pathway on cancer-associated fibroblasts in colorectal cancer and its role in immunosuppression
Damián Sánchez-Ramírez, Mónica Mendoza-Rodríguez, Omar Rafael Alemán, Fernando Candanedo-González, Miriam Rodríguez‐Sosa, Juan José Montesinos, Mauricio Salcedo, Ismael Brito-Toledo, Felipe Vaca‐Paniagua, Luis Ignacio Terrazas · 2024 · World Journal of Gastrointestinal Oncology
Microcystin-LR promotes migration via the cooperation between microRNA-221/PTEN and STAT3 signal pathway in colon cancer cell line DLD-1
Yan Ren, Mengli Yang, Rong Ma, Ying Gong, Yuntao Zou, Ting Wang, Jianzhong Wu · 2018 · Ecotoxicology and Environmental Safety
Overexpression of Jak2: A Predictor of Unfavorable Prognosis for Nasopharyngeal Carcinoma
Hong-Lin He, Ying-En Lee, Peir‐In Liang, Sung‐Wei Lee, Tzu‐Ju Chen, Ti‐Chun Chan, Chung‐Hsi Hsing, I‐Wei Chang, Yow‐Ling Shiue, Chien‐Feng Li · 2016 · Future Oncology
Identification of a Novel Quinoxaline-Isoselenourea Targeting the STAT3 Pathway as a Potential Melanoma Therapeutic
Verónica Alcolea, Deepkamal N. Karelia, Manoj Kumar Pandey, Daniel Plano, Parvesh Singh, Juan Antonio Palop, Shantu Amin, Carmen Sanmartín, Arun Kumar Sharma · 2019 · International Journal of Molecular Sciences
Development of natural product-based targeted protein degraders as anticancer agents
Cheng Chen, Yanyan Feng, Chen Zhou, Zhouyan Liu, Ziwei Tang, Ye Zhang, Tong Li, Chenglei Gu, Jichao Chen · 2024 · Bioorganic Chemistry
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Shalini Dimri, Sukanya Sukanya, Abhijit De · 2017 · Integrative Molecular Medicine
Prognostic significance of p‐STAT3 in patients with bulky cervical carcinoma undergoing neoadjuvant chemotherapy
Chel Hun Choi, Sang Yong Song, Heeseok Kang, Yoo-Young Lee, Chul‐Jung Kim, Jeong‐Won Lee, Tae‐Joong Kim, Byoung‐Gie Kim, Je–Ho Lee, Duk‐Soo Bae · 2010 · Journal of obstetrics and gynaecology research
Phosphorylated transducer and activator of transcription-3 (pSTAT3) immunohistochemical expression in paired primary and metastatic colorectal cancer
Esmeralda Celia Marginean, Joanna Gotfrit, Horia Marginean, Daniel W. Yokom, Justin Bateman, Manijeh Daneshmand, Shelly Sud, Allen M. Gown, Derek J. Jonker, Timothy R. Asmis et al. · 2020 · Translational Oncology
m6A-Mediated Tumor Invasion and Methylation Modification in Breast Cancer Microenvironment
Fei Liu, Xiaopeng Yu, Guijin He · 2021 · Journal of Oncology
Development and Validation of Ten-RNA Binding Protein Signature Predicts Overall Survival in Osteosarcoma
Jian Zhang, Xinxin Miao, Tianlong Wu, Jingyu Jia, Xigao Cheng · 2021 · Frontiers in Molecular Biosciences
Decursin inhibits tumor progression in head and neck squamous cell carcinoma by downregulating CXCR7 expressionin vitro
Mina Joo, Jong Beom Heo, Solbi Kim, Nayoung Kim, Heung Jin Jeon, Yueun An, Gyu‐Yong Song, Jin‐Man Kim, Hyo Jin Lee · 2021 · Oncology Reports
Nuclear Expression of p-STAT3 Is Associated with Poor Prognosis in ER(−) Breast Cancer
Tsuyoshi Nakagawa, Goshi Oda, Hiroshi Kawachi, Toshiaki Ishikawa, Kentaro Okamoto, Hiroyuki Uetake · 2022 · Clinics and Practice
New basic approach to treat non‐small cell lung cancer based on RNA ‐interference
Christina Makowiecki, Andrea Nolte, Besmire Sutaj, Timea Keller, Meltem Avci‐Adali, Heidi Stoll, Christian Schlensak, Hans Peter Wendel, Tobias Walker · 2013 · Thoracic Cancer
PTPLAD2 is a tumor suppressor in esophageal squamous cell carcinogenesis
Shaojun Zhu, Zhipeng Wang, Zhipei Zhang, Jian Wang, Yanhong Li, Yao Li, Qibing Mei, Wei Zhang · 2014 · FEBS Letters
The expression of stat3, bcl-xl and mmp-2 proteins in colon adenocarcinomas and their relationship with prognostic factors
Gökhan Artaş, Halil Ibrahim Ozercan · 2014 · Turkish Journal of Pathology
Identification of novel STAT3 inhibitors bearing 2-acetyl-7-phenylamino benzofuran scaffold for antitumour study
Feng Wang, Kai‐Rui Feng, Jiaying Zhao, Jianwei Zhang, Xin‐Wei Shi, Jian Er Zhou, Dingding Gao, Guo‐Qiang Lin, Ping Tian · 2020 · Bioorganic & Medicinal Chemistry
Mono-Carbonyl Curcumin Analogs for Cancer Therapy
Takashi Maruyama, Hiroyuki Yamakoshi, Yoshiharu Iwabuchi, Hiroyuki Shibata · 2023 · Biological and Pharmaceutical Bulletin
Effects and mechanisms of Helicobacter pylori on cancers development and immunotherapy
Xiaotian Zhong, Huiling Zheng, Shiqing Zhao, Ziye Wang, Yi Su, Kaili Zhong, Mopei Wang, Yanyan Shi · 2024 · Frontiers in Immunology
Long Non-coding RNA ZFPM2-AS1: A Novel Biomarker in the Pathogenesis of Human Cancers
Gabriel B. K. Sasa, Cheng Xuan, Guoliang Lyu, Xianfeng Ding, Meiyu Fang · 2022 · Molecular Biotechnology
Podocarpusflavone A inhibits cell growth of skin cutaneous melanoma by suppressing STAT3 signaling
Huijuan Meng, Yunyan Pang, Guoyan Liu, Zengxiang Luo, Haiyang Tan, Xiangming Liu · 2020 · Journal of Dermatological Science
Activation of pro-oncogenic pathways in colorectal hyperplastic polyps
Catherine Do, Claudine Bertrand, Julien Palasse, Marie‐Bernadette Delisle, Elizabeth Cohen‐Jonathan Moyal, Catherine Seva · 2013 · BMC Cancer
The Antiproliferative and Colony-suppressive Activities of STAT3 Inhibitors in Human Cancer Cells Is Compromised Under Hypoxic Conditions
Jilai Tian, Hui Xiao, Ruohan Wu, Yang Cao, Chenglong Li, Ronald X. Xu, Christopher R. Pierson, Jonathan L. Finlay, Fang Yang, Ning Gu et al. · 2017 · Anticancer Research
Induction of immunogenic cell death of tumors by newly synthesized heterocyclic quinone derivative
Keum-joo Son, Ki Ryung Choi, Chung‐Kyu Ryu, Seog Jae Lee, Ho Jeong Kim, Hyunah Lee · 2017 · PLoS ONE
ING4 enhances paclitaxel's effect on colorectal cancer growth in vitro and in vivo.
Liyu Cao, Shun‐Hua Chen, Cong Zhang, Cong Chen, Na-Na Lu, Yan Jiang, Yongping Cai, Yu Yin, Jianming Xu · 2015 · PubMed Central
The Epithelial to Mesenchymal Transition in Colorectal Cancer Progression: The Emerging Role of Succinate Dehydrogenase Alterations and Succinate Accumulation
Mimmo Turano, Rosario Vicidomini, Francesca Cammarota, Valeria D’Agostino, Francesca Duraturo, Paola Izzo, Marina De Rosa · 2023 · Biomedicines
IDO1 Inhibition Promotes Activation of Tumor-intrinsic STAT3 Pathway and Induces Adverse Tumor-protective Effects
Long‐Bo Yu, Lingyan Xu, Yunjie Chen, Yicheng Rong, Yi Zou, Shushan Ge, Tiancong Wu, Yisheng Lai, Qiang Xu, Wenjie Guo et al. · 2024 · The Journal of Immunology
STAT3 promotes chronic lymphocytic leukemia progression through upregulating SMYD3 expression
Wei Ma, Yingying Zhang, Yu Meng Qi, Shi-Dong Guo · 2018 · Archives of Medical Science
Intestinal Epithelial Deletion of Sphk1 Prevents Colitis-Associated Cancer Development by Inhibition of Epithelial STAT3 Activation
Seung Bin Park, Byung-il Choi, Beom Jae Lee, Nam Joo Kim, Yoon A Jeong, Moon Kyung Joo, Hyo Jung Kim, Jong‐Jae Park, Jae J. Kim, Yoon-Seok Noh et al. · 2019 · Digestive Diseases and Sciences
The fiber metabolite butyrate reduces gp130 by targeting TRAF5 in colorectal cancer cells
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Blockade of the SRC/STAT3/BCL-2 Signaling Axis Sustains the Cytotoxicity in Human Colorectal Cancer Cell Lines Induced by Dehydroxyhispolon Methyl Ether
Ya-Chu Hsieh, Yuan‐Chang Dai, Kur‐Ta Cheng, Weiting Yang, Modukuri V. Ramani, Gottumukkala Venkata Subbaraju, Yi–Ju Chen, Chia‐Che Chang · 2023 · Biomedicines
Astaxanthin-loaded PLGA nanoparticles inhibit survival of MKN-45 gastric cancer cell line by modulating JAK2/STAT3/mTOR/PI3K pathway
Mohammad Hossein YektaKooshali, Mahdieh SobhZahedi, Seyed Mohammad Taghi Razavi Tousi, Masoud Hamidi, Leila Modiri · 2025 · BMC Cancer
TGF-β and IL-6 family signalling crosstalk: an integrated model
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Glioblastoma invasion factor ODZ1 is induced by microenvironmental signals through activation of a Stat3-dependent transcriptional pathway
Verónica Vidal, Olga Gutierrez, Ana Talamillo, Carlos Velásquez, José L. Fernández-Luna · 2021 · Scientific Reports
(E)-4-(3-(3,5-dimethoxyphenyl)allyl)-2-methoxyphenol inhibits growth of colon tumors in mice
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Lentivirus-mediated siRNA knockdown of SPHK1 inhibits proliferation and tumorigenesis of neuroblastoma
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Cetuximab promotes SN38 sensitivity via suppression of heat shock protein 27 in colorectal cancer cells with wild-type RAS
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Probing the Depths of Molecular Complexity: STAT3 as a Key Architect in Colorectal Cancer Pathogenesis
Muhammad Suleman, Safir Ullah Khan, Shahid Ali, Abdullah Alghamdi, Mohammed Alissa, Rayan Y. Mushtaq, Sérgio Crovella · 2024 · Current Gene Therapy
Defining the mucosal ecosystem: epithelial–mesenchymal interdependence in gastrointestinal health and disease
Frances J. England, Manqiang Lin, Michael J. Sigal, Simon John Leedham · 2025 · Nature Reviews Gastroenterology & Hepatology
Synthesis and structure-activity relationship studies of naphthoquinones as STAT3 inhibitors
Mitsuaki Yamashita, Yuto Nakamori, Arisa Tsukamoto, Nagisa Furuno, Akira Iida · 2023 · Bioorganic & Medicinal Chemistry