State-dependent responses to intracranial brain stimulation in a patient with depression
Open accessAbstract
Deep brain stimulation is a promising treatment for severe depression, but lack of efficacy in randomized trials raises questions regarding anatomical targeting. We implanted multi-site intracranial electrodes in a severely depressed patient and systematically assessed the acute response to focal electrical neuromodulation. We found an elaborate repertoire of distinctive emotional responses that were rapid in onset, reproducible, and context and state dependent. Results provide proof of concept for personalized, circuit-specific medicine in psychiatry.
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Alternative measures are under study, such as scales for symptom subdimensions or analysis of movements, speech, or facial expression.
“alternative measures are under study for example scales for symptom subdimensions or analysis of movements, speech, or facial expression [82][83][84].”
From Deep brain stimulation for depression. (2022) · cites this paper as [83]
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“Although routinely used in epilepsy, the intracranial EEG platform has rarely been used for other disorders (11, 12).”
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- Authors
- Scangos, K. W., Makhoul, G. S., Sugrue, L. P., Chang, E. F., & Krystal, A. D.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Scangos, Katherine W.
- Venue
- Nature Medicine
- Published
- 2021-01-18
- Volume
- 27
- Issue
- 2
- Pages
- 229-231
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC8284979
- OpenAlex
- W3122210758
- Cited by
- 243
- References
- 28
- Citations by year
- 2026: 38 · 2025: 32 · 2024: 38 · 2023: 56 · 2022: 39 · 2021: 40
- FWCI
- 20.68
- Type
- journal article
- Language
- en
- Update notices
- correction (2022-08-08)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (K23NS110962)
- NARSAD Young Investigator Grant Ray and Dagmar Dolby Family Fund
- Ray and Dagmar Dolby Family Fund
- Topics
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- treatment-resistant depression, deep brain stimulation, electrical neuromodulation, emotional responses, context-dependent responses, mood changes, precision psychiatry
- MeSH terms
- Adult, Brain, Brain Mapping, Major Depressive Disorder, Electric Stimulation, Electrodes, Female, Humans, Deep Brain Stimulation
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