Evaluation of the effectiveness of biodegradable electrospun caprolactoneand poly(lactic acid-ε-caprolactone) nerve conduits for peripheral nerveregenerations in a rat sciatic nerve defect model
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BACKGROUND/AIM: The aim of this study was to compare electrospun caprolactone (EC) and poly(lactic acid-ε-caprolactone) (PLCL) nerve conduits with nerve graft in a rat sciatic nerve defect model. MATERIALS AND METHODS: A total of 32 male Wistar albino rats were divided into 4 groups, with 8 rats in each group. A nerve defect of 1 cm was constructed in the left sciatic nerve of the rats. These defects were left denuded in the sham group, and reconstructed with nerve grafts, PLCL, and EC nerve conduits in the other groups. After 3 months, nerve regenerations were evaluated macroscopically, microscopically, and electrophysiologically. The numbers of myelinated axons in the cross-sections of the nerves were compared between the groups. RESULTS: Macroscopically, all nerve coaptations were intact and biodegradation was detected in nerve conduits. Electromyographic assessment and count of myelinated axons in the cross-sections of the nerves displayed the best regeneration in the nerve graft group (P < 0.001) and similar results were obtained in the PLCL and EC nerve conduit groups (P = 0.79). Light and electron microscopy studies demonstrated nerve regeneration in both nerve conduit groups. CONCLUSION: EC nerve conduits and PLCL nerve conduits yielded similar results and may be alternatives to nerve grafts as they biodegrade.
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In neural tissue engineering, PLCL combined with neurotrophic factors can significantly improve nerve cell adhesion and axonal extension and promote neural tissue repair.
“For example, in neural tissue engineering, when PLCL is combined with neurotrophic factors, it can significantly improve nerve cell adhesion and axonal extension, and promote the repair of neural tissue [28].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [28]
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Application of PLCL as a biodegradable polymer in biomedical engineering
Zhao, Y., & Liu, H. (2026) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-026-07016-3 · Cited by 7 · see citing works
- Authors
- DADACI, M., KARAGÜLLE, N., SÖNMEZ, E., DADACI, Z., İŞCİ, E. T., İNCE, B., VARGEL, İ., PİŞKİN, E., & ERK, A. Y.
- Affiliations
- Mersin Üniversitesi (TR)
- Izmir Kâtip Çelebi University (TR)
- Necmettin Erbakan University (TR)
- Hacettepe University (TR)
- Venue
- TURKISH JOURNAL OF MEDICAL SCIENCES
- Published
- 2016
- Volume
- 46
- Issue
- 2
- Pages
- 539-548
- ISSN
- 1300-0144 (ISSN-L)
- 1303-6165
- OpenAlex
- W2334781871
- Cited by
- 7
- References
- 37
- Citations by year
- 2026: 1 · 2021: 4 · 2020: 1 · 2018: 1
- FWCI
- 0.19
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- TURKISH JOURNAL OF MEDICAL SCIENCES (publishedVersion)
- PubMed (publishedVersion)
- Hacettepe University Institutional Repository (hacettepe.edu.tr) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- nerve conduits, electrospun scaffolds, ε-caprolactone, peripheral nerve regeneration, sciatic nerve defect, nerve grafts, biodegradable biomaterials, myelinated axons, nerve coaptation, rat model
- MeSH terms
- Animals, Male, Nerve Regeneration, Polyesters, Sciatic Nerve, Rats, Sprague-Dawley, Rats, Wistar, Rats
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