Activation of STAT3 is a marker of poor prognosis in human colorectal cancer
Open accessAbstract
It is known that the signal transducer and activator of transcription 3 (STAT3) is a key signaling molecule implicated in the regulation of growth and malignant transformation. Constitutive activation of STAT3 has been observed in a number of tumour-derived cell lines, as well as in a wide variety of human malignancies. The present study was conducted to examine p-STAT3 (activated form of STAT3) expression and its association with clinicopathological factors and prognosis in human colorectal adenocarcinomas. Expression of p-STAT3 was immunohistochemically examined in 108 cases of colorectal adenocarcinoma tissue obtained at surgery. and was found in 57.4% of tumours (62 of 108). p-STAT3 immunoreactivity significantly correlated with the depth grading of tumour invasion (p<0.001), lymphatic invasion (p<0.05), Dukes' classification (p<0.05), stage (p<0.001) and prognosis after operation (p<0.001). Expression of p-STAT3 was a marker of poor prognosis in overall survival (p<0.01). Expression of p-STAT3 was detected by Western blot analysis in three colon carcinoma tissue samples obtained at surgery. To our knowledge, this is the first study on the poor prognosis of p-STAT3 in human colorectal adenocarcinomas. These findings suggest that expression of p-STAT3 is an important factor related to tumour invasion and poor prognosis of human colorectal adenocarcinoma.
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Aberrant STAT3 activation is an important early event during the development and progression of HNSCC and CRC.
“Aberrant STAT3 activation represents an important early event during the development and progression of HNSCC and CRC (4, 8)”
From Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer (2022) · cites this paper as [4]
The Discussion (page not provided) links activated STAT3 to tumour progression and reports stronger p-STAT3 expression in deeper invasive areas of colorectal cancers. The Introduction notes STAT3 activation in head and neck cancers, but this paper does not establish that activation is an important early event in the development of either HNSCC or CRC. (LLM, conf=0.86)
Experimental — accuracy not yet measuredOver 95% of patients with HNSCC and 57.4% of patients with CRC have persistent aberrant STAT3 activation.
“This is especially the case in over 95% of patients with head and neck squamous cell carcinoma (HNSCC) and 57.4% of patients with colorectal cancer (CRC) (3–5).”
From Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer (2022) · cites this paper as [4]
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- Authors
- Kusaba, T., Nakayama, T., Yamazumi, K., Yakata, Y., Yoshizaki, A., Inoue, K., Nagayasu, T., & Sekine, I.
- Affiliations
- Nagasaki University (JP)
- Venue
- Oncology Reports
- Publisher
- Spandidos Publications
- Published
- 2006-06-01
- Volume
- 15
- Issue
- 6
- Pages
- 1445-51
- ISSN
- 1021-335X (ISSN-L)
- 1791-2431
- OpenAlex
- W2004349741
- Cited by
- 238
- References
- 33
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 14 · 2023: 11 · 2022: 17 · 2021: 23 · 2020: 14 · 2019: 16 · 2018: 14 · 2017: 13 · 2016: 17 · 2015: 17 · 2014: 10 · 2013: 14 · 2012: 20
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Oncology Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- STAT3, phosphorylated STAT3, colorectal adenocarcinoma, prognostic factors, tumor invasion, lymphatic invasion, Dukes classification, tumor stage, overall survival, oncogenic signaling
- MeSH terms
- Adenocarcinoma, Adult, Aged, Aged, 80 and over, Female, Humans, Lymphatic Metastasis, Male, Middle Aged, Neoplasm Staging, Colorectal Neoplasms, Disease-Free Survival, STAT3 Transcription Factor
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