The DOI matches its Crossref record; 35 of the 36 references it cites were found in a registry or an index.
Dietary intake patterns are reflected in metabolomic profiles: potential role in dietary assessment studies
Open accessAbstract
Background It has been suggested that metabolomics could play a role in dietary assessment and identification of novel biomarkers of dietary intake.Objective This study examined the link between habitual dietary patterns and metabolomic profiles.Design A total of 160 volunteers participated in a double-blind, randomized, placebo-controlled dietary intervention. We collected biofluids and recorded 3-d food diaries. Food data were reduced to 33 food groups, and a k-means cluster analysis was performed to identify dietary patterns. (1)H Nuclear magnetic resonance (NMR) spectra were acquired for plasma and urine samples, and gas chromatography was used for plasma fatty acid profiling.Results Cluster analysis identified 3 distinct dietary patterns on the basis of the energy contribution of different food groups. Dietary clusters were reflected in plasma fatty acid profiles and in metabolomic data. (1)H NMR spectra of urine allowed the identification of metabolites associated with different dietary patterns. Several of the metabolites identified were linked to the intake of specific food groups; in particular, there was a positive association between O-acetylcarnitine and phenylacetylglutamine and red-meat and vegetable intakes, respectively.Conclusions Habitual dietary patterns are shown in metabolomic data. This approach successfully identified potential biomarkers of red-meat and vegetable intakes.
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“Several studies found an inverse relation between red meat intake and the glycine concentration in biofluids (37,38).”
From Amino acids, lipid metabolites, and ferritin as potential mediators linking red meat consumption to type 2 diabetes (2015) · cites this paper as [38]
In the citing paper
“Furthermore, acylcarnitines have previously been linked to red meat intake (38).”
From Amino acids, lipid metabolites, and ferritin as potential mediators linking red meat consumption to type 2 diabetes (2015) · cites this paper as [38]
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Scalbert, A., Brennan, L., Manach, C., Andres-Lacueva, C., Dragsted, L. O., Draper, J., Rappaport, S. M., van der Hooft, J. J., & Wishart, D. S. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.076133 · Cited by 519
Self-citationGlycine Metabolism and Its Alterations in Obesity and Metabolic Diseases
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The Mediterranean diet, plasma metabolome, and cardiovascular disease risk
Li, J., Guasch‐Ferré, M., Chung, W., Ruiz‐Canela, M., Toledo, E., Corella, D., Bhupathiraju, S. N., Tobias, D. K., Tabung, F. K., Hu, J., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa209 · Cited by 373
Metadata
- Authors
- O'Sullivan, A., Gibney, M. J., & Brennan, L.
- Affiliations
- University College Dublin (IE)
- Corresponding author
- Gibney, Michael J
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2011-02
- Volume
- 93
- Issue
- 2
- Pages
- 314-321
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2168306106
- Cited by
- 297
- References
- 36
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 15 · 2023: 11 · 2022: 11 · 2021: 17 · 2020: 25 · 2019: 23 · 2018: 24 · 2017: 24 · 2016: 23 · 2015: 21 · 2014: 26 · 2013: 24 · 2012: 19
- FWCI
- 7.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Keywords
- dietary habits, metabolomics, dietary biomarkers, dietary assessment, plasma fatty acid profile, urinary metabolites, phenylacetylglutamine, red meat consumption, vegetable consumption, food diary, plasma metabolites
- MeSH terms
- Acetylcarnitine, Adolescent, Adult, Energy Intake, Chromatography, Gas, Diet, Double-Blind Method, Fatty Acids, Female, Glutamine, Humans, Male, Meat, Middle Aged, Magnetic Resonance Spectroscopy, Vegetables, Biomarkers, Nutrition Assessment, Diet Records, Cluster Analysis, Metabolome, Young Adult
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