The DOI matches its Crossref record; 69 of the 70 references it cites were found in a registry or an index.
Maternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study
Open accessAbstract
Background Periconceptional folate is essential for proper neurodevelopment.Objective Maternal folic acid intake was examined in relation to the risk of autism spectrum disorder (ASD) and developmental delay (DD).Design Families enrolled in the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study from 2003 to 2009 were included if their child had a diagnosis of ASD (n = 429), DD (n = 130), or typical development (TD; n = 278) confirmed at the University of California Davis Medical Investigation of Neurodevelopmental Disorders Institute by using standardized clinical assessments. Average daily folic acid was quantified for each mother on the basis of dose, brands, and intake frequency of vitamins, supplements, and breakfast cereals reported through structured telephone interviews.Results Mean (±SEM) folic acid intake was significantly greater for mothers of TD children than for mothers of children with ASD in the first month of pregnancy (P1; 779.0 ± 36.1 and 655.0 ± 28.7 μg, respectively; P < 0.01). A mean daily folic acid intake of ≥600 μg (compared with <600 μg) during P1 was associated with reduced ASD risk (adjusted OR: 0.62; 95% CI: 0.42, 0.92; P = 0.02), and risk estimates decreased with increased folic acid (P-trend = 0.001). The association between folic acid and reduced ASD risk was strongest for mothers and children with MTHFR 677 C>T variant genotypes. A trend toward an association between lower maternal folic acid intake during the 3 mo before pregnancy and DD was observed, but not after adjustment for confounders.Conclusions Periconceptional folic acid may reduce ASD risk in those with inefficient folate metabolism. The replication of these findings and investigations of mechanisms involved are warranted.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Studies indicate prenatal vitamin supplementation close to delivery might reduce the risk of autism in offspring, with folate (vitamin, B9, folic acid, folacin) receiving considerable attention [231–233].”
From The contribution of environmental exposure to the etiology of autism spectrum disorder (2019) · cites this paper as [232]
In the citing paper
“Diverse environmental factors have been implicated as risk factors for ASD, including maternal stress and drug use, paternal age, nutritional status, hormones, and environmental chemicals [ 14 , 25–29 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [26]
In the citing paper
“Another attenuating influence may be negative confounding by nutrients in the fruit and vegetables that contribute pesticides, which could counter-balance the toxic impact of the pesticide given some evidence that nutrients like folate are associated with reduced risk for autism.”
From Environmental Chemical Exposures and Autism Spectrum Disorders: A Review of the Epidemiological Evidence (2014) · cites this paper as [141]
In the citing paper
“as expected given that periconceptional folic acid is associated with reduced ASD risk (35, 69)”
From Maternal Intake of Supplemental Iron and Risk of Autism Spectrum Disorder (2014) · cites this paper as [35]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hapeman, D. E., & Agresti, A. (1991) · Technometrics · doi:10.1080/00401706.1991.10484817 · Cited by 9,407
Lord, C., Rutter, M., & Le Couteur, A. (1994) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02172145 · Cited by 9,065
Agresti, A. (2002) · Wiley Series in Probability and Statistics · doi:10.1002/0471249688 · Cited by 6,746
Analysis of Incomplete Multivariate Data
Schafer, J. L. (1997) · doi:10.1201/9781439821862 · Cited by 6,012
Analysis of Incomplete Multivariate Data
Booth, D. E., & Schafer, J. L. (2000) · Technometrics · doi:10.2307/1271466 · Cited by 5,627
Equivalence of the Mediation, Confounding and Suppression Effect
MacKinnon, D. P., Krull, J. L., & Lockwood, C. M. (2000) · Prevention Science · doi:10.1023/a:1026595011371 · Cited by 4,188
Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study
(1991) · The Lancet · doi:10.1016/0140-6736(91)90133-a · Cited by 3,472
Prevention of neural tube defects: Results of the Medical Research Council vitamin study
Wald, N., Sneddon, J., Densem, J. W., Frost, C. D., & Stone, R. (1992) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(92)90076-u · Cited by 2,364
Genomic imprinting: parental influence on the genome
Reik, W., & Walter, J. (2001) · Nature Reviews Genetics · doi:10.1038/35047554 · Cited by 2,288
(2010) · Sage eBooks · doi:10.4135/9781412961288.n40 · Cited by 2,028
Flagged first, then by citations
1 of the 70 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- 1996, Food standards: amendment of standards of identity for enriched grain products to require addition of folic acid, Fed Regist, 61, 8781
- Sparrow SS, Balla DA, Cicchetti DV. Vineland Adaptive Behavior Scales: interview edition, expanded form manual. Circle Pines, MN: American Guidance Services Inc, 1984.
- Schmidt, 2011, Prenatal vitamins, one-carbon metabolism gene variants, and risk for autism, Epidemiology, 22, 476, 10.1097/EDE.0b013e31821d0e30 · DOI · Paper page
Cited by
Sorted by citations
Items 101–200 of 407
An Update on Maternal Use of Antiepileptic Medications in Pregnancy and Neurodevelopment Outcomes
Meador, K. J., & Gerard, E. E. (2015) · Journal of Pediatric Genetics · doi:10.1055/s-0035-1556741 · Cited by 59
Liu, X., Zou, M., Sun, C., Wu, L., & Chen, W.-X. (2022) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-021-04951-8 · Cited by 58
Epigenetics, nutrition and mental health. Is there a relationship?
Stevens, A. J., Rucklidge, J. J., & Kennedy, M. A. (2017) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1331524 · Cited by 61
Bennett, D. H., Busgang, S. A., Kannan, K., Parsons, P. J., Takazawa, M., Palmer, C. D., Schmidt, R. J., Doucette, J. T., Schweitzer, J. B., Gennings, C., et al. (2022) · Environment International · doi:10.1016/j.envint.2021.107075 · Cited by 61
Self-citationCristiano, C., Lama, A., Lembo, F., Mollica, M. P., Calignano, A., & Raso, G. M. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00184 · Cited by 60
Chen, H., Qin, L., Gao, R., Jin, X., Cheng, K., Zhang, S., Hu, X., Xu, W., & Wang, H. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1993781 · Cited by 59
Folinic acid improves the score of Autism in the EFFET placebo-controlled randomized trial
Renard, É., Leheup, B., Guéant‐Rodriguez, R., Oussalah, A., Quadros, E. V., & Guéant, J. (2020) · Biochimie · doi:10.1016/j.biochi.2020.04.019 · Cited by 55
Nutrient Intake Values for Folate during Pregnancy and Lactation Vary Widely around the World
Stamm, R. A., & Houghton, L. A. (2013) · Nutrients · doi:10.3390/nu5103920 · Cited by 55
Cerebral Folate Deficiency Syndrome: Early Diagnosis, Intervention and Treatment Strategies
Ramaekers, V. T., & Quadros, E. V. (2022) · Nutrients · doi:10.3390/nu14153096 · Cited by 54
Environmental Risk Factors in Autism Spectrum Disorder: A Narrative Review
Yenkoyan, K. B., Mkhitaryan, M., & Bjørklund, G. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673252471231121045529 · Cited by 59
Interpregnancy Interval and Risk of Autistic Disorder
Gunnes, N., Surén, P., Bresnahan, M. A., Hornig, M., Lie, K. K., Lipkin, W. I., Magnus, P. M., Nilsen, R. M., Reichborn‐Kjennerud, T., Schjølberg, S., et al. (2013) · Epidemiology · doi:10.1097/01.ede.0000434435.52506.f5 · Cited by 53
Barkoski, J. M., Busgang, S. A., Bixby, M., Bennett, D. H., Schmidt, R. J., Barr, D. B., Panuwet, P., Gennings, C., & Hertz‐Picciotto, I. (2019) · Environmental Research · doi:10.1016/j.envres.2019.108719 · Cited by 55
Self-citationMaternal oversupplementation with folic acid and its impact on neurodevelopment of offspring
Murray, L. K., Smith, M. J., & Jadavji, N. M. (2018) · Nutrition Reviews · doi:10.1093/nutrit/nuy025 · Cited by 53
Braun, J. M., Froehlich, T. E., Kalkbrenner, A. E., Pfeiffer, C. M., Fazili, Z., Yolton, K. A., & Lanphear, B. P. (2014) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-014-2114-x · Cited by 56
A prospective birth cohort study on cord blood folate subtypes and risk of autism spectrum disorder
Raghavan, R., Selhub, J., Paul, L., Ji, Y., Wang, G., Hong, X., ZUCKERMAN, B. S., Fallin, M. D., & Wang, X. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa208 · Cited by 56
Safe use of high intakes of folic acid: research challenges and paths forward
Boyles, A. L., Yetley, E. A. D., Thayer, K. A., & Coates, P. M. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw015 · Cited by 51
Merging Data from Genetic and Epigenetic Approaches to Better Understand Autistic Spectrum Disorder
Grayson, D. R., & Guidotti, A. (2015) · Epigenomics · doi:10.2217/epi.15.92 · Cited by 51
Increased Risk of Autism Spectrum Disorders at Short and Long Interpregnancy Intervals in Finland
Cheslack‐Postava, K., Suominen, A., Jokiranta‐Olkoniemi, E., Lehti, V., McKeague, I. W., Sourander, A., & Brown, A. S. (2014) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2014.06.009 · Cited by 48
Treatment of Folate Metabolism Abnormalities in Autism Spectrum Disorder
Frye, R. E., Rossignol, D. A., Scahill, L. D., McDougle, C. J., Huberman, H. S., & Quadros, E. V. (2020) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2020.100835 · Cited by 48
Girotto, F., Scott, L. O. M., Avchalumov, Y., Harris, J. K., Iannattone, S., Drummond-Main, C., Tobias, R., Bello‐Espinosa, L. E., Rho, J. M., Davidsen, J., et al. (2013) · Scientific Reports · doi:10.1038/srep01465 · Cited by 47
Schaevitz, L. R., Berger-Sweeney, J. E., & Ricceri, L. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.04.007 · Cited by 50
Eryilmaz, H., Dowling, K. F., Huntington, F. C., Rodriguez-Thompson, A., Soare, T. W., Beard, L. M., Lee, H., Blossom, J. C., Gollub, R. L., Susser, E., et al. (2018) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2018.1381 · Cited by 46
Autism spectrum disorder in children born preterm—role of exposure to perinatal inflammation
Meldrum, S. J., Strunk, T., Currie, A. J., Prescott, S. L., Simmer, K. N., & Whitehouse, A. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00123 · Cited by 48
Nuttall, J. R. (2015) · Nutritional Neuroscience · doi:10.1080/1028415x.2015.1103437 · Cited by 54
Schmidt, R. J., Niu, Q., Eyles, D. W., Hansen, R. L., & Iosif, A. (2019) · Autism Research · doi:10.1002/aur.2118 · Cited by 43
Self-citationEtiopathogenesis of autism spectrum disorders: Fitting the pieces of the puzzle together
Gentile, I., Zappulo, E., Militerni, R., Pascotto, A., Borgia, G., & Bravaccio, C. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2013.04.002 · Cited by 44
Pedersen, L., Parlar, S., Kvist, K., Whiteley, P., & Shattock, P. (2013) · Nutritional Neuroscience · doi:10.1179/1476830513y.0000000082 · Cited by 48
Chmielewska, A., Dziechciarz, P., Gieruszczak‐Białek, D., Horvath, A., Pieścik‐Lech, M., Ruszczyński, M., Skórka, A., & Szajewska, H. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114514004243 · Cited by 43
Desai, A., Sequeira, J. M., & Quadros, E. V. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.153 · Cited by 43
Tisato, V., Silva, J. A., Longo, G., Gallo, I., Singh, A. V., Milani, D., & Gemmati, D. (2021) · Genes · doi:10.3390/genes12050782 · Cited by 45
The basis for folinic acid treatment in neuro-psychiatric disorders
Ramaekers, V. T., Sequeira, J. M., & Quadros, E. V. (2016) · Biochimie · doi:10.1016/j.biochi.2016.04.005 · Cited by 43
Barkoski, J. M., Philippat, C., Tancredi, D. J., Schmidt, R. J., Ozonoff, S. J., Barr, D. B., Elms, W., Bennett, D. H., & Hertz‐Picciotto, I. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110495 · Cited by 45
Self-citationBatebi, N., Moghaddam, H. S., Hasanzadeh, A., Fakour, Y., Mohammadi, M. R., & Akhondzadeh, S. (2020) · Child Psychiatry & Human Development · doi:10.1007/s10578-020-01072-8 · Cited by 47
Folate status and health: challenges and opportunities
Obeid, R., Oexle, K., Rißmann, A., Pietrzik, K. F., & Koletzko, B. V. (2015) · Journal of Perinatal Medicine · doi:10.1515/jpm-2014-0346 · Cited by 44
Sadeghiyeh, T., Dastgheib, S. A., Khoram-Abadi, K. M., Morovati-Sharifabad, M., Akbarian-Bafghi, M. J., Poursharif, Z., Mirjalili, S. R., & Neámatzadeh, H. (2019) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2019.09.016 · Cited by 40
SILVA, C. V. D., Keating, E., & Pinto, E. C. B. (2017) · Porto Biomedical Journal · doi:10.1016/j.pbj.2017.05.006 · Cited by 39
Role of environmental factors and epigenetics in autism spectrum disorders
Saxena, R., Babadi, M., Namvarhaghighi, H., & Roullet, F. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.05.002 · Cited by 40
Agam, G., Taylor, Z. V., Vainer, E., & Golan, H. M. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01002-1 · Cited by 41
Pregnancy risk factors in autism: a pilot study with artificial neural networks
Grossi, E., Veggo, F., Narzisi, A., Compare, A., & Muratori, F. (2015) · Pediatric Research · doi:10.1038/pr.2015.222 · Cited by 36
Environmental risk factors for autism spectrum disorders
Liu, L., Zhang, D. X., Rodzinka-pasko, J. K., & Li, Y. (2016) · Der Nervenarzt · doi:10.1007/s00115-016-0172-3 · Cited by 39
Iglesias‐Vázquez, L., Canals, J., & Arija, V. (2018) · Acta Paediatrica · doi:10.1111/apa.14657 · Cited by 41
Choline, folic acid, Vitamin D, and fetal brain development in the psychosis spectrum
Freedman, R., Hunter, S. K., Law, A. J., Clark, A. M., Roberts, A., & Hoffman, M. C. (2021) · Schizophrenia Research · doi:10.1016/j.schres.2021.03.008 · Cited by 36
Current controversies in the relationships between autism and epilepsy
Besag, F. (2015) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2015.05.032 · Cited by 32
Knowledge, attitude and practice regarding folic acid deficiency; A hidden hunger
Hisam, A., Rahman, M. U., & Mashhadi, S. F. (2014) · Pakistan Journal of Medical Sciences · doi:10.12669/pjms.303.4716 · Cited by 32
Increased Dietary Intake of Vitamin A Promotes Aortic Valve Calcification In Vivo
Huk, D. J., Hammond, H. L., Kegechika, H., & Lincoln, J. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300388 · Cited by 34
Kaplan, Z. B., Pearce, E. N., Lee, S. Y., Shin, H., & Schmidt, R. J. (2023) · Thyroid · doi:10.1089/thy.2023.0391 · Cited by 34
Self-citationRamaekers, V. T., Sequeira, J. M., DiDuca, M., Vrancken, G., Thomas, A., Philippe, C., Peters, M., Jadot, A., & Quadros, E. V. (2019) · Autism Research and Treatment · doi:10.1155/2019/7486431 · Cited by 31
Antony, A. C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-35762-3.00039-1 · Cited by 32
Fujisawa, Y., Napoli, E., Wong, S., Song, G., Yamaguchi, R., Matsui, T., Nagasaki, K., Ogata, T., & Giulivi, C. (2014) · BBA Clinical · doi:10.1016/j.bbacli.2014.12.003 · Cited by 30
Schmidt, R. J., Schroeder, D. I., Crary-Dooley, F. K., Barkoski, J. M., Tancredi, D. J., Walker, C. K., Ozonoff, S. J., Hertz‐Picciotto, I., & LaSalle, J. M. (2016) · Current Zoology · doi:10.1093/eep/dvw024 · Cited by 31
Self-citationStrøm, M., Granström, C., Lyall, K., Ascherio, A., & Olsen, S. F. (2017) · Psychological Medicine · doi:10.1017/s0033291717002410 · Cited by 33
Chu, D., Li, L., Jiang, Y., Jianxin, T., Ji, J., Zhang, Y., Jin, N., & Liu, F. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00313 · Cited by 32
Cohort-guided insights into gene–environment interactions in autism spectrum disorders
Lipkin, W. I., Bresnahan, M. A., & Susser, E. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-022-00764-0 · Cited by 35
Maternal Race–Ethnicity, Immigrant Status, Country of Birth, and the Odds of a Child With Autism
Fairthorne, J., de Klerk, N. H., Leonard, H., Schieve, L. A., & Yeargin‐Allsopp, M. (2017) · Child Neurology Open · doi:10.1177/2329048x16688125 · Cited by 34
Graaff, J. S., Roza, S. J., Walstra, A. N., Marroun, H. E., Steegers, E. A. P., Jaddoe, V. W. V., Albert Hofman, D., Verhulst, F. C., Tiemeier, H. W., & White, T. J. H. (2015) · Zeitschrift für Ernährungswissenschaft · doi:10.1007/s00394-015-1058-z · Cited by 29
Prevention in Autism Spectrum Disorder: A Lifelong Focused Approach
Francis, K., Karantanos, G., Al-Ozairi, A., & AlKhadhari, S. (2021) · Brain Sciences · doi:10.3390/brainsci11020151 · Cited by 33
The Role of Genetics, Epigenetics, and the Environment in ASD: A Mini Review
Khogeer, A., Abumansour, I. S., & Mohammed, D. A. (2022) · Epigenomes · doi:10.3390/epigenomes6020015 · Cited by 30
Li, W., Li, Z., Li, S., Wang, X., Wilson, J. X., & Huang, G. (2018) · Nutrients · doi:10.3390/nu10030292 · Cited by 28
Impact of Maternal Stress in Pregnancy on Brain Function of the Offspring
Udagawa, J., & Hino, K. (2016) · Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) · doi:10.1265/jjh.71.188 · Cited by 29
Placental DNA methylation profile as predicting marker for autism spectrum disorder (ASD)
Ravaei, A., Emanuele, M., Nazzaro, G., Fadiga, L., & Rubini, M. (2023) · Molecular Medicine · doi:10.1186/s10020-022-00593-3 · Cited by 31
Oxidative Stress, Folate Receptor Autoimmunity, and CSF Findings in Severe Infantile Autism
Ramaekers, V. T., Sequeira, J. M., Thöny, B., & Quadros, E. V. (2020) · Autism Research and Treatment · doi:10.1155/2020/9095284 · Cited by 26
Sotelo-Orozco, J., Abbeduto, L., Hertz‐Picciotto, I., & Slupsky, C. M. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.579538 · Cited by 25
Self-citationHigh prevalence of serum folate receptor autoantibodies in children with autism spectrum disorders
Zhou, J., Liu, A., He, F., Jin, Y., Zhou, S., Xu, R., Guo, H., Zhou, W., Wei, Q., & Wang, M. (2018) · Biomarkers · doi:10.1080/1354750x.2018.1458152 · Cited by 26
Environment and autism: current state of the science
Schmidt, R. J., Lyall, K., & Hertz‐Picciotto, I. (2014) · Cutting Edge Psychiatry in Practice · doi:10.65031/ibek1613 · Cited by 24
Self-citationDevelopmental exposure to vitamin D deficiency and subsequent risk of schizophrenia
Albiñana, C., Boelt, S. G., Cohen, A. S., Zhu, Z., Musliner, K. L., Vilhjálmsson, B. J., & McGrath, J. J. (2021) · Schizophrenia Research · doi:10.1016/j.schres.2021.06.004 · Cited by 24
Vanya, M., Szücs, S., Vetró, Á., & Bártfai, G. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.12.007 · Cited by 24
Periconceptional folate deficiency leads to autism-like traits in Wistar rat offspring
Degroote, S., Hunting, D. J., & Takser, L. (2018) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2017.12.008 · Cited by 24
Medicines associated with folate–homocysteine–methionine pathway disruption
Jarc-Vidmar, M., Grželj, J., Mlinarič‐Raščan, I., Geršak, K., & Dolenc, M. S. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2364-z · Cited by 24
Vitamins, Vascular Health and Disease
Ayoub, G. (2025) · Nutrients · doi:10.3390/nu17182955 · Cited by 22
Altered metabolism of mothers of young children with Autism Spectrum Disorder: a case control study
Hollowood-Jones, K., Adams, J. B., Coleman, D. M., Ramamoorthy, S., Melnyk, S., James, S. J., Woodruff, B. K., Pollard, E. L., Snozek, C. L. H., Krüger, U., et al. (2020) · BMC Pediatrics · doi:10.1186/s12887-020-02437-7 · Cited by 24
The Expanding Genomic Landscape of Autism: Discovering the ‘Forest‘ Beyond the ‘Trees‘
Hu, V. W. (2012) · Future Neurology · doi:10.2217/fnl.12.83 · Cited by 25
Brieger, K. K., Bakulski, K. M., Pearce, C. L., Baylín, A., Dou, J., Feinberg, J. I., Croen, L., Hertz‐Picciotto, I., Newschaffer, C. J., Fallin, M. D., et al. (2021) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-021-05110-9 · Cited by 23
Self-citationMoser, S. S., Davidovitch, M., Rotem, R. S., Chodick, G., Shalev, V., & Koren, G. (2019) · Reproductive Toxicology · doi:10.1016/j.reprotox.2019.07.083 · Cited by 23
Environmental Risk Factors for Autism
Mathew, L., Kauffman, E. M., Schmidt, R. J., Hertz‐Picciotto, I., & Lyall, K. (2021) · Springer eBooks · doi:10.1007/978-3-319-91280-6_102054 · Cited by 23
Self-citationShin, H., Oh, J., Schmidt, R. J., & Pearce, E. N. (2022) · Endocrinology and Metabolism · doi:10.3803/enm.2022.1598 · Cited by 21
Self-citationVargason, T., Krüger, U., Roth, E., Delhey, L. M., Tippett, M., Rose, S., Bennuri, S. C., Slattery, J. C., Melnyk, S., James, S. J., et al. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00503 · Cited by 21
Chen, S., Alhassen, W., Yoshimura, R. F., Silva, A. D., Abbott, G. W., Baldi, P., & Alachkar, A. (2020) · Communications Biology · doi:10.1038/s42003-020-01124-8 · Cited by 21
Slattery, J., MacFabe, D., Kahler, S., & Frye, R. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666160905123953 · Cited by 20
Transtorno do espectro autista e a suplementação por ácido fólico antes e durante a gestação
Maia, C. S., de Menezes, K. M. C., Tenório, F. D. C. Â. M., Júnior, J. R. A. D. Q., & Maciel, G. E. D. S. (2019) · Jornal Brasileiro de Psiquiatria · doi:10.1590/0047-2085000000251 · Cited by 22
Joyce, E. E., Chavarro, J. E., Rando, J., Song, A., Croen, L., Fallin, M. D., Hertz‐Picciotto, I., Schmidt, R. J., Volk, H. E., Newschaffer, C. J., et al. (2022) · Autism Research · doi:10.1002/aur.2698 · Cited by 20
Self-citationAntenatal determinants of early childhood talking delay and behavioural difficulties
D’Souza, S., Crawford, C. N., Buckley, J., Underwood, L., Peterson, E. R., Bird, A. L., Morton, S., & Waldie, K. E. (2019) · Infant Behavior and Development · doi:10.1016/j.infbeh.2019.101388 · Cited by 23
Maternal folic acid supplements associated with reduced autism risk in the child
Schmidt, R. J. (2013) · BMJ Evidence-Based Medicine · doi:10.1136/eb-2013-101311 · Cited by 20
Self-citationPericonceptional Folic Acid and Risk of Autism Spectrum Disorders
Berry, R. J., Crider, K. S., & Yeargin‐Allsopp, M. (2013) · JAMA · doi:10.1001/jama.2013.198 · Cited by 20
Parenti, M., & Slupsky, C. M. (2024) · Advances in Nutrition · doi:10.1016/j.advnut.2024.100279 · Cited by 19
Vanegas, S. B. (2021) · Autism Research · doi:10.1002/aur.2489 · Cited by 28
Tasew, S., Mekonnen, H., & Goshu, A. T. (2021) · SAGE Open Medicine · doi:10.1177/20503121211049121 · Cited by 19
Cochrane, K. M., Elango, R., Devlin, A. M., Mayer, C., Hutcheon, J. A., & Karakochuk, C. D. (2023) · British Journal Of Nutrition · doi:10.1017/s0007114523001733 · Cited by 19
Autism, seasonality and the environmental perturbation of epigenome related vitamin levels
Lucock, M. D., & Leeming, R. J. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2013.03.003 · Cited by 19
Coucouvanis, J., Hallas, D. M., & Farley, J. N. (2012) · Wiley eBooks · doi:10.1002/9781118704660.ch13 · Cited by 19
Decoding the genetic landscape of autism: A comprehensive review
Al‐Beltagi, M., Saeed, N. K., Bediwy, A. S., Bediwy, E. A., & Elbeltagi, R. M. (2024) · World Journal of Clinical Pediatrics · doi:10.5409/wjcp.v13.i3.98468 · Cited by 23
Vellingiri, B., Mahalaxmi, I., Neethu, R., Arul, N., & Abhilash, V. G. (2022) · Neurology Perspectives · doi:10.1016/j.neurop.2022.01.002 · Cited by 21
Autism, Mitochondria and Polybrominated Diphenyl Ether Exposure
Wong, S., & Giulivi, C. (2016) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527315666160413122624 · Cited by 18
McKay, J. A., Adriaens, M. E., Evelo, C. T., Ford, D., & Mathers, J. C. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600079 · Cited by 18
Zhu, Y., Mordaunt, C. E., Durbin-Johnson, B. P., Caudill, M. A., Malysheva, O., Miller, J. W., Green, R., James, S. J., Melnyk, S. B., Fallin, M. D., et al. (2020) · Autism Research · doi:10.1002/aur.2428 · Cited by 22
Self-citationPediatric Environmental Health Specialty Units: An Analysis of Operations
Woolf, A. D., Sibrizzi, C. A., & Kirkland, K. (2015) · Academic Pediatrics · doi:10.1016/j.acap.2015.05.006 · Cited by 18
The Relationship between Folic Acid and Risk of Autism Spectrum Disorders
Neggers, Y. H. (2014) · Healthcare · doi:10.3390/healthcare2040429 · Cited by 19
Guo, B., Li, H., Zhai, D., & Ding, S.-B. (2019) · Nutrition Research · doi:10.1016/j.nutres.2019.02.003 · Cited by 19
Overview of the Role of Environmental Factors in Neurodevelopmental Disorders
Lein, P. J. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800228-5.00001-7 · Cited by 20
Vecchione, R., Vigna, C., Whitman, C., Kauffman, E. M., Braun, J. M., Chen, A., Xu, Y. Y., Hamra, G. B., Lanphear, B. P., Yolton, K. A., et al. (2020) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-020-04546-9 · Cited by 17
Self-citationDi, Y., Li, Z., Li, J., Cheng, Q., Zheng, Q., Zhai, C., Kang, M., Wei, C., Lan, J., Fan, J., et al. (2021) · Food & Function · doi:10.1039/d0fo02926b · Cited by 17
Metadata
- Authors
- Schmidt, R. J., Tancredi, D. J., Ozonoff, S., Hansen, R. L., Hartiala, J., Allayee, H., Schmidt, L. C., Tassone, F., & Hertz-Picciotto, I.
- Affiliations
- University of California, Davis (US)
- University of Southern California (US)
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 96
- Issue
- 1
- Pages
- 80-89
- ISSN
- 0002-9165 (ISSN-L)
- PMC
- PMC3374734
- OpenAlex
- W2156287076
- Cited by
- 408
- References
- 70
- Citations by year
- 2026: 21 · 2025: 17 · 2024: 22 · 2023: 19 · 2022: 14 · 2021: 29 · 2020: 35 · 2019: 34 · 2018: 33 · 2017: 35 · 2016: 42 · 2015: 28 · 2014: 42 · 2013: 30 · 2012: 7
- FWCI
- 26.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Environmental Protection Agency (R-829388, R-833292, 829388)
- National Institutes of Health
- National Institute of Mental Health (T32MH073124)
- National Institute of Environmental Health Sciences (P01-ES-11269, R01-ES015359-03S1, R01ES015359, P01ES011269)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12-HD051958-06, K12HD051958)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Keywords
- periconceptional period, autism spectrum disorder, developmental delay, MTHFR 677 C>T polymorphism, folate metabolism, brain development, prenatal supplementation
- MeSH terms
- California, Developmental Disabilities, Child Development Disorders, Pervasive, Child, Preschool, Diet, Female, Folic Acid, Folic Acid Deficiency, Food, Fortified, Humans, Infant, Male, Pregnancy, Pregnancy Complications, Pregnancy Trimester, First, Risk, Confounding Factors, Epidemiologic, Case-Control Studies, Dietary Supplements, Polymorphism, Single Nucleotide, Maternal Nutritional Physiological Phenomena, Methylenetetrahydrofolate Reductase (NADPH2), Genetic Association Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
