Industrial production, application, microbial biosynthesis and degradation of furanic compound, hydroxymethylfurfural (HMF)
Open accessAbstract
Biorefinery is increasingly embraced as an environmentally friendly approach that has the potential to shift current petroleum-based chemical and material manufacture to renewable sources. Furanic compounds, particularly hydroxymethylfurfurals (HMFs) are platform chemicals, from which a variety of value-added chemicals can be derived. Their biomanufacture and biodegradation therefore will have a large impact. Here, we first review the potential industrial production of 4-HMF and 5-HMF, then we summarize the known microbial biosynthesis and biodegradation pathways of furanic compounds with emphasis on the enzymes in each pathway. We especially focus on the structure, function and catalytic mechanism of MfnB (4-(hydroxymethyl)-2-furancarboxyaldehyde-phosphate synthase) and hmfH (HMF oxidase), which catalyze the formation of phosphorylated 4-HMF and the oxidation of 5-HMF to furandicarboxylic acid (2,5-FDCA), respectively. Understanding the structure-function relationship of these enzymes will provide important insights in enzyme engineering, which eventually will find industry applications in mass-production of biobased polymers and other bulk chemicals in future.
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HMF is a key biomass platform intermediate that is commonly obtained from glucose or fructose by dehydration reactions.
“HMF is a key biomass platform intermediate that is commonly obtained from glucose or fructose by dehydration reactions.”
From Biorefineries: Achievements and challenges for a bio-based economy (2022) · cites this paper as Wang et al., 2018
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“Interestingly, Fgr AldOx and Cgr AldOx were essentially inactive on aryl aldehydes, including benzaldehyde, cinnamaldehyde, furfural, and 5-hydroxymethylfurfural, the last two of which are of particular interest as biomass-derived platform chemicals [36,51,54,55].”
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“[25] Therefore, the presence of 5-HMF in the hydrolysates highlights both the challenges and opportunities of designing hydrolysis processes that maximize sugar release while controlling inhibitor formation.”
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- Authors
- Wang, Y., 1 Department of Chemistry and Biochemistry, U. O. N. G.-D., A. Brown, C., Chen, R., & 2 School of Chemical & Biomolecular Engineering, G. I. O. T.
- Affiliations
- University of North Georgia (US)
- Georgia Institute of Technology (US)
- Corresponding author
- Wang, Yu
- Chen, Rachel
- ORCID
- Venue
- AIMS Microbiology
- Published
- 2018
- Volume
- 4
- Issue
- 2
- Pages
- 261-273
- ISSN
- 2471-1888 (ISSN-L)
- PMC
- PMC6604932
- OpenAlex
- W2793721810
- Cited by
- 56
- References
- 64
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 6 · 2023: 10 · 2022: 8 · 2021: 9 · 2020: 5 · 2019: 1 · 2018: 1
- FWCI
- 0.33
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- AIMS Microbiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Catalysis for Biomass Conversion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Enzyme Catalysis and Immobilization
- Keywords
- 5-hydroxymethylfurfural, furanic compounds, furandicarboxylic acid, biodegradation pathways, microbial production, enzyme mechanism, structure-function relationship, enzyme engineering, biorefinery, bio-based polymers, platform chemicals
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