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Cited by 35Corneal surgery and disordersCorneal Surgery and TreatmentsOcular Infections and Treatments

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Persistent Haze and Disorganization of Anterior Stromal Collagen Appear Unrelated Following Phototherapeutic Keratectomy

Connon, Che J, Marshall, John, Patmore, Ann L, Brahma, Meek, Keith M·2003·Journal of Refractive Surgery
DOI 10.3928/1081-597x-20030501-09
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Abstract

ABSTRACT PURPOSE: The theoretical effects on corneal transparency induced by changes in collagen fibril packing following phototherapeutic keratectomy were compared to changes in objective measurements of haze. METHODS: Phototherapeutic keratectomy was performed on the right eyes of four young rabbits; left eyes were used as controls. Postoperative slitlamp measurements of haze were taken at regular intervals up to 19 months. Wounded stromas were studied by synchrotron x-ray diffraction to calculate the average interfibrillar spacing of the collagen fibrils. These data were combined with transmission electron microscope measurements, and the summation of scattered fields method was used to predict the transmission of visible light. RESULTS: Objective measurements of haze were higher than the baseline control throughout the study. Electron micrographs of anterior stroma in 8-month-old wounds displayed irregularly spaced and poorly organized fibrils and x-ray diffraction indicated larger mean interfibrillar spacing compared to the controls. However, the predicted transmission of visible light through the anterior stromal scar tissue was not significantly different than normal. CONCLUSIONS: Following phototherapeutic keratectomy, anterior corneal collagen fibrils were more widely spaced and unevenly organized than in the normal rabbit cornea. However, this did not cause a significant loss of transparency and was therefore unlikely to contribute to haze. [J Refract Surg 2003;19:323-332]

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  • Corneal opacity during corneal wound healing, or transitory haze following refractive surgery or corneal cross-linking, is caused by activated corneal keratocytes; once activated, these cells have a lower refractive index than the surrounding connective tissue.

    “Corneal opacity during corneal wound healing, or transitory haze following refractive surgery or corneal cross-linking, is caused by activated corneal keratocytes (Connon et al., 2003, Moller-Pedersen, 2004). Once activated, these cells have a lower refractive index than the surrounding connective tissue.”

    From Corneal structure and transparency (2015) · cites this paper as Connon et al., 2003

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Research works printed but not linked: 44

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Metadata

Authors
Connon, C. J., Marshall, J., Patmore, A. L., Brahma, & Meek, K. M.
Affiliations
Cardiff University (GB)
ORCID
Venue
Journal of Refractive Surgery
Publisher
SLACK, Inc.
Published
2003-05
Volume
19
Issue
3
Pages
323-332
ISSN
  • 1042-962X (ISSN-L)
  • 1081-597X
DOI
10.3928/1081-597x-20030501-09
OpenAlex
W2781229
Cited by
35
References
0
Citations by year
2024: 2 · 2023: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 1
FWCI
1.87
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Refractive Surgery (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • Research Portal (King's College London) (submittedVersion)
Topics
  • Health Sciences › Medicine › Ophthalmology › Corneal surgery and disorders
  • Health Sciences › Medicine › Ophthalmology › Corneal Surgery and Treatments
  • Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
Keywords
phototherapeutic keratectomy, corneal haze, corneal transparency, corneal wound healing, rabbit cornea
MeSH terms
Animals, Collagen, Corneal Opacity, Corneal Stroma, Postoperative Complications, Rabbits, X-Ray Diffraction, Synchrotrons, Photorefractive Keratectomy, Lasers, Excimer

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