The DOI matches its Crossref record.
Effective Management of Major Lower Extremity Wounds Using an Acellular Regenerative Tissue Matrix: A Pilot Study
Abstract
Abstract Wound healing is a significant problem in orthopedics. Graftjacket tissue matrix (Wright Medical Technology, Ine, Arlington, Tenn), a novel acellular regenerative tissue matrix, has been designed to aid wound closure. A prospective, randomized study was initiated to determine the efficacy of this tissue product in wound repair compared with conventional treatment. Lower extremity wounds are refractile to healing in patients with diabetes mellitus. Therefore, researchers used diabetic foot ulcers to evaluate the efficacy of Graftjacket tissue matrix in wound repair. Only a single administration of the tissue matrix was required. After 1 month of treatment, preliminary results demonstrate that this novel tissue matrix promotes faster healing at a statistically significant rate over conventional treatment. Because wounds in this series of patients are deep and circulation around the wound is poor, the preliminary results suggest that this tissue matrix will be applicable to other types of orthopedic wounds.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Two studies [28,30] reported wound area reduction, it ranged from 73.1 to 91.4% in ADM group compared with 34.2e80.3% in SOC group.”
From Efficacy and safety of acellular dermal matrix in diabetic foot ulcer treatment: A systematic review and meta-analysis (2017) · cites this paper as [30]
In the citing paper
“Two studies reported healing rate [17,30], wound healing rate in ADM group ranged from 3.4 to 7.2% compared with 1.0e4.8% in SOC group.”
From Efficacy and safety of acellular dermal matrix in diabetic foot ulcer treatment: A systematic review and meta-analysis (2017) · cites this paper as [30]
In the citing paper
“one study [30] estimated the possible wound healing in 12 weeks according to the healing rate in the first 4 weeks”
From Efficacy and safety of acellular dermal matrix in diabetic foot ulcer treatment: A systematic review and meta-analysis (2017) · cites this paper as [30]
In the citing paper
“Time to heal was reported in all studies, but only 4 studies [7,8,29,30]were eligible for metaanalysis.”
From Efficacy and safety of acellular dermal matrix in diabetic foot ulcer treatment: A systematic review and meta-analysis (2017) · cites this paper as [30]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 10
- 1. Naughton G Mansbridge J Gentzkow G. A metabolically active human dermal replacement for the treatment of diabetic foot ulcers. Artif Organs. 1997;21:1203-1210. · DOI
- 2. Gentzkow GD Iwasaki SD Hersnon KS et al. Use of dermagraft a cultured human dermis to treat diabetic foot ulcers. Diabetes Care. 1996; 19:350-354. · DOI
- 4. Armstrong DG. Nguyen HC Lavery LA et al. Off-loading the diabetic foot wound: a randomized clinical trial. Diabetes Care. 2001; 24:1019-1022. · DOI
- 5. Newton DJ Khan F Belch JJ Mitchell MR Leese GP. Blood flow changes in diabetic foot ulcers treated with dermal replacement therapy. J Foot Ankle Surg. 2002; 41:233-237. · DOI
- 6. Gentzkow GD Iwasaki SD. Hershon KS et al. Use of dermagraft a cultured human dermis to treat diabetic foot ulcers. Diabetes Care. 1996; 19:350-254. · DOI
- 7- Falanga V Sabolinski M. A bilayered living skin construct (APLIGRAF) accelerates complete closure of hard-to-heal venous ulcers. Wound Repair Regen. 1999;7:201-207. · DOI · Paper page
- 8. Veves A Falanga V Armstrong DG. Sabolinski ML. Graftskin a human skin equivalent is effective in the management of noninfected neuropathic diabetic foot ulcers: a prospective randomized multicenter clinical trial. Diabetes Care. 200 i ; 24:290-295. · DOI · Paper page
- 9. Sheehan P Jones P Caselli A Giurini JM Veves A. Percent change in wound area of diabetic foot ulcers over a 4-week period is a robust predictor of complete healing in a 12- week prospective trial. Diabetes Care. 2003; 26:1879-1882. · DOI
- 10. Oyibo SO. Jude EB Tarawneh I et al. The effects of ulcer size and site patient's age sex and type and duration of diabetes on the outcome of diabetic foot ulcers. Diabet Med. 3001; 18:133-138. · DOI
- 11. Margolis DJ. Allen-Taylor L Hoffstad O Berlin JA. Diabetic neuropathic foot ulcers: the association of wound size wound duration and wound grade on healing. Diabetes Care. 2002; 25:1835-1839. · DOI
Cited by
Consequences of ineffective decellularization of biologic scaffolds on the host response
Keane, T. J., Londono, R., Turner, N. J., & Badylak, S. F. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2011.10.054 · Cited by 613
Guo, X., Mu, D., & Gao, F. (2017) · International Journal of Surgery · doi:10.1016/j.ijsu.2017.02.008 · Cited by 80
Sui, L., Xie, Q., Jiang, H.-T., & Li, X.-D. (2024) · BMC Endocrine Disorders · doi:10.1186/s12902-024-01550-3 · Cited by 14
Metadata
- Authors
- Brigido, S. A., Boc, S. F., & Lopez, R. C.
- Venue
- Orthopedics
- Publisher
- SLACK, Inc.
- Published
- 2004-01
- Volume
- 27
- Issue
- 1
- ISSN
- 0147-7447
- 1938-2367
- Cited by
- 66
- References
- 0
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Effective Management of Major Lower Extremity Wounds Using an Acellular Regenerative Tissue Matrix: A Pilot Study. https://app.cochat.ai/papers/10.3928/0147-7447-20040102-14
- The paper
- Brigido, S. A., Boc, S. F., & Lopez, R. C. (2004). Effective Management of Major Lower Extremity Wounds Using an Acellular Regenerative Tissue Matrix: A Pilot Study. Orthopedics. https://doi.org/10.3928/0147-7447-20040102-14
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
