In vitro protective effect of mangiferin against glycated protein-iron chelate induced toxicity in human umbilical vein endothelial cells
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Incubation of HUVECs with glycated protein alone, or in combination with iron chelate, resulted in increased lipid peroxidation, accompanied by depletion of SOD, catalase, glutathione peroxidase and glutathione reductase levels.
“Similarly, incubation of HUVECs with glycated protein alone, or in combination with iron chelate, resulted in increased lipid peroxidation (LPO), accompanied by depletion of SOD, catalase, glutathione peroxidase and glutathione reductase levels.”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [94]
The Results (p. 4) report increased lipid peroxidation and reduced SOD, catalase, GPx and GR in HUVECs treated with glycated protein–iron chelate. Table 1 (p. 5) also shows lower levels of all four enzymes with glycated protein alone, but the non-abstract Results text does not establish increased lipid peroxidation for that treatment alone. (LLM, conf=0.85)
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- Davies, M.J. and R.T. Dean, 1997. The Pathology of Protein Oxidation, Radical Mediated Protein Oxidation. Oxford Science Publications, Oxford, pp: 203-237.
- Halliwell, B.J. and M.C. Gutteridge, 1990. Role of Free Radicals and Catalytic Metal Ions in Human Disease: An Overview. In: Methods in Enzymology. Packer, L. and A.N. Glazer (Eds.), Vol. 186, Academic Press, New York, pp: 1-85.
- Scartezzini, P. and E. Speroni, 2000. Review on some plants of Indian traditionalmedicine with antioxidant activity. J. Ethnopharmacol., 71: 23-43.
- Siow, R.C., H. Sato, D.S. Leake, J.D. Pearson, S. Bannai and G.E. Mann, 1998. Vitamin C protects human arterial smooth muscle cells against atherogenic lipoproteins: Effects of antioxidant vitaniins C and E on oxidized LDL-induced adaptive increases in cystine transport and glutathione. Arterioscler Thromb Vasc. Biol., 18: 1662-70.
- Wu, J.T., 1993b. Review of diabetes: Identification of markers for early detection, glycemic control and monitoring clinical complications. J. Clin. Lab. Anal., 7: 293-300.
- Yagi, K., 1998. Pathophysiology of Lipid Peroxides and Related Free Radicals, Japan Scientific Societies Press, Tokyo.
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Mangiferin: A natural miracle bioactive compound against lifestyle related disorders
Imran, M., Arshad, M. S., Butt, M. S., Kwon, J.-H., Arshad, M. U., & Sultan, M. T. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0449-y · Cited by 366 · see citing works
Mangiferin: An effective therapeutic agent against several disorders (Review)
Du, S., Liu, H., Lei, T., Xie, X., Wang, H., He, X., Tong, R., & Wang, Y. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9529 · Cited by 139 · see citing works
“These data suggest that mangiferin (5 and 10 µM) has a protective effect against glycated protein-iron chelate-induced toxicity (94), which provides a promising perspective for the prevention of oxidative stress and toxicant-associated disease.”
Morozkina, S. N., Nhung Vu, T. H., Generalova, Y. E., Snetkov, P. P., & Uspenskaya, M. V. (2021) · Biomolecules · doi:10.3390/biom11010079 · Cited by 82 · see citing works
- Authors
- Venugopal, R., Sakthiseka, D., Rajkapoor, B., & Nishigaki, I.
- Venue
- Journal of Biological Sciences
- Publisher
- Science Alert
- Published
- 2007-09-15
- Volume
- 7
- Issue
- 7
- Pages
- 1227-1232
- ISSN
- 1727-3048 (ISSN-L)
- OpenAlex
- W2054928114
- Cited by
- 12
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 1 · 2013: 1 · 2012: 1
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Biological Sciences (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- mangiferin, advanced glycation end products, endothelial cell cytotoxicity, human umbilical vein endothelial cells, protective effect, oxidative stress
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