Adherence challenges and long-acting injectable antipsychotic treatment in patients with schizophrenia
Abstract
Medication nonadherence has been associated with persistence of psychotic symptoms, relapse, and hospitalization in patients with schizophrenia. Patients with untreated psychosis are significantly less likely to achieve remission, whereas antipsychotic drug adherence has been associated with recovery. As such, adherence to antipsychotic drug treatment is a key issue for nurses and treatment team members caring for patients who typically are on chronic, progressive disease course. Long-acting injectable (LAI) anti-psychotic drugs, developed to improve adherence and provide and alternative antipsychotic drug treatment fro schizophrenia, have been associated with improved treatment outcomes including reduction of relapse rates approximately 30% and reduction in hospitalizations. However, LAI antipsychotic drugs remain underutilized in the United States despite a growing body of literature supporting positive outcomes of LAI versus oral antipsychotic drugs. Mental health nurses are in a key position to support improved adherence inpatients with schizophrenia through use of practical educational strategies that help patients, family members, and health care providers better understand and manage treatment.
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Evidence stresses the pivotal impact of therapeutic adherence on the quality of healthcare delivery, including increased demand for help and adherence to scheduled appointments, reduced rates of hospitalizations/rehospitalizations, reduction or elimination of sudden and unsupervised treatment interruptions, and decreased hospitalization costs.
“Evidence also stresses the pivotal impact of therapeutic adherence on the quality of healthcare delivery, including increased demand for help and adherence to scheduled appointments [49], reduced rates of hospitalizations/rehospitalizations [33,61,63,70], reduction or elimination of sudden and unsupervised treatment interruptions [46], and decreased hospitalization costs [63].”
From Therapeutic Adherence of People with Mental Disorders: An Evolutionary Concept Analysis (2023) · cites this paper as [70]
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Therapeutic Adherence of People with Mental Disorders: An Evolutionary Concept Analysis
Laranjeira, C., Carvalho, D., Valentim, O., Moutinho, L., Morgado, T., Tomás, C., Gomes, J., & Querido, A. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20053869 · Cited by 45 · see citing works
- Authors
- Morton, N. K., & Zubek, D.
- Affiliations
- Richmond Behavioral Health Authority (US)
- Venue
- Journal of Psychosocial Nursing and Mental Health Services
- Publisher
- SLACK, Inc.
- Published
- 2013-03
- Volume
- 51
- Issue
- 3
- Pages
- 13-18
- ISSN
- 0279-3695 (ISSN-L)
- 1938-2413
- OpenAlex
- W2331145048
- Cited by
- 16
- References
- 22
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 4
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychosocial Nursing and Mental Health Services (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Social Sciences › Psychology › Clinical Psychology › Psychiatric care and mental health services
- Keywords
- schizophrenia, medication adherence, long-acting injectable antipsychotics, relapse prevention, hospitalization reduction, psychiatric nursing, patient education, psychosis remission
- MeSH terms
- Paliperidone Palmitate, Olanzapine, Benzodiazepines, Delayed-Action Preparations, Fluphenazine, Haloperidol, Humans, Injections, Isoxazoles, Palmitates, Schizophrenia, Antipsychotic Agents, Risperidone, Medication Adherence
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