The DOI matches its Crossref record; 14 of the 15 references it cites were found in a registry or an index.
Sequenced Treatment Alternatives to Relieve Depression (STAR*D): Part 2: Study Outcomes
Abstract
This article reviews the main outcome findings from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. The study compared the efficacy and tolerability of a range of antidepressant therapies through four sequential levels of treatment with the goal of achieving remission. Remission rates based on the primary outcome measure (Hamilton Rating Scale for Depression) were 28% (Level 1 citalopram), 17% to 30% (Level 2 treatments), 12% to 25% (Level 3 treatments), and 7% to 14% (Level 4 treatments). For patients not responding adequately to an initial trial of citalopram, subsequent treatment strategies may be effective. When more treatment steps are required, however, lower acute remission rates, greater degrees of treatment intolerance, and higher relapse rates during follow up are seen. There were few differences among treatments within each level related to efficacy or tolerability, although patients had clear preferences for or against certain treatments.
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“while a larger study, the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study, revealed that 50% to 66% of depression patients did not recover fully on antidepressant medications.33”
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Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Nierenberg, A. A., Stewart, J. W., Warden, D., Niederehe, G., Thase, M. E., Lavori, P. W., Lebowitz, B. D., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.11.1905 · Cited by 5,643
Trivedi, M. H., Rush, A. J., Wisniewski, S. R., Nierenberg, A. A., Warden, D., Ritz, L., Norquist, G., Howland, R. H., Lebowitz, B., McGrath, P. J., et al. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.1.28 · Cited by 3,879
Self-citationSequenced treatment alternatives to relieve depression (STAR*D): Rationale and design
Rush, A. J., Fava, M., Wisniewski, S. R., Lavori, P. W., Trivedi, M. H., Sackeim, H. A., Thase, M. E., Nierenberg, A. A., Quitkin, F. M., Kashner, T. M., et al. (2004) · Controlled Clinical Trials · doi:10.1016/s0197-2456(03)00112-0 · Cited by 1,076
Bupropion-SR, Sertraline, or Venlafaxine-XR after Failure of SSRIs for Depression
Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Stewart, J. W., Nierenberg, A. A., Thase, M. E., Ritz, L., Biggs, M. M., Warden, D., Luther, J. F., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052963 · Cited by 1,033
Medication Augmentation after the Failure of SSRIs for Depression
Trivedi, M. H., Fava, M., Wisniewski, S. R., Thase, M. E., Quitkin, F., Warden, D., Ritz, L., Nierenberg, A. A., Lebowitz, B. D., Biggs, M. M., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052964 · Cited by 1,002
Fava, M., Rush, A. J., Alpert, J. E., Balasubramani, G. K., Wisniewski, S. R., Carmin, C. N., Biggs, M. M., Zisook, S., Leuchter, A., Howland, R., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06111868 · Cited by 927
Self-citationNierenberg, A. A., D, M. F. M., Trivedi, M. H., Wisniewski, S. R., Thase, M. E., McGrath, P. J., Alpert, J. E., Warden, D., Luther, J. F., Niederehe, G., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.9.1519 · Cited by 585
D, M. F. M., Rush, A. J., Wisniewski, S. R., Nierenberg, A. A., Alpert, J. E., McGrath, P. J., Thase, M. E., Warden, D., Biggs, M. M., Luther, J. F., et al. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.7.1161 · Cited by 367
McGrath, P. J., Stewart, J. W., D, M. F. M., Trivedi, M. H., Wisniewski, S. R., Nierenberg, A. A., Thase, M. E., Davis, L. L., Biggs, M. M., Shores‐Wilson, K., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.9.1531 · Cited by 350
Thase, M. E., Friedman, E. S., Biggs, M. M., Wisniewski, S. R., Trivedi, M. H., Luther, J. F., Fava, M., Nierenberg, A. A., McGrath, P. J., Warden, D., et al. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.5.739 · Cited by 332
Research works printed but not linked: 2
- 10.1176/ajp.2006.163.7.1161 · DOI
- Gilmer, W.S., Gollan, J.K., Wisniewski, S.R., Howland, R.H., Trivedi, M.H., Miyahara, S., . (in press). Does the duration of index episode affect the treatment outcome of major depressive disorder? A STAR*D report. Journal of Clinical Psychiatry.
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Scangos, K. W., Khambhati, A. N., Daly, P. M., Makhoul, G. S., Sugrue, L. P., Zamanian, H., Liu, T. X., Rao, V. R., Sellers, K. K., Dawes, H. E., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01480-w · Cited by 535
State-dependent responses to intracranial brain stimulation in a patient with depression
Scangos, K. W., Makhoul, G. S., Sugrue, L. P., Chang, E. F., & Krystal, A. D. (2021) · Nature Medicine · doi:10.1038/s41591-020-01175-8 · Cited by 243
Almeida, R. N. D., Galvão, A. C. D. M., da Silva, F. S., Silva, E. A. D. S., Palhano-Fontes, F., Maia-de-Oliveira, J. P., de Araújo, L.-S. B., Lobão-Soares, B., & Galvão-Coelho, N. L. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.01234 · Cited by 177
Chen, M.-H., Li, C.-T., Lin, W.-C., Hong, C.-J., Tu, P.-C., Bai, Y.-M., Cheng, C.-M., & Su, T.-P. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.08.078 · Cited by 159
The role of neuroinflammation and neurovascular dysfunction in major depressive disorder
Jeon, S. W., & Kim, Y. (2018) · Journal of Inflammation Research · doi:10.2147/jir.s141033 · Cited by 123
Metadata
- Authors
- Howland, R. H.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Howland, Robert H.
- ORCID
- Howland, Robert H.
- Venue
- Journal of Psychosocial Nursing and Mental Health Services
- Publisher
- SLACK, Inc.
- Published
- 2008-10
- Volume
- 46
- Issue
- 10
- Pages
- 21-24
- ISSN
- 0279-3695 (ISSN-L)
- 1938-2413
- OpenAlex
- W146502225
- Cited by
- 115
- References
- 15
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 9 · 2023: 12 · 2022: 9 · 2021: 7 · 2020: 7 · 2019: 9 · 2018: 7 · 2017: 7 · 2016: 3 · 2015: 10 · 2014: 3 · 2013: 2 · 2012: 3
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychosocial Nursing and Mental Health Services (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- depression, antidepressants, STAR*D, sequential therapy, citalopram, remission, treatment response, treatment intolerance, relapse, patient preferences, antidepressant efficacy
- MeSH terms
- Antidepressive Agents, Combined Modality Therapy, Depressive Disorder, Humans, Remission Induction, Research Design, Randomized Controlled Trials as Topic, Treatment Outcome
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