Cited by 112Microbial Metabolites in Food BiotechnologyGut microbiota and healthProbiotics and Fermented Foods

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High purity galacto-oligosaccharides enhance specific Bifidobacterium species and their metabolic activity in the mouse gut microbiome

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Monteagudo-Mera, A., Arthur, J.C., Jobin, C., Keku, T., Bruno-Barcena, J.M., Azcarate-Peril, M.A.·2016·Beneficial Microbes

DOI 10.3920/bm2015.0114PMC PMC4974821

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Abstract

Prebiotics are selectively fermented ingredients that result in specific changes in the composition and/or activity of the gastrointestinal microbiota, thus conferring benefit(s) upon the host health. The aim of this study was to evaluate the influence of a β(1-4)galacto-oligosaccharides (GOS) formulation consisting of 90% pure GOS (GOS90), on the composition and activity of the mouse gut microbiota. Germ-free mice were colonised with microbiota from four pathogen-free wt 129 mice donors (SPF), and stools were collected during a feeding trial in which GOS90 was delivered orally for 14 days. Pyrosequencing of 16S rDNA amplicons showed that Bifidobacterium and specific Lactobacillus , Bacteroides and Clostridiales were more prevalent in GOS90-fed mice after 14 days, although the prebiotic impact on Bifidobacterium varied among individual mice. Prebiotic feeding also resulted in decreased abundance of Bacteroidales, Helicobacter and Clostridium. High-throughput quantitative PCR showed an increased abundance of Bifidobacterium adolescentis, Bifidobacterium pseudocatenulatum, Bifidobacterium lactis and Bifidobacterium gallicum in the prebiotic-fed mice. Control female mice showed a higher diversity (phylogenetic diversity (PD) = 15.1±3.4 in stools and PD = 13.0±0.6 in intestinal contents) than control males (PD = 7.8±1.6 in stool samples and PD = 9.5±1.0 in intestinal contents). GOS90 did not modify inflammatory biomarkers (interleukin (IL)-6, IL-12, IL-1β, interferon gamma and tumour necrosis factor alpha). Decreased butyrate, acetate and lactate concentrations in stools of prebiotic fed mice suggested an increase in colonic absorption and reduced excretion. Overall, our results demonstrate that GOS90 is capable of modulating the intestinal microbiome resulting in expansion of the probiome (autochtonous commensal intestinal bacteria considered to have a beneficial influence on health).

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Flagged first, then by citations

Research works printed but not linked: 9

American Journal of Gastreoenterology Suppl, 1, 22
American Journal of Clinical Nutrition, 73, 496S
Gut, 58, A289
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Journal of Applied Microbiology, 104, 305
FASEB Journal 28 Suppl, 719.6
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International Journal of Molecular Medicine, 25, 331
Frontiers in Cellular and Infection Microbiology, 5, 3

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See all 112

Authors: Monteagudo-Mera, A., Arthur, J. C., Jobin, C., Keku, T., Bruno-Barcena, J. M., & Azcarate-Peril, M. A.
Affiliations: University of North Carolina at Chapel Hill (US)
Department of Plant and Microbial Biology, 4550A Thomas Hall, Campus Box 7615, Raleigh, NC 27695, USA
Microbiome Core Facility, Center for Gastrointestinal Biology and Disease, University of North Carolina, 312 Isaac Taylor Hall, Chapel Hill, NC 27599, USA
ORCID: Monteagudo-Mera, A.
Arthur, J.C.
Jobin, C.
Keku, T.
Venue: Beneficial Microbes
Publisher: Walter de Gruyter GmbH
Published: 2016
Volume: 7
Issue: 2
Pages: 247-264
ISSN: 1876-2883 (ISSN-L)
1876-2891
DOI: 10.3920/bm2015.0114
PMC: PMC4974821
OpenAlex: W2262506242
Cited by: 112
References: 91
Citations by year: 2026: 5 · 2025: 6 · 2024: 14 · 2023: 10 · 2022: 8 · 2021: 14 · 2020: 13 · 2019: 7 · 2018: 13 · 2017: 17 · 2016: 5
FWCI: 14.66
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
creativecommons.org/licenses/by-nc-nd/4.0/ (unspecified)
Locations: Beneficial Microbes (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (K01DK103952, P30‐DK34987, P30DK034987)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: galactooligosaccharides, prebiotics, Bifidobacterium, gut microbiota, germ-free mice, Bifidobacterium adolescentis, Bifidobacterium animalis subsp. lactis, Bifidobacterium pseudocatenulatum, short-chain fatty acids, butyrate, interleukin-6, inflammation, microbial diversity, Clostridiales, Bacteroidales
MeSH terms: Gastrointestinal Microbiome, Animals, Bacteria, Bifidobacterium, Female, Fermentation, Galactose, Male, Oligosaccharides, Interleukin-6, Interleukin-12, Gastrointestinal Tract, Mice, Prebiotics, Mice, 129 Strain

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High purity galacto-oligosaccharides enhance specific Bifidobacterium species and their metabolic activity in the mouse gut microbiome

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