The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
COVID-19, immune system response, hyperinflammation and repurposing antirheumatic drugs
Open accessAbstract
In the Wuhan Province of China, in December 2019, the novel coronavirus 2019 (COVID-19) has caused a severe involvement of the lower respiratory tract leading to an acute respiratory syndrome. Subsequently, coronavirus 2 (SARS-CoV-2) provoked a pandemic which is considered a life-threatening disease. The SARS-CoV-2, a family member of betacoronaviruses, possesses single-stranded positive-sense RNA with typical structural proteins, involving the envelope, membrane, nucleocapsid and spike proteins that are responsible for the viral infectivity, and nonstructural proteins. The effectual host immune response including innate and adaptive immunity against SARS-Cov-2 seems crucial to control and resolve the viral infection. However, the severity and outcome of the COVID-19 might be associated with the excessive production of proinflammatory cytokines “cytokine storm” leading to an acute respiratory distress syndrome. Regretfully, the exact pathophysiology and treatment, especially for the severe COVID-19, is still uncertain. The results of preliminary studies have shown that immune-modulatory or immune-suppressive treatments such as hydroxychloroquine, interleukin (IL)-6 and IL-1 antagonists, commonly used in rheumatology, might be considered as treatment choices for COVID-19, particularly in severe disease. In this review, to gain better information about appropriate anti-inflammatory treatments, mostly used in rheumatology for COVID-19, we have focused the attention on the structural features of SARS-CoV-2, the host immune response against SARS-CoV-2 and its association with the cytokine storm.
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Citations
Cites
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BackgroundThe epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak
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Efficacy and safety of low-dose colchicine after myocardial infarction
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Cited by
Aboudounya, M. M., & Heads, R. J. (2021) · Mediators of Inflammation · doi:10.1155/2021/8874339 · Cited by 346
Bader, F., Manla, Y., Atallah, B., & Starling, R. C. (2021) · Heart Failure Reviews · doi:10.1007/s10741-020-10008-2 · Cited by 259
Mesenchymal stem cell immunomodulation: in pursuit of controlling COVID-19 related cytokine storm
Song, N., Wakimoto, H., Rossignoli, F., Bhere, D., Ciccocioppo, R., Chen, K.-S., Khalsa, J. K., Mastrolia, I., Samarelli, A. V., Dominici, M., et al. (2021) · Stem Cells · doi:10.1002/stem.3354 · Cited by 62
Gomes, I. C., Karmirian, K., Oliveira, J., Pedrosa, C., Rosman, F. C., Chimelli, L., & Rehen, S. (2020) · doi:10.20944/preprints202009.0297.v1 · Cited by 51
Salman, E., Çelikbilek, N., Aydoğan, S., Özdem, B., Gökay, S., Kırca, F., Toyran, A., Bilici Salman, R., & Dinç, B. (2021) · Mikrobiyoloji Bulteni · doi:10.5578/mb.20219706 · Cited by 15
Metadata
- Authors
- TUFAN, A., AVANOĞLU GÜLER, A., & MATUCCI-CERINIC, M.
- Venue
- TURKISH JOURNAL OF MEDICAL SCIENCES
- Published
- 2020-04-21
- Volume
- 50
- Issue
- SI-1
- Pages
- 620-632
- ISSN
- 1300-0144 (ISSN-L)
- 1303-6165
- OpenAlex
- W3017027582
- Cited by
- 495
- References
- 13
- FWCI
- 13.64
- Type
- journal article
- Language
- en
- Open access
- diamond
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- TUFAN, A., AVANOĞLU GÜLER, A., & MATUCCI-CERINIC, M. (2020). COVID-19, immune system response, hyperinflammation and repurposing antirheumatic drugs. TURKISH JOURNAL OF MEDICAL SCIENCES. https://doi.org/10.3906/sag-2004-168
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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