Cited by 367Mangiferin and Mango ExtractsNatural Compound Pharmacology StudiesNatural Antidiabetic Agents Studies

Mangiferin: A natural miracle bioactive compound against lifestyle related disorders

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Imran, Muhammad, Arshad, Muhammad Sajid, Butt, Masood Sadiq, Kwon, Joong-Ho, Arshad, Muhammad Umair, Sultan, Muhammad Tauseef·2017·Lipids in Health and Disease

Abstract

The current review article is an attempt to explain the therapeutic potential of mangiferin, a bioactive compound of the mango, against lifestyle-related disorders. Mangiferin (2-β-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one) can be isolated from higher plants as well as the mango fruit and their byproducts (i.e. peel, seed, and kernel). It possesses several health endorsing properties such as antioxidant, antimicrobial, antidiabetic, antiallergic, anticancer, hypocholesterolemic, and immunomodulatory. It suppresses the activation of peroxisome proliferator activated receptor isoforms by changing the transcription process. Mangiferin protects against different human cancers, including lung, colon, breast, and neuronal cancers, through the suppression of tumor necrosis factor α expression, inducible nitric oxide synthase potential, and proliferation and induction of apoptosis. It also protects against neural and breast cancers by suppressing the expression of matrix metalloproteinase (MMP)-9 and MMP-7 and inhibiting enzymatic activity, metastatic potential, and activation of the β-catenin pathway. It has the capacity to block lipid peroxidation, in order to provide a shielding effect against physiological threats. Additionally, mangiferin enhances the capacity of the monocyte-macrophage system and possesses antibacterial activity against gram-positive and gram-negative bacteria. This review summarizes the literature pertaining to mangiferin and its associated health claims.

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  • MGF offers a wide plethora of promising beneficial properties such as antioxidant, antiviral, anti-inflammatory, immunomodulatory, and cytoprotective effects.

    “It has been widely reported that MGF offers a wide plethora of promising beneficial properties such as antioxidant, antiviral, anti-inflammatory, immunomodulatory, and cytoprotective effects [20,21].”

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Authors
Imran, M., Arshad, M. S., Butt, M. S., Kwon, J.-H., Arshad, M. U., & Sultan, M. T.
Affiliations
  • Imperial College of Business Studies (PK)
  • Government College University, Faisalabad (PK)
  • University of Agriculture Faisalabad (PK)
  • Kyungpook National University (KR)
  • Bahauddin Zakariya University (PK)
Corresponding author
  • Arshad, Muhammad Sajid
  • Arshad, Muhammad Umair
Venue
Lipids in Health and Disease
Published
2017-05-02
Volume
16
Issue
1
Pages
84-84
ISSN
1476-511X (ISSN-L)
OpenAlex
W2610241935
Cited by
366
References
125
Citations by year
2026: 38 · 2025: 46 · 2024: 57 · 2023: 59 · 2022: 39 · 2021: 42 · 2020: 41 · 2019: 31 · 2018: 11 · 2017: 1
FWCI
4.94
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Lipids in Health and Disease (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Natural Compound Pharmacology Studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Keywords
mangiferin, mango, lifestyle-related diseases, antioxidant activity, antidiabetic activity, anticancer activity, neuroprotection, breast cancer, lung cancer, colon cancer, MMP-9, matrix metalloproteinase-7, β-catenin signaling, TNF-α, inducible nitric oxide synthase, apoptosis, immunomodulation, antimicrobial activity, hypocholesterolemic activity, xanthones
MeSH terms
Anti-Inflammatory Agents, Antineoplastic Agents, Phytogenic, Antioxidants, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Humans, Hyperlipidemias, Hypoglycemic Agents, Neoplasms, Neuralgia, Oxidative Stress, Nootropic Agents, Mangifera, Xanthones, Cognitive Dysfunction

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